{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:48:02Z","timestamp":1792788482225,"version":"4.5.0"},"reference-count":71,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Cardiovascular Medicine"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.tcm.2024.08.005","type":"journal-article","created":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T01:28:37Z","timestamp":1724808517000},"page":"96-104","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["The current state and future of renal denervation: A review"],"prefix":"10.1016","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6029-3963","authenticated-orcid":false,"given":"Aneel S.","family":"Maini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mansi","family":"Maini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tayo","family":"Addo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek","family":"Koshti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Koshy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A.","family":"de Lemos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Price","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dharam J.","family":"Kumbhani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"364","key":"10.1016\/j.tcm.2024.08.005_bib0001","first-page":"1","article-title":"Hypertension prevalence among adults aged 18 and over: United States, 2017-2018","author":"Ostchega","year":"2020","journal-title":"NCHS Data Brief"},{"issue":"12","key":"10.1016\/j.tcm.2024.08.005_bib0002","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1097\/HJH.0000000000003480","volume":"41","author":"Mancia","year":"2023","journal-title":"J Hypertens"},{"issue":"19","key":"10.1016\/j.tcm.2024.08.005_bib0003","doi-asserted-by":"crossref","first-page":"e127","DOI":"10.1016\/j.jacc.2017.11.006","volume":"71","author":"Whelton","year":"2018","journal-title":"J Am Coll Cardiol"},{"issue":"16","key":"10.1016\/j.tcm.2024.08.005_bib0004","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1093\/eurheartj\/ehs368","article-title":"Resistant hypertension: a frequent and ominous finding among hypertensive patients with atherothrombosis","volume":"34","author":"Kumbhani","year":"2013","journal-title":"Eur Heart J"},{"issue":"5","key":"10.1016\/j.tcm.2024.08.005_bib0005","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.mayocp.2018.12.033","article-title":"Prevalence of apparent treatment-resistant hypertension in the united states according to the 2017 high blood pressure guideline","volume":"94","author":"Patel","year":"2019","journal-title":"Mayo Clin Proc"},{"issue":"2","key":"10.1016\/j.tcm.2024.08.005_bib0006","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1161\/HYPERTENSIONAHA.118.12191","article-title":"Prevalence of apparent treatment-resistant hypertension in the United States","volume":"73","author":"Carey","year":"2019","journal-title":"Hypertension."},{"issue":"22","key":"10.1016\/j.tcm.2024.08.005_bib0007","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1056\/NEJMoa1511939","article-title":"A randomized trial of intensive versus standard blood-pressure control","volume":"373","author":"Group","year":"2015","journal-title":"N Engl J Med"},{"issue":"16","key":"10.1016\/j.tcm.2024.08.005_bib0008","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1001\/jama.1953.03690160001001","article-title":"Splanchnicectomy for essential hypertension; results in 1,266 cases","volume":"152","author":"Smithwick","year":"1953","journal-title":"J Am Med Assoc"},{"issue":"1","key":"10.1016\/j.tcm.2024.08.005_bib0009","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1152\/physrev.1997.77.1.75","article-title":"Neural control of renal function","volume":"77","author":"DiBona","year":"1997","journal-title":"Physiol Rev"},{"issue":"3 Pt 2","key":"10.1016\/j.tcm.2024.08.005_bib0010","doi-asserted-by":"crossref","first-page":"140S","DOI":"10.1093\/ajh\/2.3.140S","article-title":"Noradrenaline release and the pathophysiology of primary human hypertension","volume":"2","author":"Esler","year":"1989","journal-title":"Am J Hypertens"},{"issue":"2","key":"10.1016\/j.tcm.2024.08.005_bib0011","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1161\/01.HYP.0000103160.35395.9E","article-title":"Sympathetic augmentation in hypertension: role of nerve firing, norepinephrine reuptake, and Angiotensin neuromodulation","volume":"43","author":"Schlaich","year":"2004","journal-title":"Hypertension"},{"issue":"6","key":"10.1016\/j.tcm.2024.08.005_bib0012","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1038\/s41440-023-01266-2","article-title":"Emerging topics on renal denervation in hypertension: anatomical and functional aspects of renal nerves","volume":"46","author":"Katsurada","year":"2023","journal-title":"Hypertens Res"},{"issue":"5","key":"10.1016\/j.tcm.2024.08.005_bib0013","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1161\/CIRCULATIONAHA.118.037654","article-title":"A three-arm randomized trial of different renal denervation devices and techniques in patients with resistant hypertension (RADIOSOUND-HTN)","volume":"139","author":"Fengler","year":"2019","journal-title":"Circulation"},{"issue":"7","key":"10.1016\/j.tcm.2024.08.005_bib0014","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.jacc.2014.03.059","article-title":"Anatomic assessment of sympathetic peri-arterial renal nerves in man","volume":"64","author":"Sakakura","year":"2014","journal-title":"J Am Coll Cardiol"},{"issue":"9917","key":"10.1016\/j.tcm.2024.08.005_bib0015","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/S0140-6736(13)62192-3","article-title":"Percutaneous renal denervation in patients with treatment-resistant hypertension: final 3-year report of the Symplicity HTN-1 study","volume":"383","author":"Krum","year":"2014","journal-title":"Lancet"},{"issue":"9756","key":"10.1016\/j.tcm.2024.08.005_bib0016","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1016\/S0140-6736(10)62039-9","article-title":"Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial","volume":"376","author":"Symplicity","year":"2010","journal-title":"Lancet"},{"issue":"15","key":"10.1016\/j.tcm.2024.08.005_bib0017","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1056\/NEJMoa1402670","article-title":"A controlled trial of renal denervation for resistant hypertension","volume":"370","author":"Bhatt","year":"2014","journal-title":"N Engl J Med"},{"issue":"10361","key":"10.1016\/j.tcm.2024.08.005_bib0018","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/S0140-6736(22)01787-1","article-title":"Long-term outcomes after catheter-based renal artery denervation for resistant hypertension: final follow-up of the randomised SYMPLICITY HTN-3 Trial","volume":"400","author":"Bhatt","year":"2022","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.tcm.2024.08.005_bib0019","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1093\/eurheartj\/ehu441","article-title":"Predictors of blood pressure response in the SYMPLICITY HTN-3 trial","volume":"36","author":"Kandzari","year":"2015","journal-title":"Eur Heart J"},{"issue":"11","key":"10.1016\/j.tcm.2024.08.005_bib0020","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1161\/CIRCULATIONAHA.121.057687","article-title":"Clinical trial design principles and outcomes definitions for device-based therapies for hypertension: a consensus document from the hypertension academic research consortium","volume":"145","author":"Kandzari","year":"2022","journal-title":"Circulation"},{"issue":"10137","key":"10.1016\/j.tcm.2024.08.005_bib0021","doi-asserted-by":"crossref","first-page":"2346","DOI":"10.1016\/S0140-6736(18)30951-6","article-title":"Effect of renal denervation on blood pressure in the presence of antihypertensive drugs: 6-month efficacy and safety results from the SPYRAL HTN-ON MED proof-of-concept randomised trial","volume":"391","author":"Kandzari","year":"2018","journal-title":"Lancet"},{"issue":"10333","key":"10.1016\/j.tcm.2024.08.005_bib0022","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1016\/S0140-6736(22)00455-X","article-title":"Long-term efficacy and safety of renal denervation in the presence of antihypertensive drugs (SPYRAL HTN-ON MED): a randomised, sham-controlled trial","volume":"399","author":"Mahfoud","year":"2022","journal-title":"Lancet"},{"issue":"19","key":"10.1016\/j.tcm.2024.08.005_bib0023","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1016\/j.jacc.2023.08.045","article-title":"Safety and efficacy of renal denervation in patients taking antihypertensive medications","volume":"82","author":"Kandzari","year":"2023","journal-title":"J Am Coll Cardiol"},{"issue":"10234","key":"10.1016\/j.tcm.2024.08.005_bib0024","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1016\/S0140-6736(20)30554-7","article-title":"Efficacy of catheter-based renal denervation in the absence of antihypertensive medications (SPYRAL HTN-OFF MED Pivotal): a multicentre, randomised, sham-controlled trial","volume":"395","author":"Bohm","year":"2020","journal-title":"Lancet"},{"issue":"10137","key":"10.1016\/j.tcm.2024.08.005_bib0025","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1016\/S0140-6736(18)31082-1","article-title":"Endovascular ultrasound renal denervation to treat hypertension (RADIANCE-HTN SOLO): a multicentre, international, single-blind, randomised, sham-controlled trial","volume":"391","author":"Azizi","year":"2018","journal-title":"Lancet"},{"issue":"22","key":"10.1016\/j.tcm.2024.08.005_bib0026","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1161\/CIRCULATIONAHA.119.040451","article-title":"Six-month results of treatment-blinded medication titration for hypertension control after randomization to endovascular ultrasound renal denervation or a sham procedure in the RADIANCE-HTN SOLO Trial","volume":"139","author":"Azizi","year":"2019","journal-title":"Circulation"},{"issue":"24","key":"10.1016\/j.tcm.2024.08.005_bib0027","doi-asserted-by":"crossref","first-page":"2922","DOI":"10.1016\/j.jcin.2020.09.054","article-title":"12-month results from the unblinded phase of the RADIANCE-HTN SOLO trial of ultrasound renal denervation","volume":"13","author":"Azizi","year":"2020","journal-title":"JACC Cardiovasc Interv"},{"issue":"10293","key":"10.1016\/j.tcm.2024.08.005_bib0028","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1016\/S0140-6736(21)00788-1","article-title":"Ultrasound renal denervation for hypertension resistant to a triple medication pill (RADIANCE-HTN TRIO): a randomised, multicentre, single-blind, sham-controlled trial","volume":"397","author":"Azizi","year":"2021","journal-title":"Lancet"},{"issue":"12","key":"10.1016\/j.tcm.2024.08.005_bib0029","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1001\/jamacardio.2022.3904","article-title":"Effects of renal denervation vs sham in resistant hypertension after medication escalation: prespecified Analysis at 6 Months of the RADIANCE-HTN TRIO randomized clinical trial","volume":"7","author":"Azizi","year":"2022","journal-title":"JAMA Cardiol"},{"issue":"8","key":"10.1016\/j.tcm.2024.08.005_bib0030","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1001\/jama.2023.0713","article-title":"Endovascular ultrasound renal denervation to treat hypertension: the RADIANCE II randomized clinical trial","volume":"329","author":"Azizi","year":"2023","journal-title":"JAMA"},{"key":"10.1016\/j.tcm.2024.08.005_bib0031","article-title":"Patient-level pooled analysis of endovascular ultrasound renal denervation or a sham procedure at 6 months following medication escalation: the RADIANCE clinical trial program","author":"Azizi","year":"2023","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.tcm.2024.08.005_bib0032","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1161\/HYPERTENSIONAHA.110.163014","article-title":"Catheter-based renal sympathetic denervation for resistant hypertension: durability of blood pressure reduction out to 24 months","volume":"57","author":"Symplicity","year":"2011","journal-title":"Hypertension"},{"issue":"25","key":"10.1016\/j.tcm.2024.08.005_bib0033","doi-asserted-by":"crossref","first-page":"2976","DOI":"10.1161\/CIRCULATIONAHA.112.130880","article-title":"Renal sympathetic denervation for treatment of drug-resistant hypertension: one-year results from the Symplicity HTN-2 randomized, controlled trial","volume":"126","author":"Esler","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.tcm.2024.08.005_bib0034","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.ahj.2023.12.005","article-title":"Overview of the 2023 FDA circulatory system devices advisory panel meeting on the symplicity spyral renal denervation system","volume":"269","author":"Chitturi","year":"2024","journal-title":"Am Heart J"},{"issue":"5","key":"10.1016\/j.tcm.2024.08.005_bib0035","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1161\/CIRCULATIONAHA.118.037937","article-title":"Status of renal denervation therapy for hypertension","volume":"139","author":"Ram","year":"2019","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.tcm.2024.08.005_bib0036","first-page":"93","article-title":"Reduced blood pressure-lowering effect of catheter-based renal denervation in patients with isolated systolic hypertension: data from SYMPLICITY HTN-3 and the global SYMPLICITY registry","volume":"38","author":"Mahfoud","year":"2017","journal-title":"Eur Heart J"},{"issue":"17","key":"10.1016\/j.tcm.2024.08.005_bib0037","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1016\/j.jacc.2017.08.056","article-title":"Renal sympathetic denervation protects the failing heart via inhibition of neprilysin activity in the kidney","volume":"70","author":"Polhemus","year":"2017","journal-title":"J Am Coll Cardiol"},{"issue":"21","key":"10.1016\/j.tcm.2024.08.005_bib0038","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.1016\/j.jacc.2018.08.2186","article-title":"Renal denervation prevents heart failure progression via inhibition of the renin-angiotensin system","volume":"72","author":"Sharp","year":"2018","journal-title":"J Am Coll Cardiol"},{"issue":"3","key":"10.1016\/j.tcm.2024.08.005_bib0039","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.ijcard.2012.09.019","article-title":"First-in-man safety evaluation of renal denervation for chronic systolic heart failure: primary outcome from REACH-Pilot study","volume":"162","author":"Davies","year":"2013","journal-title":"Int J Cardiol"},{"issue":"10","key":"10.1016\/j.tcm.2024.08.005_bib0040","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.jacc.2011.11.034","article-title":"Renal sympathetic denervation reduces left ventricular hypertrophy and improves cardiac function in patients with resistant hypertension","volume":"59","author":"Brandt","year":"2012","journal-title":"J Am Coll Cardiol"},{"issue":"33","key":"10.1016\/j.tcm.2024.08.005_bib0041","doi-asserted-by":"crossref","DOI":"10.1093\/eurheartj\/ehu093","article-title":"Effect of renal denervation on left ventricular mass and function in patients with resistant hypertension: data from a multi-centre cardiovascular magnetic resonance imaging trial","volume":"35","author":"Mahfoud","year":"2014","journal-title":"Eur Heart J"},{"key":"10.1016\/j.tcm.2024.08.005_bib0042","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.123.010543","article-title":"Modulation of pulsatile left ventricular afterload by renal denervation in heart failure with preserved ejection fraction","author":"Rommel","year":"2023","journal-title":"Circ Heart Fail"},{"issue":"3","key":"10.1016\/j.tcm.2024.08.005_bib0043","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.120.007421","article-title":"Renal sympathetic denervation in patients with heart failure with preserved ejection fraction","volume":"14","author":"Kresoja","year":"2021","journal-title":"Circ Heart Fail"},{"issue":"3","key":"10.1016\/j.tcm.2024.08.005_bib0044","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1001\/jama.2019.21187","article-title":"Effect of renal denervation and catheter ablation vs catheter ablation alone on atrial fibrillation recurrence among patients with paroxysmal atrial fibrillation and hypertension: the ERADICATE-AF randomized clinical trial","volume":"323","author":"Steinberg","year":"2020","journal-title":"JAMA"},{"issue":"5","key":"10.1016\/j.tcm.2024.08.005_bib0045","doi-asserted-by":"crossref","DOI":"10.1093\/europace\/euad107","article-title":"The evaluate renal artery denervation in addition to catheter ablation to eliminate atrial fibrillation (ERADICATE-AF) trial: arrhythmia suppression, blood pressure control, and potential interactions","volume":"25","author":"Steinberg","year":"2023","journal-title":"Europace"},{"issue":"1","key":"10.1016\/j.tcm.2024.08.005_bib0046","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.jacep.2020.07.019","article-title":"Renal denervation for the management of refractory ventricular arrhythmias: a systematic review","volume":"7","author":"Hawson","year":"2021","journal-title":"JACC Clin Electrophysiol"},{"issue":"20","key":"10.1016\/j.tcm.2024.08.005_bib0047","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.118.009938","article-title":"Renal denervation reduced ventricular arrhythmia after myocardial infarction by inhibiting sympathetic activity and remodeling","volume":"7","author":"Zhang","year":"2018","journal-title":"J Am Heart Assoc"},{"issue":"1","key":"10.1016\/j.tcm.2024.08.005_bib0048","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s11325-014-0991-z","article-title":"Effect of renal sympathetic denervation on apnea-hypopnea index in patients with obstructive sleep apnea: a systematic review and meta-analysis","volume":"19","author":"Shantha","year":"2015","journal-title":"Sleep Breath"},{"issue":"4","key":"10.1016\/j.tcm.2024.08.005_bib0049","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1161\/HYPERTENSIONAHA.111.173799","article-title":"Effects of renal sympathetic denervation on blood pressure, sleep apnea course, and glycemic control in patients with resistant hypertension and sleep apnea","volume":"58","author":"Witkowski","year":"2011","journal-title":"Hypertension"},{"issue":"25","key":"10.1016\/j.tcm.2024.08.005_bib0050","doi-asserted-by":"crossref","first-page":"3372","DOI":"10.1016\/j.jacc.2018.09.075","article-title":"Secretory capacity of pancreatic beta-cells is enhanced 6 months after renal denervation in hypertensive patients","volume":"72","author":"Ott","year":"2018","journal-title":"J Am Coll Cardiol"},{"issue":"18","key":"10.1016\/j.tcm.2024.08.005_bib0051","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1161\/CIRCULATIONAHA.110.991869","article-title":"Effect of renal sympathetic denervation on glucose metabolism in patients with resistant hypertension: a pilot study","volume":"123","author":"Mahfoud","year":"2011","journal-title":"Circulation"},{"issue":"8","key":"10.1016\/j.tcm.2024.08.005_bib0052","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.006196","article-title":"Blood pressure response to main renal artery and combined main renal artery plus branch renal denervation in patients with resistant hypertension","volume":"6","author":"Fengler","year":"2017","journal-title":"J Am Heart Assoc"},{"issue":"2","key":"10.1016\/j.tcm.2024.08.005_bib0053","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1097\/HJH.0000000000001160","article-title":"Denervation of the distal renal arterial branches vs. conventional main renal artery treatment: a randomized controlled trial for treatment of resistant hypertension","volume":"35","author":"Pekarskiy","year":"2017","journal-title":"J Hypertens"},{"key":"10.1016\/j.tcm.2024.08.005_bib0054","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.aanat.2015.11.004","article-title":"The morphological substrate for Renal Denervation: nerve distribution patterns and parasympathetic nerves. A post-mortem histological study","volume":"204","author":"van Amsterdam","year":"2016","journal-title":"Ann Anat"},{"issue":"23","key":"10.1016\/j.tcm.2024.08.005_bib0055","doi-asserted-by":"crossref","first-page":"3006","DOI":"10.1016\/j.jacc.2019.04.015","article-title":"Renal denervation update from the international sympathetic nervous system summit: JACC state-of-the-art review","volume":"73","author":"Kiuchi","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.tcm.2024.08.005_bib0056","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.3389\/fphys.2018.01249","article-title":"The role of calcitonin gene related peptide (CGRP) in neurogenic vasodilation and its cardioprotective effects","volume":"9","author":"Kee","year":"2018","journal-title":"Front Physiol"},{"issue":"1","key":"10.1016\/j.tcm.2024.08.005_bib0057","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s12265-021-10149-1","article-title":"Mapping renal innervations by renal nerve stimulation and characterizations of blood pressure response patterns","volume":"15","author":"Zhou","year":"2022","journal-title":"J Cardiovasc Transl Res"},{"issue":"9671","key":"10.1016\/j.tcm.2024.08.005_bib0058","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1016\/S0140-6736(09)60566-3","article-title":"Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study","volume":"373","author":"Krum","year":"2009","journal-title":"Lancet"},{"issue":"11","key":"10.1016\/j.tcm.2024.08.005_bib0059","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/j.jacc.2014.11.071","article-title":"Brain-derived neurotrophic factor as a marker for immediate assessment of the success of renal sympathetic denervation","volume":"65","author":"Dorr","year":"2015","journal-title":"J Am Coll Cardiol"},{"issue":"23","key":"10.1016\/j.tcm.2024.08.005_bib0060","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1093\/eurheartj\/ehac065","article-title":"Renal denervation therapy for hypertension: all that glitters is not gold","volume":"43","author":"Ram","year":"2022","journal-title":"Eur Heart J"},{"issue":"2","key":"10.1016\/j.tcm.2024.08.005_bib0061","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1161\/HYPERTENSIONAHA.114.04176","article-title":"Reinnervation of renal afferent and efferent nerves at 5.5 and 11 months after catheter-based radiofrequency renal denervation in sheep","volume":"65","author":"Booth","year":"2015","journal-title":"Hypertension"},{"issue":"4","key":"10.1016\/j.tcm.2024.08.005_bib0062","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1161\/HYPERTENSIONAHA.122.20853","article-title":"Catheter-based renal denervation: 9-year follow-up data on safety and blood pressure reduction in patients with resistant hypertension","volume":"80","author":"Sesa-Ashton","year":"2023","journal-title":"Hypertension"},{"issue":"10","key":"10.1016\/j.tcm.2024.08.005_bib0063","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1093\/ajh\/hpy108","article-title":"Cost-effectiveness of renal denervation therapy for treatment-resistant hypertension: a best case scenario","volume":"31","author":"Chowdhury","year":"2018","journal-title":"Am J Hypertens"},{"key":"10.1016\/j.tcm.2024.08.005_bib0064","doi-asserted-by":"crossref","DOI":"10.1093\/ehjqcco\/qcae001","article-title":"Cost-effectiveness of catheter-based radiofrequency renal denervation for the treatment of uncontrolled hypertension: an analysis for the UK based on recent clinical evidence","author":"Sharp","year":"2024","journal-title":"Eur Heart J Qual Care Clin Outcomes"},{"issue":"10","key":"10.1016\/j.tcm.2024.08.005_bib0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.cjca.2023.06.285","article-title":"Cost-effectiveness of radiofrequency renal denervation for treatment of uncontrolled hypertension: a Canadian perspective","volume":"39","author":"Feldman","year":"2023","journal-title":"Canadian J Cardiol"},{"key":"10.1016\/j.tcm.2024.08.005_bib0066","doi-asserted-by":"crossref","unstructured":"Kandzari D., Cao K., Lobo M.D., Sharp A.S.P., Schmieder R.E., Esler M., et al. Cost-effectiveness of renal denervation for uncontrolled hypertension in the presence of antihypertensive drugs: an analysis for the U.S. based on 6-month primary results from the SPYRAL HTN-ON MED randomized trial. JSCAI other endovascular interventions (including renal denervation and AAA). 2023;2(3).","DOI":"10.1016\/j.jscai.2023.100799"},{"issue":"7","key":"10.1016\/j.tcm.2024.08.005_bib0067","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1161\/CIRCRESAHA.118.313220","article-title":"Adherence in Hypertension","volume":"124","author":"Burnier","year":"2019","journal-title":"Circ Res"},{"key":"10.1016\/j.tcm.2024.08.005_bib0068","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCULATIONAHA.124.069291","article-title":"Effect of alcohol-mediated renal denervation on blood pressure in the presence of antihypertensive medications: primary results from the TARGET BP I randomized clinical trial","author":"Kandzari","year":"2024","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/j.tcm.2024.08.005_bib0069","doi-asserted-by":"crossref","first-page":"738","DOI":"10.4244\/EIJV9I6A118","article-title":"Beta radiation for renal nerve denervation: initial feasibility and safety","volume":"9","author":"Waksman","year":"2013","journal-title":"EuroIntervention"},{"issue":"1","key":"10.1016\/j.tcm.2024.08.005_bib0070","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s12967-023-03919-9","article-title":"Renal nerve stimulation identifies renal innervation and optimizes the strategy for renal denervation in canine","volume":"21","author":"Liu","year":"2023","journal-title":"J Transl Med"},{"key":"10.1016\/j.tcm.2024.08.005_bib0071","doi-asserted-by":"crossref","DOI":"10.1002\/ccd.31065","article-title":"Overview of the 2023 FDA circulatory system devices advisory panel meeting on the recor paradise ultrasound-based renal denervation system","author":"Haberman","year":"2024","journal-title":"Catheter Cardiovasc Interv"}],"container-title":["Trends in Cardiovascular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050173824000781?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050173824000781?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T12:13:22Z","timestamp":1738930402000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050173824000781"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":71,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["S1050173824000781"],"URL":"https:\/\/doi.org\/10.1016\/j.tcm.2024.08.005","relation":{},"ISSN":["1050-1738"],"issn-type":[{"value":"1050-1738","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The current state and future of renal denervation: A review","name":"articletitle","label":"Article Title"},{"value":"Trends in Cardiovascular Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tcm.2024.08.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}