{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T17:58:26Z","timestamp":1782410306973,"version":"3.54.5"},"reference-count":49,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,3,26]],"date-time":"2020-03-26T00:00:00Z","timestamp":1585180800000},"content-version":"am","delay-in-days":330,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Cardiovascular Medicine"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.tcm.2018.08.007","type":"journal-article","created":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T18:15:12Z","timestamp":1534961712000},"page":"200-204","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["The role of GPCR signaling in cardiac Epithelial to Mesenchymal Transformation (EMT)"],"prefix":"10.1016","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2035-5795","authenticated-orcid":false,"given":"Canan G.","family":"Nebigil","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"D\u00e9saubry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tcm.2018.08.007_bib0001","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/nrc822","article-title":"Epithelial-mesenchymal transitions in tumour progression","volume":"2","author":"Thiery","year":"2002","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.tcm.2018.08.007_bib0002","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/0012-1606(77)90278-0","article-title":"The development of the conduction system in the mouse embryo heart. I. The first embryonic A-V conduction pathway","volume":"56","author":"Viragh","year":"1977","journal-title":"Dev Biol"},{"key":"10.1016\/j.tcm.2018.08.007_bib0003","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1161\/CIRCRESAHA.109.203083","article-title":"Epicardium and myocardium separate from a common precursor pool by crosstalk between bone morphogenetic protein- and fibroblast growth factor-signaling pathways","volume":"105","year":"2009","journal-title":"Circ Res"},{"key":"10.1016\/j.tcm.2018.08.007_bib0004","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1159\/000047867","article-title":"The origin, formation and developmental significance of the epicardium: a review","volume":"169","author":"Manner","year":"2001","journal-title":"Cells Tissues Organs"},{"key":"10.1016\/j.tcm.2018.08.007_bib0005","doi-asserted-by":"crossref","first-page":"e53694","DOI":"10.1371\/journal.pone.0053694","article-title":"Characterization of epicardial-derived cardiac interstitial cells: differentiation and mobilization of heart fibroblast progenitors","volume":"8","author":"Ruiz-Villalba","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.tcm.2018.08.007_bib0006","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1007\/s00395-011-0181-0","article-title":"In vitro epithelial-to-mesenchymal transformation in human adult epicardial cells is regulated by TGFbeta-signaling and WT1","volume":"106","author":"Bax","year":"2011","journal-title":"Basic Res Cardiol"},{"key":"10.1016\/j.tcm.2018.08.007_bib0007","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1634\/stemcells.2006-0366","article-title":"Epicardial cells of human adults can undergo an epithelial-to-mesenchymal transition and obtain characteristics of smooth muscle cells in vitro","volume":"25","author":"van Tuyn","year":"2007","journal-title":"Stem Cells"},{"key":"10.1016\/j.tcm.2018.08.007_bib0008","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1038\/nbt.2682","article-title":"Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction","volume":"31","author":"Zangi","year":"2013","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.tcm.2018.08.007_bib0009","first-page":"145","article-title":"The ontogeny, activation and function of the epicardium during heart development and regeneration","author":"Simoes","year":"2018","journal-title":"Development"},{"key":"10.1016\/j.tcm.2018.08.007_bib0010","article-title":"Cardiac regeneration: epicardial mediated repair","volume":"282","author":"Kennedy-Lydon","year":"2015","journal-title":"Proc Biol Sci"},{"key":"10.1016\/j.tcm.2018.08.007_bib0011","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1073\/pnas.1417232112","article-title":"Adipogenesis and epicardial adipose tissue: a novel fate of the epicardium induced by mesenchymal transformation and PPARgamma activation","volume":"112","author":"Yamaguchi","year":"2015","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.tcm.2018.08.007_bib0012","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.pharmthera.2018.01.002","article-title":"Cardiac repair by epicardial EMT: current targets and a potential role for the primary cilium","volume":"186","author":"Blom","year":"2018","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.tcm.2018.08.007_bib0013","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.phrs.2017.07.020","article-title":"The epicardium as a source of multipotent adult cardiac progenitor cells: their origin, role and fate","volume":"127","author":"Smits","year":"2018","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.tcm.2018.08.007_bib0014","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.2353\/ajpath.2007.070251","article-title":"The emerging role of valve interstitial cell phenotypes in regulating heart valve pathobiology","volume":"171","author":"Liu","year":"2007","journal-title":"Am J Pathol"},{"key":"10.1016\/j.tcm.2018.08.007_bib0015","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a013912","article-title":"How to make a heart valve: from embryonic development to bioengineering of living valve substitutes","volume":"4","author":"MacGrogan","year":"2014","journal-title":"Cold Spring Harb Perspect Med"},{"key":"10.1016\/j.tcm.2018.08.007_bib0016","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1100\/tsw.2007.294","article-title":"Origin, fate, and function of Epicardium-Derived Cells (EPDCs) in normal and abnormal cardiac development","volume":"7","author":"Lie-Venema","year":"2007","journal-title":"Sci World J"},{"key":"10.1016\/j.tcm.2018.08.007_bib0017","article-title":"Epicardium-Derived-Cells in annulus fibrosis development and persistence of accessory atrioventricular pathways","volume":"28","author":"Kolditz","year":"2007","journal-title":"Eur Heart J"},{"key":"10.1016\/j.tcm.2018.08.007_bib0018","first-page":"1056","article-title":"Epicardium-Derived Cells (EPDCs) in development, cardiac disease and repair of ischemia","volume":"14","author":"Gittenberger-de Groot","year":"2010","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.tcm.2018.08.007_bib0019","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1161\/CIRCULATIONAHA.106.668178","article-title":"Preservation of left ventricular function and attenuation of remodeling after transplantation of human epicardium-derived cells into the infarcted mouse heart","volume":"116","author":"Winter","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.tcm.2018.08.007_bib0020","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1755-1536-5-15","article-title":"Cardiac fibroblasts, fibrosis and extracellular matrix remodeling in heart disease","volume":"5","author":"Fan","year":"2012","journal-title":"Fibrogenesis Tissue Repair"},{"key":"10.1016\/j.tcm.2018.08.007_bib0021","doi-asserted-by":"crossref","first-page":"H538","DOI":"10.1152\/ajpheart.01114.2010","article-title":"CCR2 mediates the uptake of bone marrow-derived fibroblast precursors in angiotensin II-induced cardiac fibrosis","volume":"301","author":"Xu","year":"2011","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.tcm.2018.08.007_bib0022","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.yjmcc.2015.12.019","article-title":"Epicardium-derived fibroblasts in heart development and disease","volume":"91","author":"Fang","year":"2016","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.tcm.2018.08.007_bib0023","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/1291537","article-title":"Epicardial fat: physiological, pathological, and therapeutic implications","author":"Salazar","year":"2016","journal-title":"Cardiol Res Pract"},{"key":"10.1016\/j.tcm.2018.08.007_bib0024","doi-asserted-by":"crossref","DOI":"10.1002\/stem.2866","article-title":"A prokineticin-driven epigenetic switch regulates human epicardial cell stemness and fate","author":"Qureshi","year":"2018","journal-title":"Stem Cells"},{"key":"10.1016\/j.tcm.2018.08.007_bib0025","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.tips.2018.04.002","article-title":"GPCRs and signal transducers: interaction stoichiometry","volume":"39","author":"Gurevich","year":"2018","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.tcm.2018.08.007_bib0026","doi-asserted-by":"crossref","first-page":"5443","DOI":"10.1074\/jbc.M116.763854","article-title":"Conformational profiling of the AT1 angiotensin II receptor reflects biased agonism, G protein coupling, and cellular context","volume":"292","author":"Devost","year":"2017","journal-title":"J Biol Chem"},{"key":"10.1016\/j.tcm.2018.08.007_bib0027","doi-asserted-by":"crossref","first-page":"5444","DOI":"10.1111\/bph.12965","article-title":"Biased beta2-adrenoceptor signalling in heart failure: pathophysiology and drug discovery","volume":"172","author":"Woo","year":"2015","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.tcm.2018.08.007_bib0028","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.tcm.2009.04.007","article-title":"Prokineticin receptors in cardiovascular function: foe or friend?","volume":"19","author":"Nebigil","year":"2009","journal-title":"Trends Cardiovasc Med"},{"key":"10.1016\/j.tcm.2018.08.007_bib0029","doi-asserted-by":"crossref","first-page":"25541","DOI":"10.1038\/srep25541","article-title":"Prokineticin receptor-1 signaling promotes Epicardial to Mesenchymal Transition during heart development","volume":"6","author":"Arora","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.tcm.2018.08.007_bib0030","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1161\/ATVBAHA.108.162404","article-title":"Prokineticin receptor-1 induces neovascularization and epicardial-derived progenitor cell differentiation","volume":"28","author":"Urayama","year":"2008","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.tcm.2018.08.007_bib0031","doi-asserted-by":"crossref","first-page":"3261","DOI":"10.1002\/jcp.25797","article-title":"Epithelial-Mesenchymal Transition (EMT): A biological process in the development, stem cell differentiation, and tumorigenesis","volume":"232","author":"Chen","year":"2017","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.tcm.2018.08.007_bib0032","doi-asserted-by":"crossref","first-page":"12804","DOI":"10.1038\/s41598-017-13198-2","article-title":"Prokineticin receptor-1-dependent paracrine and autocrine pathways control cardiac tcf21+ fibroblast progenitor cell transformation into adipocytes and vascular cells","volume":"7","author":"Qureshi","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.tcm.2018.08.007_bib0033","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/S0006-3223(02)01470-1","article-title":"Developing novel treatments for mood disorders: accelerating discovery","volume":"52","author":"Tamminga","year":"2002","journal-title":"Biological Psychiatry"},{"key":"10.1016\/j.tcm.2018.08.007_bib0034","doi-asserted-by":"crossref","first-page":"3575","DOI":"10.1111\/bph.12678","article-title":"Lysophospholipid receptor nomenclature review: IUPHAR Review 8","volume":"171","author":"Kihara","year":"2014","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.tcm.2018.08.007_bib0035","doi-asserted-by":"crossref","first-page":"H507","DOI":"10.1152\/ajpheart.2000.278.2.H507","article-title":"Role of kinins in chronic heart failure and in the therapeutic effect of ACE inhibitors in kininogen-deficient rats","volume":"278","author":"Liu","year":"2000","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.tcm.2018.08.007_bib0036","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1165\/rcmb.2007-0065OC","article-title":"Sphingosine kinase 1 regulates differentiation of human and mouse lung fibroblasts mediated by TGF-beta1","volume":"37","author":"Kono","year":"2007","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.tcm.2018.08.007_bib0037","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S0736-5748(01)00022-3","article-title":"Developmentally regulated serotonin 5-HT2B receptors","volume":"19","author":"Nebigil","year":"2001","journal-title":"Int J Dev Neurosci"},{"key":"10.1016\/j.tcm.2018.08.007_bib0038","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S1050-1738(01)00135-9","article-title":"A novel role for serotonin in heart","volume":"11","author":"Nebigil","year":"2001","journal-title":"Trends Cardiovasc Med"},{"key":"10.1016\/j.tcm.2018.08.007_bib0039","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1096\/fj.02-1122fje","article-title":"Serotonin is a novel survival factor of cardiomyocytes: mitochondria as a target of 5-HT2B receptor signaling","volume":"17","author":"Nebigil","year":"2003","journal-title":"FASEB J"},{"key":"10.1016\/j.tcm.2018.08.007_bib0040","doi-asserted-by":"crossref","first-page":"9508","DOI":"10.1073\/pnas.97.17.9508","article-title":"Serotonin 2B receptor is required for heart development","volume":"97","author":"Nebigil","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.tcm.2018.08.007_bib0041","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1161\/01.CIR.0000081520.25714.D9","article-title":"Functional consequence of serotonin\/5-HT2B receptor signaling in heart: role of mitochondria in transition between hypertrophy and heart failure?","volume":"108","author":"Nebigil","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.tcm.2018.08.007_bib0042","doi-asserted-by":"crossref","first-page":"e2782","DOI":"10.1371\/journal.pone.0002782","article-title":"Modulation of serotonin transporter function during fetal development causes dilated heart cardiomyopathy and lifelong behavioral abnormalities","volume":"3","author":"Noorlander","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.tcm.2018.08.007_bib0043","first-page":"68","article-title":"Paroxetine may increase risk for congenital malformations","volume":"18","author":"Cuzzell","year":"2006","journal-title":"Dermatol Nurs"},{"key":"10.1016\/j.tcm.2018.08.007_bib0044","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0167-0115(01)00236-1","article-title":"The novel peptide apelin lowers blood pressure via a nitric oxide-dependent mechanism","volume":"99","author":"Tatemoto","year":"2001","journal-title":"Regul Peptides"},{"key":"10.1016\/j.tcm.2018.08.007_bib0045","doi-asserted-by":"crossref","first-page":"Ii187","DOI":"10.1161\/01.CIR.0000138382.57325.5c","article-title":"Apelin has in vivo inotropic effects on normal and failing hearts","volume":"110","author":"Berry","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.tcm.2018.08.007_bib0046","article-title":"Xenopus apelin and msr are required for cardiovascular development","volume":"122","author":"Inui","year":"2005","journal-title":"Mech Dev"},{"key":"10.1016\/j.tcm.2018.08.007_bib0047","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.devcel.2007.01.011","article-title":"Apelin and its receptor control heart field formation during zebrafish gastrulation","volume":"12","author":"Zeng","year":"2007","journal-title":"Dev Cell"},{"key":"10.1016\/j.tcm.2018.08.007_bib0048","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.devcel.2013.11.002","article-title":"ELABELA: a hormone essential for heart development signals via the apelin receptor","volume":"27","author":"Chng","year":"2013","journal-title":"Dev Cell"},{"key":"10.1016\/j.tcm.2018.08.007_bib0049","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.bbrc.2010.01.076","article-title":"Identification of genes related to heart failure using global gene expression profiling of human failing myocardium","volume":"393","author":"Min","year":"2010","journal-title":"Biochem Bioph Res Commun"}],"container-title":["Trends in Cardiovascular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050173818301701?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050173818301701?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T04:58:19Z","timestamp":1760936299000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050173818301701"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":49,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["S1050173818301701"],"URL":"https:\/\/doi.org\/10.1016\/j.tcm.2018.08.007","relation":{},"ISSN":["1050-1738"],"issn-type":[{"value":"1050-1738","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of GPCR signaling in cardiac Epithelial to Mesenchymal Transformation (EMT)","name":"articletitle","label":"Article Title"},{"value":"Trends in Cardiovascular Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tcm.2018.08.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}