{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T07:07:41Z","timestamp":1789715261724,"version":"4.0.1"},"reference-count":66,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2007,9,1]],"date-time":"2007-09-01T00:00:00Z","timestamp":1188604800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trends in Endocrinology & Metabolism"],"published-print":{"date-parts":[[2007,9]]},"DOI":"10.1016\/j.tem.2007.07.003","type":"journal-article","created":{"date-parts":[[2007,8,11]],"date-time":"2007-08-11T11:09:33Z","timestamp":1186830573000},"page":"266-272","source":"Crossref","is-referenced-by-count":322,"title":["Abdominal adiposity and the polycystic ovary syndrome"],"prefix":"10.1016","volume":"18","author":[{"given":"H\u00e9ctor F.","family":"Escobar-Morreale","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 L. San","family":"Mill\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tem.2007.07.003_bib1","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1210\/jc.84.6.1897","article-title":"Polycystic ovary syndrome (PCOS): arguably the most common endocrinopathy is associated with significant morbidity in women","volume":"84","author":"Carmina","year":"1999","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2007.07.003_bib2","doi-asserted-by":"crossref","first-page":"4006","DOI":"10.1210\/jc.84.11.4006","article-title":"A survey of the polycystic ovary syndrome in the Greek island of Lesbos: hormonal and metabolic profile","volume":"84","author":"Diamanti-Kandarakis","year":"1999","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2007.07.003_bib3","doi-asserted-by":"crossref","first-page":"2434","DOI":"10.1210\/jc.85.7.2434","article-title":"A prospective study of the prevalence of the polycystic ovary syndrome in unselected Caucasian women from Spain","volume":"85","author":"Asunci\u00f3n","year":"2000","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2007.07.003_bib4","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1210\/jc.2003-032046","article-title":"The prevalence and features of the polycystic ovary syndrome in an unselected population","volume":"89","author":"Azziz","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2007.07.003_bib5","doi-asserted-by":"crossref","first-page":"2500","DOI":"10.1210\/jc.2006-2725","article-title":"Abdominal fat quantity and distribution in women with polycystic ovary syndrome and extent of its relation to insulin resistance","volume":"92","author":"Carmina","year":"2007","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2007.07.003_bib6","first-page":"377","article-title":"Diagnostic criteria for polycystic ovary syndrome: Towards a rational approach","volume":"Vol. 4","author":"Zawadzki","year":"1992"},{"key":"10.1016\/j.tem.2007.07.003_bib7","doi-asserted-by":"crossref","unstructured":"The Rotterdam ESHRE\/ASRM-sponsored PCOS consensus workshop group. (2004) Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum. Reprod. 19, 41\u201347","DOI":"10.1093\/humrep\/deh098"},{"key":"10.1016\/j.tem.2007.07.003_bib8","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1210\/jc.2005-2153","article-title":"Controversy in clinical endocrinology: diagnosis of polycystic ovarian syndrome: the Rotterdam criteria are premature","volume":"91","author":"Azziz","year":"2006","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2007.07.003_bib9","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1210\/jc.2005-2501","article-title":"Controversy in clinical endocrinology: diagnosis of polycystic ovarian syndrome: in defense of the Rotterdam criteria","volume":"91","author":"Franks","year":"2006","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2007.07.003_bib10","doi-asserted-by":"crossref","first-page":"4237","DOI":"10.1210\/jc.2006-0178","article-title":"Position statement: criteria for defining polycystic ovary syndrome as a predominantly hyperandrogenic syndrome: an Androgen Excess Society guideline","volume":"91","author":"Azziz","year":"2006","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2007.07.003_bib11","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.tem.2006.01.003","article-title":"Human ovarian theca cells in culture","volume":"17","author":"Wickenheisser","year":"2006","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.tem.2007.07.003_bib12","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1210\/er.2004-0004","article-title":"The molecular-genetic basis of functional hyperandrogenism and the polycystic ovary syndrome","volume":"26","author":"Escobar-Morreale","year":"2005","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.tem.2007.07.003_bib13","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1038\/sj.ijo.0801994","article-title":"Obesity and the polycystic ovary syndrome","volume":"26","author":"Gambineri","year":"2002","journal-title":"Int. J. Obes. Relat. Metab. Disord."},{"key":"10.1016\/j.tem.2007.07.003_bib14","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1210\/er.18.6.774","article-title":"Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis","volume":"18","author":"Dunaif","year":"1997","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.tem.2007.07.003_bib15","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1210\/er.20.4.535","article-title":"The insulin-related ovarian regulatory system in health and disease","volume":"20","author":"Poretsky","year":"1999","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.tem.2007.07.003_bib16","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/0026-0495(92)90175-A","article-title":"Hyperinsulinemia and human chorionic gonadotropin synergistically promote the growth of ovarian follicular cysts in rats","volume":"41","author":"Poretsky","year":"1992","journal-title":"Metabolism"},{"key":"10.1016\/j.tem.2007.07.003_bib17","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1210\/jcem-72-6-1308","article-title":"Insulin resistance and hyperinsulinemia induce hyperandrogenism in a young type B insulin-resistant female","volume":"72","author":"DeClue","year":"1991","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2007.07.003_bib18","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1210\/jc.82.2.644","article-title":"The impact of insulin secretion on the ovarian response to exogenous gonadotropins in polycystic ovary syndrome","volume":"82","author":"Fulghesu","year":"1997","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2007.07.003_bib19","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1093\/humupd\/dmh010","article-title":"The follicular excess in polycystic ovaries, due to intra-ovarian hyperandrogenism, may be the main culprit for the follicular arrest","volume":"10","author":"Jonard","year":"2004","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.tem.2007.07.003_bib20","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1001\/archinte.166.19.2081","article-title":"Prevalence and characteristics of the polycystic ovary syndrome in overweight and obese women","volume":"166","author":"Alvarez-Blasco","year":"2006","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.tem.2007.07.003_bib21","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.2337\/dc06-0877","article-title":"Increased prevalence of gestational diabetes mellitus among women with diagnosed polycystic ovary syndrome: a population-based study","volume":"29","author":"Lo","year":"2006","journal-title":"Diabetes Care"},{"key":"10.1016\/j.tem.2007.07.003_bib22","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1046\/j.1365-2265.2000.00884.x","article-title":"The prevalence of polycystic ovaries in women with type 2 diabetes mellitus","volume":"52","author":"Conn","year":"2000","journal-title":"Clin. Endocrinol. (Oxf.)"},{"key":"10.1016\/j.tem.2007.07.003_bib23","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.2337\/diacare.24.6.1050","article-title":"Prevalence of polycystic ovary syndrome among premenopausal women with type 2 diabetes","volume":"24","author":"Peppard","year":"2001","journal-title":"Diabetes Care"},{"key":"10.1016\/j.tem.2007.07.003_bib24","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1097\/01.md.0000133625.73570.54","article-title":"Clinical course of genetic diseases of the insulin receptor (type A and Rabson-Mendenhall syndromes): a 30-year prospective","volume":"83","author":"Musso","year":"2004","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.tem.2007.07.003_bib25","doi-asserted-by":"crossref","first-page":"851","DOI":"10.7326\/0003-4819-97-6-851","article-title":"Insulin resistance associated with androgen excess in women with autoantibodies to the insulin receptor","volume":"97","author":"Taylor","year":"1982","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.tem.2007.07.003_bib26","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1093\/humrep\/15.1.86","article-title":"Clinical presentation of PCOS following development of an insulinoma: case report","volume":"15","author":"Murray","year":"2000","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.tem.2007.07.003_bib27","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1046\/j.1365-2796.2003.01132.x","article-title":"Insulinoma presenting with hyperandrogenism: a case report and a literature review","volume":"253","author":"Stanciu","year":"2003","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.tem.2007.07.003_bib28","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1210\/jc.2006-2641","article-title":"Hyperandrogenism and polycystic ovary syndrome (PCOS) in women with type 1 diabetes Mellitus","volume":"92","author":"Codner","year":"2007","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2007.07.003_bib29","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/S0301-2115(02)00359-7","article-title":"The role of leptin in fertility","volume":"106","author":"Goumenou","year":"2003","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.tem.2007.07.003_bib30","doi-asserted-by":"crossref","first-page":"6364","DOI":"10.1210\/jc.2005-1490","article-title":"The polycystic ovary syndrome associated with morbid obesity may resolve after weight loss induced by bariatric surgery","volume":"90","author":"Escobar-Morreale","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2007.07.003_bib31","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1016\/j.fertnstert.2004.11.070","article-title":"Prevalence of insulin resistance in the polycystic ovary syndrome using the homeostasis model assessment","volume":"83","author":"DeUgarte","year":"2005","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.tem.2007.07.003_bib32","unstructured":"National Institutes of Health (1998) Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults\u2013The evidence report. Obes. Res. 6(Suppl 2), 51S\u2013209S"},{"key":"10.1016\/j.tem.2007.07.003_bib33","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1056\/NEJMra041536","article-title":"Polycystic ovary syndrome","volume":"352","author":"Ehrmann","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.tem.2007.07.003_bib34","doi-asserted-by":"crossref","first-page":"2548","DOI":"10.1210\/jc.2004-0395","article-title":"Adipose tissue as an endocrine organ","volume":"89","author":"Kershaw","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2007.07.003_bib35","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1093\/humrep\/del146","article-title":"Adiponectin and resistin in PCOS: a clinical, biochemical and molecular genetic study","volume":"21","author":"Escobar-Morreale","year":"2006","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.tem.2007.07.003_bib36","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1210\/er.2002-0010","article-title":"Insulin resistance and chronic cardiovascular inflammatory syndrome","volume":"24","author":"Fernandez-Real","year":"2003","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.tem.2007.07.003_bib37","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1210\/en.141.6.1971","article-title":"The in vivo and in vitro effects of exogenous leptin on ovulation in the rat","volume":"141","author":"Duggal","year":"2000","journal-title":"Endocrinology"},{"key":"10.1016\/j.tem.2007.07.003_bib38","doi-asserted-by":"crossref","first-page":"2711","DOI":"10.1210\/endo-126-5-2711","article-title":"Effects of tumor necrosis factor-alpha in vitro on steroidogenesis of healthy and atretic follicles of the rat: theca as a target","volume":"126","author":"Roby","year":"1990","journal-title":"Endocrinology"},{"key":"10.1016\/j.tem.2007.07.003_bib39","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1095\/biolreprod61.4.993","article-title":"Tumor necrosis factor-alpha stimulates proliferation of rat ovarian theca-interstitial cells","volume":"61","author":"Spaczynski","year":"1999","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.tem.2007.07.003_bib40","doi-asserted-by":"crossref","first-page":"4864","DOI":"10.1210\/en.137.11.4864","article-title":"Tumor necrosis factor-alpha and its second messenger, ceramide, stimulate apoptosis in cultured ovarian follicles","volume":"137","author":"Kaipia","year":"1996","journal-title":"Endocrinology"},{"key":"10.1016\/j.tem.2007.07.003_bib41","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1385\/ENDO:8:2:109","article-title":"Tumor necrosis factor-alpha (TNF-alpha) inhibits steroidogenesis of bovine ovarian granulosa and thecal cells in vitro. Involvement of TNF-alpha receptors","volume":"8","author":"Spicer","year":"1998","journal-title":"Endocrine"},{"key":"10.1016\/j.tem.2007.07.003_bib42","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1095\/biolreprod58.1.207","article-title":"Adipose obese gene product, leptin, inhibits bovine ovarian thecal cell steroidogenesis","volume":"58","author":"Spicer","year":"1998","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.tem.2007.07.003_bib43","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1210\/jc.82.7.2343","article-title":"Interleukin-6 and the interleukin-6 receptor in the human adrenal gland: expression and effects on steroidogenesis","volume":"82","author":"Path","year":"1997","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2007.07.003_bib44","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/0002-9378(86)90676-9","article-title":"Hyperinsulinemia in hyperthecosis of the ovaries","volume":"154","author":"Nagamani","year":"1986","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.tem.2007.07.003_bib45","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1210\/jcem-70-3-699","article-title":"Suppression of hyperandrogenism does not improve peripheral or hepatic insulin resistance in the polycystic ovary syndrome","volume":"70","author":"Dunaif","year":"1990","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2007.07.003_bib46","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1046\/j.1365-2265.2003.01753.x","article-title":"Effects of sex steroids on components of the insulin resistance syndrome in transsexual subjects","volume":"58","author":"Elbers","year":"2003","journal-title":"Clin. Endocrinol. (Oxf.)"},{"key":"10.1016\/j.tem.2007.07.003_bib47","series-title":"Polycystic ovary syndrome","first-page":"262","article-title":"Fetal programming of polycystic ovary syndrome","author":"Abbott","year":"2007"},{"key":"10.1016\/j.tem.2007.07.003_bib48","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1053\/beem.2002.0203","article-title":"Adult polycystic ovary syndrome begins in childhood","volume":"16","author":"Franks","year":"2002","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2007.07.003_bib49","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1210\/jc.2005-2757","article-title":"Review: Fetal programming of polycystic ovary syndrome by androgen excess: evidence from experimental, clinical, and genetic association studies","volume":"91","author":"Xita","year":"2006","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2007.07.003_bib50","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1210\/jc.79.5.1328","article-title":"Ovarian hyperandrogynism as a result of congenital adrenal virilizing disorders: evidence for perinatal masculinization of neuroendocrine function in women","volume":"79","author":"Barnes","year":"1994","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2007.07.003_bib51","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1210\/jcem-73-3-525","article-title":"Maturation of hypothalamic-pituitary-gonadal function in normal human fetuses: circulating levels of gonadotropins, their common alpha-subunit and free testosterone, and discrepancy between immunological and biological activities of circulating follicle-stimulating hormone","volume":"73","author":"Beck-Peccoz","year":"1991","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2007.07.003_bib52","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0015-0282(16)54828-6","article-title":"Gestational hyperandrogenism","volume":"57","author":"McClamrock","year":"1992","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.tem.2007.07.003_bib53","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1210\/jc.2006-1665","article-title":"Differential gene expression profile in omental adipose tissue in women with polycystic ovary syndrome","volume":"92","author":"Corton","year":"2007","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2007.07.003_bib54","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1210\/er.2005-0005","article-title":"Adiponectin and adiponectin receptors","volume":"26","author":"Kadowaki","year":"2005","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.tem.2007.07.003_bib55","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/S0015-0282(16)58500-8","article-title":"Evidence for heterogeneous etiologies of adrenal dysfunction in polycystic ovary syndrome","volume":"66","author":"Gonzalez","year":"1996","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.tem.2007.07.003_bib56","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/s00125-003-1090-z","article-title":"Obesity, and not insulin resistance, is the major determinant of serum inflammatory cardiovascular risk markers in pre-menopausal women","volume":"46","author":"Escobar-Morreale","year":"2003","journal-title":"Diabetologia"},{"key":"10.1016\/j.tem.2007.07.003_bib57","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0015-0282(03)00571-5","article-title":"Decreased total antioxidant status and increased oxidative stress in women with polycystic ovary syndrome may contribute to the risk of cardiovascular disease","volume":"80","author":"Fenkci","year":"2003","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.tem.2007.07.003_bib58","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1210\/jc.2005-1696","article-title":"Reactive oxygen species-induced oxidative stress in the development of insulin resistance and hyperandrogenism in polycystic ovary syndrome","volume":"91","author":"Gonzalez","year":"2006","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2007.07.003_bib59","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S1043-2760(02)00612-4","article-title":"The role of lifestyle modification in polycystic ovary syndrome","volume":"13","author":"Norman","year":"2002","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.tem.2007.07.003_bib60","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1210\/er.2002-0015","article-title":"Insulin-lowering agents in the management of polycystic ovary syndrome","volume":"24","author":"De Leo","year":"2003","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.tem.2007.07.003_bib61","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1210\/jc.2004-0176","article-title":"Orlistat is as beneficial as metformin in the treatment of polycystic ovarian syndrome","volume":"90","author":"Jayagopal","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2007.07.003_bib62","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/S0015-0282(03)02162-9","article-title":"Sibutramine has a positive effect on clinical and metabolic parameters in obese patients with polycystic ovary syndrome","volume":"80","author":"Sabuncu","year":"2003","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.tem.2007.07.003_bib63","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1365-2265.2004.01973.x","article-title":"Effect of flutamide and metformin administered alone or in combination in dieting obese women with polycystic ovary syndrome","volume":"60","author":"Gambineri","year":"2004","journal-title":"Clin. Endocrinol. (Oxf.)"},{"key":"10.1016\/j.tem.2007.07.003_bib64","doi-asserted-by":"crossref","first-page":"3970","DOI":"10.1210\/jc.2005-2250","article-title":"Treatment with flutamide, metformin, and their combination added to a hypocaloric diet in overweight-obese women with polycystic ovary syndrome: a randomized, 12-month, placebo-controlled study","volume":"91","author":"Gambineri","year":"2006","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2007.07.003_bib65","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1093\/humupd\/dmi054","article-title":"Low-dose flutamide-metformin therapy for hyperinsulinemic hyperandrogenism in non-obese adolescents and women","volume":"12","author":"Ibanez","year":"2006","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.tem.2007.07.003_bib66","doi-asserted-by":"crossref","first-page":"2870","DOI":"10.1210\/jc.87.6.2870","article-title":"Additive effects of insulin-sensitizing and anti-androgen treatment in young, nonobese women with hyperinsulinism, hyperandrogenism, dyslipidemia, and anovulation","volume":"87","author":"Ibanez","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."}],"container-title":["Trends in Endocrinology & Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043276007001129?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043276007001129?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T23:17:15Z","timestamp":1556752635000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043276007001129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,9]]},"references-count":66,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2007,9]]}},"alternative-id":["S1043276007001129"],"URL":"https:\/\/doi.org\/10.1016\/j.tem.2007.07.003","relation":{},"ISSN":["1043-2760"],"issn-type":[{"value":"1043-2760","type":"print"}],"subject":[],"published":{"date-parts":[[2007,9]]}}}