{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T20:11:47Z","timestamp":1789157507738,"version":"build-2803163510"},"reference-count":91,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272982"],"award-info":[{"award-number":["82272982"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Cell Biology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.tcb.2026.08.013","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T20:14:16Z","timestamp":1789071256000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["The emerging cellular metal ions\u2013immune axis in cancer"],"prefix":"10.1016","author":[{"given":"Sha","family":"Qin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minmin","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desheng","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongguang","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tcb.2026.08.013_bb0005","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/s41568-024-00787-3","article-title":"Dendritic cell maturation in cancer","volume":"25","author":"Moon","year":"2025","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.tcb.2026.08.013_bb0010","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/s41587-025-02629-5","article-title":"Engineering innate immune cells for cancer immunotherapy","volume":"43","author":"Tarannum","year":"2025","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.tcb.2026.08.013_bb0015","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1016\/j.immuni.2023.09.005","article-title":"CD8+ T cells in the cancer-immunity cycle","volume":"56","author":"Giles","year":"2023","journal-title":"Immunity"},{"key":"10.1016\/j.tcb.2026.08.013_bb0020","first-page":"67","article-title":"Immune-modulative nano-gel-nano system for patient-favorable cancer therapy","volume":"43","author":"Kim","year":"2025","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.tcb.2026.08.013_bb0025","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.1038\/s41551-025-01425-5","article-title":"Engineering multi-specific nano-antibodies for cancer immunotherapy","volume":"9","author":"Fan","year":"2025","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.tcb.2026.08.013_bb0030","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1021\/acs.chemrev.4c00577","article-title":"Metal ion signaling in biomedicine","volume":"125","author":"Rodriguez","year":"2025","journal-title":"Chem. Rev."},{"key":"10.1016\/j.tcb.2026.08.013_bb0035","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/s41392-024-02071-0","article-title":"Homeostasis and metabolism of iron and other metal ions in neurodegenerative diseases","volume":"10","author":"Chen","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.tcb.2026.08.013_bb0040","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1038\/s41551-024-01221-7","article-title":"Strategies for the development of metalloimmunotherapies","volume":"8","author":"Sun","year":"2024","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.tcb.2026.08.013_bb0045","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s12943-025-02225-w","article-title":"Biometallic ions and derivatives: a new direction for cancer immunotherapy","volume":"24","author":"Zhao","year":"2025","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.tcb.2026.08.013_bb0050","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1007\/s12011-024-04289-z","article-title":"Iron metabolism, calcium, magnesium and trace elements: a review","volume":"203","author":"Roli\u0107","year":"2025","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.tcb.2026.08.013_bb0055","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/s41467-024-54705-0","article-title":"Structural basis for metal ion transport by the human SLC11 proteins DMT1 and NRAMP1","volume":"16","author":"Liziczai","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tcb.2026.08.013_bb0060","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s10534-019-00183-7","article-title":"Iron uptake by ZIP8 and ZIP14 in human proximal tubular epithelial cells","volume":"32","author":"van Raaij","year":"2019","journal-title":"Biometals"},{"key":"10.1016\/j.tcb.2026.08.013_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2021.108800","article-title":"Effect of zinc depletion\/repletion on intestinal iron absorption and iron status in rats","volume":"97","author":"Kondaiah","year":"2021","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.tcb.2026.08.013_bb0070","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1016\/j.cmet.2024.07.009","article-title":"Zinc transporter 1 functions in copper uptake and cuproptosis","volume":"36","author":"Li","year":"2024","journal-title":"Cell Metab."},{"key":"10.1016\/j.tcb.2026.08.013_bb0075","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.tcb.2026.08.013_bb0080","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41586-019-1170-y","article-title":"CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy","volume":"569","author":"Wang","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.tcb.2026.08.013_bb0085","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.cytogfr.2025.06.007","article-title":"Ferroptosis in immune cells: implications for tumor immunity and cancer therapy","volume":"84","author":"Gao","year":"2025","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.tcb.2026.08.013_bb0090","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.jconrel.2024.06.053","article-title":"Manganese-induced photothermal-ferroptosis for synergistic tumor therapy","volume":"372","author":"Chen","year":"2024","journal-title":"J. Control. Release"},{"key":"10.1016\/j.tcb.2026.08.013_bb0095","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1080\/15548627.2023.2165323","article-title":"Copper-dependent autophagic degradation of GPX4 drives ferroptosis","volume":"19","author":"Xue","year":"2023","journal-title":"Autophagy"},{"key":"10.1016\/j.tcb.2026.08.013_bb0100","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.7150\/jca.83556","article-title":"PERK\/ATF3-reduced ER stress on high potassium environment in the suppression of tumor ferroptosis","volume":"14","author":"Pu","year":"2023","journal-title":"J. Cancer"},{"key":"10.1016\/j.tcb.2026.08.013_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2025.123135","article-title":"Mitigation of arteriosclerosis through transcriptional regulation of ferroptosis and lipid metabolism by magnesium","volume":"319","author":"Yu","year":"2025","journal-title":"Biomaterials"},{"key":"10.1016\/j.tcb.2026.08.013_bb0110","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1111\/cns.13657","article-title":"Zinc attenuates ferroptosis and promotes functional recovery in contusion spinal cord injury by activating Nrf2\/GPX4 defense pathway","volume":"27","author":"Ge","year":"2021","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.tcb.2026.08.013_bb0115","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.freeradbiomed.2024.01.041","article-title":"Zinc deficiency drives ferroptosis resistance by lactate production in esophageal squamous cell carcinoma","volume":"213","author":"Yang","year":"2024","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.tcb.2026.08.013_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156377","article-title":"Investigating the interaction between calcium signaling and ferroptosis for novel cancer treatment","volume":"137","author":"Yan","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.tcb.2026.08.013_bb0125","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/imr.13276","article-title":"Copper homeostasis and cuproptosis in cancer immunity and therapy","volume":"321","author":"Liu","year":"2024","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.tcb.2026.08.013_bb0130","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1186\/s13578-022-00948-7","article-title":"A new thinking: deciphering the aberrance and clinical implication of copper-death signatures in clear cell renal cell carcinoma","volume":"12","author":"Jiang","year":"2022","journal-title":"Cell Biosci."},{"key":"10.1016\/j.tcb.2026.08.013_bb0135","doi-asserted-by":"crossref","first-page":"10206","DOI":"10.1021\/acsnano.3c00326","article-title":"Type-I AIE photosensitizer loaded biomimetic system boosting cuproptosis to inhibit breast cancer metastasis and rechallenge","volume":"17","author":"Ning","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.tcb.2026.08.013_bb0140","article-title":"Copper-bacteriochlorin nanosheet as a specific pyroptosis inducer for robust tumor immunotherapy","volume":"35","author":"Zhang","year":"2023","journal-title":"Adv. Mater."},{"key":"10.1016\/j.tcb.2026.08.013_bb0145","article-title":"Disruption of zinc homeostasis by a novel platinum(IV)-terthiophene complex for antitumor immunity","volume":"62","author":"Su","year":"2023","journal-title":"Angew. Chem. Int. Ed. Eng."},{"key":"10.1016\/j.tcb.2026.08.013_bb0150","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1038\/s41422-018-0090-y","article-title":"Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis","volume":"28","author":"Zhou","year":"2018","journal-title":"Cell Res."},{"key":"10.1016\/j.tcb.2026.08.013_bb0155","doi-asserted-by":"crossref","first-page":"6335","DOI":"10.1016\/j.cell.2025.08.013","article-title":"Tumors hijack macrophages for iron supply to promote bone metastasis and anemia","volume":"188","author":"Han","year":"2025","journal-title":"Cell"},{"key":"10.1016\/j.tcb.2026.08.013_bb0160","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1126\/science.abf0529","article-title":"Copper induces cell death by targeting lipoylated TCA cycle proteins","volume":"375","author":"Tsvetkov","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.tcb.2026.08.013_bb0165","doi-asserted-by":"crossref","first-page":"4129","DOI":"10.1158\/0008-5472.CAN-20-0471","article-title":"Intratumoral copper modulates PD-L1 expression and influences tumor immune evasion","volume":"80","author":"Voli","year":"2020","journal-title":"Cancer Res."},{"key":"10.1016\/j.tcb.2026.08.013_bb0170","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2023.1208485","article-title":"Iron-mediated oxidative stress induces PD-L1 expression via activation of c-Myc in lung adenocarcinoma","volume":"11","author":"Battaglia","year":"2023","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.tcb.2026.08.013_bb0175","first-page":"2442","article-title":"Disulfiram combined with copper induces immunosuppression via PD-L1 stabilization in hepatocellular carcinoma","volume":"9","author":"Zhou","year":"2019","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.tcb.2026.08.013_bb0180","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.gendis.2023.01.026","article-title":"The link between intracellular calcium signaling and exosomal PD-L1 in cancer progression and immunotherapy","volume":"11","author":"Alam","year":"2024","journal-title":"Genes Dis."},{"key":"10.1016\/j.tcb.2026.08.013_bb0185","doi-asserted-by":"crossref","first-page":"8116","DOI":"10.1021\/jacs.1c02537","article-title":"Mild magnetic hyperthermia-activated innate immunity for liver cancer therapy","volume":"143","author":"Pan","year":"2021","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.tcb.2026.08.013_bb0190","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.ade5393","article-title":"Na, K-ATPase \u03b11 cooperates with its endogenous ligand to reprogram immune microenvironment of lung carcinoma and promotes immune escape","volume":"9","author":"Yang","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.tcb.2026.08.013_bb0195","first-page":"880","article-title":"The role of redox-active iron, copper, manganese, and redox-inactive zinc in toxicity, oxidative stress, and human diseases","volume":"24","author":"Jomova","year":"2025","journal-title":"EXCLI J."},{"key":"10.1016\/j.tcb.2026.08.013_bb0200","article-title":"Disruption of NF-\u03baB-mediated copper homeostasis sensitizes breast cancer to cuproptosis","volume":"12","author":"Zhang","year":"2025","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.tcb.2026.08.013_bb0205","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/s12011-023-03715-y","article-title":"Dietary zinc ameliorates TNBS-induced colitis in mice associated with regulation of Th1\/Th2\/Th17 balance and NF-\u03baB\/NLRP3 signaling pathway","volume":"202","author":"Wen","year":"2024","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.tcb.2026.08.013_bb0210","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/s41586-023-06017-4","article-title":"A druggable copper-signalling pathway that drives inflammation","volume":"617","author":"Solier","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.tcb.2026.08.013_bb0215","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1080\/15548627.2025.2465396","article-title":"Lysosomal Fe2+ influx through MCOLN1 channel prevents sustained inflammation by limiting PHDs-regulated NFKB activation in macrophages","volume":"21","author":"Wang","year":"2025","journal-title":"Autophagy"},{"key":"10.1016\/j.tcb.2026.08.013_bb0220","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1080\/15548627.2021.1954779","article-title":"LRRK2 is required for CD38-mediated NAADP-Ca2+ signaling and the downstream activation of TFEB (transcription factor EB) in immune cells","volume":"18","author":"Nabar","year":"2022","journal-title":"Autophagy"},{"key":"10.1016\/j.tcb.2026.08.013_bb0225","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1038\/s41423-021-00669-w","article-title":"Manganese salts function as potent adjuvants","volume":"18","author":"Zhang","year":"2021","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.tcb.2026.08.013_bb0230","doi-asserted-by":"crossref","first-page":"5685","DOI":"10.1038\/s41467-022-33301-0","article-title":"A protein-based cGAS-STING nanoagonist enhances T cell-mediated anti-tumor immune responses","volume":"13","author":"Wang","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tcb.2026.08.013_bb0235","article-title":"Manganese-coordinated polyvalent aptameric system (COMPASS) enables DC-targeted mRNA\/Mn2+ co-delivery for cancer immunotherapy","volume":"65","author":"Liu","year":"2026","journal-title":"Angew. Chem. Int. Ed. Eng."},{"key":"10.1016\/j.tcb.2026.08.013_bb0240","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1126\/science.aat1022","article-title":"DNA-induced liquid phase condensation of cGAS activates innate immune signaling","volume":"361","author":"Du","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.tcb.2026.08.013_bb0245","article-title":"Zinc-organometallic framework vaccine controlled-release Zn2+ regulates tumor extracellular matrix degradation potentiate efficacy of immunotherapy","volume":"10","author":"Ding","year":"2023","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.tcb.2026.08.013_bb0250","doi-asserted-by":"crossref","first-page":"15905","DOI":"10.1021\/acsnano.3c03962","article-title":"Manganese-based immunostimulatory metal-organic framework activates the cGAS-STING pathway for cancer metalloimmunotherapy","volume":"17","author":"Zheng","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.tcb.2026.08.013_bb0255","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1021\/acs.jafc.1c06681","article-title":"Iron activates cGAS-STING signaling and promotes hepatic inflammation","volume":"70","author":"Li","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.tcb.2026.08.013_bb0260","doi-asserted-by":"crossref","first-page":"6754","DOI":"10.1038\/s41467-026-73379-4","article-title":"Iron overload in the tumor microenvironment induces CD8+ T cell ferroptosis and dysfunction","volume":"17","author":"Lin","year":"2026","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tcb.2026.08.013_bb0265","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.816282","article-title":"Iron metabolism and immune regulation","volume":"13","author":"Ni","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.tcb.2026.08.013_bb0270","doi-asserted-by":"crossref","first-page":"335","DOI":"10.14348\/molcells.2021.0061","article-title":"Regulatory role of zinc in immune cell signaling","volume":"44","author":"Kim","year":"2021","journal-title":"Mol. Cell"},{"key":"10.1016\/j.tcb.2026.08.013_bb0275","doi-asserted-by":"crossref","first-page":"4302","DOI":"10.3390\/ijms25084302","article-title":"Zinc ionophore pyrithione mimics CD28 costimulatory signal in CD3 activated T cells","volume":"25","author":"Jakobs","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tcb.2026.08.013_bb0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119754","article-title":"Berberine and\/or zinc protect against methotrexate-induced intestinal damage: role of GSK-3\u03b2\/NRF2 and JAK1\/STAT-3 signaling pathways","volume":"281","author":"Hassanein","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.tcb.2026.08.013_bb0285","article-title":"SOX4-ZIP14-zinc metabolism mediates oncogenesis and suppresses T cell immunity in nasopharyngeal carcinoma","volume":"6","author":"Yang","year":"2025","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.tcb.2026.08.013_bb0290","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.cell.2021.12.039","article-title":"Magnesium sensing via LFA-1 regulates CD8+ T cell effector function","volume":"185","author":"L\u00f6tscher","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.tcb.2026.08.013_bb0295","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1016\/j.cmet.2022.08.016","article-title":"Tumor-associated macrophages are shaped by intratumoral high potassium via Kir2.1","volume":"34","author":"Chen","year":"2022","journal-title":"Cell Metab."},{"key":"10.1016\/j.tcb.2026.08.013_bb0300","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/nature19364","article-title":"Ionic immune suppression within the tumour microenvironment limits T cell effector function","volume":"537","author":"Eil","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.tcb.2026.08.013_bb0305","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/s41419-020-03173-7","article-title":"Quantifying the efficacy of checkpoint inhibitors on CD8+ cytotoxic T cells for immunotherapeutic applications via single-cell interaction","volume":"11","author":"Sullivan","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.tcb.2026.08.013_bb0310","doi-asserted-by":"crossref","DOI":"10.1002\/jcp.31203","article-title":"Expression of cell surface zinc transporter LIV1 in triple negative breast cancer is an indicator of poor prognosis and therapy failure","volume":"239","author":"Saravanan","year":"2024","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.tcb.2026.08.013_bb0315","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.725595","article-title":"The transcription of ZIP9 is associated with the macrophage polarization and the pathogenesis of hepatocellular carcinoma","volume":"13","author":"Gou","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.tcb.2026.08.013_bb0320","doi-asserted-by":"crossref","first-page":"441","DOI":"10.4049\/jimmunol.1800689","article-title":"Zip6 transporter is an essential component of the lymphocyte activation machinery","volume":"202","author":"Colomar-Carando","year":"2019","journal-title":"J. Immunol."},{"key":"10.1016\/j.tcb.2026.08.013_bb0325","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.109518","article-title":"Copper transporter gene ATP7A: a predictive biomarker for immunotherapy and targeted therapy in hepatocellular carcinoma","volume":"114","author":"Shao","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.tcb.2026.08.013_bb0330","doi-asserted-by":"crossref","first-page":"3794","DOI":"10.7150\/thno.82975","article-title":"Ferritin light chain promotes the reprogramming of glioma immune microenvironment and facilitates glioma progression","volume":"13","author":"Li","year":"2023","journal-title":"Theranostics"},{"key":"10.1016\/j.tcb.2026.08.013_bb0335","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abo0981","article-title":"The ZFP36 family of RNA binding proteins regulates homeostatic and autoreactive T cell responses","volume":"7","author":"Cook","year":"2022","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.tcb.2026.08.013_bb0340","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s12865-022-00485-5","article-title":"ThPOK inhibits the immune escape of gastric cancer cells by inducing STPG1 to inactivate the ERK pathway","volume":"23","author":"Chen","year":"2022","journal-title":"BMC Immunol."},{"key":"10.1016\/j.tcb.2026.08.013_bb0345","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01344-21","article-title":"The CCCH-type zinc finger antiviral protein relieves immunosuppression of T cells induced by avian leukosis virus subgroup J via the NLP-PKC-\u03b4-NFAT pathway","volume":"96","author":"Zhu","year":"2022","journal-title":"J. Virol."},{"key":"10.1016\/j.tcb.2026.08.013_bb0350","article-title":"Zinc-finger protein CXXC5 promotes breast carcinogenesis by regulating the TSC1\/mTOR signaling pathway","volume":"299","author":"Wang","year":"2023","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tcb.2026.08.013_bb0355","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.3724\/abbs.2023136","article-title":"ZNF205 positively regulates RLR antiviral signaling by targeting RIG-I","volume":"55","author":"Zhong","year":"2023","journal-title":"Acta Biochim. Biophys. Sin. Shanghai"},{"key":"10.1016\/j.tcb.2026.08.013_bb0360","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2024.110256","article-title":"Ionic reverberation modulates the cellular fate of CD8+ tissue resident memory T cells (TRMs) in patients with renal cell carcinoma: a novel mechanism","volume":"264","author":"Singh","year":"2024","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.tcb.2026.08.013_bb0365","doi-asserted-by":"crossref","DOI":"10.1126\/science.aau0135","article-title":"T cell stemness and dysfunction in tumors are triggered by a common mechanism","volume":"363","author":"Vodnala","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.tcb.2026.08.013_bb0370","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12279","article-title":"Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels","volume":"11","author":"Chen","year":"2022","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/j.tcb.2026.08.013_bb0375","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1016\/j.apsb.2021.11.001","article-title":"The regulatory and modulatory roles of TRP family channels in malignant tumors and relevant therapeutic strategies","volume":"12","author":"Zhong","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.tcb.2026.08.013_bb0380","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1002\/emmm.201302989","article-title":"STIM1 and STIM2-mediated Ca2+ influx regulates antitumour immunity by CD8+ T cells","volume":"5","author":"Weidinger","year":"2013","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.tcb.2026.08.013_bb0385","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/1476-4598-10-109","article-title":"Tumor cell-selective apoptosis induction through targeting of K(V)10.1 via bifunctional TRAIL antibody","volume":"10","author":"Hartung","year":"2011","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.tcb.2026.08.013_bb0390","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.bioorg.2019.03.045","article-title":"Synthesis of TPEN variants to improve cancer cells selective killing capacity","volume":"87","author":"Schaefer-ramadan","year":"2019","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.tcb.2026.08.013_bb0395","article-title":"Inhibition of calcium signaling prevents exhaustion and enhances anti-leukemia efficacy of CAR-T cells via SOCE-calcineurin-NFAT and glycolysis pathways","volume":"9","author":"Shao","year":"2022","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.tcb.2026.08.013_bb0400","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.canlet.2018.06.006","article-title":"Targeting Orai1-mediated store-operated calcium entry by RP4010 for anti-tumor activity in esophagus squamous cell carcinoma","volume":"432","author":"Cui","year":"2018","journal-title":"Cancer Lett."},{"key":"10.1016\/j.tcb.2026.08.013_bb0405","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.pharep.2015.11.006","article-title":"Modulation of the voltage-gated potassium channel Kv2.1 by the anti-tumor alkylphospholipid perifosine","volume":"68","author":"Delgado-Ram\u00edrez","year":"2016","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.tcb.2026.08.013_bb0410","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2023.116415","article-title":"Isopimaric acid, an ion channel regulator, regulates calcium and oxidative phosphorylation pathways to inhibit breast cancer proliferation and metastasis","volume":"462","author":"Li","year":"2023","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tcb.2026.08.013_bb0415","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1038\/nnano.2016.168","article-title":"Iron oxide nanoparticles inhibit tumour growth by inducing pro-inflammatory macrophage polarization in tumour tissues","volume":"11","author":"Zanganeh","year":"2016","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.tcb.2026.08.013_bb0420","doi-asserted-by":"crossref","first-page":"7311","DOI":"10.1038\/s41467-021-27559-z","article-title":"Copper depletion modulates mitochondrial oxidative phosphorylation to impair triple negative breast cancer metastasis","volume":"12","author":"Ramchandani","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tcb.2026.08.013_bb0425","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1200\/JCO.22.01989","article-title":"Pembrolizumab plus pemetrexed and platinum in nonsquamous non-small-cell lung cancer: 5-year outcomes from the phase 3 KEYNOTE-189 study","volume":"41","author":"Garassino","year":"2023","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.tcb.2026.08.013_bb0430","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1186\/s12951-024-02726-8","article-title":"Repolarizing neutrophils via MnO2 nanoparticle-activated STING pathway enhances Salmonella-mediated tumor immunotherapy","volume":"22","author":"Lu","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.tcb.2026.08.013_bb0435","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1080\/10715762.2020.1763333","article-title":"Protective effects of zinc L-carnosine against hydrogen peroxide-induced DNA damage and micronucleus formation in CCD-18co human colon fibroblast cells","volume":"54","author":"Ooi","year":"2020","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.tcb.2026.08.013_bb0440","article-title":"Zinc finger and SCAN domain-containing protein 18 is a potential DNA methylation-modified tumor suppressor and biomarker in breast cancer","volume":"14","author":"Wang","year":"2023","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.tcb.2026.08.013_bb0445","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/s41586-025-08974-4","article-title":"Activation of lysosomal iron triggers ferroptosis in cancer","volume":"642","author":"Ca\u00f1eque","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.tcb.2026.08.013_bb0450","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1038\/s41557-020-0513-5","article-title":"CD44 regulates epigenetic plasticity by mediating iron endocytosis","volume":"12","author":"M\u00fcller","year":"2020","journal-title":"Nat. Chem."},{"key":"10.1016\/j.tcb.2026.08.013_bb0455","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1038\/nchem.2778","article-title":"Salinomycin kills cancer stem cells by sequestering iron in lysosomes","volume":"9","author":"Mai","year":"2017","journal-title":"Nat. Chem."}],"container-title":["Trends in Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0962892426001698?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0962892426001698?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T19:51:23Z","timestamp":1789156283000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0962892426001698"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":91,"alternative-id":["S0962892426001698"],"URL":"https:\/\/doi.org\/10.1016\/j.tcb.2026.08.013","relation":{},"ISSN":["0962-8924"],"issn-type":[{"value":"0962-8924","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The emerging cellular metal ions\u2013immune axis in cancer","name":"articletitle","label":"Article Title"},{"value":"Trends in Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tcb.2026.08.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}