{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T06:08:18Z","timestamp":1776319698435,"version":"3.50.1"},"reference-count":63,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["tcmonline.org","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Cardiovascular Medicine"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.tcm.2016.04.012","type":"journal-article","created":{"date-parts":[[2016,5,2]],"date-time":"2016-05-02T16:49:05Z","timestamp":1462207745000},"page":"681-689","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Mechanistic insights into mitral regurgitation due to atrial fibrillation: \u201cAtrial functional mitral regurgitation\u201d"],"prefix":"10.1016","volume":"26","author":[{"given":"Jackson J.","family":"Liang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank E.","family":"Silvestry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tcm.2016.04.012_bib1","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0140-6736(06)69208-8","article-title":"Burden of valvular heart diseases: a population-based study","volume":"368","author":"Nkomo","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.tcm.2016.04.012_bib2","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1016\/S0140-6736(09)60692-9","article-title":"Mitral regurgitation","volume":"373","author":"Enriquez-Sarano","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.tcm.2016.04.012_bib3","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/nrcardio.2010.202","article-title":"Epidemiology of valvular heart disease in the adult","volume":"8","author":"Iung","year":"2011","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.tcm.2016.04.012_bib4","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.1001\/jama.285.18.2370","article-title":"Prevalence of diagnosed atrial fibrillation in adults: national implications for rhythm management and stroke prevention: the anticoagulation and risk factors in atrial fibrillation (atria) study","volume":"285","author":"Go","year":"2001","journal-title":"J Am Med Assoc"},{"key":"10.1016\/j.tcm.2016.04.012_bib5","doi-asserted-by":"crossref","first-page":"e101","DOI":"10.1016\/j.jacc.2010.09.013","volume":"57","author":"Fuster","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.tcm.2016.04.012_bib6","doi-asserted-by":"crossref","first-page":"3028","DOI":"10.1161\/01.CIR.99.23.3028","article-title":"Characterization of different subsets of atrial fibrillation in general practice in France: the ALFA Study","volume":"99","author":"L\u00e9vy","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.tcm.2016.04.012_bib7","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1136\/hrt.16.2.189","article-title":"Lone auricular fibrillation","volume":"16","author":"Evans","year":"1954","journal-title":"Br Heart J"},{"key":"10.1016\/j.tcm.2016.04.012_bib8","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0033-0620(62)80025-5","article-title":"Anatomy of mitral insufficiency","volume":"5","author":"Levy","year":"1962","journal-title":"Prog Cardiovasc Dis"},{"key":"10.1016\/j.tcm.2016.04.012_bib9","doi-asserted-by":"crossref","first-page":"i3","DOI":"10.1093\/ejechocard\/jeq153","article-title":"Anatomy of the mitral valve: understanding the mitral valve complex in mitral regurgitation","volume":"11","author":"McCarthy","year":"2010","journal-title":"Eur J Echocardiogr"},{"key":"10.1016\/j.tcm.2016.04.012_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0022-5223(19)42269-1","article-title":"A new reconstructive operation for correction of mitral and tricuspid insufficiency","volume":"61","author":"Carpentier","year":"1971","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.tcm.2016.04.012_bib11","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.ahj.2012.05.014","article-title":"Anatomy, mechanics, and pathophysiology of the mitral annulus","volume":"164","author":"Silbiger","year":"2012","journal-title":"Am Heart J"},{"key":"10.1016\/j.tcm.2016.04.012_bib12","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1161\/01.CIR.0000025426.39426.83","article-title":"Effect of annular shape on leaflet curvature in reducing mitral leaflet stress","volume":"106","author":"Salgo","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.tcm.2016.04.012_bib13","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1093\/eurheartj\/ehs109","article-title":"Guidelines on the management of valvular heart disease (version 2012)","volume":"33","author":"Members","year":"2012","journal-title":"Eur Heart J"},{"key":"10.1016\/j.tcm.2016.04.012_bib14","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/S0022-5223(19)37942-5","article-title":"Reconstructive surgery of mitral valve incompetence: ten-year appraisal","volume":"79","author":"Carpentier","year":"1980","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.tcm.2016.04.012_bib15","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/S0022-5223(96)70332-X","article-title":"Extensive calcification of the mitral valve anulus: Pathology and surgical management","volume":"111","author":"Carpentier","year":"1996","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.tcm.2016.04.012_bib16","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1161\/01.CIR.96.6.1999","article-title":"Insights from three-dimensional echocardiography into the mechanism of functional mitral regurgitation: direct in vivo demonstration of altered leaflet tethering geometry","volume":"96","author":"Otsuji","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.tcm.2016.04.012_bib17","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.jacc.2008.05.007","volume":"52","author":"Bonow","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.tcm.2016.04.012_bib18","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.ijcard.2011.11.023","article-title":"Functional mitral regurgitation: from normal to pathological anatomy of mitral valve","volume":"163","author":"Di Mauro","year":"2013","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.tcm.2016.04.012_bib19","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/S0002-9149(97)89217-X","article-title":"Effect of isolated left atrial enlargement on mitral annular size and valve competence","volume":"77","author":"Tanimoto","year":"1996","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.tcm.2016.04.012_bib20","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1111\/j.1540-8175.2009.00904.x","article-title":"Mitral regurgitation associated with mitral annular dilation in patients with lone atrial fibrillation: an echocardiographic study","volume":"26","author":"Kihara","year":"2009","journal-title":"Echocardiography"},{"key":"10.1016\/j.tcm.2016.04.012_bib21","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1016\/j.jacc.2011.06.032","article-title":"Evidence of atrial functional mitral regurgitation due to atrial fibrillation: reversal with arrhythmia control","volume":"58","author":"Gertz","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.tcm.2016.04.012_bib22","doi-asserted-by":"crossref","first-page":"183","DOI":"10.4330\/wjc.v4.i5.183","article-title":"Clinically unrecognized mitral regurgitation is prevalent in lone atrial fibrillation","volume":"4","author":"Sharma","year":"2012","journal-title":"World J Cardiol"},{"key":"10.1016\/j.tcm.2016.04.012_bib23","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1253\/circj.66.913","article-title":"Impact of atrial fibrillation on tricuspid and mitral annular dilatation and valvular regurgitation","volume":"66","author":"Zhou","year":"2002","journal-title":"Circ J"},{"key":"10.1016\/j.tcm.2016.04.012_bib24","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1093\/europace\/eur098","article-title":"The impact of mitral regurgitation on patients undergoing catheter ablation of atrial fibrillation","volume":"13","author":"Gertz","year":"2011","journal-title":"Europace"},{"key":"10.1016\/j.tcm.2016.04.012_bib25","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1093\/europace\/eut252","article-title":"The role of valvular regurgitation in catheter ablation outcomes of patients with long-standing persistent atrial fibrillation","volume":"16","author":"Zhao","year":"2013","journal-title":"Europace"},{"key":"10.1016\/j.tcm.2016.04.012_bib26","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s10840-013-9784-8","article-title":"Mitral regurgitation recovery and atrial reverse remodeling following pulmonary vein isolation procedure in patients with atrial fibrillation: a clinical observation proof-of-concept cardiac MRI study","volume":"37","author":"Reddy","year":"2013","journal-title":"J Interv Card Electrophysiol"},{"key":"10.1016\/j.tcm.2016.04.012_bib27","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1093\/ehjci\/jet191","article-title":"Mechanisms of atrial mitral regurgitation: insights using 3D transoesophageal echo","volume":"15","author":"Ring","year":"2013","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.tcm.2016.04.012_bib28","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1161\/01.CIR.89.2.724","article-title":"Echocardiographic predictors of nonrheumatic atrial fibrillation. The Framingham Heart Study","volume":"89","author":"Vaziri","year":"1994","journal-title":"Circulation"},{"key":"10.1016\/j.tcm.2016.04.012_bib29","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1161\/01.CIR.96.7.2455","article-title":"Incidence of and risk factors for atrial fibrillation in older adults","volume":"96","author":"Psaty","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.tcm.2016.04.012_bib30","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1161\/01.CIR.53.2.273","article-title":"Relation between echocardiographically determined left atrial size and atrial fibrillation","volume":"53","author":"Henry","year":"1976","journal-title":"Circulation"},{"key":"10.1016\/j.tcm.2016.04.012_bib31","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1161\/01.CIR.82.3.792","article-title":"Atrial enlargement as a consequence of atrial fibrillation. A prospective echocardiographic study","volume":"82","author":"Sanfilippo","year":"1990","journal-title":"Circulation"},{"key":"10.1016\/j.tcm.2016.04.012_bib32","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ijcard.2004.03.010","article-title":"Changes in left atrial size in patients with persistent atrial fibrillation: a prospective echocardiographic study with a 5-year follow-up period","volume":"101","author":"Wozakowska-Kaplon","year":"2005","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.tcm.2016.04.012_bib33","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1002\/clc.4960140806","article-title":"Changes in left atrial size in patients with lone atrial fibrillation","volume":"14","author":"Suarez","year":"1991","journal-title":"Clin Cardiol"},{"key":"10.1016\/j.tcm.2016.04.012_bib34","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/0002-9149(87)90253-0","article-title":"Relation between left atrial dimension and duration of atrial fibrillation","volume":"60","author":"Petersen","year":"1987","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.tcm.2016.04.012_bib35","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/S0008-6363(02)00258-4","article-title":"Electrical, contractile and structural remodeling during atrial fibrillation","volume":"54","author":"Allessie","year":"2002","journal-title":"Cardiovasc Res"},{"issue":"suppl 4","key":"10.1016\/j.tcm.2016.04.012_bib36","first-page":"iv5","article-title":"Anatomy of the mitral valve","volume":"88","author":"Ho","year":"2002","journal-title":"Heart"},{"key":"10.1016\/j.tcm.2016.04.012_bib37","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1161\/01.CIR.46.2.227","article-title":"The mitral apparatus: functional anatomy of mitral regurgitation","volume":"46","author":"Perloff","year":"1972","journal-title":"Circulation"},{"key":"10.1016\/j.tcm.2016.04.012_bib38","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1016\/0735-1097(93)90593-P","article-title":"Changes in left and right atrial size after cardioversion of atrial fibrillation: role of mitral valve disease","volume":"22","author":"Gosselink","year":"1993","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.tcm.2016.04.012_bib39","first-page":"993","article-title":"Change in atrial volume following restoration of sinus rhythm in patients with atrial fibrillation: a prospective echocardiographic study","volume":"10","author":"Welikovitch","year":"1994","journal-title":"Can J Cardiol"},{"key":"10.1016\/j.tcm.2016.04.012_bib40","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1161\/CIRCULATIONAHA.104.484766","article-title":"Successful radiofrequency ablation in patients with previous atrial fibrillation results in a significant decrease in left atrial size","volume":"112","author":"Beukema","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.tcm.2016.04.012_bib41","doi-asserted-by":"crossref","first-page":"2896","DOI":"10.1161\/CIRCULATIONAHA.104.523928","article-title":"Reverse remodeling of the left cardiac chambers after catheter ablation after 1 year in a series of patients with isolated atrial fibrillation","volume":"112","author":"Reant","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.tcm.2016.04.012_bib42","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1016\/j.amjcard.2005.11.043","article-title":"Effect of radiofrequency catheter ablation for atrial fibrillation on left atrial cavity size","volume":"97","author":"Tops","year":"2006","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.tcm.2016.04.012_bib43","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s10840-008-9349-4","article-title":"Assessment of left atrial shape and volume in structural remodeling secondary to atrial fibrillation","volume":"25","author":"Floria","year":"2009","journal-title":"J Interv Card Electrophysiol"},{"key":"10.1016\/j.tcm.2016.04.012_bib44","first-page":"284","article-title":"Pure annular dilation as a cause of mitral regurgitation: a clinically distinct entity of female heart disease","volume":"18","author":"Glower","year":"2009","journal-title":"J Heart Valve Dis"},{"key":"10.1016\/j.tcm.2016.04.012_bib45","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1016\/S0735-1097(02)01838-7","article-title":"Isolated annular dilation does not usually cause important functional mitral regurgitation: comparison between patients with lone atrial fibrillation and those with idiopathic or ischemic cardiomyopathy","volume":"39","author":"Otsuji","year":"2002","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.tcm.2016.04.012_bib46","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1111\/echo.12629","article-title":"Does left atrial enlargement contribute to mitral leaflet tethering in patients with functional mitral regurgitation? Proposed role of atriogenic leaflet tethering","volume":"31","author":"Silbiger","year":"2014","journal-title":"Echocardiography"},{"issue":"11 suppl 1","key":"10.1016\/j.tcm.2016.04.012_bib47","doi-asserted-by":"crossref","first-page":"S263","DOI":"10.1161\/CIRCULATIONAHA.112.000396","article-title":"Creation of nonischemic functional mitral regurgitation by annular dilatation and nonplanar modification in a chronic in vivo swine model","volume":"128","author":"Yamauchi","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.tcm.2016.04.012_bib48","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.jbiomech.2013.11.035","article-title":"Determination of the tensile mechanical properties of the segmented mitral valve annulus","volume":"47","author":"Gunning","year":"2014","journal-title":"J Biomech"},{"key":"10.1016\/j.tcm.2016.04.012_bib49","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1136\/hrt.59.6.712","article-title":"A histological study of the atrioventricular junction in hearts with normal and prolapsed leaflets of the mitral valve","volume":"59","author":"Angelini","year":"1988","journal-title":"Br Heart J"},{"key":"10.1016\/j.tcm.2016.04.012_bib50","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1093\/ejcts\/ezs029","article-title":"Mitral valve repair for severe mitral regurgitation secondary to lone atrial fibrillation","volume":"42","author":"Vohra","year":"2012","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.tcm.2016.04.012_bib51","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1056\/NEJMoa021375","article-title":"A comparison of rate control and rhythm control in patients with atrial fibrillation","volume":"347","author":"Van Gelder","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.tcm.2016.04.012_bib52","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1056\/NEJMoa021375","article-title":"A comparison of rate control and rhythm control in patients with recurrent persistent atrial fibrillation","volume":"347","author":"Van Gelder","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.tcm.2016.04.012_bib53","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1161\/01.CIR.0000121736.16643.11","article-title":"Relationships Between Sinus Rhythm, Treatment, and Survival in the Atrial Fibrillation Follow-Up Investigation of Rhythm Management (AFFIRM) Study","volume":"109","author":"Investigators","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.tcm.2016.04.012_bib54","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/0735-1097(92)90003-6","article-title":"Antiarrhythmic drug therapy and cardiac mortality in atrial fibrillation","volume":"20","author":"Flaker","year":"1992","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.tcm.2016.04.012_bib55","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1001\/archinternmed.2012.2266","article-title":"Comparative effectiveness of rhythm control vs rate control drug treatment effect on mortality in patients with atrial fibrillation","volume":"172","author":"Ionescu-Ittu","year":"2012","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.tcm.2016.04.012_bib56","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.hrthm.2004.09.028","article-title":"Effect of rate and rhythm control on left ventricular function and cardiac dimensions in patients with persistent atrial fibrillation: results from the RAte Control versus Electrical Cardioversion for Persistent Atrial Fibrillation (RACE) study","volume":"2","author":"Hagens","year":"2005","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.tcm.2016.04.012_bib57","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1253\/circj.CJ-08-0608","article-title":"Optimal treatment strategy for patients with paroxysmal atrial fibrillation: J-RHYTHM Study","volume":"73","author":"Ogawa","year":"2009","journal-title":"Circ J"},{"key":"10.1016\/j.tcm.2016.04.012_bib58","doi-asserted-by":"crossref","first-page":"720","DOI":"10.7326\/0003-4819-141-9-200411020-00015","article-title":"Is there a role for maintaining sinus rhythm in patients with atrial fibrillation?","volume":"141","author":"Zimetbaum","year":"2004","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.tcm.2016.04.012_bib59","doi-asserted-by":"crossref","first-page":"2585","DOI":"10.1001\/archinte.1996.00440210109011","article-title":"Chronic atrial fibrillation: success of serial cardioversion therapy and safety of oral anticoagulation","volume":"156","author":"Van Gelder","year":"1996","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.tcm.2016.04.012_bib60","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1016\/S0735-1097(97)00385-9","article-title":"Electrical remodeling of the human atrium: similar effects in patients with chronic atrial fibrillation and atrial flutter","volume":"30","author":"Franz","year":"1997","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.tcm.2016.04.012_bib61","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1161\/CIRCULATIONAHA.113.004742","article-title":"Dominant frequency increase rate predicts transition from paroxysmal to long-term persistent atrial fibrillation","volume":"129","author":"Martins","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.tcm.2016.04.012_bib62","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1093\/ejechocard\/jeq010","article-title":"Atrial asynchrony and function before and after electrical cardioversion for persistent atrial fibrillation","volume":"11","author":"Dell\u05f3Era","year":"2010","journal-title":"Eur J Echocardiogr"},{"key":"10.1016\/j.tcm.2016.04.012_bib63","series-title":"Carpentier\u05f3s reconstructive surgery: from valve analysis to valve reconstruction","first-page":"27","article-title":"Surgical anatomy and physiology","author":"Carpentier","year":"2010"}],"container-title":["Trends in Cardiovascular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050173816300299?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050173816300299?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,19]],"date-time":"2020-09-19T10:15:01Z","timestamp":1600510501000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050173816300299"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":63,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["S1050173816300299"],"URL":"https:\/\/doi.org\/10.1016\/j.tcm.2016.04.012","relation":{},"ISSN":["1050-1738"],"issn-type":[{"value":"1050-1738","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mechanistic insights into mitral regurgitation due to atrial fibrillation: \u201cAtrial functional mitral regurgitation\u201d","name":"articletitle","label":"Article Title"},{"value":"Trends in Cardiovascular Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tcm.2016.04.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}