{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T05:40:01Z","timestamp":1791092401164,"version":"4.1.0"},"reference-count":20,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2004,5,1]],"date-time":"2004-05-01T00:00:00Z","timestamp":1083369600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trends in Endocrinology &amp; Metabolism"],"published-print":{"date-parts":[[2004,5]]},"DOI":"10.1016\/j.tem.2004.03.006","type":"journal-article","created":{"date-parts":[[2004,4,3]],"date-time":"2004-04-03T10:19:42Z","timestamp":1080987582000},"page":"139-142","source":"Crossref","is-referenced-by-count":82,"title":["Is aldosterone bad for the heart?"],"prefix":"10.1016","volume":"15","author":[{"given":"John W.","family":"Funder","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tem.2004.03.006_BIB1","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1056\/NEJM199909023411001","article-title":"The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized aldactone evaluation study investigators","volume":"341","author":"Pitt","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.tem.2004.03.006_BIB2","doi-asserted-by":"crossref","first-page":"4828","DOI":"10.1210\/en.2002-220120","article-title":"Selective aldosterone blockade prevents angiotensin II\/salt-induced vascular inflammation in the rat heart","volume":"143","author":"Rocha","year":"2002","journal-title":"Endocrinology"},{"key":"10.1016\/j.tem.2004.03.006_BIB3","doi-asserted-by":"crossref","first-page":"2694","DOI":"10.1161\/01.CIR.99.20.2694","article-title":"Activation of cardiac aldosterone production in rat myocardial infarction: effect of angiotensin II receptor blockade and role in cardiac fibrosis","volume":"99","author":"Silvestre","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.tem.2004.03.006_BIB4","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1210\/en.141.5.1901","article-title":"Sodium-induced cardiac aldosterone synthesis causes cardiac hypertrophy","volume":"141","author":"Takeda","year":"2000","journal-title":"Endocrinology"},{"key":"10.1016\/j.tem.2004.03.006_BIB5","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1161\/01.HYP.0000067463.13172.EA","article-title":"Effects of the selective aldosterone blocker eplerenone versus the calcium antagonist amlodipine in systolic hypertension","volume":"41","author":"White","year":"2003","journal-title":"Hypertension"},{"key":"10.1016\/j.tem.2004.03.006_BIB6","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1056\/NEJMoa030207","article-title":"Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction","volume":"348","author":"Pitt","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.tem.2004.03.006_BIB7","doi-asserted-by":"crossref","first-page":"6056","DOI":"10.1073\/pnas.80.19.6056","article-title":"Renal mineralocorticoid receptors and hippocampal corticosterone binding species have identical intrinsic steroid specificity","volume":"80","author":"Krozowski","year":"1983","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tem.2004.03.006_BIB8","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1126\/science.3037703","article-title":"Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor","volume":"237","author":"Arriza","year":"1987","journal-title":"Science"},{"key":"10.1016\/j.tem.2004.03.006_BIB9","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1126\/science.2845584","article-title":"Mineralocorticoid action: target-tissue specificity is enzyme, not receptor, mediated","volume":"242","author":"Funder","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.tem.2004.03.006_BIB10","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/S0140-6736(88)90742-8","article-title":"Localisation of 11 \u03b2-hydroxysteroid dehydrogenase \u2013 tissue specific protector of the mineralocorticoid receptor","volume":"2","author":"Edwards","year":"1988","journal-title":"Lancet"},{"key":"10.1016\/j.tem.2004.03.006_BIB11","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1210\/endo-125-4-2224","article-title":"Vascular type I aldosterone binding sites are physiological mineralocorticoid receptors","volume":"125","author":"Funder","year":"1989","journal-title":"Endocrinology"},{"key":"10.1016\/j.tem.2004.03.006_BIB12","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/0039-128X(94)90096-5","article-title":"Enzymes and receptors: challenges and future directions","volume":"59","author":"Funder","year":"1994","journal-title":"Steroids"},{"key":"10.1016\/j.tem.2004.03.006_BIB13","doi-asserted-by":"crossref","first-page":"5264","DOI":"10.1210\/en.137.12.5264","article-title":"Exclusion of corticosterone from epithelial mineralocorticoid receptors is insufficient for selectivity of aldosterone action: in vivo binding studies","volume":"137","author":"Funder","year":"1996","journal-title":"Endocrinology"},{"key":"10.1016\/j.tem.2004.03.006_BIB14","doi-asserted-by":"crossref","first-page":"9202","DOI":"10.1073\/pnas.1633591100","article-title":"Differential binding of NAD+ and NADH allows the transcriptional corepressor carboxyl-terminal binding protein to serve as a metabolic sensor","volume":"100","author":"Fjeld","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tem.2004.03.006_BIB15","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1126\/science.1069300","article-title":"Regulation of corepressor function by nuclear NADH","volume":"295","author":"Zhang","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.tem.2004.03.006_BIB16","doi-asserted-by":"crossref","first-page":"3698","DOI":"10.1128\/MCB.22.11.3698-3706.2002","article-title":"Ligand-selective potentiation of rat mineralocorticoid receptor activation function 1 by a CBP-containing histone acetyltransferase complex","volume":"22","author":"Kitagawa","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.tem.2004.03.006_BIB17","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1210\/en.2002-220926","article-title":"Early inflammatory responses in experimental cardiac hypertrophy and fibrosis: effects of 11\u03b2hydroxysteroid dehydrogenase inactivation","volume":"144","author":"Young","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.tem.2004.03.006_BIB18","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1161\/hc3001.091458","article-title":"Eplerenone suppresses constrictive remodeling and collagen accumulation after angioplasty in porcine coronary arteries","volume":"104","author":"Ward","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.tem.2004.03.006_BIB19","doi-asserted-by":"crossref","first-page":"4145","DOI":"10.1210\/en.137.10.4145","article-title":"High glucose stimulates aldosterone-induced hypertrophy via type I mineralocorticoid receptors in neonatal rat cardiomyocytes","volume":"137","author":"Sato","year":"1996","journal-title":"Endocrinology"},{"key":"10.1016\/j.tem.2004.03.006_BIB20","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1161\/01.RES.0000080521.15238.E5","article-title":"A transgenic model of aldosterone-driven cardiac hypertrophy and heart failure","volume":"93","author":"Qin","year":"2003","journal-title":"Circ. Res."}],"container-title":["Trends in Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S104327600400061X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S104327600400061X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T06:35:09Z","timestamp":1682663709000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S104327600400061X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,5]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2004,5]]}},"alternative-id":["S104327600400061X"],"URL":"https:\/\/doi.org\/10.1016\/j.tem.2004.03.006","relation":{},"ISSN":["1043-2760"],"issn-type":[{"value":"1043-2760","type":"print"}],"subject":[],"published":{"date-parts":[[2004,5]]}}}