{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:45:39Z","timestamp":1790394339364,"version":"4.1.0"},"reference-count":98,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","cell.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","bmn.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Endocrinology & Metabolism"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.tem.2016.12.001","type":"journal-article","created":{"date-parts":[[2017,1,4]],"date-time":"2017-01-04T19:47:37Z","timestamp":1483559257000},"page":"273-284","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":154,"title":["ApoE, ApoE Receptors, and the Synapse in Alzheimer's Disease"],"prefix":"10.1016","volume":"28","author":[{"given":"Courtney","family":"Lane-Donovan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Herz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tem.2016.12.001_bib0005","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.neuron.2014.08.005","article-title":"More than cholesterol transporters: lipoprotein receptors in CNS function and neurodegeneration","volume":"83","author":"Lane-Donovan","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.tem.2016.12.001_bib0010","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.cell.2015.01.036","article-title":"A century of cholesterol and coronaries: from plaques to genes to statins","volume":"161","author":"Goldstein","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.tem.2016.12.001_bib0015","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1001\/jamaneurol.2014.2011","article-title":"Effects of the absence of apolipoprotein E on lipoproteins, neurocognitive function, and retinal function","volume":"71","author":"Mak","year":"2014","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.tem.2016.12.001_bib0020","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.brainresrev.2009.11.002","article-title":"Role of glial cells in the formation and maintenance of synapses","volume":"63","author":"Pfrieger","year":"2010","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.tem.2016.12.001_bib0025","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1161\/ATVBAHA.116.307023","article-title":"Central nervous system lipoproteins: ApoE and regulation of cholesterol metabolism","volume":"36","author":"Mahley","year":"2016","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.tem.2016.12.001_bib0030","doi-asserted-by":"crossref","first-page":"10141","DOI":"10.1523\/JNEUROSCI.1054-16.2016","article-title":"Genetic restoration of plasma ApoE improves cognition and partially restores synaptic defects in ApoE-deficient mice","volume":"36","author":"Lane-Donovan","year":"2016","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tem.2016.12.001_bib0035","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.jalz.2016.03.001","article-title":"2016 Alzheimer's disease facts and figures","volume":"12","author":"Alzheimer's Association","year":"2016","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.tem.2016.12.001_bib0040","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jalz.2011.03.003","article-title":"Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging\u2013Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease","volume":"7","author":"Sperling","year":"2011","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.tem.2016.12.001_bib0045","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/S1474-4422(12)70228-4","article-title":"Brain imaging and fluid biomarker analysis in young adults at genetic risk for autosomal dominant Alzheimer's disease in the presenilin 1 E280A kindred: a case-control study","volume":"11","author":"Reiman","year":"2012","journal-title":"Lancet Neurol."},{"issue":"Suppl. 1","key":"10.1016\/j.tem.2016.12.001_bib0050","doi-asserted-by":"crossref","first-page":"S171","DOI":"10.3233\/JAD-150202","article-title":"Evolving evidence for the value of neuroimaging methods and biological markers in subjects categorized with subjective cognitive decline","volume":"48","author":"Lista","year":"2015","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.tem.2016.12.001_bib0055","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.3233\/JAD-150446","article-title":"Subjective memory complaints in APOE\u025b4 carriers are associated with high amyloid-\u03b2 burden","volume":"49","author":"Zwan","year":"2015","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.tem.2016.12.001_bib0060","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.trci.2015.12.002","article-title":"A genetics-based biomarker risk algorithm for predicting risk of Alzheimer's disease","volume":"2","author":"Lutz","year":"2016","journal-title":"Alzheimers Dement. (N. Y.)"},{"key":"10.1016\/j.tem.2016.12.001_bib0065","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/nrneurol.2012.263","article-title":"Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy","volume":"9","author":"Liu","year":"2013","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.tem.2016.12.001_bib0070","doi-asserted-by":"crossref","first-page":"89ra57","DOI":"10.1126\/scitranslmed.3002156","article-title":"Human ApoE isoforms differentially regulate brain amyloid-\u03b2 peptide clearance","volume":"3","author":"Castellano","year":"2011","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.tem.2016.12.001_bib0075","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1038\/npp.2014.302","article-title":"Disrupted functional and structural networks in cognitively normal elderly subjects with the APOE \u025b4 allele","volume":"40","author":"Chen","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.tem.2016.12.001_bib0080","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1001\/jamaneurol.2013.4544","article-title":"Brain differences in infants at differential genetic risk for late-onset Alzheimer disease: a cross-sectional imaging study","volume":"71","author":"Dean","year":"2014","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.tem.2016.12.001_bib0085","doi-asserted-by":"crossref","first-page":"a006312","DOI":"10.1101\/cshperspect.a006312","article-title":"Apolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease","volume":"2","author":"Holtzman","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.tem.2016.12.001_bib0090","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.neuron.2014.01.045","article-title":"ApoE and A\u03b2 in Alzheimer's disease: accidental encounters or partners?","volume":"81","author":"Kanekiyo","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.tem.2016.12.001_bib0095","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1750-1326-8-25","article-title":"LRP1 is critical for the surface distribution and internalization of the NR2B NMDA receptor subtype","volume":"8","author":"Maier","year":"2013","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.tem.2016.12.001_bib0100","doi-asserted-by":"crossref","first-page":"21909","DOI":"10.1074\/jbc.M112.444364","article-title":"Low density lipoprotein receptor-related protein 1 (LRP1) modulates N-methyl-d-aspartate (NMDA) receptor-dependent intracellular signaling and NMDA-induced regulation of postsynaptic protein complexes","volume":"288","author":"Nakajima","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tem.2016.12.001_bib0105","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.neuron.2005.07.007","article-title":"Modulation of synaptic plasticity and memory by Reelin involves differential splicing of the lipoprotein receptor Apoer2","volume":"47","author":"Beffert","year":"2005","journal-title":"Neuron"},{"key":"10.1016\/j.tem.2016.12.001_bib0110","doi-asserted-by":"crossref","first-page":"122","DOI":"10.3389\/fncel.2016.00122","article-title":"New Insights into Reelin-mediated signaling pathways","volume":"10","author":"Lee","year":"2016","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.tem.2016.12.001_bib0115","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.yebeh.2005.09.005","article-title":"Reelin mouse mutants as models of cortical development disorders","volume":"8","author":"D\u2019Arcangelo","year":"2006","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.tem.2016.12.001_bib0120","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.nbd.2016.05.012","article-title":"Reelin-immunoreactive neurons in entorhinal cortex layer II selectively express intracellular amyloid in early Alzheimer's disease","volume":"93","author":"Kobro-Flatmoen","year":"2016","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.tem.2016.12.001_bib0125","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1038\/nrn2009","article-title":"Reelin, lipoprotein receptors and synaptic plasticity","volume":"7","author":"Herz","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.tem.2016.12.001_bib0130","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1128\/MCB.24.3.1378-1386.2004","article-title":"Receptor clustering is involved in Reelin signaling","volume":"24","author":"Strasser","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.tem.2016.12.001_bib0135","doi-asserted-by":"crossref","first-page":"8209","DOI":"10.1523\/JNEUROSCI.1951-05.2005","article-title":"Reelin modulates NMDA receptor activity in cortical neurons","volume":"25","author":"Chen","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tem.2016.12.001_bib0140","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1038\/nn1503","article-title":"Regulation of NMDA receptor trafficking by amyloid-\u03b2","volume":"8","author":"Snyder","year":"2005","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.tem.2016.12.001_bib0145","doi-asserted-by":"crossref","first-page":"39944","DOI":"10.1074\/jbc.M205147200","article-title":"Reelin and ApoE receptors cooperate to enhance hippocampal synaptic plasticity and learning","volume":"277","author":"Weeber","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tem.2016.12.001_bib0150","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1101\/lm.2153511","article-title":"Reelin supplementation enhances cognitive ability, synaptic plasticity, and dendritic spine density","volume":"18","author":"Rogers","year":"2011","journal-title":"Learn. Mem."},{"key":"10.1016\/j.tem.2016.12.001_bib0155","doi-asserted-by":"crossref","first-page":"4125","DOI":"10.1523\/JNEUROSCI.21-12-04125.2001","article-title":"Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: in vitro and in vivo mechanisms related to Alzheimer's disease","volume":"21","author":"Dineley","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tem.2016.12.001_bib0160","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.neuron.2010.04.029","article-title":"Deleterious effects of amyloid beta oligomers acting as an extracellular scaffold for mGluR5","volume":"66","author":"Renner","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.tem.2016.12.001_bib0165","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1038\/nature07761","article-title":"Cellular prion protein mediates impairment of synaptic plasticity by amyloid-\u03b2 oligomers","volume":"457","author":"Lauren","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.tem.2016.12.001_bib0170","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1073\/pnas.0408305102","article-title":"Regulation of a protein phosphatase cascade allows convergent dopamine and glutamate signals to activate ERK in the striatum","volume":"102","author":"Valjent","year":"2005","journal-title":"Proc. Natl Acad. Sci. U. S. A."},{"key":"10.1016\/j.tem.2016.12.001_bib0175","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0896-6273(02)00633-5","article-title":"Tyrosine phosphatase STEP is a tonic brake on induction of long-term potentiation","volume":"34","author":"Pelkey","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.tem.2016.12.001_bib0180","doi-asserted-by":"crossref","first-page":"24274","DOI":"10.1074\/jbc.M111683200","article-title":"Striatal enriched phosphatase 61 dephosphorylates Fyn at phosphotyrosine 420","volume":"277","author":"Nguyen","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tem.2016.12.001_bib0185","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/nn.2785","article-title":"A\u03b21-42 inhibition of LTP is mediated by a signaling pathway involving caspase-3, Akt1 and GSK-3\u03b2","volume":"14","author":"Jo","year":"2011","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.tem.2016.12.001_bib0190","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1126\/science.1242077","article-title":"Human LilrB2 is a \u03b2-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer's model","volume":"341","author":"Kim","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.tem.2016.12.001_bib0195","doi-asserted-by":"crossref","first-page":"12211","DOI":"10.1523\/JNEUROSCI.3321-07.2007","article-title":"Activation of glycogen synthase kinase-3 inhibits long-term potentiation with synapse-associated impairments","volume":"27","author":"Zhu","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tem.2016.12.001_bib0200","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/416535a","article-title":"Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo","volume":"416","author":"Walsh","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.tem.2016.12.001_bib0205","doi-asserted-by":"crossref","first-page":"15938","DOI":"10.1073\/pnas.0908176106","article-title":"Reelin signaling antagonizes \u03b2-amyloid at the synapse","volume":"106","author":"Durakoglugil","year":"2009","journal-title":"Proc. Natl Acad. Sci. U. S. A."},{"key":"10.1016\/j.tem.2016.12.001_bib0210","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.neuropharm.2012.08.015","article-title":"The involvement of Reelin in neurodevelopmental disorders","volume":"68","author":"Folsom","year":"2013","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.tem.2016.12.001_bib0215","doi-asserted-by":"crossref","first-page":"2727","DOI":"10.1523\/JNEUROSCI.3758-06.2007","article-title":"Reelin depletion in the entorhinal cortex of human amyloid precursor protein transgenic mice and humans with Alzheimer's disease","volume":"27","author":"Chin","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tem.2016.12.001_bib0220","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1016\/j.neurobiolaging.2010.01.010","article-title":"Alzheimer disease pathology in cognitively healthy elderly: a genome-wide study","volume":"32","author":"Kramer","year":"2011","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.tem.2016.12.001_bib0225","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/nature13185","article-title":"Transcriptional landscape of the prenatal human brain","volume":"508","author":"Miller","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.tem.2016.12.001_bib0230","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nature05453","article-title":"Genome-wide atlas of gene expression in the adult mouse brain","volume":"445","author":"Lein","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.tem.2016.12.001_bib0235","doi-asserted-by":"crossref","first-page":"ra67","DOI":"10.1126\/scisignal.aaa6674","article-title":"Reelin protects against amyloid beta toxicity in vivo","volume":"8","author":"Lane-Donovan","year":"2015","journal-title":"Sci. Signal."},{"key":"10.1016\/j.tem.2016.12.001_bib0240","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.neuron.2009.01.015","article-title":"Synaptic AMPA receptor plasticity and behavior","volume":"61","author":"Kessels","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.tem.2016.12.001_bib0245","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1146\/annurev-physiol-021014-071753","article-title":"Long-term potentiation: from CaMKII to AMPA receptor trafficking","volume":"78","author":"Herring","year":"2016","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.tem.2016.12.001_bib0250","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.neuron.2013.10.025","article-title":"AMPARs and synaptic plasticity: the last 25 years","volume":"80","author":"Huganir","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.tem.2016.12.001_bib0255","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1007\/s11064-010-0371-4","article-title":"Calcium signalling and Alzheimer's disease","volume":"36","author":"Berridge","year":"2011","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.tem.2016.12.001_bib0260","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1111\/j.1471-4159.2007.05135.x","article-title":"Increased intraneuronal resting [Ca2+] in adult Alzheimer's disease mice","volume":"105","author":"Lopez","year":"2008","journal-title":"J. Neurochem."},{"key":"10.1016\/j.tem.2016.12.001_bib0265","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.neuron.2008.06.008","article-title":"A\u03b2 plaques lead to aberrant regulation of calcium homeostasis in vivo resulting in structural and functional disruption of neuronal networks","volume":"59","author":"Kuchibhotla","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.tem.2016.12.001_bib0270","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ceca.2011.11.008","article-title":"Amyloid beta peptide 1-42 disturbs intracellular calcium homeostasis through activation of GluN2B-containing N-methyl-d-aspartate receptors in cortical cultures","volume":"51","author":"Ferreira","year":"2012","journal-title":"Cell Calcium"},{"key":"10.1016\/j.tem.2016.12.001_bib0275","doi-asserted-by":"crossref","first-page":"E2518","DOI":"10.1073\/pnas.1306832110","article-title":"A\u03b2 induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss","volume":"110","author":"Talantova","year":"2013","journal-title":"Proc. Natl Acad. Sci. U. S. A."},{"key":"10.1016\/j.tem.2016.12.001_bib0280","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.neuron.2014.03.030","article-title":"Extrasynaptic NMDA receptor involvement in central nervous system disorders","volume":"82","author":"Parsons","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.tem.2016.12.001_bib0285","first-page":"597","article-title":"The amyloid beta ion channel hypothesis of Alzheimer's disease","volume":"3","author":"Shirwany","year":"2007","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"10.1016\/j.tem.2016.12.001_bib0290","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.ceca.2011.05.013","article-title":"Presenilins function in ER calcium leak and Alzheimer's disease pathogenesis","volume":"50","author":"Supnet","year":"2011","journal-title":"Cell Calcium"},{"key":"10.1016\/j.tem.2016.12.001_bib0295","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.tins.2008.06.005","article-title":"Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease","volume":"31","author":"Bezprozvanny","year":"2008","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.tem.2016.12.001_bib0300","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/nrn3486","article-title":"Molecular mechanisms of dendrite stability","volume":"14","author":"Koleske","year":"2013","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.tem.2016.12.001_bib0305","doi-asserted-by":"crossref","first-page":"38772","DOI":"10.1074\/jbc.M306416200","article-title":"Phosphatidylinositol 3-kinase interacts with the adaptor protein Dab1 in response to Reelin signaling and is required for normal cortical lamination","volume":"278","author":"Bock","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tem.2016.12.001_bib0310","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.tins.2014.08.011","article-title":"Synapse rearrangements upon learning: from divergent\u2013sparse connectivity to dedicated sub-circuits","volume":"37","author":"Caroni","year":"2014","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.tem.2016.12.001_bib0315","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.cellsig.2012.11.001","article-title":"Signaling mechanisms and functional roles of cofilin phosphorylation and dephosphorylation","volume":"25","author":"Mizuno","year":"2013","journal-title":"Cell. Signal."},{"key":"10.1016\/j.tem.2016.12.001_bib0320","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1523\/JNEUROSCI.2934-08.2009","article-title":"Reelin stabilizes the actin cytoskeleton of neuronal processes by inducing n-cofilin phosphorylation at serine3","volume":"29","author":"Chai","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tem.2016.12.001_bib0325","doi-asserted-by":"crossref","DOI":"10.1093\/cercor\/bhw216","article-title":"Reelin regulates the maturation of dendritic spines, synaptogenesis and glial ensheathment of newborn granule cells","author":"Bosch","year":"2016","journal-title":"Cereb. Cortex."},{"key":"10.1016\/j.tem.2016.12.001_bib0330","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/nn1630","article-title":"Role of p21-activated kinase pathway defects in the cognitive deficits of Alzheimer disease","volume":"9","author":"Zhao","year":"2006","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.tem.2016.12.001_bib0335","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.neuroscience.2003.08.007","article-title":"Apolipoprotein E isoform-specific regulation of dendritic spine morphology in apolipoprotein E transgenic mice and Alzheimer's disease patients","volume":"122","author":"Ji","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.tem.2016.12.001_bib0340","doi-asserted-by":"crossref","first-page":"6027","DOI":"10.1074\/jbc.R800009200","article-title":"Understanding the association of apolipoprotein E4 with Alzheimer disease: clues from its structure","volume":"284","author":"Zhong","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tem.2016.12.001_bib0345","doi-asserted-by":"crossref","first-page":"50380","DOI":"10.1074\/jbc.M204898200","article-title":"Apolipoprotein E4 forms a molten globule. A potential basis for its association with disease","volume":"277","author":"Morrow","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tem.2016.12.001_bib0350","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/j.jmb.2006.06.080","article-title":"Amino-terminal domain stability mediates apolipoprotein E aggregation into neurotoxic fibrils","volume":"361","author":"Hatters","year":"2006","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.tem.2016.12.001_bib0355","doi-asserted-by":"crossref","first-page":"55483","DOI":"10.1074\/jbc.M409324200","article-title":"Impaired recycling of apolipoprotein E4 is associated with intracellular cholesterol accumulation","volume":"279","author":"Heeren","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tem.2016.12.001_bib0360","doi-asserted-by":"crossref","first-page":"12011","DOI":"10.1073\/pnas.0914984107","article-title":"ApoE4 reduces glutamate receptor function and synaptic plasticity by selectively impairing ApoE receptor recycling","volume":"107","author":"Chen","year":"2010","journal-title":"Proc. Natl Acad. Sci. U. S. A."},{"key":"10.1016\/j.tem.2016.12.001_bib0365","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.neuron.2013.08.024","article-title":"Reelin mobilizes a VAMP7-dependent synaptic vesicle pool and selectively augments spontaneous neurotransmission","volume":"80","author":"Bal","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.tem.2016.12.001_bib0370","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.neuron.2011.06.010","article-title":"v-SNARE composition distinguishes synaptic vesicle pools","volume":"71","author":"Hua","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.tem.2016.12.001_bib0375","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/j.1471-4159.2012.07908.x","article-title":"APOE genotype affects the pre-synaptic compartment of glutamatergic nerve terminals","volume":"124","author":"Dumanis","year":"2013","journal-title":"J. Neurochem."},{"key":"10.1016\/j.tem.2016.12.001_bib0380","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/nature12776","article-title":"Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways","volume":"504","author":"Chung","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.tem.2016.12.001_bib0385","doi-asserted-by":"crossref","first-page":"10186","DOI":"10.1073\/pnas.1609896113","article-title":"Novel allele-dependent role for APOE in controlling the rate of synapse pruning by astrocytes","volume":"113","author":"Chung","year":"2016","journal-title":"Proc. Natl Acad. Sci. U.S.A."},{"key":"10.1016\/j.tem.2016.12.001_bib0390","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1523\/JNEUROSCI.4178-07.2008","article-title":"A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function","volume":"28","author":"Cahoy","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tem.2016.12.001_bib0395","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1242\/jcs.040717","article-title":"Low-density lipoprotein receptor-related protein 1 is an essential receptor for myelin phagocytosis","volume":"122","author":"Gaultier","year":"2009","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.tem.2016.12.001_bib0400","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/nn1703","article-title":"Astrocytic Ca2+ signaling evoked by sensory stimulation in vivo","volume":"9","author":"Wang","year":"2006","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.tem.2016.12.001_bib0405","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0959-4388(00)00223-3","article-title":"A neuron\u2013glia signalling network in the active brain","volume":"11","author":"Bezzi","year":"2001","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.tem.2016.12.001_bib0410","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.neuron.2014.02.007","article-title":"Gliotransmitters travel in time and space","volume":"81","author":"Araque","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.tem.2016.12.001_bib0415","doi-asserted-by":"crossref","first-page":"e10418","DOI":"10.1371\/journal.pone.0010418","article-title":"Lrp4 regulates initiation of ureteric budding and is crucial for kidney formation \u2013 a mouse model for Cenani\u2013Lenz syndrome","volume":"5","author":"Karner","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.tem.2016.12.001_bib0420","doi-asserted-by":"crossref","first-page":"3523","DOI":"10.1093\/hmg\/ddi381","article-title":"Abnormal development of the apical ectodermal ridge and polysyndactyly in Megf7-deficient mice","volume":"14","author":"Johnson","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.tem.2016.12.001_bib0425","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.ygeno.2006.08.005","article-title":"Defective splicing of Megf7\/Lrp4, a regulator of distal limb development, in autosomal recessive mulefoot disease","volume":"88","author":"Johnson","year":"2006","journal-title":"Genomics"},{"key":"10.1016\/j.tem.2016.12.001_bib0430","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.ajhg.2010.03.004","article-title":"LRP4 mutations alter Wnt\/\u03b2-catenin signaling and cause limb and kidney malformations in Cenani\u2013Lenz syndrome","volume":"86","author":"Li","year":"2010","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.tem.2016.12.001_bib0435","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1001\/jamaneurol.2015.0853","article-title":"Impaired synaptic development, maintenance, and neuromuscular transmission in LRP4-related myasthenia","volume":"72","author":"Selcen","year":"2015","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.tem.2016.12.001_bib0440","doi-asserted-by":"crossref","first-page":"e00220","DOI":"10.7554\/eLife.00220","article-title":"APP interacts with LRP4 and Agrin to coordinate the development of the neuromuscular junction in mice","volume":"2","author":"Choi","year":"2013","journal-title":"Elife"},{"key":"10.1016\/j.tem.2016.12.001_bib0445","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.cell.2008.10.002","article-title":"Lrp4 is a receptor for Agrin and forms a complex with MuSK","volume":"135","author":"Kim","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.tem.2016.12.001_bib0450","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.neuron.2008.10.006","article-title":"LRP4 serves as a coreceptor of Agrin","volume":"60","author":"Zhang","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.tem.2016.12.001_bib0455","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1471-2156-8-5","article-title":"Congenital syndactyly in cattle: four novel mutations in the low density lipoprotein receptor-related protein 4 gene (LRP4)","volume":"8","author":"Drogemuller","year":"2007","journal-title":"BMC Genet."},{"key":"10.1016\/j.tem.2016.12.001_bib0460","doi-asserted-by":"crossref","first-page":"4993","DOI":"10.1242\/dev.02696","article-title":"LDL-receptor-related protein 4 is crucial for formation of the neuromuscular junction","volume":"133","author":"Weatherbee","year":"2006","journal-title":"Development"},{"key":"10.1016\/j.tem.2016.12.001_bib0465","doi-asserted-by":"crossref","first-page":"e04287","DOI":"10.7554\/eLife.04287","article-title":"Synaptic plasticity and cognitive function are disrupted in the absence of Lrp4","volume":"3","author":"Gomez","year":"2014","journal-title":"Elife"},{"key":"10.1016\/j.tem.2016.12.001_bib0470","doi-asserted-by":"crossref","first-page":"e0116701","DOI":"10.1371\/journal.pone.0116701","article-title":"Lrp4 domains differentially regulate limb\/brain development and synaptic plasticity","volume":"10","author":"Pohlkamp","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.tem.2016.12.001_bib0475","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1038\/nn.4326","article-title":"Lrp4 in astrocytes modulates glutamatergic transmission","volume":"19","author":"Sun","year":"2016","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.tem.2016.12.001_bib0480","doi-asserted-by":"crossref","first-page":"5370","DOI":"10.1523\/JNEUROSCI.5255-05.2006","article-title":"GABAergic network activation of glial cells underlies hippocampal heterosynaptic depression","volume":"26","author":"Serrano","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tem.2016.12.001_bib0485","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1002\/glia.22289","article-title":"APOE genotype alters glial activation and loss of synaptic markers in mice","volume":"60","author":"Zhu","year":"2012","journal-title":"Glia"},{"key":"10.1016\/j.tem.2016.12.001_bib0490","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/nrn3880","article-title":"Immune attack: the role of inflammation in Alzheimer disease","volume":"16","author":"Heppner","year":"2015","journal-title":"Nat. Rev. Neurosci."}],"container-title":["Trends in Endocrinology & Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043276016301709?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043276016301709?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T13:46:32Z","timestamp":1601300792000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043276016301709"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":98,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["S1043276016301709"],"URL":"https:\/\/doi.org\/10.1016\/j.tem.2016.12.001","relation":{},"ISSN":["1043-2760"],"issn-type":[{"value":"1043-2760","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ApoE, ApoE Receptors, and the Synapse in Alzheimer's Disease","name":"articletitle","label":"Article Title"},{"value":"Trends in Endocrinology & Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tem.2016.12.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}