{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:35:43Z","timestamp":1790872543623,"version":"4.1.0"},"reference-count":66,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T00:00:00Z","timestamp":1225497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trends in Cardiovascular Medicine"],"published-print":{"date-parts":[[2008,11]]},"DOI":"10.1016\/j.tcm.2009.01.002","type":"journal-article","created":{"date-parts":[[2009,4,3]],"date-time":"2009-04-03T08:40:29Z","timestamp":1238748029000},"page":"299-305","source":"Crossref","is-referenced-by-count":27,"title":["Endothelium-Driven Myocardial Growth or Nitric Oxide at the Crossroads"],"prefix":"10.1016","volume":"18","author":[{"given":"Daniela","family":"Tirziu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Simons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tcm.2009.01.002_bib1","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1161\/01.HYP.0000053552.86367.12","article-title":"Enhancement of ischemia-induced angiogenesis by eNOS overexpression","volume":"41","author":"Amano","year":"2003","journal-title":"Hypertension"},{"key":"10.1016\/j.tcm.2009.01.002_bib2","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1161\/01.RES.82.2.195","article-title":"Nonuniformity of endothelial constitutive nitric oxide synthase distribution in cardiac endothelium","volume":"82","author":"Andries","year":"1998","journal-title":"Circ Res"},{"key":"10.1016\/j.tcm.2009.01.002_bib3","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/416337a","article-title":"Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms","volume":"416","author":"Barouch","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.tcm.2009.01.002_bib4","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1124\/mol.105.014449","article-title":"Nitric oxide inhibits endothelin-1-induced cardiomyocyte hypertrophy through cGMP-mediated suppression of extracellular-signal regulated kinase phosphorylation","volume":"68","author":"Cheng","year":"2005","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.tcm.2009.01.002_bib5","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1161\/01.RES.0000077012.11088.BC","article-title":"Phenotyping hypertrophy: eschew obfuscation","volume":"92","author":"Dorn","year":"2003","journal-title":"Circ Res"},{"key":"10.1016\/j.tcm.2009.01.002_bib6","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/j.cardiores.2005.12.014","article-title":"Caveolins and the regulation of endothelial nitric oxide synthase in the heart","volume":"69","author":"Feron","year":"2006","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.tcm.2009.01.002_bib7","doi-asserted-by":"crossref","first-page":"11363","DOI":"10.1073\/pnas.162100799","article-title":"Inhibition of calcineurin-NFAT hypertrophy signaling by cGMP-dependent protein kinase type I in cardiac myocytes","volume":"99","author":"Fiedler","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.tcm.2009.01.002_bib8","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.cardiores.2004.04.002","article-title":"Interference of antihypertrophic molecules and signaling pathways with the Ca2+-calcineurin-NFAT cascade in cardiac myocytes","volume":"63","author":"Fiedler","year":"2004","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.tcm.2009.01.002_bib9","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S0008-6363(01)00412-6","article-title":"Distribution and role of Na(+)\/K(+) ATPase in endocardial endothelium","volume":"52","author":"Fransen","year":"2001","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.tcm.2009.01.002_bib10","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/978-1-4419-9029-7_4","article-title":"The endocardial endothelial Na+\/K+ ATPase and cardiac contraction","volume":"538","author":"Fransen","year":"2003","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.tcm.2009.01.002_bib11","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1161\/01.RES.0000129178.56294.17","article-title":"Caveolae and caveolins in the cardiovascular system","volume":"94","author":"Gratton","year":"2004","journal-title":"Circ Res"},{"key":"10.1016\/j.tcm.2009.01.002_bib12","doi-asserted-by":"crossref","first-page":"H971","DOI":"10.1152\/ajpheart.2000.278.3.H971","article-title":"Modulation of mouse cardiac function in vivo by eNOS and ANP","volume":"278","author":"Gyurko","year":"2000","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.tcm.2009.01.002_bib13","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1006\/jsre.1996.0226","article-title":"VEGF improves myocardial blood flow but produces EDRF-mediated hypotension in porcine hearts","volume":"63","author":"Hariawala","year":"1996","journal-title":"J Surg Res"},{"key":"10.1016\/j.tcm.2009.01.002_bib14","doi-asserted-by":"crossref","first-page":"3198","DOI":"10.1172\/JCI32573","article-title":"Cardiomyocyte GATA4 functions as a stress-responsive regulator of angiogenesis in the murine heart","volume":"117","author":"Heineke","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1016\/j.tcm.2009.01.002_bib15","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1161\/01.CIR.0000055319.94801.FC","article-title":"Downregulation of cytoskeletal muscle LIM protein by nitric oxide: impact on cardiac myocyte hypertrophy","volume":"107","author":"Heineke","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.tcm.2009.01.002_bib16","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1161\/01.CIR.101.2.118","article-title":"Effect of intracoronary recombinant human vascular endothelial growth factor on myocardial perfusion: evidence for a dose-dependent effect","volume":"101","author":"Hendel","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.tcm.2009.01.002_bib17","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1067\/mhj.2001.118471","article-title":"Intracoronary administration of recombinant human vascular endothelial growth factor to patients with coronary artery disease","volume":"142","author":"Henry","year":"2001","journal-title":"Am Heart J"},{"key":"10.1016\/j.tcm.2009.01.002_bib18","first-page":"H1054","article-title":"VEGF upregulates ecNOS message, protein, and NO production in human endothelial cells","volume":"274","author":"Hood","year":"1998","journal-title":"Am J Physiol"},{"key":"10.1016\/j.tcm.2009.01.002_bib19","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.1161\/01.ATV.17.11.2793","article-title":"Vascular endothelial growth factor\/vascular permeability factor produces nitric oxide-dependent hypotension. Evidence for a maintenance role in quiescent adult endothelium","volume":"17","author":"Horowitz","year":"1997","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.tcm.2009.01.002_bib20","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1038\/nature04027","article-title":"The N-end rule pathway as a nitric oxide sensor controlling the levels of multiple regulators","volume":"437","author":"Hu","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.tcm.2009.01.002_bib21","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.cellsig.2005.08.004","article-title":"Cell signalling diversity of the Gqalpha family of heterotrimeric G proteins","volume":"18","author":"Hubbard","year":"2006","journal-title":"Cell Signal"},{"key":"10.1016\/j.tcm.2009.01.002_bib22","doi-asserted-by":"crossref","first-page":"H1070","DOI":"10.1152\/ajpheart.00940.2003","article-title":"Pressure overload-induced LV hypertrophy and dysfunction in mice are exacerbated by congenital NOS3 deficiency","volume":"286","author":"Ichinose","year":"2004","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.tcm.2009.01.002_bib23","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1161\/01.HYP.0000215207.54689.31","article-title":"Vascular endothelial growth factor blockade promotes the transition from compensatory cardiac hypertrophy to failure in response to pressure overload","volume":"47","author":"Izumiya","year":"2006","journal-title":"Hypertension"},{"key":"10.1016\/j.tcm.2009.01.002_bib24","doi-asserted-by":"crossref","first-page":"4891","DOI":"10.1073\/pnas.0837428100","article-title":"Endothelial nitric oxide synthase overexpression attenuates congestive heart failure in mice","volume":"100","author":"Jones","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.tcm.2009.01.002_bib25","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1038\/79510","article-title":"The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals","volume":"6","author":"Kureishi","year":"2000","journal-title":"Nat Med"},{"key":"10.1016\/j.tcm.2009.01.002_bib26","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1023\/A:1026061507004","article-title":"Molecular mechanisms in endothelial regulation of cardiac function","volume":"253","author":"Kuruvilla","year":"2003","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.tcm.2009.01.002_bib27","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1113\/jphysiol.2001.014126","article-title":"Role of cyclic GMP-dependent protein kinase in the contractile response to exogenous nitric oxide in rat cardiac myocytes","volume":"540","author":"Layland","year":"2002","journal-title":"J Physiol"},{"key":"10.1016\/j.tcm.2009.01.002_bib28","doi-asserted-by":"crossref","first-page":"15030","DOI":"10.1073\/pnas.0507533102","article-title":"RGS4 and RGS5 are in vivo substrates of the N-end rule pathway","volume":"102","author":"Lee","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.tcm.2009.01.002_bib29","first-page":"H1317","article-title":"Hemodynamic effects of intracoronary VEGF delivery: evidence of tachyphylaxis and NO dependence of response","volume":"273","author":"Lopez","year":"1997","journal-title":"Am J Physiol"},{"key":"10.1016\/j.tcm.2009.01.002_bib30","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.cardiores.2006.02.002","article-title":"Are myocardial eNOS and nNOS involved in the beta-adrenergic and muscarinic regulation of inotropy? A systematic investigation","volume":"70","author":"Martin","year":"2006","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.tcm.2009.01.002_bib31","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1161\/01.RES.0000088351.58510.21","article-title":"Nitric oxide and cardiac function: ten years after, and continuing","volume":"93","author":"Massion","year":"2003","journal-title":"Circ Res"},{"key":"10.1016\/j.tcm.2009.01.002_bib32","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.cbpb.2005.05.048","article-title":"Regulation of the mammalian heart function by nitric oxide","volume":"142","author":"Massion","year":"2005","journal-title":"Comp Biochem Physiol A Mol Integr Physiol"},{"key":"10.1016\/j.tcm.2009.01.002_bib33","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1161\/ATVBAHA.107.145375","article-title":"Endothelial nitric oxide synthase activity is essential for vasodilation during blood flow recovery but not for arteriogenesis","volume":"27","author":"Mees","year":"2007","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.tcm.2009.01.002_bib34","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/S0008-6363(02)00459-5","article-title":"Expression of ten RGS proteins in human myocardium: functional characterization of an upregulation of RGS4 in heart failure","volume":"55","author":"Mittmann","year":"2002","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.tcm.2009.01.002_bib35","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0031-6997(25)06663-3","article-title":"Nitric oxide: physiology, pathophysiology, and pharmacology","volume":"43","author":"Moncada","year":"1991","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.tcm.2009.01.002_bib36","doi-asserted-by":"crossref","first-page":"3099","DOI":"10.1161\/CIRCULATIONAHA.108.767673","article-title":"Follistatin-like 1 is an Akt-regulated cardioprotective factor that is secreted by the heart","volume":"117","author":"Oshima","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.tcm.2009.01.002_bib37","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M803440200","article-title":"Follistatin-like 1, a secreted muscle protein, promotes endothelial cell function and revascularization in ischemic tissue through a nitric oxide synthesis-dependent mechanism","author":"Ouchi","year":"2008","journal-title":"J Biol Chem"},{"key":"10.1016\/j.tcm.2009.01.002_bib38","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1253\/circj.66.851","article-title":"Overexpression of endothelial nitric oxide synthase attenuates cardiac hypertrophy induced by chronic isoproterenol infusion","volume":"66","author":"Ozaki","year":"2002","journal-title":"Circ J"},{"key":"10.1016\/j.tcm.2009.01.002_bib39","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1023\/A:1011453809750","article-title":"The role of nitric oxide in the failing heart","volume":"6","author":"Paulus","year":"2001","journal-title":"Heart Fail Rev"},{"key":"10.1016\/j.tcm.2009.01.002_bib40","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1161\/01.CIR.92.8.2119","article-title":"Paracrine coronary endothelial control of left ventricular function in humans","volume":"92","author":"Paulus","year":"1995","journal-title":"Circulation"},{"key":"10.1016\/j.tcm.2009.01.002_bib41","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1083\/jcb.200507083","article-title":"Follistatin induction by nitric oxide through cyclic GMP: a tightly regulated signaling pathway that controls myoblast fusion","volume":"172","author":"Pisconti","year":"2006","journal-title":"J Cell Biol"},{"key":"10.1016\/j.tcm.2009.01.002_bib42","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1172\/JCI6713","article-title":"RGS4 causes increased mortality and reduced cardiac hypertrophy in response to pressure overload","volume":"104","author":"Rogers","year":"1999","journal-title":"J Clin Invest"},{"key":"10.1016\/j.tcm.2009.01.002_bib43","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1006\/jmcc.2000.1307","article-title":"RGS4 reduces contractile dysfunction and hypertrophic gene induction in Galpha q overexpressing mice","volume":"33","author":"Rogers","year":"2001","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.tcm.2009.01.002_bib44","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1161\/HYPERTENSIONAHA.107.093666","article-title":"LA419, a novel nitric oxide donor, prevents pathological cardiac remodeling in pressure-overloaded rats via endothelial nitric oxide synthase pathway regulation","volume":"50","author":"Ruiz-Hurtado","year":"2007","journal-title":"Hypertension"},{"key":"10.1016\/j.tcm.2009.01.002_bib45","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1161\/hc3601.094298","article-title":"Endothelial nitric oxide synthase limits left ventricular remodeling after myocardial infarction in mice","volume":"104","author":"Scherrer-Crosbie","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.tcm.2009.01.002_bib46","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.cardiores.2007.04.031","article-title":"Cardiomyocytes as effectors of nitric oxide signalling","volume":"75","author":"Seddon","year":"2007","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.tcm.2009.01.002_bib47","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0033-0620(96)80005-3","article-title":"The cardiac endothelium: cardioactive mediators","volume":"39","author":"Shah","year":"1996","journal-title":"Prog Cardiovasc Dis"},{"key":"10.1016\/j.tcm.2009.01.002_bib48","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0163-7258(99)00072-8","article-title":"Paracrine and autocrine effects of nitric oxide on myocardial function","volume":"86","author":"Shah","year":"2000","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.tcm.2009.01.002_bib49","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1161\/01.RES.74.5.970","article-title":"8-bromo-cGMP reduces the myofilament response to Ca2+ in intact cardiac myocytes","volume":"74","author":"Shah","year":"1994","journal-title":"Circ Res"},{"key":"10.1016\/j.tcm.2009.01.002_bib50","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1172\/JCI24682","article-title":"Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure","volume":"115","author":"Shiojima","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.tcm.2009.01.002_bib51","doi-asserted-by":"crossref","first-page":"37670","DOI":"10.1074\/jbc.M204572200","article-title":"Akt signaling mediates postnatal heart growth in response to insulin and nutritional status","volume":"277","author":"Shiojima","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.tcm.2009.01.002_bib52","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1038\/79646","article-title":"Molecular multitasking: statins lead to more arteries, less plaque","volume":"6","author":"Simons","year":"2000","journal-title":"Nat Med"},{"key":"10.1016\/j.tcm.2009.01.002_bib53","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1016\/j.lfs.2004.11.028","article-title":"Human endothelial nitric oxide synthase gene delivery protects against cardiac remodeling and reduces oxidative stress after myocardial infarction","volume":"76","author":"Smith","year":"2005","journal-title":"Life Sci"},{"key":"10.1016\/j.tcm.2009.01.002_bib54","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1126\/science.1281928","article-title":"Biochemistry of nitric oxide and its redox-activated forms","volume":"258","author":"Stamler","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.tcm.2009.01.002_bib55","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1172\/JCI21968","article-title":"Oxidant stress from nitric oxide synthase-3 uncoupling stimulates cardiac pathologic remodeling from chronic pressure load","volume":"115","author":"Takimoto","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.tcm.2009.01.002_bib56","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1161\/01.CIR.99.3.441","article-title":"RGS4 inhibits G-protein signaling in cardiomyocytes","volume":"99","author":"Tamirisa","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.tcm.2009.01.002_bib57","doi-asserted-by":"crossref","first-page":"3188","DOI":"10.1172\/JCI32024","article-title":"Myocardial hypertrophy in the absence of external stimuli is induced by angiogenesis in mice","volume":"117","author":"Tirziu","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1016\/j.tcm.2009.01.002_bib58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vph.2008.08.003","article-title":"Endothelium as master regulator of organ development and growth","volume":"50","author":"Tirziu","year":"2009","journal-title":"Vascul Pharmacol"},{"key":"10.1016\/j.tcm.2009.01.002_bib59","doi-asserted-by":"crossref","first-page":"H1144","DOI":"10.1152\/ajpheart.00773.2006","article-title":"Vasomotor control in mice overexpressing human endothelial nitric oxide synthase","volume":"293","author":"Van Deel","year":"2007","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.tcm.2009.01.002_bib60","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1161\/01.RES.84.9.1020","article-title":"Activation of distinct cAMP-dependent and cGMP-dependent pathways by nitric oxide in cardiac myocytes","volume":"84","author":"Vila-Petroff","year":"1999","journal-title":"Circ Res"},{"key":"10.1016\/j.tcm.2009.01.002_bib61","doi-asserted-by":"crossref","first-page":"3176","DOI":"10.1172\/JCI34126","article-title":"Cardiac growth and angiogenesis coordinated by intertissue interactions","volume":"117","author":"Walsh","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1016\/j.tcm.2009.01.002_bib62","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0163-7258(02)00326-1","article-title":"Regulators of G-protein signalling: multifunctional proteins with impact on signalling in the cardiovascular system","volume":"97","author":"Wieland","year":"2003","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.tcm.2009.01.002_bib63","doi-asserted-by":"crossref","first-page":"23341","DOI":"10.1074\/jbc.M513341200","article-title":"The sarcolemmal calcium pump, alpha-1 syntrophin, and neuronal nitric-oxide synthase are parts of a macromolecular protein complex","volume":"281","author":"Williams","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.tcm.2009.01.002_bib64","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1073\/pnas.96.2.657","article-title":"Nitric oxide synthase in cardiac sarcoplasmic reticulum","volume":"96","author":"Xu","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.tcm.2009.01.002_bib65","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1161\/01.HYP.36.1.97","article-title":"Mechanisms of reduced nitric oxide\/cGMP-mediated vasorelaxation in transgenic mice overexpressing endothelial nitric oxide synthase","volume":"36","author":"Yamashita","year":"2000","journal-title":"Hypertension"},{"key":"10.1016\/j.tcm.2009.01.002_bib66","doi-asserted-by":"crossref","first-page":"10999","DOI":"10.1073\/pnas.0501444102","article-title":"Endothelial nitric oxide synthase is critical for ischemic remodeling, mural cell recruitment, and blood flow reserve","volume":"102","author":"Yu","year":"2005","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["Trends in Cardiovascular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050173809000176?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050173809000176?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,8]],"date-time":"2025-02-08T21:01:48Z","timestamp":1739048508000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050173809000176"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11]]},"references-count":66,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2008,11]]}},"alternative-id":["S1050173809000176"],"URL":"https:\/\/doi.org\/10.1016\/j.tcm.2009.01.002","relation":{},"ISSN":["1050-1738"],"issn-type":[{"value":"1050-1738","type":"print"}],"subject":[],"published":{"date-parts":[[2008,11]]}}}