{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:12:35Z","timestamp":1791303155719,"version":"4.1.0"},"reference-count":73,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2006,10,1]],"date-time":"2006-10-01T00:00:00Z","timestamp":1159660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,10,1]],"date-time":"2006-10-01T00:00:00Z","timestamp":1159660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["bmn.com","cell.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Endocrinology &amp; Metabolism"],"published-print":{"date-parts":[[2006,10]]},"DOI":"10.1016\/j.tem.2006.08.003","type":"journal-article","created":{"date-parts":[[2006,8,31]],"date-time":"2006-08-31T08:49:18Z","timestamp":1157014158000},"page":"314-320","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":125,"title":["Importance of TNF\u03b1 and neutral lipases in human adipose tissue lipolysis"],"prefix":"10.1016","volume":"17","author":[{"given":"Dominique","family":"Langin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Arner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tem.2006.08.003_bib1","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S1043-2760(03)00024-9","article-title":"The adipocyte in insulin resistance: key molecules and the impact of the thiazolidinediones","volume":"14","author":"Arner","year":"2003","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.tem.2006.08.003_bib2","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1055\/s-2007-978670","article-title":"Millenium fat cell lipolysis reveals unsuspected novel tracks","volume":"32","author":"Langin","year":"2000","journal-title":"Horm. Metab. Res."},{"key":"10.1016\/j.tem.2006.08.003_bib3","first-page":"409","article-title":"Regulation of lipolysis in humans. Pathophysiological modulation in obesity, diabetes, and hyperlipidaemia","volume":"24","author":"Large","year":"1998","journal-title":"Diabetes Metab."},{"key":"10.1016\/j.tem.2006.08.003_bib4","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1016\/S0022-2275(20)32199-4","article-title":"Hormone-sensitive lipase expression and activity in relation to lipolysis in human fat cells","volume":"39","author":"Large","year":"1998","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.tem.2006.08.003_bib5","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/nature04140","article-title":"Insulin disrupts \u03b2-adrenergic signalling to protein kinase A in adipocytes","volume":"437","author":"Zhang","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.tem.2006.08.003_bib6","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1161\/01.ATV.0000183728.14712.d8","article-title":"An unsuspected metabolic role for atrial natriuretic peptides. The control of lipolysis, lipid mobilization, and systemic nonesterified fatty acids levels in Humans","volume":"25","author":"Lafontan","year":"2005","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.tem.2006.08.003_bib7","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1097\/01.mol.0000169354.20395.1c","article-title":"Lipolysis: pathway under construction","volume":"16","author":"Zechner","year":"2005","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/j.tem.2006.08.003_bib8","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1093\/oxfordjournals.jbchem.a121917","article-title":"Human recombinant TNF suppresses lipoprotein lipase activity and stimulates lipolysis in 3T3-L1 cells","volume":"101","author":"Kawakami","year":"1987","journal-title":"J. Biochem. (Tokyo)"},{"key":"10.1016\/j.tem.2006.08.003_bib9","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/nri1184","article-title":"Signalling pathways of the TNF superfamily: a double-edged sword","volume":"3","author":"Aggarwal","year":"2003","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.tem.2006.08.003_bib10","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1074\/jbc.M109498200","article-title":"Mapping of early signalling events in TNF-\u03b1-mediated lipolysis in human fat cells","volume":"277","author":"Ryden","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tem.2006.08.003_bib11","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.biochi.2004.10.019","article-title":"Positive and negative regulation of insulin signaling through IRS-1 phosphorylation","volume":"87","author":"Gual","year":"2005","journal-title":"Biochimie"},{"key":"10.1016\/j.tem.2006.08.003_bib12","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.cellsig.2005.08.009","article-title":"Signalling mechanisms regulating lipolysis","volume":"18","author":"Carmen","year":"2005","journal-title":"Cell. Signal."},{"key":"10.1016\/j.tem.2006.08.003_bib13","first-page":"1557","article-title":"Tumor necrosis factor \u03b1-mediated insulin resistance, but not dedifferentiation, is abrogated by MEK1\/2 inhibitors in 3T3-L1 adipocytes","volume":"14","author":"Engelman","year":"2000","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.tem.2006.08.003_bib14","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1210\/me.2002-0131","article-title":"Three mitogen-activated protein kinases inhibit insulin signaling by different mechanisms in 3T3-L1 adipocytes","volume":"17","author":"Fujishiro","year":"2003","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.tem.2006.08.003_bib15","doi-asserted-by":"crossref","first-page":"6770","DOI":"10.1074\/jbc.274.10.6770","article-title":"Tumor necrosis factor \u03b1 stimulates lipolysis in adipocytes by decreasing Gi protein concentrations","volume":"274","author":"Gasic","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tem.2006.08.003_bib16","doi-asserted-by":"crossref","first-page":"5069","DOI":"10.1210\/endo.142.12.8518","article-title":"Inhibition of proteasome activity blocks the ability of TNF\u03b1 to down-regulate G(i) proteins and stimulate lipolysis","volume":"142","author":"Botion","year":"2001","journal-title":"Endocrinology"},{"key":"10.1016\/j.tem.2006.08.003_bib17","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.bbrc.2004.04.010","article-title":"Targets for TNF-\u03b1-induced lipolysis in human adipocytes","volume":"318","author":"Ryden","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.tem.2006.08.003_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/oxfordjournals.jbchem.a122990","article-title":"Inhibitory effect of tumor necrosis factor on gene expression of hormone sensitive lipase in 3T3-L1 adipocytes","volume":"107","author":"Sumida","year":"1990","journal-title":"J. Biochem."},{"key":"10.1016\/j.tem.2006.08.003_bib19","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.1210\/endo.134.6.8194485","article-title":"Tumor necrosis factor increases the rate of lipolysis in primary cultures of adipocytes without altering levels of hormone-sensitive lipase","volume":"134","author":"Green","year":"1994","journal-title":"Endocrinology"},{"key":"10.1016\/j.tem.2006.08.003_bib20","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.mce.2005.06.002","article-title":"Isoproterenol, TNF\u03b1, and insulin downregulate adipose triglyceride lipase in 3T3-L1 adipocytes","volume":"240","author":"Kralisch","year":"2005","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.tem.2006.08.003_bib21","doi-asserted-by":"crossref","first-page":"E115","DOI":"10.1152\/ajpendo.00317.2005","article-title":"The adipose tissue triglyceride lipase ATGL\/PNPLA2 is downregulated by insulin and TNF\u03b1 in 3T3-L1 adipocytes and is a target for transactivation by PPAR\u03b3","volume":"291","author":"Kim","year":"2006","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2006.08.003_bib22","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1080\/15216540400009968","article-title":"The central role of perilipin a in lipid metabolism and adipocyte lipolysis","volume":"56","author":"Tansey","year":"2004","journal-title":"IUBMB Life"},{"key":"10.1016\/j.tem.2006.08.003_bib23","doi-asserted-by":"crossref","first-page":"24665","DOI":"10.1074\/jbc.273.38.24665","article-title":"Overexpression of perilipin A and B blocks the ability of tumor necrosis factor \u03b1 to increase lipolysis in 3T3-L1 adipocytes","volume":"273","author":"Souza","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tem.2006.08.003_bib24","doi-asserted-by":"crossref","first-page":"2929","DOI":"10.2337\/diabetes.51.10.2929","article-title":"Tumor necrosis factor-\u03b1 stimulates lipolysis in differentiated human adipocytes through activation of extracellular signal-related kinase and elevation of intracellular cAMP","volume":"51","author":"Zhang","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.tem.2006.08.003_bib25","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1002\/jcb.10565","article-title":"TNF-\u03b1 induction of lipolysis is mediated through activation of the extracellular signal related kinase pathway in 3T3-L1 adipocytes","volume":"89","author":"Souza","year":"2003","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.tem.2006.08.003_bib26","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1126\/science.7678183","article-title":"Adipose expression of tumor necrosis factor-\u03b1: direct role in obesity-linked insulin resistance","volume":"259","author":"Hotamisligil","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.tem.2006.08.003_bib27","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1172\/JCI117936","article-title":"Increased adipose tissue expression of tumor necrosis factor-\u03b1 in human obesity and insulin resistance","volume":"95","author":"Hotamisligil","year":"1995","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tem.2006.08.003_bib28","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.2337\/diabetes.51.5.1493","article-title":"Insulin and rosiglitazone regulation of lipolysis and lipogenesis in human adipose tissue in vitro","volume":"51","author":"McTernan","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.tem.2006.08.003_bib29","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.2337\/diabetes.54.6.1726","article-title":"A human-specific role of cell death-inducing DFFA (DNA fragmentation factor-\u03b1)-like effector A (CIDEA) in adipocyte lipolysis and obesity","volume":"54","author":"Nordstrom","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.tem.2006.08.003_bib30","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1093\/ajcn\/81.6.1275","article-title":"Changes in adipose tissue gene expression with energy-restricted diets in obese women","volume":"81","author":"Dahlman","year":"2005","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.tem.2006.08.003_bib31","doi-asserted-by":"crossref","first-page":"43109","DOI":"10.1074\/jbc.M506336200","article-title":"Perilipin targets a novel pool of lipid droplets for lipolytic attack by hormone-sensitive lipase","volume":"280","author":"Moore","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tem.2006.08.003_bib32","doi-asserted-by":"crossref","first-page":"8537","DOI":"10.1073\/pnas.89.18.8537","article-title":"Mechanism of hormone-stimulated lipolysis in adipocytes: translocation of hormone-sensitive lipase to the lipid storage droplet","volume":"89","author":"Egan","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tem.2006.08.003_bib33","doi-asserted-by":"crossref","first-page":"15837","DOI":"10.1074\/jbc.M601097200","article-title":"Perilipin promotes hormone-sensitive lipase-mediated adipocyte lipolysis via phosphorylation-dependent and -independent mechanisms","volume":"281","author":"Miyoshi","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tem.2006.08.003_bib34","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1083\/jcb.200210169","article-title":"Perilipin A is essential for the translocation of hormone-sensitive lipase during lipolytic activation","volume":"161","author":"Sztalryd","year":"2003","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.tem.2006.08.003_bib35","doi-asserted-by":"crossref","first-page":"5528","DOI":"10.1073\/pnas.96.10.5528","article-title":"Interaction of rat hormone-sensitive lipase with adipocyte lipid-binding protein","volume":"96","author":"Shen","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tem.2006.08.003_bib36","doi-asserted-by":"crossref","first-page":"52399","DOI":"10.1074\/jbc.M410301200","article-title":"Physical association between the adipocyte fatty acid-binding protein and hormone-sensitive lipase: a fluorescence resonance energy transfer analysis","volume":"279","author":"Smith","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tem.2006.08.003_bib37","doi-asserted-by":"crossref","first-page":"E187","DOI":"10.1152\/ajpendo.00256.2004","article-title":"Investigation of in vivo fatty acid metabolism in AFABP\/aP2(\u2212\/\u2212) mice","volume":"288","author":"Baar","year":"2005","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2006.08.003_bib38","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1073\/pnas.97.2.787","article-title":"Targeted disruption of hormone-sensitive lipase results in male sterility and adipocyte hypertrophy, but not in obesity","volume":"97","author":"Osuga","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tem.2006.08.003_bib39","doi-asserted-by":"crossref","first-page":"12946","DOI":"10.1074\/jbc.M108640200","article-title":"Hormone-sensitive lipase deficiency in mice changes the plasma lipid profile by affecting the tissue-specific expression pattern of lipoprotein lipase in adipose tissue and muscle","volume":"277","author":"Haemmerle","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tem.2006.08.003_bib40","doi-asserted-by":"crossref","first-page":"36380","DOI":"10.1074\/jbc.M213032200","article-title":"Hormone-sensitive lipase null mice exhibit signs of impaired insulin sensitivity whereas insulin secretion is intact","volume":"278","author":"Mulder","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tem.2006.08.003_bib41","doi-asserted-by":"crossref","first-page":"E1182","DOI":"10.1152\/ajpendo.00259.2003","article-title":"Resistance to high-fat diet-induced obesity and altered expression of adipose-specific genes in HSL-deficient mice","volume":"285","author":"Harada","year":"2003","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2006.08.003_bib42","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1126\/science.1100747","article-title":"Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase","volume":"306","author":"Zimmermann","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.tem.2006.08.003_bib43","doi-asserted-by":"crossref","first-page":"48968","DOI":"10.1074\/jbc.M407841200","article-title":"Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities","volume":"279","author":"Jenkins","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tem.2006.08.003_bib44","doi-asserted-by":"crossref","first-page":"47066","DOI":"10.1074\/jbc.M403855200","article-title":"Desnutrin, an adipocyte gene encoding a novel patatin domain-containing protein, is induced by fasting and glucocorticoids: ectopic expression of desnutrin increases triglyceride hydrolysis","volume":"279","author":"Villena","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tem.2006.08.003_bib45","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1194\/jlr.M500290-JLR200","article-title":"Expression, regulation and triglyceride hydrolase activity of adiponutrin family members","volume":"46","author":"Lake","year":"2005","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.tem.2006.08.003_bib46","doi-asserted-by":"crossref","first-page":"148","DOI":"10.2337\/diabetes.55.01.06.db05-0982","article-title":"Adipose triglyceride lipase: function, regulation by insulin, and comparison with adiponutrin","volume":"55","author":"Kershaw","year":"2006","journal-title":"Diabetes"},{"key":"10.1016\/j.tem.2006.08.003_bib47","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1126\/science.1123965","article-title":"Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase","volume":"312","author":"Haemmerle","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.tem.2006.08.003_bib48","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1007\/s00125-006-0272-x","article-title":"Human adipose triglyceride lipase is not regulated by obesity and exhibits low in vitro triglyceride hydrolase activity","volume":"49","author":"Mairal","year":"2006","journal-title":"Diabetologia"},{"key":"10.1016\/j.tem.2006.08.003_bib49","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.cmet.2006.03.005","article-title":"Adipose triglyceride lipase-mediated lipolysis of cellular fat stores is activated by CGI-58 and defective in Chanarin\u2013Dorfman syndrome","volume":"3","author":"Lass","year":"2006","journal-title":"Cell Metab."},{"key":"10.1016\/j.tem.2006.08.003_bib50","doi-asserted-by":"crossref","first-page":"42062","DOI":"10.1074\/jbc.M407462200","article-title":"Perilipin A mediates the reversible binding of CGI-58 to lipid droplets in 3T3-L1 adipocytes","volume":"279","author":"Subramanian","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tem.2006.08.003_bib51","doi-asserted-by":"crossref","first-page":"30490","DOI":"10.1074\/jbc.M403920200","article-title":"CGI-58 interacts with perilipin and is localized to lipid droplets. Possible involvement of CGI-58 mislocalization in Chanarin\u2013Dorfman syndrome","volume":"279","author":"Yamaguchi","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tem.2006.08.003_bib52","doi-asserted-by":"crossref","first-page":"4806","DOI":"10.1074\/jbc.M110355200","article-title":"Hormone-sensitive lipase deficiency in mice causes diglyceride accumulation in adipose tissue, muscle, and testis","volume":"277","author":"Haemmerle","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tem.2006.08.003_bib53","doi-asserted-by":"crossref","first-page":"3190","DOI":"10.2337\/diabetes.54.11.3190","article-title":"Adipocyte lipases and defect of lipolysis in human obesity","volume":"54","author":"Langin","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.tem.2006.08.003_bib54","doi-asserted-by":"crossref","first-page":"40683","DOI":"10.1074\/jbc.M400541200","article-title":"Carboxylesterase 3 (EC 3.1.1.1) is a major adipocyte lipase","volume":"279","author":"Soni","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tem.2006.08.003_bib55","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.2337\/db05-0585","article-title":"Identification of a novel member of the carboxylesterase family that hydrolyzes triacylglycerol: a potential role in adipocyte lipolysis","volume":"55","author":"Okazaki","year":"2006","journal-title":"Diabetes"},{"key":"10.1016\/j.tem.2006.08.003_bib56","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.2337\/db05-1498","article-title":"The ATGL gene is associated with free fatty acids, triglycerides, and type 2 diabetes","volume":"55","author":"Schoenborn","year":"2006","journal-title":"Diabetes"},{"key":"10.1016\/j.tem.2006.08.003_bib57","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1172\/JCI113997","article-title":"Influence of body fat distribution on free fatty acid metabolism in obesity","volume":"83","author":"Jensen","year":"1989","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tem.2006.08.003_bib58","doi-asserted-by":"crossref","first-page":"2568","DOI":"10.1172\/JCI119444","article-title":"In vivo resistance of lipolysis to epinephrine. A new feature of childhood onset obesity","volume":"99","author":"Bougn\u00e8res","year":"1997","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tem.2006.08.003_bib59","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.beem.2005.07.004","article-title":"Human fat cell lipolysis: biochemistry, regulation and clinical role","volume":"19","author":"Arner","year":"2005","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab"},{"key":"10.1016\/j.tem.2006.08.003_bib60","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1016\/S0022-2275(20)32429-9","article-title":"Decreased expression and function of adipocyte hormone-sensitive lipase in subcutaneous fat cells of obese subjects","volume":"40","author":"Large","year":"1999","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.tem.2006.08.003_bib61","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1007\/BF00403911","article-title":"Adipocyte lipolysis in normal weight subjects with obesity among first-degree relatives","volume":"39","author":"Hellstr\u00f6m","year":"1996","journal-title":"Diabetologia"},{"key":"10.1016\/j.tem.2006.08.003_bib62","doi-asserted-by":"crossref","first-page":"284","DOI":"10.2337\/diab.47.2.284","article-title":"Human hormone-sensitive lipase: genetic mapping, identification of a new dinucleotide repeat, and association with obesity and NIDDM","volume":"47","author":"Magr\u00e9","year":"1998","journal-title":"Diabetes"},{"key":"10.1016\/j.tem.2006.08.003_bib63","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1007\/s001250051099","article-title":"The putative role of the hormone-sensitive lipase gene in the pathogenesis of type II diabetes mellitus and abdominal obesity","volume":"41","author":"Klannemark","year":"1998","journal-title":"Diabetologia"},{"key":"10.1016\/j.tem.2006.08.003_bib64","doi-asserted-by":"crossref","first-page":"2410","DOI":"10.2337\/diabetes.50.10.2410","article-title":"A common hormone-sensitive lipase i6 gene polymorphism is associated with decreased human adipocyte lipolytic function","volume":"50","author":"Hoffstedt","year":"2001","journal-title":"Diabetes"},{"key":"10.1016\/j.tem.2006.08.003_bib65","doi-asserted-by":"crossref","first-page":"4854","DOI":"10.1073\/pnas.91.11.4854","article-title":"Tumor necrosis factor \u03b1 inhibits signaling from the insulin receptor","volume":"91","author":"Hotamisligil","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tem.2006.08.003_bib66","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.2337\/diabetes.53.5.1285","article-title":"From blood monocytes to adipose tissue-resident macrophages: induction of diapedesis by human mature adipocytes","volume":"53","author":"Curat","year":"2004","journal-title":"Diabetes"},{"key":"10.1016\/j.tem.2006.08.003_bib67","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1096\/fj.04-2204com","article-title":"Weight loss regulates inflammation-related genes in white adipose tissue of obese subjects","volume":"18","author":"Clement","year":"2004","journal-title":"FASEB J."},{"key":"10.1016\/j.tem.2006.08.003_bib68","doi-asserted-by":"crossref","first-page":"881","DOI":"10.2337\/diab.45.7.881","article-title":"Effects of an engineered human anti-TNF-\u03b1 antibody (CDP571) on insulin sensitivity and glycemic control in patients with NIDDM","volume":"45","author":"Ofei","year":"1996","journal-title":"Diabetes"},{"key":"10.1016\/j.tem.2006.08.003_bib69","first-page":"1316","article-title":"No increased insulin sensitivity after a single intravenous administration of a recombinant human tumor necrosis factor receptor: Fc fusion protein in obese insulin-resistant patients","volume":"85","author":"Paquot","year":"2000","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2006.08.003_bib70","first-page":"4196","article-title":"Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-\u03b1, in vivo","volume":"82","author":"Mohamed-Ali","year":"1997","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2006.08.003_bib71","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1016\/S0140-6736(04)16359-9","article-title":"The nicotinic acid receptor-a new mechanism for an old drug","volume":"363","author":"Karpe","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.tem.2006.08.003_bib72","doi-asserted-by":"crossref","first-page":"3155","DOI":"10.1016\/j.bmcl.2004.04.015","article-title":"In vitro SAR of (5-(2H)-isoxazolonyl) ureas, potent inhibitors of hormone-sensitive lipase","volume":"14","author":"Lowe","year":"2004","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.tem.2006.08.003_bib73","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1124\/jpet.105.086926","article-title":"Specific inhibition of hormone-sensitive lipase improves lipid profile while reducing plasma glucose","volume":"315","author":"Claus","year":"2005","journal-title":"J. Pharmacol. Exp. Ther."}],"container-title":["Trends in Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043276006001536?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043276006001536?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T20:36:56Z","timestamp":1760906216000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043276006001536"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10]]},"references-count":73,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2006,10]]}},"alternative-id":["S1043276006001536"],"URL":"https:\/\/doi.org\/10.1016\/j.tem.2006.08.003","relation":{},"ISSN":["1043-2760"],"issn-type":[{"value":"1043-2760","type":"print"}],"subject":[],"published":{"date-parts":[[2006,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Importance of TNF\u03b1 and neutral lipases in human adipose tissue lipolysis","name":"articletitle","label":"Article Title"},{"value":"Trends in Endocrinology & Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tem.2006.08.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}