{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T11:30:22Z","timestamp":1788780622891,"version":"build-2803163510"},"reference-count":45,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["tcmonline.org","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Cardiovascular Medicine"],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.1016\/j.tcm.2017.11.004","type":"journal-article","created":{"date-parts":[[2017,11,28]],"date-time":"2017-11-28T03:15:11Z","timestamp":1511838911000},"page":"295-302","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Idiopathic malignant premature ventricular contractions"],"prefix":"10.1016","volume":"28","author":[{"given":"James E.","family":"Ip","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce B.","family":"Lerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tcm.2017.11.004_bib1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1056\/NEJM198501243120401","article-title":"Long-term follow-up of asymptomatic healthy subjects with frequent and complex ventricular ectopy","volume":"312","author":"Kennedy","year":"1985","journal-title":"N Engl J Med"},{"key":"10.1016\/j.tcm.2017.11.004_bib2","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1161\/01.CIR.89.1.206","article-title":"Short-coupled variant of torsade de pointes. A new electrocardiographic entity in the spectrum of idiopathic ventricular tachyarrhythmias","volume":"89","author":"Leenhardt","year":"1994","journal-title":"Circulation"},{"key":"10.1016\/j.tcm.2017.11.004_bib3","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1111\/j.1540-8167.1997.tb00997.x","article-title":"Mode of onset of malignant ventricular arrhythmias in idiopathic ventricular fibrillation","volume":"8","author":"Viskin","year":"1997","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.tcm.2017.11.004_bib4","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1161\/01.CIR.0000027564.55739.B1","article-title":"Mapping and ablation of idiopathic ventricular fibrillation","volume":"106","author":"Ha\u00efssaguerre","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.tcm.2017.11.004_bib5","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/S0140-6736(02)07807-8","article-title":"Role of Purkinje conducting system in triggering of idiopathic ventricular fibrillation","volume":"359","author":"Ha\u00efssaguerre","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.tcm.2017.11.004_bib6","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1016\/j.jacc.2005.05.077","article-title":"Malignant entity of idiopathic ventricular fibrillation and polymorphic ventricular tachycardia initiated by premature extrasystoles originating from the right ventricular outflow tract","volume":"46","author":"Noda","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.tcm.2017.11.004_bib7","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.hrthm.2014.08.029","article-title":"Idiopathic ventricular arrhythmias originating from the moderator band: electrocardiographic characteristics and treatment by catheter ablation","volume":"12","author":"Sadek","year":"2015","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.tcm.2017.11.004_bib8","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1111\/j.1540-8167.2005.50040.x","article-title":"The \u201cshort-coupled\u201d variant of right ventricular outflow ventricular tachycardia: a not-so-benign form of benign ventricular tachycardia?","volume":"16","author":"Viskin","year":"2005","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.tcm.2017.11.004_bib9","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1016\/j.hrthm.2009.06.017","article-title":"Arrhythmias originating from the right ventricular outflow tract: how to distinguish \u201cmalignant\u201d from \u201cbenign\u201d?","volume":"6","author":"Shimizu","year":"2009","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.tcm.2017.11.004_bib10","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1253\/circj.CJ-12-0864","article-title":"Positive QRS complex in lead I as a malignant sign in right ventricular outflow tract tachycardia: comparison between polymorphic and monomorphic ventricular tachycardia","volume":"77","author":"Kurosaki","year":"2013","journal-title":"Circ J"},{"key":"10.1016\/j.tcm.2017.11.004_bib11","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1111\/j.1540-8167.2011.02232.x","article-title":"Electrocardiographic determinants of the polymorphic QRS morphology in idiopathic right ventricular outflow tract tachycardia","volume":"23","author":"Igarashi","year":"2012","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.tcm.2017.11.004_bib12","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.1016\/j.hrthm.2014.08.012","article-title":"Second coupling interval of nonsustained ventricular tachycardia to distinguish malignant from benign outflow tract ventricular tachycardias","volume":"11","author":"Kim","year":"2014","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.tcm.2017.11.004_bib13","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.hrthm.2013.12.030","article-title":"Catheter ablation of ventricular fibrillation: importance of left ventricular outflow tract and papillary muscle triggers","volume":"11","author":"Van Herendael","year":"2014","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.tcm.2017.11.004_bib14","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1111\/jce.12478","article-title":"Ventricular fibrillation triggered by PVCs from papillary muscles: clinical features and ablation","volume":"25","author":"Santoro","year":"2014","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.tcm.2017.11.004_bib15","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.ijcard.2014.11.119","article-title":"Short-coupled polymorphic ventricular tachycardia at rest linked to a novel ryanodine receptor (RyR2) mutation: leaky RyR2 channels under non-stress conditions","volume":"180","author":"Cheung","year":"2014","journal-title":"Int J Cardiol"},{"issue":"4","key":"10.1016\/j.tcm.2017.11.004_bib16","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.jacc.2009.03.065","article-title":"Long-term follow-up of idiopathic ventricular fibrillation ablation: a multicenter study","volume":"54","author":"Knecht","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.tcm.2017.11.004_bib17","doi-asserted-by":"crossref","first-page":"H1002","DOI":"10.1152\/ajpheart.01237.2009","article-title":"Arrhythmogenesis by single ectopic beats originating in the Purkinje system","volume":"299","author":"Deo","year":"2010","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.tcm.2017.11.004_bib18","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1161\/CIRCULATIONAHA.105.546432","article-title":"Reversal of cardiomyopathy in patients with repetitive monomorphic ventricular ectopy originating from the right ventricular outflow tract","volume":"112","author":"Yarlagadda","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.tcm.2017.11.004_bib19","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/j.jacc.2004.12.073","article-title":"Radiofrequency catheter ablation of premature ventricular complexes from right ventricular outflow tract improves left ventricular dilation and clinical status in patients without structural heart disease","volume":"45","author":"Takemoto","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.tcm.2017.11.004_bib20","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.hrthm.2010.03.036","article-title":"Relationship between burden of premature ventricular complexes and left ventricular function","volume":"7","author":"Baman","year":"2010","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.tcm.2017.11.004_bib21","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.ejheart.2006.02.011","article-title":"\u2018Frequent\u2019 ventricular bigeminy\u2014a reversible cause of dilated cardiomyopathy. How frequent is \u2018frequent\u2019?","volume":"8","author":"Shanmugam","year":"2006","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.tcm.2017.11.004_bib22","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1136\/hrt.2008.159558","article-title":"Prognostic significance of frequent premature ventricular contractions originating from the ventricular outflow tract in patients with normal left ventricular function","volume":"95","author":"Niwano","year":"2009","journal-title":"Heart"},{"key":"10.1016\/j.tcm.2017.11.004_bib23","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.hrthm.2013.10.055","article-title":"Ventricular premature depolarization QRS duration as a new marker of risk for the development of ventricular premature depolarization-induced cardiomyopathy","volume":"11","author":"Carballeira Pol","year":"2014","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.tcm.2017.11.004_bib24","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.hrthm.2011.08.015","article-title":"Relation of symptoms and symptom duration to premature ventricular complex-induced cardiomyopathy","volume":"9","author":"Yokokawa","year":"2012","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.tcm.2017.11.004_bib25","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1161\/CIRCEP.115.003091","article-title":"Fatigue as presenting symptom and a high burden of premature ventricular contractions are independently associated with increased ventricular wall stress in patients with normal left ventricular function","volume":"8","author":"van Huls van Taxis","year":"2015","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.tcm.2017.11.004_bib26","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.hrthm.2014.12.017","article-title":"Effect of ablation of frequent premature ventricular complexes on left ventricular function in patients with nonischemic cardiomyopathy","volume":"12","author":"El Kadri","year":"2015","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.tcm.2017.11.004_bib27","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1016\/j.jacc.2012.08.977","article-title":"New unipolar electrogram criteria to identify irreversibility of nonischemic left ventricular cardiomyopathy","volume":"60","author":"Campos","year":"2012","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.tcm.2017.11.004_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.hrthm.2017.07.025","article-title":"Clinical recognition of pure premature ventricular complex-induced cardiomyopathy at presentation","author":"Penela","year":"2017","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.tcm.2017.11.004_bib29","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.hrthm.2013.10.033","article-title":"Relative efficacy of catheter ablation vs antiarrhythmic drugs in treating premature ventricular contractions: a single-center retrospective study","volume":"11","author":"Zhong","year":"2014","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.tcm.2017.11.004_bib30","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.1067\/mhj.2002.125516","article-title":"Effect of atenolol on symptomatic ventricular arrhythmia without structural heart disease: a randomized placebo-controlled study","volume":"144","author":"Krittayaphong","year":"2002","journal-title":"Am Heart J"},{"key":"10.1016\/j.tcm.2017.11.004_bib31","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1136\/hrt.2009.188722","article-title":"Beneficial effects of catheter ablation on left ventricular and right ventricular function in patients with frequent premature ventricular contractions and preserved ejection fraction","volume":"96","author":"Wijnmaalen","year":"2010","journal-title":"Heart"},{"key":"10.1016\/j.tcm.2017.11.004_bib32","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1111\/jce.12503","article-title":"Reappraisal of cardiac magnetic resonance imaging in idiopathic outflow tract arrhythmias","volume":"25","author":"Markowitz","year":"2014","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.tcm.2017.11.004_bib33","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1161\/CIRCEP.111.962381","article-title":"Left ventricular systolic dysfunction induced by ventricular ectopy: a novel model for premature ventricular contraction-induced cardiomyopathy","volume":"4","author":"Huizar","year":"2011","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.tcm.2017.11.004_bib34","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.hrthm.2015.11.016","article-title":"Impact of ventricular ectopic burden in a premature ventricular contraction-induced cardiomyopathy animal model","volume":"13","author":"Tan","year":"2016","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.tcm.2017.11.004_bib35","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1161\/CIRCEP.115.003047","article-title":"Abnormal left ventricular mechanics of ventricular ectopic beats: insights into origin and coupling interval in premature ventricular contraction-induced cardiomyopathy","volume":"8","author":"Potfay","year":"2015","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.tcm.2017.11.004_bib36","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.hrthm.2015.10.037","article-title":"JPH-2 interacts with Cai-handling proteins and ion channels in dyads: contribution to premature ventricular contraction-induced cardiomyopathy","volume":"13","author":"Jiang","year":"2016","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.tcm.2017.11.004_bib37","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1023\/A:1025418531853","article-title":"The influence of premature ventricular contractions on left ventricular function in asymptomatic children without structural heart disease: an echocardiographic evaluation","volume":"19","author":"Sun","year":"2003","journal-title":"Int J Cardiovasc Imaging"},{"key":"10.1016\/j.tcm.2017.11.004_bib38","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1111\/jce.12391","article-title":"Coupling interval dispersion and body mass index are independent predictors of idiopathic premature ventricular complex-induced cardiomyopathy","volume":"25","author":"Kawamura","year":"2014","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.tcm.2017.11.004_bib39","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/j.hrthm.2011.02.034","article-title":"The role of interpolation in PVC-induced cardiomyopathy","volume":"8","author":"Olgun","year":"2011","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.tcm.2017.11.004_bib40","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1111\/j.1540-8167.2011.02021.x","article-title":"Characteristics of premature ventricular complexes as correlates of reduced left ventricular systolic function: study of the burden, duration, coupling interval, morphology, and site of origin of PVCs","volume":"22","author":"Del Carpio Munoz","year":"2011","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.tcm.2017.11.004_bib41","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1016\/j.hrthm.2012.04.036","article-title":"Impact of QRS duration of frequent premature ventricular complexes on the development of cardiomyopathy","volume":"9","author":"Yokokawa","year":"2012","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.tcm.2017.11.004_bib42","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.hrthm.2015.08.025","article-title":"Premature ventricular contraction-induced cardiomyopathy: related clinical and electrophysiologic parameters","volume":"13","author":"Sadron Blaye-Felice","year":"2016","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.tcm.2017.11.004_bib43","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1111\/jce.12967","article-title":"A new combined parameter to predict premature ventricular complexes induced cardiomyopathy: impact and recognition of epicardial origin","volume":"27","author":"Hamon","year":"2016","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.tcm.2017.11.004_bib44","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1016\/j.hrthm.2012.05.019","article-title":"Predictors of recovery of left ventricular dysfunction after ablation of frequent ventricular premature depolarizations","volume":"9","author":"Deyell","year":"2012","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.tcm.2017.11.004_bib45","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.hrthm.2015.09.025","article-title":"Diffuse fibrosis leads to a decrease in unipolar voltage: validation in a swine model of premature ventricular contraction-induced cardiomyopathy","volume":"13","author":"Tanaka","year":"2016","journal-title":"Heart Rhythm"}],"container-title":["Trends in Cardiovascular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050173817301688?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050173817301688?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T04:04:50Z","timestamp":1660017890000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050173817301688"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":45,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["S1050173817301688"],"URL":"https:\/\/doi.org\/10.1016\/j.tcm.2017.11.004","relation":{},"ISSN":["1050-1738"],"issn-type":[{"value":"1050-1738","type":"print"}],"subject":[],"published":{"date-parts":[[2018,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Idiopathic malignant premature ventricular contractions","name":"articletitle","label":"Article Title"},{"value":"Trends in Cardiovascular Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tcm.2017.11.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}