{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:18:38Z","timestamp":1790709518590,"version":"4.1.0"},"reference-count":100,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,6,4]],"date-time":"2027-06-04T00:00:00Z","timestamp":1812067200000},"content-version":"am","delay-in-days":338,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100005292","name":"Brigham and Women's Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005292","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100032645","name":"Hevolution Foundation","doi-asserted-by":"publisher","award":["HF-GRO-231,1991483"],"award-info":[{"award-number":["HF-GRO-231,1991483"]}],"id":[{"id":"10.13039\/100032645","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100032645","name":"Hevolution Foundation","doi-asserted-by":"publisher","award":["HF-GRO-231,19923825"],"award-info":[{"award-number":["HF-GRO-231,19923825"]}],"id":[{"id":"10.13039\/100032645","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016888","name":"Bayer Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016888","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R37AG13925"],"award-info":[{"award-number":["R37AG13925"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U54AG075941"],"award-info":[{"award-number":["U54AG075941"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5P01AI17539702"],"award-info":[{"award-number":["5P01AI17539702"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1U01AG08616801"],"award-info":[{"award-number":["1U01AG08616801"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5R01AG06416502"],"award-info":[{"award-number":["5R01AG06416502"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R33AG061456"],"award-info":[{"award-number":["R33AG061456"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005971","name":"Deutsche Herzstiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005971","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001655","name":"Deutscher Akademischer Austauschdienst","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001655","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Cardiovascular Medicine"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.tcm.2025.12.004","type":"journal-article","created":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T00:09:37Z","timestamp":1766189377000},"page":"281-292","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Yin and Yang of cellular senescence in ischemia-induced myocardial injury"],"prefix":"10.1016","volume":"36","author":[{"given":"Rosalie","family":"Wolff von Gudenberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasper","family":"Iske","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Roeschl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Stawowy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James L.","family":"Kirkland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjang","family":"Ruhparwar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3058-3166","authenticated-orcid":false,"given":"Stefan G.","family":"Tullius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tcm.2025.12.004_bib0001","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118199","article-title":"An inhibitor role of Nrf2 in the regulation of myocardial senescence and dysfunction after myocardial infarction","volume":"259","author":"Luo","year":"2020","journal-title":"Life Sci"},{"issue":"10","key":"10.1016\/j.tcm.2025.12.004_bib0002","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13249","article-title":"Clearance of senescent cells during cardiac ischemia-reperfusion injury improves recovery","volume":"19","author":"Dookun","year":"2020","journal-title":"Aging Cell"},{"issue":"31","key":"10.1016\/j.tcm.2025.12.004_bib0003","doi-asserted-by":"crossref","first-page":"2983","DOI":"10.1093\/eurheartj\/ehz919","article-title":"Senescence-induced inflammation: an important player and key therapeutic target in atherosclerosis","volume":"41","author":"Stojanovic","year":"2020","journal-title":"Eur Heart J"},{"issue":"5","key":"10.1016\/j.tcm.2025.12.004_bib0004","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2018100492","article-title":"Length-independent telomere damage drives post-mitotic cardiomyocyte senescence","volume":"38","author":"Anderson","year":"2019","journal-title":"EMBO J"},{"issue":"9","key":"10.1016\/j.tcm.2025.12.004_bib0005","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0074535","article-title":"Senescent cardiac fibroblast is critical for cardiac fibrosis after myocardial infarction","volume":"8","author":"Zhu","year":"2013","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.tcm.2025.12.004_bib0006","doi-asserted-by":"crossref","DOI":"10.1111\/acel.12945","article-title":"Pharmacological clearance of senescent cells improves survival and recovery in aged mice following acute myocardial infarction","volume":"18","author":"Walaszczyk","year":"2019","journal-title":"Aging Cell"},{"issue":"1","key":"10.1016\/j.tcm.2025.12.004_bib0007","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/s41514-023-00113-5","article-title":"Senescent cardiomyocytes contribute to cardiac dysfunction following myocardial infarction","volume":"9","author":"Redgrave","year":"2023","journal-title":"NPJ Aging"},{"issue":"10","key":"10.1016\/j.tcm.2025.12.004_bib0008","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/s41581-022-00601-z","article-title":"Cellular senescence: the good, the bad and the unknown","volume":"18","author":"Huang","year":"2022","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.tcm.2025.12.004_bib0009","doi-asserted-by":"crossref","first-page":"773","DOI":"10.3389\/fcell.2020.00773","article-title":"Senescence in wound repair: emerging strategies to target chronic healing wounds","volume":"8","author":"Wilkinson","year":"2020","journal-title":"Front Cell Dev Biol"},{"issue":"7742","key":"10.1016\/j.tcm.2025.12.004_bib0010","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/s41586-018-0784-9","article-title":"L1 drives IFN in senescent cells and promotes age-associated inflammation","volume":"566","author":"De Cecco","year":"2019","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.tcm.2025.12.004_bib0011","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2023.166642","article-title":"Senescent cardiac fibroblasts: a key role in cardiac fibrosis","volume":"1869","author":"Osorio","year":"2023","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"issue":"18","key":"10.1016\/j.tcm.2025.12.004_bib0012","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.118.009111","article-title":"Postinfarction hearts are protected by premature senescent cardiomyocytes via GATA 4-dependent CCN 1 secretion","volume":"7","author":"Cui","year":"2018","journal-title":"J Am Heart Assoc"},{"issue":"4","key":"10.1016\/j.tcm.2025.12.004_bib0013","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1536\/ihj.18-701","article-title":"Activation of DNA damage response and cellular senescence in cardiac fibroblasts limit cardiac fibrosis after myocardial infarction","volume":"60","author":"Shibamoto","year":"2019","journal-title":"Int Heart J"},{"issue":"14","key":"10.1016\/j.tcm.2025.12.004_bib0014","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1016\/j.jacc.2008.01.011","article-title":"Aging-related defects are associated with adverse cardiac remodeling in a mouse model of reperfused myocardial infarction","volume":"51","author":"Bujak","year":"2008","journal-title":"J Am Coll Cardiol"},{"issue":"7","key":"10.1016\/j.tcm.2025.12.004_bib0015","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.006349","article-title":"Haplodeficiency of Ataxia Telangiectasia mutated accelerates heart failure after myocardial infarction","volume":"6","author":"Jia","year":"2017","journal-title":"J Am Heart Assoc"},{"issue":"1","key":"10.1016\/j.tcm.2025.12.004_bib0016","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jacc.2010.08.623","article-title":"The aging heart and post-infarction left ventricular remodeling","volume":"57","author":"Shih","year":"2011","journal-title":"J Am Coll Cardiol"},{"issue":"7589","key":"10.1016\/j.tcm.2025.12.004_bib0017","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/nature16932","article-title":"Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan","volume":"530","author":"Baker","year":"2016","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.tcm.2025.12.004_bib0018","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1161\/CIRCRESAHA.115.307778","article-title":"Revisiting cardiac cellular composition","volume":"118","author":"Pinto","year":"2016","journal-title":"Circ Res"},{"issue":"11","key":"10.1016\/j.tcm.2025.12.004_bib0019","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1006\/jmcc.2000.1239","article-title":"Impaired cell shortening and relengthening with increased pacing frequency are intrinsic to the senescent mouse cardiomyocyte","volume":"32","author":"Lim","year":"2000","journal-title":"J Mol Cell Cardiol"},{"issue":"4","key":"10.1016\/j.tcm.2025.12.004_bib0020","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1111\/acel.12344","article-title":"The Achilles' heel of senescent cells: from transcriptome to senolytic drugs","volume":"14","author":"Zhu","year":"2015","journal-title":"Aging Cell"},{"issue":"12","key":"10.1016\/j.tcm.2025.12.004_bib0021","doi-asserted-by":"crossref","first-page":"4911","DOI":"10.1021\/acs.nanolett.1c00064","article-title":"Mechanical fingerprint of senescence in endothelial cells","volume":"21","author":"Chala","year":"2021","journal-title":"Nano Lett"},{"issue":"4","key":"10.1016\/j.tcm.2025.12.004_bib0022","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/s41569-021-00624-2","article-title":"The role of cellular senescence in cardiac disease: basic biology and clinical relevance","volume":"19","author":"Mehdizadeh","year":"2022","journal-title":"Nat Rev Cardiol"},{"issue":"3","key":"10.1016\/j.tcm.2025.12.004_bib0023","doi-asserted-by":"crossref","DOI":"10.1111\/acel.12931","article-title":"Aged-senescent cells contribute to impaired heart regeneration","volume":"18","author":"Lewis-McDougall","year":"2019","journal-title":"Aging Cell"},{"issue":"19","key":"10.1016\/j.tcm.2025.12.004_bib0024","doi-asserted-by":"crossref","first-page":"6249","DOI":"10.1113\/JP274775","article-title":"Decline in cellular function of aged mouse c-kit(+) cardiac progenitor cells","volume":"595","author":"Castaldi","year":"2017","journal-title":"J Physiol"},{"issue":"5","key":"10.1016\/j.tcm.2025.12.004_bib0025","doi-asserted-by":"crossref","first-page":"399","DOI":"10.18632\/aging.100669","article-title":"Age-related changes in tissue macrophages precede cardiac functional impairment","volume":"6","author":"Pinto","year":"2014","journal-title":"Aging (Albany NY)"},{"issue":"28","key":"10.1016\/j.tcm.2025.12.004_bib0026","doi-asserted-by":"crossref","first-page":"2698","DOI":"10.1093\/eurheartj\/ehac153","article-title":"Adult T-cells impair neonatal cardiac regeneration","volume":"43","author":"Dolejsi","year":"2022","journal-title":"Eur Heart J"},{"key":"10.1016\/j.tcm.2025.12.004_bib0027","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s13578-019-0297-8","article-title":"Cardioprotective effects of microRNA-18a on acute myocardial infarction by promoting cardiomyocyte autophagy and suppressing cellular senescence via brain derived neurotrophic factor","volume":"9","author":"Lin","year":"2019","journal-title":"Cell Biosci"},{"issue":"7439","key":"10.1016\/j.tcm.2025.12.004_bib0028","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/nature11919","article-title":"MicroRNA-34a regulates cardiac ageing and function","volume":"495","author":"Boon","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.tcm.2025.12.004_bib0029","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.cyto.2016.04.006","article-title":"Higher circulating levels of chemokines CXCL10, CCL20 and CCL22 in patients with ischemic heart disease","volume":"83","author":"Safa","year":"2016","journal-title":"Cytokine"},{"issue":"7","key":"10.1016\/j.tcm.2025.12.004_bib0030","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1016\/j.yexcr.2008.01.014","article-title":"TGF-beta1-induced cardiac myofibroblasts are nonproliferating functional cells carrying DNA damages","volume":"314","author":"Petrov","year":"2008","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.tcm.2025.12.004_bib0031","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.bbrc.2022.01.077","article-title":"P16ink4a overexpression ameliorates cardiac remodeling of mouse following myocardial infarction via CDK4\/pRb pathway","volume":"595","author":"Shi","year":"2022","journal-title":"Biochem Biophys Res Commun"},{"issue":"12","key":"10.1016\/j.tcm.2025.12.004_bib0032","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0083513","article-title":"Deficiency of ataxia telangiectasia mutated kinase modulates cardiac remodeling following myocardial infarction: involvement in fibrosis and apoptosis","volume":"8","author":"Foster","year":"2013","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.tcm.2025.12.004_bib0033","doi-asserted-by":"crossref","first-page":"H445","DOI":"10.1152\/ajpheart.00338.2016","article-title":"Ataxia telangiectasia-mutated kinase deficiency exacerbates left ventricular dysfunction and remodeling late after myocardial infarction","volume":"311","author":"Daniel","year":"2016","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"2","key":"10.1016\/j.tcm.2025.12.004_bib0034","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.bbalip.2016.11.003","article-title":"Palmitate promotes inflammatory responses and cellular senescence in cardiac fibroblasts","volume":"1862","author":"Sokolova","year":"2017","journal-title":"Biochim Biophys Acta Mol Cell Biol Lipids"},{"issue":"1","key":"10.1016\/j.tcm.2025.12.004_bib0035","doi-asserted-by":"crossref","first-page":"4289","DOI":"10.1038\/s41467-020-18039-x","article-title":"Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation","volume":"11","author":"Iske","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.tcm.2025.12.004_bib0036","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.actbio.2021.08.028","article-title":"Local delivery of a senolytic drug in ischemia and reperfusion-injured heart attenuates cardiac remodeling and restores impaired cardiac function","volume":"135","author":"Lee","year":"2021","journal-title":"Acta Biomater"},{"issue":"556","key":"10.1016\/j.tcm.2025.12.004_bib0037","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aat5185","article-title":"Hypoxia-induced interaction of filamin with Drp1 causes mitochondrial hyperfission-associated myocardial senescence","volume":"11","author":"Nishimura","year":"2018","journal-title":"Sci Signal"},{"issue":"1","key":"10.1016\/j.tcm.2025.12.004_bib0038","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1096\/fj.12-226225","article-title":"Dynamin-related protein 1 (Drp1)-mediated diastolic dysfunction in myocardial ischemia-reperfusion injury: therapeutic benefits of Drp1 inhibition to reduce mitochondrial fission","volume":"28","author":"Sharp","year":"2014","journal-title":"FASEB J"},{"issue":"8","key":"10.1016\/j.tcm.2025.12.004_bib0039","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1038\/emboj.2011.69","article-title":"p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype","volume":"30","author":"Freund","year":"2011","journal-title":"EMBO J"},{"issue":"9","key":"10.1016\/j.tcm.2025.12.004_bib0040","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0012700","article-title":"CXCL10 can inhibit endothelial cell proliferation independently of CXCR3","volume":"5","author":"Campanella","year":"2010","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.tcm.2025.12.004_bib0041","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1128\/JVI.78.4.1665-1674.2004","article-title":"Selective induction of Th2-attracting chemokines CCL17 and CCL22 in human B cells by latent membrane protein 1 of Epstein-Barr virus","volume":"78","author":"Nakayama","year":"2004","journal-title":"J Virol"},{"issue":"1","key":"10.1016\/j.tcm.2025.12.004_bib0042","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1097\/FJC.0b013e31815bd23d","article-title":"Roles of MAPK and NF-kappaB in interleukin-6 induction by lipopolysaccharide in vascular smooth muscle cells","volume":"51","author":"Son","year":"2008","journal-title":"J Cardiovasc Pharmacol"},{"issue":"5","key":"10.1016\/j.tcm.2025.12.004_bib0043","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/nrcardio.2014.28","article-title":"The inflammatory response in myocardial injury, repair, and remodelling","volume":"11","author":"Frangogiannis","year":"2014","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.tcm.2025.12.004_bib0044","doi-asserted-by":"crossref","DOI":"10.1016\/j.mad.2022.111740","article-title":"Pharmacological clearance of senescent cells improves cardiac remodeling and function after myocardial infarction in female aged mice","volume":"208","author":"Salerno","year":"2022","journal-title":"Mech Ageing Dev"},{"issue":"4","key":"10.1016\/j.tcm.2025.12.004_bib0045","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1177\/1758834014530023","article-title":"The PI3K\/AKT\/mTOR pathway in breast cancer: targets, trials and biomarkers","volume":"6","author":"Paplomata","year":"2014","journal-title":"Ther Adv Med Oncol"},{"key":"10.1016\/j.tcm.2025.12.004_bib0046","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.atherosclerosis.2017.03.023","article-title":"Accelerated cellular senescence as underlying mechanism for functionally impaired bone marrow-derived progenitor cells in ischemic heart disease","volume":"260","author":"Nollet","year":"2017","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.tcm.2025.12.004_bib0047","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.ijcard.2016.01.066","article-title":"Telomere shortening and telomerase activity in ischaemic cardiomyopathy patients - potential markers of ventricular arrhythmia","volume":"207","author":"Sawhney","year":"2016","journal-title":"Int J Cardiol"},{"issue":"4","key":"10.1016\/j.tcm.2025.12.004_bib0048","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.yjmcc.2005.01.014","article-title":"Post-infarction ventricular remodeling: an array of molecular events","volume":"38","author":"Prabhu","year":"2005","journal-title":"J Mol Cell Cardiol"},{"issue":"16","key":"10.1016\/j.tcm.2025.12.004_bib0049","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.2174\/092986706777585086","article-title":"Targeting the inflammatory response in healing myocardial infarcts","volume":"13","author":"Frangogiannis","year":"2006","journal-title":"Curr Med Chem"},{"issue":"10","key":"10.1016\/j.tcm.2025.12.004_bib0050","doi-asserted-by":"crossref","first-page":"3294","DOI":"10.1161\/01.CIR.96.10.3294","article-title":"Cardiovascular death and left ventricular remodeling two years after myocardial infarction: baseline predictors and impact of long-term use of captopril: information from the Survival and Ventricular Enlargement (SAVE) trial","volume":"96","author":"St John Sutton","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.tcm.2025.12.004_bib0051","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154277","article-title":"Calycosin reduces myocardial fibrosis and improves cardiac function in post-myocardial infarction mice by suppressing TGFBR1 signaling pathways","volume":"104","author":"Chen","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.tcm.2025.12.004_bib0052","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.ejphar.2018.10.023","article-title":"Calcitonin gene-related peptide inhibits the cardiac fibroblasts senescence in cardiac fibrosis via up-regulating klotho expression","volume":"843","author":"Li","year":"2019","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.tcm.2025.12.004_bib0053","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.omtn.2020.04.001","article-title":"miR-1468-3p promotes aging-related cardiac fibrosis","volume":"20","author":"Lin","year":"2020","journal-title":"Mol Ther Nucleic Acids"},{"issue":"2","key":"10.1016\/j.tcm.2025.12.004_bib0054","first-page":"293","article-title":"The microRNA miR-17-3p inhibits mouse cardiac fibroblast senescence by targeting Par4","volume":"128","author":"Du","year":"2015","journal-title":"J Cell Sci"},{"issue":"3","key":"10.1016\/j.tcm.2025.12.004_bib0055","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1007\/s11357-012-9407-9","article-title":"MicroRNA-22 increases senescence and activates cardiac fibroblasts in the aging heart","volume":"35","author":"Jazbutyte","year":"2013","journal-title":"Age (Dordr)"},{"issue":"12","key":"10.1016\/j.tcm.2025.12.004_bib0056","first-page":"1355","article-title":"MicroRNA-34a regulates cardiac fibrosis after myocardial infarction by targeting Smad4","volume":"18","author":"Huang","year":"2014","journal-title":"Expert Opin Ther Targets"},{"issue":"17","key":"10.1016\/j.tcm.2025.12.004_bib0057","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1161\/CIRCULATIONAHA.118.033042","article-title":"miR-22 in smooth muscle cells: a potential therapy for cardiovascular disease","volume":"137","author":"Huang","year":"2018","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.tcm.2025.12.004_bib0058","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1093\/cvr\/cvu184","article-title":"The microRNA-15 family inhibits the TGFbeta-pathway in the heart","volume":"104","author":"Tijsen","year":"2014","journal-title":"Cardiovasc Res"},{"issue":"1","key":"10.1016\/j.tcm.2025.12.004_bib0059","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1093\/cvr\/cvp015","article-title":"MicroRNA expression in response to murine myocardial infarction: miR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue","volume":"82","author":"Roy","year":"2009","journal-title":"Cardiovasc Res"},{"issue":"3","key":"10.1016\/j.tcm.2025.12.004_bib0060","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1093\/cvr\/cvq053","article-title":"Downregulation of microRNA-29 by antisense inhibitors and a PPAR-gamma agonist protects against myocardial ischaemia-reperfusion injury","volume":"87","author":"Ye","year":"2010","journal-title":"Cardiovasc Res"},{"issue":"3","key":"10.1016\/j.tcm.2025.12.004_bib0061","doi-asserted-by":"crossref","first-page":"664","DOI":"10.7150\/thno.15162","article-title":"miR-17-3p contributes to exercise-induced cardiac growth and protects against myocardial ischemia-reperfusion injury","volume":"7","author":"Shi","year":"2017","journal-title":"Theranostics"},{"issue":"8","key":"10.1016\/j.tcm.2025.12.004_bib0062","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/nchembio.1018","article-title":"Hydrogen sulfide anion regulates redox signaling via electrophile sulfhydration","volume":"8","author":"Nishida","year":"2012","journal-title":"Nat Chem Biol"},{"key":"10.1016\/j.tcm.2025.12.004_bib0063","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.toxrep.2023.04.013","article-title":"Dasatinib targets c-src kinase in cardiotoxicity","volume":"10","author":"Elmadani","year":"2023","journal-title":"Toxicol Rep"},{"issue":"9","key":"10.1016\/j.tcm.2025.12.004_bib0064","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.123.031972","article-title":"Patients with coronary microvascular dysfunction have less circulating alpha-klotho","volume":"13","author":"Akhiyat","year":"2024","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.tcm.2025.12.004_bib0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.103912","article-title":"Orally-active, clinically-translatable senolytics restore alpha-klotho in mice and humans","volume":"77","author":"Zhu","year":"2022","journal-title":"EBioMedicine"},{"issue":"7683","key":"10.1016\/j.tcm.2025.12.004_bib0066","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/nature24676","article-title":"IL-11 is a crucial determinant of cardiovascular fibrosis","volume":"552","author":"Schafer","year":"2017","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.tcm.2025.12.004_bib0067","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0068893","article-title":"Interleukin-16 promotes cardiac fibrosis and myocardial stiffening in heart failure with preserved ejection fraction","volume":"8","author":"Tamaki","year":"2013","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.tcm.2025.12.004_bib0068","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1200\/JCO.2010.31.6208","article-title":"Phase I study of Navitoclax (ABT-263), a novel bcl-2 family inhibitor, in patients with small-cell lung cancer and other solid tumors","volume":"29","author":"Gandhi","year":"2011","journal-title":"J Clin Oncol"},{"issue":"5","key":"10.1016\/j.tcm.2025.12.004_bib0069","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1021\/acsbiomaterials.1c01611","article-title":"A senolytic-eluting coronary stent for the prevention of In-stent restenosis","volume":"8","author":"Kim","year":"2022","journal-title":"ACS Biomater Sci Eng"},{"issue":"6","key":"10.1016\/j.tcm.2025.12.004_bib0070","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1536\/ihj.19-131","article-title":"Fisetin alleviates atrial inflammation, remodeling, and vulnerability to atrial fibrillation after myocardial infarction","volume":"60","author":"Liu","year":"2019","journal-title":"Int Heart J"},{"issue":"3","key":"10.1016\/j.tcm.2025.12.004_bib0071","article-title":"Cardiac fibroblast p38 MAPK: a critical regulator of myocardial remodeling","volume":"6","author":"Turner","year":"2019","journal-title":"J Cardiovasc Dev Dis"},{"key":"10.1016\/j.tcm.2025.12.004_bib0072","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.jnutbio.2018.08.010","article-title":"Fisetin inhibits cardiac hypertrophy by suppressing oxidative stress","volume":"62","author":"Dong","year":"2018","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.tcm.2025.12.004_bib0073","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/2647807","article-title":"Resveratrol inhibits ischemia-induced myocardial senescence signals and NLRP3 inflammasome activation","volume":"2020","author":"Feng","year":"2020","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.tcm.2025.12.004_bib0074","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.ebiom.2018.11.056","article-title":"Heme oxygenase-1 prevents heart against myocardial infarction by attenuating ischemic injury-induced cardiomyocytes senescence","volume":"39","author":"Shan","year":"2019","journal-title":"EBioMedicine"},{"issue":"2","key":"10.1016\/j.tcm.2025.12.004_bib0075","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.pharmthera.2011.12.010","article-title":"Post-infarct cardiac rupture: recent insights on pathogenesis and therapeutic interventions","volume":"134","author":"Gao","year":"2012","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.tcm.2025.12.004_bib0076","doi-asserted-by":"crossref","DOI":"10.1016\/j.critrevonc.2025.104628","article-title":"Cellular senescence in tumor immune escape: mechanisms, implications, and therapeutic potential","volume":"208","author":"You","year":"2025","journal-title":"Crit Rev Oncol Hematol"},{"issue":"6","key":"10.1016\/j.tcm.2025.12.004_bib0077","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1158\/1541-7786.MCR-21-0029","article-title":"Selective vulnerability of senescent glioblastoma cells to BCL-XL inhibition","volume":"20","author":"Rahman","year":"2022","journal-title":"Mol Cancer Res"},{"issue":"12","key":"10.1016\/j.tcm.2025.12.004_bib0078","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1038\/s42255-021-00491-8","article-title":"The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in mice","volume":"3","author":"Xu","year":"2021","journal-title":"Nat Metab"},{"issue":"7","key":"10.1016\/j.tcm.2025.12.004_bib0079","doi-asserted-by":"crossref","DOI":"10.3390\/cancers16071321","article-title":"Antineoplastic drug synergy of Artesunate with Navitoclax in models of high-grade serous ovarian cancer","volume":"16","author":"McCorkle","year":"2024","journal-title":"Cancers (Basel)"},{"issue":"1","key":"10.1016\/j.tcm.2025.12.004_bib0080","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/j.1476-5381.2010.00680.x","article-title":"Effects of the calcium sensitizer OR-1896, a metabolite of levosimendan, on post-infarct heart failure and cardiac remodelling in diabetic Goto-Kakizaki rats","volume":"160","author":"Louhelainen","year":"2010","journal-title":"Br J Pharmacol"},{"issue":"8","key":"10.1016\/j.tcm.2025.12.004_bib0081","first-page":"2387","article-title":"Angiotensin II receptor blocker reverses heart failure by attenuating local oxidative stress and preserving resident stem cells in rats with myocardial infarction","volume":"10","author":"Wen","year":"2018","journal-title":"Am J Transl Res"},{"issue":"9335","key":"10.1016\/j.tcm.2025.12.004_bib0082","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/S0140-6736(02)09895-1","article-title":"Effects of losartan and captopril on mortality and morbidity in high-risk patients after acute myocardial infarction: the OPTIMAAL randomised trial. Optimal trial in Myocardial infarction with Angiotensin II antagonist Losartan","volume":"360","author":"Dickstein","year":"2002","journal-title":"Lancet"},{"issue":"23","key":"10.1016\/j.tcm.2025.12.004_bib0083","doi-asserted-by":"crossref","first-page":"24270","DOI":"10.18632\/aging.202143","article-title":"Metformin protects against myocardial ischemia-reperfusion injury and cell pyroptosis via AMPK\/NLRP3 inflammasome pathway","volume":"12","author":"Zhang","year":"2020","journal-title":"Aging (Albany NY)"},{"issue":"18","key":"10.1016\/j.tcm.2025.12.004_bib0084","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000042196","article-title":"Meta-analysis of the efficacy and safety of SGLT-2 inhibitors in patients with heart failure and type 2 diabetes mellitus","volume":"104","author":"Yao","year":"2025","journal-title":"Medicine"},{"issue":"7","key":"10.1016\/j.tcm.2025.12.004_bib0085","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1038\/s43587-024-00642-y","article-title":"SGLT2 inhibition eliminates senescent cells and alleviates pathological aging","volume":"4","author":"Katsuumi","year":"2024","journal-title":"Nat Aging"},{"issue":"11","key":"10.1016\/j.tcm.2025.12.004_bib0086","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1038\/hr.2012.96","article-title":"Renoprotective and antioxidant effects of cilnidipine in hypertensive patients","volume":"35","author":"Soeki","year":"2012","journal-title":"Hypertens Res"},{"issue":"1","key":"10.1016\/j.tcm.2025.12.004_bib0087","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-97441-x","article-title":"Metformin selectively dampens the acute inflammatory response through an AMPK-dependent mechanism","volume":"11","author":"Postler","year":"2021","journal-title":"Sci Rep"},{"issue":"9","key":"10.1016\/j.tcm.2025.12.004_bib0088","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1007\/s00125-017-4342-z","article-title":"The mechanisms of action of metformin","volume":"60","author":"Rena","year":"2017","journal-title":"Diabetologia"},{"issue":"8","key":"10.1016\/j.tcm.2025.12.004_bib0089","article-title":"Oxidative stress-driven cellular senescence: mechanistic crosstalk and therapeutic horizons","volume":"14","author":"Stojanovic","year":"2025","journal-title":"Antioxidants (Basel)"},{"issue":"1","key":"10.1016\/j.tcm.2025.12.004_bib0090","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s00395-016-0593-y","article-title":"Targeted myocardial delivery of GDF11 gene rejuvenates the aged mouse heart and enhances myocardial regeneration after ischemia-reperfusion injury","volume":"112","author":"Du","year":"2017","journal-title":"Basic Res Cardiol"},{"issue":"4","key":"10.1016\/j.tcm.2025.12.004_bib0091","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13128","article-title":"miR-155-5p inhibition rejuvenates aged mesenchymal stem cells and enhances cardioprotection following infarction","volume":"19","author":"Hong","year":"2020","journal-title":"Aging Cell"},{"issue":"10","key":"10.1016\/j.tcm.2025.12.004_bib0092","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1111\/j.1582-4934.2012.01568.x","article-title":"Mesenchymal stem cells conditioned with glucose depletion augments their ability to repair-infarcted myocardium","volume":"16","author":"Choudhery","year":"2012","journal-title":"J Cell Mol Med"},{"issue":"8","key":"10.1016\/j.tcm.2025.12.004_bib0093","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1038\/nm.3267","article-title":"Tumorigenicity as a clinical hurdle for pluripotent stem cell therapies","volume":"19","author":"Lee","year":"2013","journal-title":"Nat Med"},{"issue":"7504","key":"10.1016\/j.tcm.2025.12.004_bib0094","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/nature13233","article-title":"Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts","volume":"510","author":"Chong","year":"2014","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.tcm.2025.12.004_bib0095","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1038\/s41591-023-02543-w","article-title":"Senolytic therapy in mild Alzheimer's disease: a phase 1 feasibility trial","volume":"29","author":"Gonzales","year":"2023","journal-title":"Nat Med"},{"key":"10.1016\/j.tcm.2025.12.004_bib0096","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.ebiom.2018.12.052","article-title":"Senolytics in idiopathic pulmonary fibrosis: results from a first-in-human, open-label, pilot study","volume":"40","author":"Justice","year":"2019","journal-title":"EBioMedicine"},{"key":"10.1016\/j.tcm.2025.12.004_bib0097","series-title":"Montreal heart institute","year":"2024"},{"key":"10.1016\/j.tcm.2025.12.004_bib0098","series-title":"NCT06230861","year":"2024"},{"issue":"15","key":"10.1016\/j.tcm.2025.12.004_bib0099","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1056\/NEJMoa2312572","article-title":"Microaxial flow pump or standard care in infarct-related cardiogenic shock","volume":"390","author":"M\u00f8ller","year":"2024","journal-title":"N Engl J Med"},{"issue":"10","key":"10.1016\/j.tcm.2025.12.004_bib0100","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1016\/j.healun.2022.07.007","article-title":"Biology of myocardial recovery in advanced heart failure with long-term mechanical support","volume":"41","author":"Tseliou","year":"2022","journal-title":"J Heart Lung Transplant"}],"container-title":["Trends in Cardiovascular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050173825001616?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050173825001616?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T15:48:21Z","timestamp":1780588101000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050173825001616"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":100,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S1050173825001616"],"URL":"https:\/\/doi.org\/10.1016\/j.tcm.2025.12.004","relation":{},"ISSN":["1050-1738"],"issn-type":[{"value":"1050-1738","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Yin and Yang of cellular senescence in ischemia-induced myocardial injury","name":"articletitle","label":"Article Title"},{"value":"Trends in Cardiovascular Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tcm.2025.12.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}