{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:11:29Z","timestamp":1791295889344,"version":"4.1.0"},"reference-count":65,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2004,7,1]],"date-time":"2004-07-01T00:00:00Z","timestamp":1088640000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trends in Endocrinology &amp; Metabolism"],"published-print":{"date-parts":[[2004,7]]},"DOI":"10.1016\/j.tem.2004.05.001","type":"journal-article","created":{"date-parts":[[2004,6,8]],"date-time":"2004-06-08T18:49:43Z","timestamp":1086720583000},"page":"198-203","source":"Crossref","is-referenced-by-count":23,"title":["Generating new pancreas from old"],"prefix":"10.1016","volume":"15","author":[{"given":"Anandwardhan A.","family":"Hardikar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tem.2004.05.001_BIB1","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1172\/JCI119383","article-title":"Cloning and sequencing of the pancreatic islet neogenesis associated protein (INGAP) gene and its expression in islet neogenesis in hamsters","volume":"99","author":"Rafaeloff","year":"1997","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tem.2004.05.001_BIB2","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0026-0495(83)80009-2","article-title":"Virus-induced diabetes in mice","volume":"32","author":"Yoon","year":"1983","journal-title":"Metabolism"},{"key":"10.1016\/j.tem.2004.05.001_BIB3","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1210\/en.138.4.1750","article-title":"Differentiation of new insulin-producing cells is induced by injury in adult pancreatic islets","volume":"138","author":"Fernandes","year":"1997","journal-title":"Endocrinology"},{"key":"10.1016\/j.tem.2004.05.001_BIB4","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1677\/joe.0.1620189","article-title":"Effect of partial pancreatectomy on diabetic status in BALB\/c mice","volume":"162","author":"Hardikar","year":"1999","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.tem.2004.05.001_BIB5","first-page":"E822","article-title":"Prior streptozotocin treatment does not inhibit pancreas regeneration after 90% pancreatectomy in rats","volume":"276","author":"Finegood","year":"1999","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.tem.2004.05.001_BIB6","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/ng0197-106","article-title":"Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence","volume":"15","author":"Stoffers","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/j.tem.2004.05.001_BIB7","doi-asserted-by":"crossref","first-page":"507","DOI":"10.2337\/diabetes.48.3.507","article-title":"The homeodomain protein IDX-1 increases after an early burst of proliferation during pancreatic regeneration","volume":"48","author":"Sharma","year":"1999","journal-title":"Diabetes"},{"key":"10.1016\/j.tem.2004.05.001_BIB8","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1146\/annurev.cellbio.15.1.393","article-title":"Vertebrate endoderm development","volume":"15","author":"Wells","year":"1999","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.tem.2004.05.001_BIB9","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0925-4773(02)00332-5","article-title":"Role of endothelial cells in early pancreas and liver development","volume":"120","author":"Lammert","year":"2003","journal-title":"Mech. Dev."},{"key":"10.1016\/j.tem.2004.05.001_BIB10","doi-asserted-by":"crossref","first-page":"7117","DOI":"10.1073\/pnas.1232230100","article-title":"Human pancreatic precursor cells secrete FGF2 to stimulate clustering into hormone-expressing islet-like cell aggregates","volume":"100","author":"Hardikar","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tem.2004.05.001_BIB11","doi-asserted-by":"crossref","first-page":"4905","DOI":"10.1242\/dev.127.22.4905","article-title":"Regulation of pancreas development by hedgehog signaling","volume":"127","author":"Hebrok","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.tem.2004.05.001_BIB12","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1101\/gad.14.15.1866","article-title":"Activin receptor patterning of foregut organogenesis","volume":"14","author":"Kim","year":"2000","journal-title":"Genes Dev."},{"key":"10.1016\/j.tem.2004.05.001_BIB13","doi-asserted-by":"crossref","first-page":"4243","DOI":"10.1242\/dev.124.21.4243","article-title":"Notochord to endoderm signaling is required for pancreas development","volume":"124","author":"Kim","year":"1997","journal-title":"Development"},{"key":"10.1016\/j.tem.2004.05.001_BIB14","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1126\/science.1064344","article-title":"Induction of pancreatic differentiation by signals from blood vessels","volume":"294","author":"Lammert","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.tem.2004.05.001_BIB15","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1242\/dev.125.6.1017","article-title":"Follistatin regulates the relative proportions of endocrine versus exocrine tissue during pancreatic development","volume":"125","author":"Miralles","year":"1998","journal-title":"Development"},{"key":"10.1016\/j.tem.2004.05.001_BIB16","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1073\/pnas.97.4.1607","article-title":"Neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas","volume":"97","author":"Gradwohl","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tem.2004.05.001_BIB17","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.1242\/dev.129.10.2447","article-title":"Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors","volume":"129","author":"Gu","year":"2002","journal-title":"Development"},{"key":"10.1016\/j.tem.2004.05.001_BIB18","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1242\/dev.125.12.2213","article-title":"Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic \u03b2 cells","volume":"125","author":"Sussel","year":"1998","journal-title":"Development"},{"key":"10.1016\/j.tem.2004.05.001_BIB19","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/386399a0","article-title":"The Pax4 gene is essential for differentiation of insulin-producing \u03b2 cells in the mammalian pancreas","volume":"386","author":"Sosa-Pineda","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.tem.2004.05.001_BIB20","unstructured":"Hardikar, A. and Gershengorn, M. Chapter 51: stem cells. In Diabetes Mellitus: A Fundamental and Clinical Text (3rd ed), (LeRoith, D., et al. eds), (in press)."},{"key":"10.1016\/j.tem.2004.05.001_BIB21","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1126\/science.287.5459.1777","article-title":"Genomics: journey to the center of biology","volume":"287","author":"Lander","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.tem.2004.05.001_BIB22","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S1534-5807(03)00035-2","article-title":"Single-cell transcript analysis of pancreas development","volume":"4","author":"Chiang","year":"2003","journal-title":"Dev. Cell"},{"key":"10.1016\/j.tem.2004.05.001_BIB23","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/33311","article-title":"Regulatory factor linked to late-onset diabetes?","volume":"392","author":"Dutta","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.tem.2004.05.001_BIB24","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/0014-5793(90)80314-9","article-title":"The human islet amyloid polypeptide (IAPP) gene. Organization, chromosomal localization and functional identification of a promoter region","volume":"267","author":"Christmanson","year":"1990","journal-title":"FEBS Lett."},{"key":"10.1016\/j.tem.2004.05.001_BIB25","doi-asserted-by":"crossref","first-page":"4251","DOI":"10.1002\/j.1460-2075.1993.tb06109.x","article-title":"IPF1, a homeodomain-containing transactivator of the insulin gene","volume":"12","author":"Ohlsson","year":"1993","journal-title":"EMBO J."},{"key":"10.1016\/j.tem.2004.05.001_BIB26","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1210\/me.10.11.1327","article-title":"Transcriptional activation of the GLUT2 gene by the IPF-1\/STF-1\/IDX-1 homeobox factor","volume":"10","author":"Waeber","year":"1996","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.tem.2004.05.001_BIB27","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.2337\/diabetes.45.12.1826","article-title":"PDX-1 induces insulin and glucokinase gene expressions in \u03b1 TC1 clone 6 cells in the presence of \u03b2cellulin","volume":"45","author":"Watada","year":"1996","journal-title":"Diabetes"},{"key":"10.1016\/j.tem.2004.05.001_BIB28","doi-asserted-by":"crossref","first-page":"11225","DOI":"10.1074\/jbc.M111272200","article-title":"Reduction in pancreatic transcription factor PDX-1 impairs glucose-stimulated insulin secretion","volume":"277","author":"Brissova","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tem.2004.05.001_BIB29","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/S0006-291X(02)02000-4","article-title":"Regeneration therapy of pancreatic \u03b2 cells: towards a cure for diabetes?","volume":"296","author":"Yamaoka","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.tem.2004.05.001_BIB30","doi-asserted-by":"crossref","first-page":"S30","DOI":"10.2337\/diabetes.50.2007.S30","article-title":"Endocrine pancreas plasticity under physiological and pathological conditions","volume":"50","author":"Bernard-Kargar","year":"2001","journal-title":"Diabetes"},{"key":"10.1016\/j.tem.2004.05.001_BIB31","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1097\/00006676-200010000-00015","article-title":"Pancreatic inflammation, apoptosis, and growth: sequential events after partial pancreatectomy in pigs","volume":"21","author":"Morisset","year":"2000","journal-title":"Pancreas"},{"key":"10.1016\/j.tem.2004.05.001_BIB32","first-page":"107","article-title":"Is there pancreatic regeneration? Morphological and functional certification after a corporocaudal splenopancreatectomy","volume":"30","author":"Schlegel","year":"2000","journal-title":"Acta Gastroenterol. Latinoam."},{"key":"10.1016\/j.tem.2004.05.001_BIB33","doi-asserted-by":"crossref","first-page":"232","DOI":"10.2337\/diabetes.37.2.232","article-title":"Discordance of exocrine and endocrine growth after 90% pancreatectomy in rats","volume":"37","author":"Brockenbrough","year":"1988","journal-title":"Diabetes"},{"key":"10.1016\/j.tem.2004.05.001_BIB34","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1177\/002215540305101012","article-title":"Clusterin expression in the early process of pancreas regeneration in the pancreatectomized rat","volume":"51","author":"Min","year":"2003","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.tem.2004.05.001_BIB35","doi-asserted-by":"crossref","first-page":"6152","DOI":"10.1073\/pnas.88.14.6152","article-title":"Enhanced insulin-like growth factor I gene expression in regenerating rat pancreas","volume":"88","author":"Smith","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tem.2004.05.001_BIB36","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.2337\/diabetes.42.12.1715","article-title":"A second pathway for regeneration of adult exocrine and endocrine pancreas. A possible recapitulation of embryonic development","volume":"42","author":"Bonner-Weir","year":"1993","journal-title":"Diabetes"},{"key":"10.1016\/j.tem.2004.05.001_BIB37","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1679\/aohc.62.337","article-title":"Regional differences in the cellular proliferation activity of the regenerating rat pancreas after partial pancreatectomy","volume":"62","author":"Hayashi","year":"1999","journal-title":"Arch. Histol. Cytol."},{"key":"10.1016\/j.tem.2004.05.001_BIB38","doi-asserted-by":"crossref","first-page":"7999","DOI":"10.1073\/pnas.97.14.7999","article-title":"In vitro cultivation of human islet from expanded ductal tissue","volume":"97","author":"Bonner-Weir","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tem.2004.05.001_BIB39","doi-asserted-by":"crossref","first-page":"10760","DOI":"10.1016\/S0021-9258(18)67451-4","article-title":"Differential regulation of glucokinase activity in pancreatic islets and liver of the rat","volume":"261","author":"Bedoya","year":"1986","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tem.2004.05.001_BIB40","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1210\/mend-5-2-226","article-title":"Expression of reg\/PSP, a pancreatic exocrine gene: relationship to changes in islet \u03b2-cell mass","volume":"5","author":"Miyaura","year":"1991","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.tem.2004.05.001_BIB41","first-page":"164","article-title":"Islet cell differentiation and proliferation induced by a pancreatic cytosol extract","volume":"39","author":"Clas","year":"1988","journal-title":"Surg. Forum"},{"key":"10.1016\/j.tem.2004.05.001_BIB42","first-page":"191","article-title":"Trophic stimulation of the ductal\/islet cell axis: a new approach to the treatment of diabetes","volume":"108","author":"Rosenberg","year":"1990","journal-title":"Surgery"},{"key":"10.1016\/j.tem.2004.05.001_BIB43","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1097\/00006676-198902000-00005","article-title":"The effect of cellophane wrapping of the pancreas in the Syrian golden hamster: autoradiographic observations","volume":"4","author":"Rosenberg","year":"1989","journal-title":"Pancreas"},{"key":"10.1016\/j.tem.2004.05.001_BIB44","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1002\/(SICI)1097-0029(19981115)43:4<337::AID-JEMT8>3.0.CO;2-U","article-title":"Induction of islet cell neogenesis in the adult pancreas: the partial duct obstruction model","volume":"43","author":"Rosenberg","year":"1998","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/j.tem.2004.05.001_BIB45","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1172\/JCI119383","article-title":"Cloning and sequencing of the pancreatic islet neogenesis associated protein (INGAP) gene and its expression in islet neogenesis in hamsters","volume":"99","author":"Rafaeloff","year":"1997","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tem.2004.05.001_BIB46","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0014-5793(95)01457-8","article-title":"Identification of differentially expressed genes induced in pancreatic islet neogenesis","volume":"378","author":"Rafaeloff","year":"1996","journal-title":"FEBS Lett."},{"key":"10.1016\/j.tem.2004.05.001_BIB47","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/978-1-4615-3448-8_10","article-title":"Regeneration of pancreatic endocrine cells in interferon-\u03b3 transgenic mice","volume":"321","author":"Sarvetnick","year":"1992","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.tem.2004.05.001_BIB48","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1242\/dev.118.1.33","article-title":"Epithelial cell proliferation and islet neogenesis in IFN-\u03b3 transgenic mice","volume":"118","author":"Gu","year":"1993","journal-title":"Development"},{"key":"10.1016\/j.tem.2004.05.001_BIB49","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1083\/jcb.200304153","article-title":"The stromal cell-derived factor-1\u03b1\/CXCR4 ligand\u2013receptor axis is critical for progenitor survival and migration in the pancreas","volume":"163","author":"Kayali","year":"2003","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.tem.2004.05.001_BIB50","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0303-7207(00)00234-3","article-title":"Transcription factor expression during pancreatic islet regeneration","volume":"164","author":"Kritzika","year":"2000","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.tem.2004.05.001_BIB51","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1097\/00006676-200011000-00011","article-title":"IFN-\u03b3 overexpression within the pancreas is not sufficient to rescue Pax4, Pax6,and Pdx-1 mutant mice from death","volume":"21","author":"Krakowski","year":"2000","journal-title":"Pancreas"},{"key":"10.1016\/j.tem.2004.05.001_BIB52","first-page":"985","article-title":"Growth factors in the regenerating pancreas of \u03b3-interferon transgenic mice","volume":"74","author":"Arnush","year":"1996","journal-title":"Lab. Invest."},{"key":"10.1016\/j.tem.2004.05.001_BIB53","doi-asserted-by":"crossref","first-page":"3533","DOI":"10.1242\/dev.127.16.3533","article-title":"Expression of neurogenin3 reveals an islet cell precursor population in the pancreas","volume":"127","author":"Schwitzgebel","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.tem.2004.05.001_BIB54","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1056\/NEJM200007273430401","article-title":"Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen","volume":"343","author":"Shapiro","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.tem.2004.05.001_BIB55","doi-asserted-by":"crossref","first-page":"157","DOI":"10.2337\/diabetes.49.2.157","article-title":"Insulin-secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic mice","volume":"49","author":"Soria","year":"2000","journal-title":"Diabetes"},{"key":"10.1016\/j.tem.2004.05.001_BIB56","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1126\/science.1058866","article-title":"Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets","volume":"292","author":"Lumelsky","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.tem.2004.05.001_BIB57","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.2337\/diabetes.50.8.1691","article-title":"Insulin production by human embryonic stem cells","volume":"50","author":"Assady","year":"2001","journal-title":"Diabetes"},{"key":"10.1016\/j.tem.2004.05.001_BIB58","doi-asserted-by":"crossref","first-page":"8078","DOI":"10.1073\/pnas.122210699","article-title":"In vitrotrans-differentiation of adult hepatic stem cells into pancreatic endocrine hormone-producing cells","volume":"99","author":"Yang","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tem.2004.05.001_BIB59","doi-asserted-by":"crossref","first-page":"E259","DOI":"10.1152\/ajpendo.00393.2002","article-title":"Stem\/progenitor cells derived from adult tissues: potential for the treatment of diabetes mellitus","volume":"284","author":"Lechner","year":"2003","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2004.05.001_BIB60","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1002\/path.1158","article-title":"Pancreatic stem cells","volume":"197","author":"Bonner-Weir","year":"2002","journal-title":"J. Pathol."},{"key":"10.1016\/j.tem.2004.05.001_BIB61","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/nbt841","article-title":"Bone marrow-derived stem cells initiate pancreatic regeneration","volume":"21","author":"Hess","year":"2003","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.tem.2004.05.001_BIB62","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nature00870","article-title":"Pluripotency of mesenchymal stem cells derived from adult marrow","volume":"418","author":"Jiang","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.tem.2004.05.001_BIB63","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1172\/JCI0214327","article-title":"Origin of endothelial progenitors in human postnatal bone marrow","volume":"109","author":"Reyes","year":"2002","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tem.2004.05.001_BIB64","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1172\/JCI200316502","article-title":"In vivoderivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion","volume":"111","author":"Ianus","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tem.2004.05.001_BIB65","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1126\/science.1088949","article-title":"Islet regeneration during the reversal of autoimmune diabetes in NOD mice","volume":"302","author":"Kodama","year":"2003","journal-title":"Science"}],"container-title":["Trends in Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043276004000852?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043276004000852?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T20:26:34Z","timestamp":1682713594000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043276004000852"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,7]]},"references-count":65,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2004,7]]}},"alternative-id":["S1043276004000852"],"URL":"https:\/\/doi.org\/10.1016\/j.tem.2004.05.001","relation":{},"ISSN":["1043-2760"],"issn-type":[{"value":"1043-2760","type":"print"}],"subject":[],"published":{"date-parts":[[2004,7]]}}}