{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T17:49:23Z","timestamp":1791913763872,"version":"4.3.4"},"reference-count":18,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2025QC2114Z"],"award-info":[{"award-number":["ZR2025QC2114Z"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273975"],"award-info":[{"award-number":["82273975"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82504560"],"award-info":[{"award-number":["82504560"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Cell Surface"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.tcsw.2026.100174","type":"journal-article","created":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T16:01:07Z","timestamp":1776182467000},"page":"100174","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Plasma membrane transporters Alp1 and Nrt1 mediate the uptake of benzamidine conjugates in fungi"],"prefix":"10.1016","volume":"15","author":[{"given":"Xueyang","family":"Jin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaohua","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoyun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqiang","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tcsw.2026.100174_bb0005","doi-asserted-by":"crossref","unstructured":"Aguilar-Zapata, D., Petraitiene, R. and Petraitis, V., 2015. Echinocandins: the expanding antifungal armamentarium. Clin. Infect. Dis. 61 Suppl 6, S604\u2013611. doi;https:\/\/doi.org\/10.1093\/cid\/civ814.","DOI":"10.1093\/cid\/civ814"},{"key":"10.1016\/j.tcsw.2026.100174_bb0010","doi-asserted-by":"crossref","first-page":"4135","DOI":"10.2174\/1381612822666160607072748","article-title":"Challenges in the development of antifungal agents against candida: scope of phytochemical research","volume":"22","author":"Ahmad","year":"2016","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.tcsw.2026.100174_bb0015","doi-asserted-by":"crossref","first-page":"8075","DOI":"10.1074\/jbc.C800021200","article-title":"Saccharomyces cerevisiae YOR071C encodes the high affinity nicotinamide riboside transporter nrt1","volume":"283","author":"Belenky","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tcsw.2026.100174_bb0020","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1128\/CMR.00051-08","article-title":"Efflux-mediated antifungal drug resistance","volume":"22","author":"Cannon","year":"2009","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.tcsw.2026.100174_bb0025","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-018-07633-9","article-title":"Efflux pump-mediated resistance to antifungal compounds can be prevented by conjugation with triphenylphosphonium cation","volume":"9","author":"Chang","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tcsw.2026.100174_bb0030","doi-asserted-by":"crossref","first-page":"3985","DOI":"10.1038\/s41467-024-48445-4","article-title":"Structural insights into drug transport by an aquaglyceroporin","volume":"15","author":"Chen","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tcsw.2026.100174_bb0035","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1126\/science.aaa6097","article-title":"Infectious disease. How to bolster the antifungal pipeline","volume":"347","author":"Denning","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.tcsw.2026.100174_bb0040","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/s41573-023-00877-1","article-title":"Membrane transporters in drug development and as determinants of precision medicine","volume":"23","author":"Galetin","year":"2024","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.tcsw.2026.100174_bb0045","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1056\/NEJMra1315399","article-title":"Invasive candidiasis","volume":"373","author":"Kullberg","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.tcsw.2026.100174_bb0050","doi-asserted-by":"crossref","first-page":"3390","DOI":"10.1021\/acs.chemrev.0c00199","article-title":"Antifungal drug resistance: molecular mechanisms in Candida albicans and beyond","volume":"121","author":"Lee","year":"2021","journal-title":"Chem. Rev."},{"key":"10.1016\/j.tcsw.2026.100174_bb0055","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2018.26","article-title":"Invasive candidiasis","volume":"4","author":"Pappas","year":"2018","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.tcsw.2026.100174_bb0060","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.mib.2018.02.005","article-title":"Antifungal drug resistance: evolution, mechanisms and impact","volume":"45","author":"Revie","year":"2018","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.tcsw.2026.100174_bb0065","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1002\/yea.320100509","article-title":"APL1, a yeast gene encoding a putative permease for basic amino acids","volume":"10","author":"Sychrova","year":"1994","journal-title":"Yeast"},{"key":"10.1016\/j.tcsw.2026.100174_bb0070","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1016\/j.scib.2020.12.035","article-title":"Berberine reverses multidrug resistance in Candida albicans by hijacking the drug efflux pump Mdr1p","volume":"66","author":"Tong","year":"2021","journal-title":"Sci. Bull. (Beijing)"},{"key":"10.1016\/j.tcsw.2026.100174_bb0075","doi-asserted-by":"crossref","first-page":"13684","DOI":"10.1021\/acs.jmedchem.3c01068","article-title":"Benzamidine conjugation converts expelled potential active agents into antifungals against drug-resistant fungi","volume":"66","author":"Wang","year":"2023","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.tcsw.2026.100174_bb0080","series-title":"Clinical and Laboratory Standards Institute: Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts; Approved Standard-; CLSI Document M27-A3","author":"Wayne","year":"2008"},{"key":"10.1016\/j.tcsw.2026.100174_bb0085","article-title":"Molecular basis of SLC19A1-mediated folate and cyclic dinucleotide transport","volume":"16","author":"Zhang","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tcsw.2026.100174_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2023.114874","article-title":"New antifungal strategies: drug combination and co-delivery","volume":"198","author":"Zhu","year":"2023","journal-title":"Adv. Drug Deliv. Rev."}],"container-title":["The Cell Surface"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468233026000071?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468233026000071?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T17:08:48Z","timestamp":1791911328000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2468233026000071"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":18,"alternative-id":["S2468233026000071"],"URL":"https:\/\/doi.org\/10.1016\/j.tcsw.2026.100174","relation":{},"ISSN":["2468-2330"],"issn-type":[{"value":"2468-2330","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Plasma membrane transporters Alp1 and Nrt1 mediate the uptake of benzamidine conjugates in fungi","name":"articletitle","label":"Article Title"},{"value":"The Cell Surface","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tcsw.2026.100174","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"100174"}}