{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T02:44:48Z","timestamp":1789526688348,"version":"build-2803163510"},"reference-count":44,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2005,4,1]],"date-time":"2005-04-01T00:00:00Z","timestamp":1112313600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trends in Endocrinology &amp; Metabolism"],"published-print":{"date-parts":[[2005,4]]},"DOI":"10.1016\/j.tem.2005.02.010","type":"journal-article","created":{"date-parts":[[2005,3,11]],"date-time":"2005-03-11T12:32:50Z","timestamp":1110544370000},"page":"104-107","source":"Crossref","is-referenced-by-count":120,"title":["Aldosterone as a cardiovascular risk factor"],"prefix":"10.1016","volume":"16","author":[{"given":"GianPaolo","family":"Rossi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Boscaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Ronconi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W.","family":"Funder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tem.2005.02.010_bib1","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/S0735-1097(00)00796-8","article-title":"Spironolactone inhibits the transcardiac extraction of aldosterone in patients with congestive heart failure","volume":"36","author":"Tsutamoto","year":"2000","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.tem.2005.02.010_bib2","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1161\/01.CIR.103.1.72","article-title":"Aldosterone production is activated in failing ventricle in humans","volume":"103","author":"Mizuno","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.tem.2005.02.010_bib3","doi-asserted-by":"crossref","unstructured":"Gomez-Sanchez, E. et al. Effect of 3\u03b2-hydroxysteroid dehydrogenase inhibition by trilostane on blood pressure in the Dahl salt-sensitive rat. Am. J. Physiol. Regul. Integr. Comp. Physiol. 288, R389\u2013R393","DOI":"10.1152\/ajpregu.00441.2004"},{"key":"10.1016\/j.tem.2005.02.010_bib4","doi-asserted-by":"crossref","first-page":"2797","DOI":"10.1210\/jc.81.8.2797","article-title":"Regulation of aldosterone synthase in human vascular endothelial cells by angiotensin II and adrenocorticotropin","volume":"81","author":"Takeda","year":"1996","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2005.02.010_bib5","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1210\/en.141.5.1901","article-title":"Sodium-induced cardiac aldosterone synthesis causes cardiac hypertrophy","volume":"141","author":"Takeda","year":"2000","journal-title":"Endocrinology"},{"key":"10.1016\/j.tem.2005.02.010_bib6","doi-asserted-by":"crossref","first-page":"4828","DOI":"10.1210\/en.2002-220120","article-title":"Selective aldosterone blockade prevents angiotensin II\/salt-induced vascular inflammation in the rat heart","volume":"143","author":"Rocha","year":"2002","journal-title":"Endocrinology"},{"key":"10.1016\/j.tem.2005.02.010_bib7","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0022-4731(72)90053-2","article-title":"Glucocorticoid and mineralocorticoid receptors for aldosterone","volume":"3","author":"Rousseau","year":"1972","journal-title":"J. Steroid Biochem."},{"key":"10.1016\/j.tem.2005.02.010_bib8","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1210\/endo-92-4-994","article-title":"The roles of plasma binding and receptor specificity in the mineralocorticoid action of aldosterone","volume":"92","author":"Funder","year":"1973","journal-title":"Endocrinology"},{"key":"10.1016\/j.tem.2005.02.010_bib9","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1111\/j.1440-1681.1987.tb02422.x","article-title":"High affinity aldosterone binding sites (type 1 receptors) in rat heart","volume":"14","author":"Pearce","year":"1987","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.tem.2005.02.010_bib10","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1210\/endo-125-4-2224","article-title":"Vascular type I aldosterone binding sites are physiological mineralocorticoid receptors","volume":"125","author":"Funder","year":"1989","journal-title":"Endocrinology"},{"key":"10.1016\/j.tem.2005.02.010_bib11","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1126\/science.2845584","article-title":"Mineralocorticoid action: target-tissue specificity is enzyme, not receptor, mediated","volume":"242","author":"Funder","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.tem.2005.02.010_bib12","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/S0140-6736(88)90742-8","article-title":"Localisation of 11 \u03b2-hydroxysteroid dehydrogenase \u2013 tissue specific protector of the mineralocorticoid receptor","volume":"2","author":"Edwards","year":"1988","journal-title":"Lancet"},{"key":"10.1016\/j.tem.2005.02.010_bib13","unstructured":"Gordon, R.D. et al. Low renin hypertension: perspectives, unsolved problems, future research. Trends Endocrinol. Metab. (in press)"},{"key":"10.1016\/j.tem.2005.02.010_bib14","doi-asserted-by":"crossref","first-page":"2514","DOI":"10.1073\/pnas.96.5.2514","article-title":"Epithelial sodium channel regulated by aldosterone-induced protein sgk","volume":"96","author":"Chen","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tem.2005.02.010_bib15","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1210\/jcem-44-5-924","article-title":"Evidence for an unidentified steroid in a child with apparent mineralocorticoid hypertension","volume":"44","author":"New","year":"1977","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2005.02.010_bib16","doi-asserted-by":"crossref","first-page":"5264","DOI":"10.1210\/en.137.12.5264","article-title":"Exclusion of corticosterone from epithelial mineralocorticoid receptors is insufficient for selectivity of aldosterone action: in vivo binding studies","volume":"137","author":"Funder","year":"1996","journal-title":"Endocrinology"},{"key":"10.1016\/j.tem.2005.02.010_bib17","doi-asserted-by":"crossref","first-page":"4145","DOI":"10.1210\/en.137.10.4145","article-title":"High glucose stimulates aldosterone-induced hypertrophy via type I mineralocorticoid receptors in neonatal rat cardiomyocytes","volume":"137","author":"Sato","year":"1996","journal-title":"Endocrinology"},{"key":"10.1016\/j.tem.2005.02.010_bib18","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1056\/NEJM199909023411001","article-title":"The effect of spironolactone on morbidity and mortality in patients with severe heart failure","volume":"341","author":"Pitt","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.tem.2005.02.010_bib19","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1056\/NEJMoa030207","article-title":"Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction","volume":"348","author":"Pitt","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.tem.2005.02.010_bib20","doi-asserted-by":"crossref","first-page":"4221","DOI":"10.1210\/jc.2003-032179","article-title":"Aldosterone to renin ratio in a primary care setting: the Bussolengo study","volume":"89","author":"Olivieri","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2005.02.010_bib21","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1210\/jc.2003-032149","article-title":"Distinguishing the antihypertensive and electrolyte effects of eplerenone","volume":"89","author":"Levy","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2005.02.010_bib22","first-page":"893","article-title":"Mineralocorticoid excess, dietary sodium, and myocardial fibrosis","volume":"120","author":"Brilla","year":"1992","journal-title":"J. Lab. Clin. Med."},{"key":"10.1016\/j.tem.2005.02.010_bib23","doi-asserted-by":"crossref","first-page":"2578","DOI":"10.1172\/JCI117269","article-title":"Mineralocorticoids, hypertension, and cardiac fibrosis","volume":"93","author":"Young","year":"1994","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tem.2005.02.010_bib24","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1136\/hrt.2003.017368","article-title":"Effects of spironolactone on endothelial function, vascular angiotensin converting enzyme activity, and other prognostic markers in patients with mild heart failure already taking optimal treatment","volume":"90","author":"Macdonald","year":"2004","journal-title":"Heart"},{"key":"10.1016\/j.tem.2005.02.010_bib25","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1161\/01.CIR.0000138680.89536.A9","article-title":"Effect of aldosterone antagonism on myocardial dysfunction in hypertensive patients with diastolic heart failure","volume":"110","author":"Mottram","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.tem.2005.02.010_bib26","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1161\/01.CIR.0000091405.00772.6E","article-title":"Effects of eplerenone, enalapril, and eplerenone\/enalapril in patients with essential hypertension and left ventricular hypertrophy: the 4E-left ventricular hypertrophy study","volume":"108","author":"Pitt","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.tem.2005.02.010_bib27","doi-asserted-by":"crossref","first-page":"24A","DOI":"10.1016\/S0895-7061(02)02333-6","article-title":"Antiproteinuric efficacy of eplerenone, enalapril and eplerenone\/enalapril combination in diabetic hypertensives with microalbuminuria","volume":"15","author":"Epstein","year":"2002","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.tem.2005.02.010_bib28","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0735-1097(02)02694-3","article-title":"Complications of inappropriate use of spironolactone in heart failure: when an old medicine spirals out of new guidelines","volume":"41","author":"Bozkurt","year":"2003","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.tem.2005.02.010_bib29","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1056\/NEJMoa033263","article-title":"Serum aldosterone and the incidence of hypertension in nonhypertensive persons","volume":"351","author":"Vasan","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.tem.2005.02.010_bib30","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1056\/NEJMp048132","article-title":"Aldosterone \u2013 villain or bystander?","volume":"351","author":"Dluhy","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.tem.2005.02.010_bib31","doi-asserted-by":"crossref","first-page":"S148","DOI":"10.1097\/00004872-200406002-00506","article-title":"Prevalence of a primary aldosteronism (PA) in newly diagnosed hypertensive patients: results of a nationwide survey in Italy","volume":"22","author":"Rossi","year":"2004","journal-title":"J. Hypertens."},{"key":"10.1016\/j.tem.2005.02.010_bib32","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1097\/00004872-199512010-00054","article-title":"Albuminuria in untreated patients with primary aldosteronism or essential hypertension","volume":"13","author":"Halimi","year":"1995","journal-title":"J. Hypertens."},{"key":"10.1016\/j.tem.2005.02.010_bib33","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1161\/01.HYP.21.6.929","article-title":"Vasodilation to acetylcholine in primary and secondary forms of human hypertension","volume":"21","author":"Taddei","year":"1993","journal-title":"Hypertension"},{"key":"10.1016\/j.tem.2005.02.010_bib34","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1093\/ajh\/6.1.8","article-title":"Prevalence of extracranial carotid artery lesions at duplex in primary aldosteronism","volume":"6","author":"Rossi","year":"1993","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.tem.2005.02.010_bib35","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1161\/01.HYP.31.1.335","article-title":"Endothelial dysfunction in hypertension is independent from the etiology and from vascular structure","volume":"31","author":"Rizzoni","year":"1998","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.tem.2005.02.010_bib36","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/S0735-1097(98)00322-2","article-title":"Relations between cardiac and vascular structure in patients with primary and secondary hypertension","volume":"32","author":"Rizzoni","year":"1998","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.tem.2005.02.010_bib37","first-page":"185","article-title":"Primary aldosteronism. A risk factor for aortic dissection?","volume":"28","author":"Tartiere","year":"2003","journal-title":"J. Mal. Vasc."},{"key":"10.1016\/j.tem.2005.02.010_bib38","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1016\/0002-9149(88)90264-0","article-title":"Left ventricular structural characteristics in unilateral renovascular hypertension and primary aldosteronism","volume":"62","author":"Suzuki","year":"1988","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.tem.2005.02.010_bib39","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1093\/ajh\/6.11.907","article-title":"Left ventricular mass and geometry before and after etiologic treatment in renovascular hypertension, aldosterone-producing adenoma, and pheochromocytoma","volume":"6","author":"Denolle","year":"1993","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.tem.2005.02.010_bib40","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1161\/01.HYP.27.5.1039","article-title":"Changes in left ventricular anatomy and function in hypertension and primary aldosteronism","volume":"27","author":"Rossi","year":"1996","journal-title":"Hypertension"},{"key":"10.1016\/j.tem.2005.02.010_bib41","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1161\/01.CIR.95.6.1471","article-title":"Remodeling of the left ventricle in primary aldosteronism due to Conn's adenoma","volume":"95","author":"Rossi","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.tem.2005.02.010_bib42","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1161\/01.HYP.0000023182.68420.EB","article-title":"Excess aldosterone is associated with alterations of myocardial texture in primary aldosteronism","volume":"40","author":"Rossi","year":"2002","journal-title":"Hypertension"},{"key":"10.1016\/j.tem.2005.02.010_bib43","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1161\/01.HYP.0000052542.68896.2B","article-title":"Myocardial ultrasonic backscatter in hypertension: relation to aldosterone and endothelin","volume":"41","author":"Kozakova","year":"2003","journal-title":"Hypertension"},{"key":"10.1016\/j.tem.2005.02.010_bib44","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.tem.2004.03.006","article-title":"Is aldosterone bad for the heart?","volume":"15","author":"Funder","year":"2004","journal-title":"Trends Endocrinol. Metab."}],"container-title":["Trends in Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043276005000391?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043276005000391?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,2,3]],"date-time":"2019-02-03T10:20:22Z","timestamp":1549189222000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043276005000391"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,4]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,4]]}},"alternative-id":["S1043276005000391"],"URL":"https:\/\/doi.org\/10.1016\/j.tem.2005.02.010","relation":{},"ISSN":["1043-2760"],"issn-type":[{"value":"1043-2760","type":"print"}],"subject":[],"published":{"date-parts":[[2005,4]]}}}