{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:41:48Z","timestamp":1791268908843,"version":"4.1.0"},"reference-count":88,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","cell.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","bmn.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Endocrinology &amp; Metabolism"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1016\/j.tem.2016.03.002","type":"journal-article","created":{"date-parts":[[2016,3,27]],"date-time":"2016-03-27T08:01:35Z","timestamp":1459065695000},"page":"335-347","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":168,"title":["Cytokine Signaling in Skeletal Muscle Wasting"],"prefix":"10.1016","volume":"27","author":[{"given":"Jin","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangxin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao-Hua","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tem.2016.03.002_bib0445","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/s12032-015-0497-y","article-title":"The prognostic role of inflammation and hormones in patients with metastatic cancer with cachexia","volume":"32","author":"Bilir","year":"2015","journal-title":"Med. Oncol."},{"key":"10.1016\/j.tem.2016.03.002_bib0450","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s13539-012-0075-5","article-title":"Predicting survival in cancer patients: the role of cachexia and hormonal, nutritional and inflammatory markers","volume":"3","author":"Utech","year":"2012","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.tem.2016.03.002_bib0455","doi-asserted-by":"crossref","first-page":"5052","DOI":"10.1096\/fj.09-150714","article-title":"TNF-alpha impairs regulation of muscle oxidative phenotype: implications for cachexia?","volume":"24","author":"Remels","year":"2010","journal-title":"FASEB J."},{"key":"10.1016\/j.tem.2016.03.002_bib0460","doi-asserted-by":"crossref","first-page":"2604","DOI":"10.1210\/jc.2013-1502","article-title":"Two weeks of reduced activity decreases leg lean mass and induces \u201canabolic resistance\u201d of myofibrillar protein synthesis in healthy elderly","volume":"98","author":"Breen","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2016.03.002_bib0465","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/523158e","article-title":"Cytokine anniversary: TNF trailblazers five centuries apart","volume":"523","author":"Libert","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.tem.2016.03.002_bib0470","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1152\/japplphysiol.90884.2008","article-title":"Anti-TNF treatment reduces rat skeletal muscle wasting in monocrotaline-induced cardiac cachexia","volume":"105","author":"Steffen","year":"2008","journal-title":"J. Appl. Physiol. (1985)"},{"key":"10.1016\/j.tem.2016.03.002_bib0475","doi-asserted-by":"crossref","first-page":"821310","DOI":"10.1155\/2013\/821310","article-title":"Tumor necrosis factor receptor 2: its contribution to acute cellular rejection and clear cell renal carcinoma","volume":"2013","author":"Wang","year":"2013","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.tem.2016.03.002_bib0480","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1002\/stem.1433","article-title":"TNF, acting through inducibly expressed TNFR2, drives activation and cell cycle entry of c-Kit+ cardiac stem cells in ischemic heart disease","volume":"31","author":"Al-Lamki","year":"2013","journal-title":"Stem Cells"},{"key":"10.1016\/j.tem.2016.03.002_bib0485","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1096\/fj.14-249813","article-title":"Genetic deletion of TNFR2 augments inflammatory response and blunts satellite-cell-mediated recovery response in a hind limb ischemia model","volume":"29","author":"Sasi","year":"2015","journal-title":"FASEB J."},{"key":"10.1016\/j.tem.2016.03.002_bib0490","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1083\/jcb.200909117","article-title":"The TWEAK\u2013Fn14 system is a critical regulator of denervation-induced skeletal muscle atrophy in mice","volume":"188","author":"Mittal","year":"2010","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.tem.2016.03.002_bib0495","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.clnu.2011.07.010","article-title":"Is IL-6 the best pro-inflammatory biomarker of clinical outcomes of cancer cachexia?","volume":"31","author":"Scheede-Bergdahl","year":"2012","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.tem.2016.03.002_bib0500","doi-asserted-by":"crossref","first-page":"4023","DOI":"10.2337\/db13-0138","article-title":"Direct effects of TNF-alpha on local fuel metabolism and cytokine levels in the placebo-controlled, bilaterally infused human leg: increased insulin sensitivity, increased net protein breakdown, and increased IL-6 release","volume":"62","author":"Bach","year":"2013","journal-title":"Diabetes"},{"key":"10.1016\/j.tem.2016.03.002_bib0505","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1111\/apt.13058","article-title":"Infliximab reverses inflammatory muscle wasting (sarcopenia) in Crohn's disease","volume":"41","author":"Subramaniam","year":"2015","journal-title":"Aliment. Pharmacol. Therap."},{"key":"10.1016\/j.tem.2016.03.002_bib0510","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.2174\/1381612811319100014","article-title":"Long-term etanercept therapy favors weight gain and ameliorates cachexia in rheumatoid arthritis patients: roles of gut hormones and leptin","volume":"19","author":"Chen","year":"2013","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.tem.2016.03.002_bib0515","first-page":"18","article-title":"A multicenter, phase II study of infliximab plus gemcitabine in pancreatic cancer cachexia","volume":"6","author":"Wiedenmann","year":"2008","journal-title":"J. Support. Oncol."},{"key":"10.1016\/j.tem.2016.03.002_bib0520","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1097\/MPA.0b013e318279b87f","article-title":"Disrupting cytokine signaling in pancreatic cancer: a phase I\/II study of etanercept in combination with gemcitabine in patients with advanced disease","volume":"42","author":"Wu","year":"2013","journal-title":"Pancreas"},{"key":"10.1016\/j.tem.2016.03.002_bib0525","doi-asserted-by":"crossref","first-page":"11","DOI":"10.5603\/PiAP.a2015.0080","article-title":"Serum levels of apoptosis-related markers (sFasL, TNF-\u03b1, p53 and bcl-2) in COPD patients","volume":"84","author":"Kosacka","year":"2016","journal-title":"Pneumonol. Alergol. Polska"},{"key":"10.1016\/j.tem.2016.03.002_bib0530","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1096\/fj.13-242123","article-title":"Regulatory circuitry of TWEAK\u2013Fn14 system and PGC-1\u03b1 in skeletal muscle atrophy program","volume":"28","author":"Hindi","year":"2014","journal-title":"FASEB J."},{"key":"10.1016\/j.tem.2016.03.002_bib0535","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.abb.2014.12.026","article-title":"Endurance training prevents TWEAK but not myostatin-mediated cardiac remodelling in cancer cachexia","volume":"567","author":"Padrao","year":"2015","journal-title":"Archiv. Biochem. Biophys."},{"key":"10.1016\/j.tem.2016.03.002_bib0540","doi-asserted-by":"crossref","first-page":"35159","DOI":"10.1074\/jbc.M113.517300","article-title":"Proinflammatory cytokine tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) suppresses satellite cell self-renewal through inversely modulating Notch and NF-\u03baB signaling pathways","volume":"288","author":"Ogura","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tem.2016.03.002_bib0545","doi-asserted-by":"crossref","first-page":"5452","DOI":"10.1093\/hmg\/ddu270","article-title":"P38\u03b1 MAPK underlies muscular dystrophy and myofiber death through a Bax-dependent mechanism","volume":"23","author":"Wissing","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.tem.2016.03.002_bib0550","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/nm.3465","article-title":"p38 MAPK signaling underlies a cell-autonomous loss of stem cell self-renewal in skeletal muscle of aged mice","volume":"20","author":"Bernet","year":"2014","journal-title":"Nat. Med."},{"key":"10.1016\/j.tem.2016.03.002_bib0555","doi-asserted-by":"crossref","first-page":"11177","DOI":"10.1074\/jbc.M115.641514","article-title":"Inhibition of stat3 activation suppresses caspase-3 and the ubiquitin-proteasome system, leading to preservation of muscle mass in cancer cachexia","volume":"290","author":"Silva","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tem.2016.03.002_bib0560","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.cmet.2012.06.011","article-title":"Cancer cachexia: mediators, signaling, and metabolic pathways","volume":"16","author":"Fearon","year":"2012","journal-title":"Cell Metab."},{"key":"10.1016\/j.tem.2016.03.002_bib0565","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1016\/j.cell.2015.08.031","article-title":"Targeting of Fn14 prevents cancer-induced cachexia and prolongs survival","volume":"162","author":"Johnston","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.tem.2016.03.002_bib0570","doi-asserted-by":"crossref","first-page":"e65248","DOI":"10.1371\/journal.pone.0065248","article-title":"TWEAK-independent Fn14 self-association and NF-\u03baB activation is mediated by the C-terminal region of the Fn14 cytoplasmic domain","volume":"8","author":"Brown","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.tem.2016.03.002_bib0575","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1083\/jcb.201006098","article-title":"Targeted ablation of TRAF6 inhibits skeletal muscle wasting in mice","volume":"191","author":"Paul","year":"2010","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.tem.2016.03.002_bib0580","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/1756-9966-31-81","article-title":"Expression of TRAF6 and ubiquitin mRNA in skeletal muscle of gastric cancer patients","volume":"31","author":"Sun","year":"2012","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.tem.2016.03.002_bib0585","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.cyto.2012.10.023","article-title":"Adipose tissue-derived factors as potential biomarkers in cachectic cancer patients","volume":"61","author":"Batista","year":"2013","journal-title":"Cytokine"},{"key":"10.1016\/j.tem.2016.03.002_bib0590","doi-asserted-by":"crossref","first-page":"3071","DOI":"10.1007\/s00520-013-1878-4","article-title":"Interleukin-6 but not tumour necrosis factor-alpha predicts survival in patients with advanced cancer","volume":"21","author":"Suh","year":"2013","journal-title":"Support. Care Cancer"},{"key":"10.1016\/j.tem.2016.03.002_bib0595","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s13539-011-0047-1","article-title":"The effect of exercise on IL-6-induced cachexia in the ApcMin\/+ mouse","volume":"3","author":"Puppa","year":"2012","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.tem.2016.03.002_bib0600","doi-asserted-by":"crossref","first-page":"206026","DOI":"10.1155\/2014\/206026","article-title":"IL-6 impairs myogenic differentiation by downmodulation of p90RSK\/eEF2 and mTOR\/p70S6K axes, without affecting AKT activity","volume":"2014","author":"Pelosi","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.tem.2016.03.002_bib0605","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1002\/jcsm.12023","article-title":"Ghrelin prevents tumour- and cisplatin-induced muscle wasting: characterization of multiple mechanisms involved","volume":"6","author":"Chen","year":"2015","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.tem.2016.03.002_bib0610","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1177\/1099800414558087","article-title":"Induction of IL-6 by cytotoxic chemotherapy is associated with loss of lean body and fat mass in tumor-free female mice","volume":"17","author":"Elsea","year":"2015","journal-title":"Biol. Res. Nurs."},{"key":"10.1016\/j.tem.2016.03.002_bib0615","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1002\/jcp.21955","article-title":"TNF-alpha-mediated reduction in PGC-1alpha may impair skeletal muscle function after cigarette smoke exposure","volume":"222","author":"Tang","year":"2010","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.tem.2016.03.002_bib0620","first-page":"R1025","article-title":"Effect of pulmonary TNF-alpha overexpression on mouse isolated skeletal muscle function","volume":"301","author":"Zuo","year":"2011","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.tem.2016.03.002_bib0625","first-page":"R75","article-title":"Superoxide release from contracting skeletal muscle in pulmonary TNF-alpha overexpression mice","volume":"306","author":"Zuo","year":"2014","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.tem.2016.03.002_bib0630","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/1465-9921-13-48","article-title":"TNF-alpha is associated with loss of lean body mass only in already cachectic COPD patients","volume":"13","author":"Eagan","year":"2012","journal-title":"Respir. Res."},{"key":"10.1016\/j.tem.2016.03.002_bib0635","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/nature11923","article-title":"CLP1 links tRNA metabolism to progressive motor-neuron loss","volume":"495","author":"Hanada","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.tem.2016.03.002_bib0640","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1093\/hmg\/ddu617","article-title":"TWEAK\/Fn14, a pathway and novel therapeutic target in myotonic dystrophy","volume":"24","author":"Yadava","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.tem.2016.03.002_bib0645","doi-asserted-by":"crossref","first-page":"3440","DOI":"10.1093\/hmg\/ddv094","article-title":"Tweak regulates astrogliosis, microgliosis and skeletal muscle atrophy in a mouse model of amyotrophic lateral sclerosis","volume":"24","author":"Bowerman","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.tem.2016.03.002_bib0650","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1093\/hmg\/ddt536","article-title":"Distinct roles of TRAF6 at early and late stages of muscle pathology in the mdx model of Duchenne muscular dystrophy","volume":"23","author":"Hindi","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.tem.2016.03.002_bib0655","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1016\/j.bbrc.2014.03.084","article-title":"The TWEAK\u2013Fn14 dyad is involved in age-associated pathological changes in skeletal muscle","volume":"446","author":"Tajrishi","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.tem.2016.03.002_bib0660","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/2044-5040-3-18","article-title":"TWEAK promotes exercise intolerance by decreasing skeletal muscle oxidative phosphorylation capacity","volume":"3","author":"Sato","year":"2013","journal-title":"Skelet. Muscle"},{"key":"10.1016\/j.tem.2016.03.002_bib0665","doi-asserted-by":"crossref","DOI":"10.1093\/eurheartj\/ehw008","article-title":"Intestinal congestion and right ventricular dysfunction: a link with appetite loss, inflammation, and cachexia in chronic heart failure","author":"Valentova","year":"2016","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.tem.2016.03.002_bib0670","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1161\/CIRCRESAHA.114.305393","article-title":"Angiotensin II induces skeletal muscle atrophy by activating TFEB-mediated MuRF1 expression","volume":"117","author":"Du Bois","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.tem.2016.03.002_bib0675","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1113\/expphysiol.2014.084095","article-title":"Angiotensin II can directly induce mitochondrial dysfunction, decrease oxidative fibre number and induce atrophy in mouse hindlimb skeletal muscle","volume":"100","author":"Kadoguchi","year":"2015","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.tem.2016.03.002_bib0680","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.exger.2014.07.017","article-title":"Losartan improves measures of activity, inflammation, and oxidative stress in older mice","volume":"58","author":"Lin","year":"2014","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.tem.2016.03.002_bib0685","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.2353\/ajpath.2010.100335","article-title":"Genetic ablation of TWEAK augments regeneration and post-injury growth of skeletal muscle in mice","volume":"177","author":"Mittal","year":"2010","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.tem.2016.03.002_bib0690","doi-asserted-by":"crossref","first-page":"3625","DOI":"10.1038\/srep03625","article-title":"Nrf2 protects against TWEAK-mediated skeletal muscle wasting","volume":"4","author":"Al-Sawaf","year":"2014","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tem.2016.03.002_bib0695","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1111\/acel.12095","article-title":"Pro-inflammatory capacity of classically activated monocytes relates positively to muscle mass and strength","volume":"12","author":"Beenakker","year":"2013","journal-title":"Aging Cell"},{"key":"10.1016\/j.tem.2016.03.002_bib0700","doi-asserted-by":"crossref","first-page":"C1179","DOI":"10.1152\/ajpcell.00062.2005","article-title":"Role of TNF-\u03b1 signaling in regeneration of cardiotoxin-injured muscle","volume":"289","author":"Chen","year":"2005","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.tem.2016.03.002_bib0705","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1073\/pnas.1018501108","article-title":"TNF-alpha promotes fracture repair by augmenting the recruitment and differentiation of muscle-derived stromal cells","volume":"108","author":"Glass","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.tem.2016.03.002_bib0710","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1177\/1358863X08098143","article-title":"Dual roles of tumor necrosis factor-alpha receptor-1 in a mouse model of hindlimb ischemia","volume":"14","author":"Jiang","year":"2009","journal-title":"Vasc. Med."},{"key":"10.1016\/j.tem.2016.03.002_bib0715","doi-asserted-by":"crossref","first-page":"2716","DOI":"10.1161\/CIRCULATIONAHA.111.047381","article-title":"Exercise training attenuates MuRF-1 expression in the skeletal muscle of patients with chronic heart failure independent of age: the randomized Leipzig Exercise Intervention in Chronic Heart Failure and Aging Catabolism Study","volume":"125","author":"Gielen","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.tem.2016.03.002_bib0720","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1016\/j.cell.2012.10.050","article-title":"A PGC-1alpha isoform induced by resistance training regulates skeletal muscle hypertrophy","volume":"151","author":"Ruas","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.tem.2016.03.002_bib0725","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1267\/ahc.12023","article-title":"Chronic exercise training down-regulates TNF-alpha and atrogin-1\/MAFbx in mouse gastrocnemius muscle atrophy induced by hindlimb unloading","volume":"45","author":"Al-Nassan","year":"2012","journal-title":"Acta Histochem. Cytochem."},{"key":"10.1016\/j.tem.2016.03.002_bib0730","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1017\/S0714980812000104","article-title":"Exercise training reduces inflammatory mediators in the intestinal tract of healthy older adult mice","volume":"31","author":"Packer","year":"2012","journal-title":"Can. J. Aging"},{"key":"10.1016\/j.tem.2016.03.002_bib0735","doi-asserted-by":"crossref","first-page":"605071","DOI":"10.1155\/2015\/605071","article-title":"Moderate exercise training attenuates the severity of experimental rodent colitis: the importance of crosstalk between adipose tissue and skeletal muscles","volume":"2015","author":"Bilski","year":"2015","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.tem.2016.03.002_bib0740","doi-asserted-by":"crossref","first-page":"520258","DOI":"10.1155\/2010\/520258","article-title":"The role of exercise-induced myokines in muscle homeostasis and the defense against chronic diseases","volume":"2010","author":"Brandt","year":"2010","journal-title":"J. Biomed. Biotechnol."},{"key":"10.1016\/j.tem.2016.03.002_bib0745","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/sc.2014.88","article-title":"Elevation of interleukin-6 and attenuation of tumor necrosis factor-alpha during wheelchair half marathon in athletes with cervical spinal cord injuries","volume":"52","author":"Ogawa","year":"2014","journal-title":"Spinal Cord"},{"key":"10.1016\/j.tem.2016.03.002_bib0750","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s00109-009-0547-z","article-title":"Phase II nonrandomized study of the efficacy and safety of COX-2 inhibitor celecoxib on patients with cancer cachexia","volume":"88","author":"Mantovani","year":"2010","journal-title":"J. Mol. Med. (Berl.)"},{"key":"10.1016\/j.tem.2016.03.002_bib0755","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.lfs.2015.10.020","article-title":"Ibuprofen ameliorates fatigue- and depressive-like behavior in tumor-bearing mice","volume":"143","author":"Norden","year":"2015","journal-title":"Life Sci."},{"key":"10.1016\/j.tem.2016.03.002_bib0760","doi-asserted-by":"crossref","first-page":"61","DOI":"10.2147\/JIR.S16508","article-title":"The effect of disease activity on body composition and resting energy expenditure in patients with rheumatoid arthritis","volume":"4","author":"Binymin","year":"2011","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.tem.2016.03.002_bib0765","doi-asserted-by":"crossref","first-page":"e0128889","DOI":"10.1371\/journal.pone.0128889","article-title":"Effects of tumour necrosis factor antagonists on insulin sensitivity\/resistance in rheumatoid arthritis: a systematic review and meta-analysis","volume":"10","author":"Burska","year":"2015","journal-title":"PLoS ONE"},{"key":"10.1016\/j.tem.2016.03.002_bib0770","doi-asserted-by":"crossref","first-page":"852","DOI":"10.3346\/jkms.2008.23.5.852","article-title":"Safety and clinical responses in ankylosing spondylitis after three months of etanercept therapy","volume":"23","author":"Choi","year":"2008","journal-title":"J. Korean Med. Sci."},{"key":"10.1016\/j.tem.2016.03.002_bib0775","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/nrd4467","article-title":"Muscle wasting in disease: molecular mechanisms and promising therapies","volume":"14","author":"Cohen","year":"2015","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.tem.2016.03.002_bib0780","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s13395-015-0060-8","article-title":"Myostatin blockade with a fully human monoclonal antibody induces muscle hypertrophy and reverses muscle atrophy in young and aged mice","volume":"5","author":"Latres","year":"2015","journal-title":"Skelet. Muscle"},{"key":"10.1016\/j.tem.2016.03.002_bib0785","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1139\/h2012-039","article-title":"The effects of chronic exercise on the inflammatory cytokines interleukin-6 and tumor necrosis factor-alpha are different with age","volume":"37","author":"Moon","year":"2012","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"10.1016\/j.tem.2016.03.002_bib0790","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.cell.2010.07.011","article-title":"Reversal of cancer cachexia and muscle wasting by ActRIIB antagonism leads to prolonged survival","volume":"142","author":"Zhou","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.tem.2016.03.002_bib0795","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1002\/ijc.29930","article-title":"Complete reversal of muscle wasting in experimental cancer cachexia: additive effects of activin type II receptor inhibition and beta-2 agonist","volume":"138","author":"Toledo","year":"2016","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.tem.2016.03.002_bib0800","doi-asserted-by":"crossref","first-page":"e102436","DOI":"10.1371\/journal.pone.0102436","article-title":"Tocilizumab, a proposed therapy for the cachexia of interleukin 6-expressing lung cancer","volume":"9","author":"Ando","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.tem.2016.03.002_bib0805","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1517\/14712598.2011.627850","article-title":"A humanized anti-IL-6 antibody (ALD518) in non-small cell lung cancer","volume":"11","author":"Bayliss","year":"2011","journal-title":"Exp. Opin. Biol. Ther."},{"key":"10.1016\/j.tem.2016.03.002_bib0810","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1038\/bjc.2012.144","article-title":"Skeletal muscle anabolism is a side effect of therapy with the MEK inhibitor: selumetinib in patients with cholangiocarcinoma","volume":"106","author":"Prado","year":"2012","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.tem.2016.03.002_bib0815","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.tem.2015.09.010","article-title":"Obesity impairs the action of the neuroendocrine ghrelin system","volume":"27","author":"Zigman","year":"2016","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.tem.2016.03.002_bib0820","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/S1470-2045(14)71154-4","article-title":"Anamorelin for patients with cancer cachexia: an integrated analysis of two phase 2, randomised, placebo-controlled, double-blind trials","volume":"16","author":"Garcia","year":"2015","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.tem.2016.03.002_bib0825","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1111\/j.1742-4658.2011.08015.x","article-title":"TNFR1-induced activation of the classical NF-kappaB pathway","volume":"278","author":"Wajant","year":"2011","journal-title":"FEBS J."},{"key":"10.1016\/j.tem.2016.03.002_bib0830","doi-asserted-by":"crossref","first-page":"e12479","DOI":"10.1371\/journal.pone.0012479","article-title":"TNF inhibits Notch-1 in skeletal muscle cells by Ezh2 and DNA methylation mediated repression: implications in Duchenne muscular dystrophy","volume":"5","author":"Acharyya","year":"2010","journal-title":"PLoS ONE"},{"key":"10.1016\/j.tem.2016.03.002_bib0835","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.bbrc.2015.02.026","article-title":"TNF alpha inhibits myogenic differentiation of C2C12 cells through NF-kappaB activation and impairment of IGF-1 signaling pathway","volume":"458","author":"Zhao","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.tem.2016.03.002_bib0840","doi-asserted-by":"crossref","first-page":"555","DOI":"10.4161\/auto.7.5.15102","article-title":"TRAF6 coordinates the activation of autophagy and ubiquitin-proteasome systems in atrophying skeletal muscle","volume":"7","author":"Paul","year":"2011","journal-title":"Autophagy"},{"key":"10.1016\/j.tem.2016.03.002_bib0845","doi-asserted-by":"crossref","first-page":"2686","DOI":"10.1073\/pnas.1400419111","article-title":"Blocking CD40\u2013TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance","volume":"111","author":"Chatzigeorgiou","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.tem.2016.03.002_bib0850","doi-asserted-by":"crossref","first-page":"7792","DOI":"10.1038\/ncomms8792","article-title":"CD163 interacts with TWEAK to regulate tissue regeneration after ischaemic injury","volume":"6","author":"Akahori","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tem.2016.03.002_bib0855","doi-asserted-by":"crossref","first-page":"ra75","DOI":"10.1126\/scisignal.2003086","article-title":"TWEAK and cIAP1 regulate myoblast fusion through the noncanonical NF-kappaB signaling pathway","volume":"5","author":"Enwere","year":"2012","journal-title":"Sci. Signal."},{"key":"10.1016\/j.tem.2016.03.002_bib0860","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/cvr\/cvv204","article-title":"TWEAK\/Fn14 interaction promotes oxidative stress through NADPH oxidase activation in macrophages","volume":"108","author":"Madrigal-Matute","year":"2015","journal-title":"Cardiovasc. Res."},{"issue":"Suppl. 1","key":"10.1016\/j.tem.2016.03.002_bib0865","doi-asserted-by":"crossref","first-page":"S98","DOI":"10.1080\/17461391.2011.654268","article-title":"Inactivity-induced oxidative stress: a central role in age-related sarcopenia?","volume":"14","author":"Derbre","year":"2014","journal-title":"Eur. J. Sport Sci."},{"key":"10.1016\/j.tem.2016.03.002_bib0870","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.ijcard.2014.06.046","article-title":"NADPH oxidase hyperactivity induces plantaris atrophy in heart failure rats","volume":"175","author":"Bechara","year":"2014","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.tem.2016.03.002_bib0875","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1126\/science.aac6468","article-title":"Disease tolerance mediated by microbiome E. coli involves inflammasome and IGF-1 signaling","volume":"350","author":"Schieber","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.tem.2016.03.002_bib0880","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1546-0096-9-15","article-title":"Monitoring serum IL-18 levels is useful for treatment of a patient with systemic juvenile idiopathic arthritis complicated by macrophage activation syndrome","volume":"9","author":"Shigemura","year":"2011","journal-title":"Pediatr. Rheumatol. Online J."}],"container-title":["Trends in Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043276016000369?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043276016000369?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,14]],"date-time":"2018-09-14T01:57:47Z","timestamp":1536890267000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043276016000369"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":88,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["S1043276016000369"],"URL":"https:\/\/doi.org\/10.1016\/j.tem.2016.03.002","relation":{},"ISSN":["1043-2760"],"issn-type":[{"value":"1043-2760","type":"print"}],"subject":[],"published":{"date-parts":[[2016,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cytokine Signaling in Skeletal Muscle Wasting","name":"articletitle","label":"Article Title"},{"value":"Trends in Endocrinology & Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tem.2016.03.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}