{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:16:52Z","timestamp":1792628212495,"version":"4.5.0"},"reference-count":114,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,11,18]],"date-time":"2019-11-18T00:00:00Z","timestamp":1574035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001349","name":"National Medical Research Council of Singapore","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Tanoto Foundation"},{"name":"Swedish National Research Council"},{"name":"Wallenberg Foundation"}],"content-domain":{"domain":["bmn.com","cell.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Cell Biology"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.tcb.2019.10.001","type":"journal-article","created":{"date-parts":[[2019,11,5]],"date-time":"2019-11-05T05:48:15Z","timestamp":1572932895000},"page":"987-1000","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":141,"title":["Laminins in Cellular Differentiation"],"prefix":"10.1016","volume":"29","author":[{"given":"Lynn","family":"Yap","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hwee Goon","family":"Tay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mien T.X.","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica S.","family":"Tjin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Tryggvason","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tcb.2019.10.001_bib1","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1126\/science.282.5391.1145","article-title":"Embryonic stem cell lines derived from human blastocysts","volume":"282","author":"Thomson","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.tcb.2019.10.001_bib2","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.cell.2006.07.024","article-title":"Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors","volume":"126","author":"Takahashi","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.tcb.2019.10.001_bib3","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/nbt.1620","article-title":"Long-term self-renewal of human pluripotent stem cells on human recombinant laminin-511","volume":"28","author":"Rodin","year":"2010","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.tcb.2019.10.001_bib4","article-title":"Clonal culturing of human embryonic stem cells on laminin-521\/E-cadherin matrix in defined and xeno-free environment","volume":"3195","author":"Rodin","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tcb.2019.10.001_bib5","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.stem.2014.09.017","article-title":"Human ESC-derived dopamine neurons show similar preclinical efficacy and potency to fetal neurons when grafted in a rat model of Parkinson's disease","volume":"15","author":"Grealish","year":"2014","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.tcb.2019.10.001_bib6","doi-asserted-by":"crossref","first-page":"e30","DOI":"10.1161\/CIRCRESAHA.108.192237","article-title":"Functional cardiomyocytes derived from human induced pluripotent stem cells","volume":"104","author":"Zhang","year":"2009","journal-title":"Circ. Res."},{"key":"10.1016\/j.tcb.2019.10.001_bib7","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.stemcr.2015.09.011","article-title":"Comparison of human embryonic stem cell-derived cardiomyocytes, cardiovascular progenitors, and bone marrow mononuclear cells for cardiac repair","volume":"5","author":"Fernandes","year":"2015","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.tcb.2019.10.001_bib8","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/nbt.4162","article-title":"Human embryonic stem cell-derived cardiomyocytes restore function in infarcted hearts of non-human primates","volume":"36","author":"Liu","year":"2018","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.tcb.2019.10.001_bib9","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.cell.2014.09.040","article-title":"Generation of functional human pancreatic beta cells in\u00a0vitro","volume":"159","author":"Pagliuca","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.tcb.2019.10.001_bib10","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.stemcr.2013.12.007","article-title":"Characterization of human induced pluripotent stem cell-derived retinal pigment epithelium cell sheets aiming for clinical application","volume":"2","author":"Kamao","year":"2014","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.tcb.2019.10.001_bib11","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1038\/ncomms3307","article-title":"Repopulation of decellularized mouse heart with human induced pluripotent stem cell-derived cardiovascular progenitor cells","volume":"4","author":"Lu","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tcb.2019.10.001_bib12","doi-asserted-by":"crossref","first-page":"3231","DOI":"10.1016\/j.celrep.2019.02.083","article-title":"In\u00a0vivo generation of post-infarct human cardiac muscle by laminin-promoted cardiovascular progenitors","volume":"26","author":"Yap","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.tcb.2019.10.001_bib13","doi-asserted-by":"crossref","first-page":"jcs203950","DOI":"10.1242\/jcs.203950","article-title":"The triple helix of collagens \u2013 an ancient protein structure that enabled animal multicellularity and tissue evolution","volume":"131","author":"Fidler","year":"2018","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.tcb.2019.10.001_bib14","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1146\/annurev-cellbio-101011-155750","article-title":"Functional diversity of laminins","volume":"28","author":"Domogatskaya","year":"2012","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.tcb.2019.10.001_bib15","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1084\/jem.145.1.204","article-title":"A murine tumor producing a matrix of basement membrane","volume":"145","author":"Orkin","year":"1977","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.tcb.2019.10.001_bib16","doi-asserted-by":"crossref","first-page":"9933","DOI":"10.1016\/S0021-9258(19)83607-4","article-title":"Laminin \u2013 a glycoprotein from basement membranes","volume":"254","author":"Timpl","year":"1979","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.tcb.2019.10.001_bib17","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1111\/1523-1747.ep12323451","article-title":"Rapid spreading and mature hemidesmosome formation in HaCaT keratinocytes induced by incubation with soluble laminin-5r","volume":"105","author":"Hormia","year":"1995","journal-title":"J.\u00a0Invest. Dermatol."},{"key":"10.1016\/j.tcb.2019.10.001_bib18","doi-asserted-by":"crossref","first-page":"10189","DOI":"10.1073\/pnas.94.19.10189","article-title":"The alpha chain of laminin-1 is independently secreted and drives\u00a0secretion of its beta- and gamma-chain partners","volume":"94","author":"Yurchenco","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.tcb.2019.10.001_bib19","doi-asserted-by":"crossref","first-page":"14853","DOI":"10.1074\/jbc.275.20.14853","article-title":"Recombinant laminin-8 (alpha4beta1gamma1). Production, purification, and interactions with integrins","volume":"275","author":"Kortesmaa","year":"2000","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.tcb.2019.10.001_bib20","doi-asserted-by":"crossref","first-page":"12741","DOI":"10.1074\/jbc.M111228200","article-title":"Recombinant human laminin-10 (alpha5beta1gamma1). Production, purification,\u00a0and migration-promoting activity on vascular endothelial cells","volume":"277","author":"Doi","year":"2002","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.tcb.2019.10.001_bib21","first-page":"61","article-title":"Novel retina specific laminin isoforms recapitulate retinal interphotoreceptor matrix to generate human embryonic stem cell-derived photoreceptors","volume":"59","author":"Tay","year":"2018","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.tcb.2019.10.001_bib22","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1038\/nature04957","article-title":"The stem-cell niche as an entity of action","volume":"441","author":"Scadden","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.tcb.2019.10.001_bib23","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0092-8674(89)90987-2","article-title":"Domains of laminin with growth-factor activity","volume":"56","author":"Panayotou","year":"1989","journal-title":"Cell"},{"key":"10.1016\/j.tcb.2019.10.001_bib24","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/ejhf.422","article-title":"Cell-based therapies for cardiac repair: a meeting report on scientific observations and European regulatory viewpoints","volume":"18","author":"Schussler-Lenz","year":"2016","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.tcb.2019.10.001_bib25","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/nbt.3857","article-title":"A futile cycle in cell therapy","volume":"35","author":"Editorial","year":"2017","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.tcb.2019.10.001_bib26","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/s41587-019-0042-1","article-title":"Regenerating the field of cardiovascular cell therapy","volume":"37","author":"Chien","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.tcb.2019.10.001_bib27","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1016\/j.celrep.2019.01.079","article-title":"Single-cell transcriptome analysis maps the developmental track of the human heart","volume":"26","author":"Cui","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.tcb.2019.10.001_bib28","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.matbio.2017.11.009","article-title":"Laminin-deficient muscular dystrophy: molecular pathogenesis and structural repair strategies","volume":"71-72","author":"Yurchenco","year":"2018","journal-title":"Matrix Biol."},{"key":"10.1016\/j.tcb.2019.10.001_bib29","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/ng1095-216","article-title":"Mutations in the laminin alpha 2-chain gene (LAMA2) cause merosin-deficient congenital muscular dystrophy","volume":"11","author":"Helbling-Leclerc","year":"1995","journal-title":"Nat. Genet."},{"key":"10.1016\/j.tcb.2019.10.001_bib30","doi-asserted-by":"crossref","first-page":"E1848","DOI":"10.1073\/pnas.1200250109","article-title":"Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling","volume":"109","author":"Lian","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.tcb.2019.10.001_bib31","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1161\/CIRCRESAHA.117.311578","article-title":"Lack of remuscularization following transplantation of human embryonic stem cell-derived cardiovascular progenitor cells in infarcted nonhuman primates","volume":"122","author":"Zhu","year":"2018","journal-title":"Circ. Res."},{"key":"10.1016\/j.tcb.2019.10.001_bib32","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.stemcr.2019.04.005","article-title":"Human embryonic stem cell-derived cardiomyocytes regenerate the infarcted pig heart but induce ventricular tachyarrhythmias","volume":"12","author":"Romagnuolo","year":"2019","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.tcb.2019.10.001_bib33","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1093\/eurheartj\/ehv189","article-title":"Human embryonic stem cell-derived cardiac progenitors for severe heart failure treatment: first clinical case report","volume":"36","author":"Menasche","year":"2015","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.tcb.2019.10.001_bib34","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.stemcr.2015.09.011","article-title":"Comparison of human embryonic stem cell-derived cardiomyocytes, cardiovascular progenitors, and bone marrow mononuclear cells for cardiac repair","volume":"5","author":"Fernandes","year":"2015","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.tcb.2019.10.001_bib35","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1006\/dbio.1997.8668","article-title":"Developmental regulation of the laminin alpha5 chain suggests a role in epithelial and endothelial cell maturation","volume":"189","author":"Sorokin","year":"1997","journal-title":"Dev. Biol."},{"key":"10.1016\/j.tcb.2019.10.001_bib36","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1128\/MCB.22.4.1194-1202.2002","article-title":"Deletion of the laminin alpha4 chain leads to impaired microvessel maturation","volume":"22","author":"Thyboll","year":"2002","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.tcb.2019.10.001_bib37","doi-asserted-by":"crossref","first-page":"35680","DOI":"10.1038\/srep35680","article-title":"Laminin-guided highly efficient endothelial commitment from human pluripotent stem cells","volume":"6","author":"Ohta","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tcb.2019.10.001_bib38","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.stemcr.2016.08.017","article-title":"Differentiation of human embryonic stem cells to endothelial progenitor cells on laminins in defined and xeno-free systems","volume":"7","author":"Nguyen","year":"2016","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.tcb.2019.10.001_bib39","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1038\/s41467-018-03337-2","article-title":"A systematic approach to the development of a safe live attenuated Zika vaccine","volume":"9","author":"Kwek","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tcb.2019.10.001_bib40","doi-asserted-by":"crossref","first-page":"6551","DOI":"10.1038\/s41598-017-06986-3","article-title":"Combinatorial extracellular matrix microenvironments for probing endothelial differentiation of human pluripotent stem cells","volume":"7","author":"Hou","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tcb.2019.10.001_bib41","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1083\/jcb.119.3.695","article-title":"The dermal-epidermal junction of human skin contains a novel laminin variant","volume":"119","author":"Marinkovich","year":"1992","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.tcb.2019.10.001_bib42","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1083\/jcb.119.3.679","article-title":"A truncated laminin chain homologous to the B2 chain: structure, spatial expression, and chromosomal assignment","volume":"119","author":"Kallunki","year":"1992","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.tcb.2019.10.001_bib43","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/ng0394-293","article-title":"Mutations in the gamma 2 chain gene (LAMC2) of kalinin\/laminin 5 in the junctional forms of epidermolysis bullosa","volume":"6","author":"Pulkkinen","year":"1994","journal-title":"Nat. Genet."},{"key":"10.1016\/j.tcb.2019.10.001_bib44","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/ng0394-299","article-title":"Herlitz's junctional epidermolysis bullosa is linked to mutations in the gene (LAMC2) for the gamma 2 subunit of nicein\/kalinin (LAMININ-5)","volume":"6","author":"Aberdam","year":"1994","journal-title":"Nat. Genet."},{"key":"10.1016\/j.tcb.2019.10.001_bib45","doi-asserted-by":"crossref","first-page":"135","DOI":"10.4161\/cam.22418","article-title":"Laminin 332 in junctional epidermolysis bullosa","volume":"7","author":"Kiritsi","year":"2013","journal-title":"Cell Adh. Migr."},{"key":"10.1016\/j.tcb.2019.10.001_bib46","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1242\/jcs.112.16.2615","article-title":"The alpha3 laminin subunit, alpha6beta4 and alpha3beta1 integrin coordinately regulate wound healing in cultured epithelial cells and in the skin","volume":"112","author":"Goldfinger","year":"1999","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.tcb.2019.10.001_bib47","doi-asserted-by":"crossref","first-page":"a004911","DOI":"10.1101\/cshperspect.a004911","article-title":"Basement membranes: cell scaffoldings and signaling platforms","volume":"3","author":"Yurchenco","year":"2011","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.tcb.2019.10.001_bib48","doi-asserted-by":"crossref","first-page":"17900","DOI":"10.1016\/S0021-9258(19)37127-3","article-title":"The anchoring filament protein kalinin is synthesized and secreted as a high molecular weight precursor","volume":"267","author":"Marinkovich","year":"1992","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.tcb.2019.10.001_bib49","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1083\/jcb.200208145","article-title":"Binding to EGF receptor of a laminin-5 EGF-like fragment liberated during MMP-dependent mammary gland involution","volume":"161","author":"Schenk","year":"2003","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.tcb.2019.10.001_bib50","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1083\/jcb.200208145","article-title":"Binding to EGF receptor of a laminin-5 EGF-like fragment liberated during MMP-dependent mammary gland involution","volume":"161","author":"Schenk","year":"2003","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.tcb.2019.10.001_bib51","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0014-4827(02)00028-9","article-title":"The role of \u03b13\u03b21 integrin in determining the supramolecular organization of laminin-5 in the extracellular matrix of keratinocytes","volume":"283","author":"deHart","year":"2003","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.tcb.2019.10.001_bib52","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1242\/jcs.112.16.2615","article-title":"The alpha3 laminin subunit, alpha6beta4 and alpha3beta1 integrin coordinately regulate wound healing in cultured epithelial cells and in the skin","volume":"112","author":"Goldfinger","year":"1999","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.tcb.2019.10.001_bib53","doi-asserted-by":"crossref","first-page":"31896","DOI":"10.1074\/jbc.M006379200","article-title":"Deposition of laminin 5 by keratinocytes regulates integrin adhesion and signaling","volume":"275","author":"Nguyen","year":"2000","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.tcb.2019.10.001_bib54","doi-asserted-by":"crossref","first-page":"43860","DOI":"10.1074\/jbc.M103404200","article-title":"Ligation of integrin alpha 3beta 1 by laminin 5 at the wound edge activates Rho-dependent adhesion of leading keratinocytes on collagen","volume":"47","author":"Nguyen","year":"2001","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.tcb.2019.10.001_bib55","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/sj.jid.5700505","article-title":"Integrin \u03b13\u03b21-dependent activation of FAK\/Src regulates Rac1-mediated keratinocyte polarization on laminin-5","volume":"127","author":"Choma","year":"2006","journal-title":"J.\u00a0Invest. Dermatol."},{"key":"10.1016\/j.tcb.2019.10.001_bib56","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1034\/j.1600-0625.2002.110501.x","article-title":"Laminin 10\/11: an alternative adhesive ligand for epidermal keratinocytes with a functional role in promoting proliferation and migration","volume":"11","author":"Pouliot","year":"2002","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.tcb.2019.10.001_bib57","doi-asserted-by":"crossref","first-page":"2400","DOI":"10.1093\/emboj\/cdg239","article-title":"Laminin-10 is crucial for hair morphogenesis","volume":"22","author":"Li","year":"2003","journal-title":"EMBO J."},{"key":"10.1016\/j.tcb.2019.10.001_bib58","doi-asserted-by":"crossref","first-page":"4432","DOI":"10.1038\/s41467-018-06934-3","article-title":"Biologically relevant laminin as chemically defined and fully human platform for human epidermal keratinocyte culture","volume":"9","author":"Tjin","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tcb.2019.10.001_bib59","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1083\/jcb.201409024","article-title":"Cell motion predicts human epidermal stemness","volume":"209","author":"Nanba","year":"2015","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.tcb.2019.10.001_bib60","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0092-8674(75)80001-8","article-title":"Serial cultivation of strains of human epidemal keratinocytes: the formation keratinizin colonies from single cell is","volume":"6","author":"Rheinwald","year":"1975","journal-title":"Cell"},{"key":"10.1016\/j.tcb.2019.10.001_bib61","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1097\/00007890-200012150-00009","article-title":"Long-term regeneration of human epidermis on third degree burns transplanted with autologous cultured epithelium grown on a fibrin matrix","volume":"70","author":"Ronfard","year":"2000","journal-title":"Transplantation"},{"key":"10.1016\/j.tcb.2019.10.001_bib62","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1056\/NEJMoa0905955","article-title":"Limbal stem-cell therapy and long-term corneal regeneration","volume":"363","author":"Rama","year":"2010","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.tcb.2019.10.001_bib63","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/nature24487","article-title":"Regeneration of the entire human epidermis using transgenic stem cells","volume":"551","author":"Hirsch","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.tcb.2019.10.001_bib64","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3389\/fphys.2012.00107","article-title":"Stem cell fate determination during development and regeneration of ectodermal organs","volume":"3","author":"Jimenez-Rojo","year":"2012","journal-title":"Front. Physiol."},{"key":"10.1016\/j.tcb.2019.10.001_bib65","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/nrneurol.2015.123","article-title":"Cell-based therapies for Parkinson disease-past insights and future potential","volume":"11","author":"Barker","year":"2015","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.tcb.2019.10.001_bib66","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1038\/nprot.2017.078","article-title":"Generation of high-purity human ventral midbrain dopaminergic progenitors for in\u00a0vitro maturation and intracerebral transplantation","volume":"12","author":"Nolbrant","year":"2017","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.tcb.2019.10.001_bib67","doi-asserted-by":"crossref","first-page":"e106","DOI":"10.1016\/S2214-109X(13)70145-1","article-title":"Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis","volume":"2","author":"Wong","year":"2014","journal-title":"Lancet Glob. Health"},{"key":"10.1016\/j.tcb.2019.10.001_bib68","doi-asserted-by":"crossref","DOI":"10.1167\/iovs.13-12757","article-title":"Dry age-related macular degeneration: mechanisms, therapeutic targets, and imaging","volume":"54","author":"Bowes Rickman","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.tcb.2019.10.001_bib69","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1159\/000431142","article-title":"Genetics in retinal diseases","volume":"55","author":"Riaz","year":"2016","journal-title":"Dev. Ophthalmol."},{"key":"10.1016\/j.tcb.2019.10.001_bib70","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1242\/jcs.1993.Supplement_17.27","article-title":"The retinal pigment epithelium: a versatile partner in vision","volume":"17","author":"Bok","year":"1993","journal-title":"J.\u00a0Cell Sci. Suppl."},{"key":"10.1016\/j.tcb.2019.10.001_bib71","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.stem.2018.05.013","article-title":"Regenerating eye tissues to preserve and restore vision","volume":"22","author":"Stern","year":"2018","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.tcb.2019.10.001_bib72","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/nbt.4114","article-title":"Phase 1 clinical study of an embryonic stem cell-derived retinal pigment epithelium patch in age-related macular degeneration","volume":"36","author":"da Cruz","year":"2018","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.tcb.2019.10.001_bib73","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.stemcr.2015.11.008","article-title":"Xeno-free and defined human embryonic stem cell-derived retinal pigment epithelial cells functionally integrate in a large-eyed preclinical model","volume":"6","author":"Plaza Reyes","year":"2016","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.tcb.2019.10.001_bib74","doi-asserted-by":"crossref","first-page":"329","DOI":"10.4103\/2008-322X.170354","article-title":"Extracellular matrix components regulate cellular polarity and tissue structure in the developing and mature retina","volume":"10","author":"Varshney","year":"2015","journal-title":"J.\u00a0Ophthalmic Vis. Res."},{"key":"10.1016\/j.tcb.2019.10.001_bib75","doi-asserted-by":"crossref","first-page":"6517","DOI":"10.1523\/JNEUROSCI.20-17-06517.2000","article-title":"Laminin expression in adult and developing retinae: evidence of two novel CNS laminins","volume":"20","author":"Libby","year":"2000","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.tcb.2019.10.001_bib76","doi-asserted-by":"crossref","first-page":"14535","DOI":"10.1021\/acs.analchem.8b04415","article-title":"Multiplexed label-free fractionation of peripheral blood mononuclear cells for identification of monocyte-platelet aggregates","volume":"90","author":"Tay","year":"2018","journal-title":"Anal. Chem."},{"key":"10.1016\/j.tcb.2019.10.001_bib77","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.stem.2018.08.014","article-title":"Regenerating eye tissues to preserve and restore vision","volume":"23","author":"Stern","year":"2018","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.tcb.2019.10.001_bib78","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1056\/NEJMoa0905955","article-title":"Limbal stem-cell therapy and long-term corneal regeneration","volume":"363","author":"Rama","year":"2010","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.tcb.2019.10.001_bib79","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1038\/s41556-019-0344-z","article-title":"Advances in stem cell research and therapeutic development","volume":"21","author":"De Luca","year":"2019","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.tcb.2019.10.001_bib80","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/0092-8674(75)90183-X","article-title":"Formation of a keratinizing epithelium in culture by a cloned cell line derived from a teratoma","volume":"6","author":"Rheinwald","year":"1975","journal-title":"Cell"},{"key":"10.1016\/j.tcb.2019.10.001_bib81","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.exer.2007.08.020","article-title":"Characterization of extracellular matrix components in the limbal epithelial stem cell compartment","volume":"85","author":"Schlotzer-Schrehardt","year":"2007","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.tcb.2019.10.001_bib82","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/stem.2191","article-title":"Cell adhesion molecules and stem cell-niche-interactions in the limbal stem cell niche","volume":"34","author":"Polisetti","year":"2016","journal-title":"Stem Cells"},{"key":"10.1016\/j.tcb.2019.10.001_bib83","doi-asserted-by":"crossref","first-page":"5152","DOI":"10.1038\/s41598-017-04916-x","article-title":"Laminin-511 and -521-based matrices for efficient ex\u00a0vivo-expansion of human limbal epithelial progenitor cells","volume":"7","author":"Polisetti","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tcb.2019.10.001_bib84","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1016\/j.celrep.2018.10.032","article-title":"Selective laminin-directed differentiation of human induced pluripotent stem cells into distinct ocular lineages","volume":"25","author":"Shibata","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.tcb.2019.10.001_bib85","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1186\/s13287-017-0738-4","article-title":"Xeno- and feeder-free differentiation of human pluripotent stem cells to two distinct ocular epithelial cell types using simple modifications of one method","volume":"8","author":"Hongisto","year":"2017","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.tcb.2019.10.001_bib86","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.stem.2018.05.016","article-title":"Stem cell therapies for treating diabetes: progress and remaining challenges","volume":"22","author":"Sneddon","year":"2018","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.tcb.2019.10.001_bib87","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.matbio.2018.03.018","article-title":"Culturing functional pancreatic islets on alpha5-laminins and curative transplantation to diabetic mice","volume":"70","author":"Sigmundsson","year":"2018","journal-title":"Matrix Biol."},{"key":"10.1016\/j.tcb.2019.10.001_bib88","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.mce.2012.01.020","article-title":"Proliferation and plasticity of human beta cells on physiologically occurring laminin isoforms","volume":"355","author":"Banerjee","year":"2012","journal-title":"Mol. Cell Endocrinol."},{"key":"10.1016\/j.tcb.2019.10.001_bib89","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1038\/nbt1259","article-title":"Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells","volume":"24","author":"D'Amour","year":"2006","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.tcb.2019.10.001_bib90","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.2337\/db12-0167","article-title":"Factors expressed by murine embryonic pancreatic mesenchyme enhance generation of insulin-producing cells from hESCs","volume":"62","author":"Guo","year":"2013","journal-title":"Diabetes"},{"key":"10.1016\/j.tcb.2019.10.001_bib91","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/nbt1393","article-title":"Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in\u00a0vivo","volume":"26","author":"Kroon","year":"2008","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.tcb.2019.10.001_bib92","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1038\/nbt.3033","article-title":"Reversal of diabetes with insulin-producing cells derived in\u00a0vitro from human pluripotent stem cells","volume":"32","author":"Rezania","year":"2014","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.tcb.2019.10.001_bib93","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.devcel.2006.01.015","article-title":"The vascular basement membrane: a niche for insulin gene expression and Beta cell proliferation","volume":"10","author":"Nikolova","year":"2006","journal-title":"Dev. Cell"},{"key":"10.1016\/j.tcb.2019.10.001_bib94","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.2337\/db11-1711","article-title":"Maturation of human embryonic stem cell-derived pancreatic progenitors into functional islets capable of treating pre-existing diabetes in mice","volume":"61","author":"Rezania","year":"2012","journal-title":"Diabetes"},{"key":"10.1016\/j.tcb.2019.10.001_bib95","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.stemcr.2018.01.040","article-title":"Functional beta cell mass from device-encapsulated hESC-derived pancreatic endoderm achieving metabolic control","volume":"10","author":"Robert","year":"2018","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.tcb.2019.10.001_bib96","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1038\/s41467-019-09404-6","article-title":"YAP inhibition enhances the differentiation of functional stem cell-derived insulin-producing beta cells","volume":"10","author":"Rosado-Olivieri","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tcb.2019.10.001_bib97","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1007\/s00125-013-2955-4","article-title":"Maturation and function of human embryonic stem cell-derived pancreatic progenitors in macroencapsulation devices following transplant into mice","volume":"56","author":"Bruin","year":"2013","journal-title":"Diabetologia"},{"key":"10.1016\/j.tcb.2019.10.001_bib98","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1002\/hep.21582","article-title":"Directed differentiation of human embryonic stem cells into functional hepatic cells","volume":"45","author":"Cai","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.tcb.2019.10.001_bib99","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1002\/hep.23506","article-title":"Generation of functional hepatocytes from human embryonic stem cells under chemically defined conditions that recapitulate liver development","volume":"51","author":"Touboul","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.tcb.2019.10.001_bib100","doi-asserted-by":"crossref","first-page":"141","DOI":"10.5966\/sctm.2013-0146","article-title":"Accurate prediction of\u00a0drug-induced liver injury using stem cell-derived populations","volume":"3","author":"Szkolnicka","year":"2014","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.tcb.2019.10.001_bib101","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/hep.23354","article-title":"Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells","volume":"51","author":"Si-Tayeb","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.tcb.2019.10.001_bib102","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/s12015-011-9330-y","article-title":"Differentiation and transplantation of human induced pluripotent stem cell-derived hepatocyte-like cells","volume":"9","author":"Asgari","year":"2013","journal-title":"Stem Cell Rev."},{"key":"10.1016\/j.tcb.2019.10.001_bib103","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1016\/j.stemcr.2015.10.016","article-title":"Recombinant laminins drive the differentiation and self-organization of hESC-derived hepatocytes","volume":"5","author":"Cameron","year":"2015","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.tcb.2019.10.001_bib104","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.biomaterials.2016.06.054","article-title":"Laminin-511 and laminin-521-based matrices for efficient hepatic specification of human pluripotent stem cells","volume":"103","author":"Kanninen","year":"2016","journal-title":"Biomaterials"},{"key":"10.1016\/j.tcb.2019.10.001_bib105","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.stemcr.2013.08.006","article-title":"Long-term self-renewal of human ES\/iPS-derived hepatoblast-like cells on human laminin 111-coated dishes","volume":"1","author":"Takayama","year":"2013","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.tcb.2019.10.001_bib106","doi-asserted-by":"crossref","DOI":"10.3791\/55355-v","article-title":"Defined and scalable generation of hepatocyte-like cells from human pluripotent stem cells","author":"Wang","year":"2017","journal-title":"J.\u00a0Vis. Exp."},{"key":"10.1016\/j.tcb.2019.10.001_bib107","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1002\/hep4.1111","article-title":"Generation of safe and therapeutically effective human induced pluripotent stem cell-derived hepatocyte-like cells for regenerative medicine","volume":"1","author":"Takayama","year":"2017","journal-title":"Hepatol. Commun."},{"key":"10.1016\/j.tcb.2019.10.001_bib108","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1083\/jcb.144.1.151","article-title":"Absence of basement membranes after targeting the LAMC1 gene results in embryonic lethality due to failure of endoderm differentiation","volume":"144","author":"Smyth","year":"1999","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.tcb.2019.10.001_bib109","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.matbio.2010.05.004","article-title":"Laminin-121 \u2013 recombinant expression and interactions with integrins","volume":"29","author":"Sasaki","year":"2010","journal-title":"Matrix. Biol."},{"key":"10.1016\/j.tcb.2019.10.001_bib110","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/(SICI)1097-0177(199612)207:4<355::AID-AJA1>3.0.CO;2-G","article-title":"Distinct alpha 7A beta 1 and alpha 7B beta 1 integrin expression patterns during mouse development: alpha 7A is restricted to skeletal muscle but alpha 7B is expressed in striated muscle, vasculature, and nervous system","volume":"207","author":"Velling","year":"1996","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.tcb.2019.10.001_bib111","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1167\/iovs.09-4645","article-title":"Defective formation of the inner limiting membrane in laminin beta2- and gamma3-null mice produces retinal dysplasia","volume":"51","author":"Pinzon-Duarte","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.tcb.2019.10.001_bib112","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1083\/jcb.116.2.559","article-title":"Human basement membrane heparan sulfate proteoglycan core protein: a 467-kD protein containing multiple domains resembling elements of the low density lipoprotein receptor, laminin, neural cell adhesion molecules, and epidermal growth factor","volume":"116","author":"Kallunki","year":"1992","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.tcb.2019.10.001_bib113","doi-asserted-by":"crossref","first-page":"17900","DOI":"10.1016\/S0021-9258(19)37127-3","article-title":"The anchoring filament protein kalinin is synthesized and secreted as a high molecular weight precursor","volume":"267","author":"Marinkovich","year":"1992","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.tcb.2019.10.001_bib114","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1083\/jcb.143.6.1713","article-title":"Roles for laminin in embryogenesis: exencephaly, syndactyly, and placentopathy in mice lacking the laminin alpha5 chain","volume":"143","author":"Miner","year":"1998","journal-title":"J.\u00a0Cell Biol."}],"container-title":["Trends in Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0962892419301643?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0962892419301643?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T12:52:49Z","timestamp":1760791969000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0962892419301643"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":114,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["S0962892419301643"],"URL":"https:\/\/doi.org\/10.1016\/j.tcb.2019.10.001","relation":{},"ISSN":["0962-8924"],"issn-type":[{"value":"0962-8924","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Laminins in Cellular Differentiation","name":"articletitle","label":"Article Title"},{"value":"Trends in Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tcb.2019.10.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}