{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T09:19:29Z","timestamp":1792660769479,"version":"4.5.0"},"reference-count":80,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","cell.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","bmn.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Endocrinology & Metabolism"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.tem.2016.12.002","type":"journal-article","created":{"date-parts":[[2017,1,10]],"date-time":"2017-01-10T11:00:18Z","timestamp":1484046018000},"page":"285-296","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":54,"title":["Cardiac Lymphatics \u2013 A New Avenue for Therapeutics?"],"prefix":"10.1016","volume":"28","author":[{"given":"Taina","family":"Vuorio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annakaisa","family":"Tirronen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seppo","family":"Yl\u00e4-Herttuala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tem.2016.12.002_bib0405","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1055\/s-0029-1240553","article-title":"Impact of lymphatic vessels on the heart","volume":"58","author":"Cui","year":"2010","journal-title":"Thorac. Cardiovasc. Surg."},{"key":"10.1016\/j.tem.2016.12.002_bib0010","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/S0092-8674(00)81511-1","article-title":"Prox1 function is required for the development of the murine lymphatic system","volume":"98","author":"Wigle","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.tem.2016.12.002_bib0015","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1002\/j.1460-2075.1996.tb00359.x","article-title":"A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases","volume":"15","author":"Joukov","year":"1996","journal-title":"EMBO J."},{"key":"10.1016\/j.tem.2016.12.002_bib0020","doi-asserted-by":"crossref","first-page":"3829","DOI":"10.1242\/dev.122.12.3829","article-title":"VEGF-C receptor binding and pattern of expression with VEGFR-3 suggests a role in lymphatic vascular development","volume":"122","author":"Kukk","year":"1996","journal-title":"Development"},{"key":"10.1016\/j.tem.2016.12.002_bib0025","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0002-9440(10)65285-6","article-title":"Angiosarcomas express mixed endothelial phenotypes of blood and lymphatic capillaries: podoplanin as a specific marker for lymphatic endothelium","volume":"154","author":"Breiteneder-Geleff","year":"1999","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.tem.2016.12.002_bib0030","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1083\/jcb.144.4.789","article-title":"LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specific receptor for hyaluronan","volume":"144","author":"Banerji","year":"1999","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.tem.2016.12.002_bib0035","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1097\/MOH.0000000000000141","article-title":"New imaging methods and tools to study vascular biology","volume":"22","author":"Lavina","year":"2015","journal-title":"Curr. Opin. Hematol."},{"key":"10.1016\/j.tem.2016.12.002_bib0040","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1161\/CIRCRESAHA.115.306544","article-title":"Lymphatic system in cardiovascular medicine","volume":"118","author":"Aspelund","year":"2016","journal-title":"Circ. Res."},{"key":"10.1016\/j.tem.2016.12.002_bib0045","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1172\/JCI63685","article-title":"Lymphatic vasculature mediates macrophage reverse cholesterol transport in mice","volume":"123","author":"Martel","year":"2013","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tem.2016.12.002_bib0050","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/nature14483","article-title":"Cardiac lymphatics are heterogeneous in origin and respond to injury","volume":"522","author":"Klotz","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.tem.2016.12.002_bib0055","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1161\/CIRCULATIONAHA.115.020143","article-title":"Selective stimulation of cardiac lymphangiogenesis reduces myocardial edema and fibrosis leading to improved cardiac function following myocardial infarction","volume":"133","author":"Henri","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.tem.2016.12.002_bib0060","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1172\/JCI71603","article-title":"Lymphangiogenic factors, mechanisms, and applications","volume":"124","author":"Zheng","year":"2014","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tem.2016.12.002_bib0065","doi-asserted-by":"crossref","first-page":"2422","DOI":"10.1101\/gad.1588407","article-title":"Lineage tracing demonstrates the venous origin of the mammalian lymphatic vasculature","volume":"21","author":"Srinivasan","year":"2007","journal-title":"Genes Dev."},{"key":"10.1016\/j.tem.2016.12.002_bib0070","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.1182\/blood-2012-05-428607","article-title":"Lymphatic endothelial progenitors bud from the cardinal vein and intersomitic vessels in mammalian embryos","volume":"120","author":"Yang","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.tem.2016.12.002_bib0075","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1038\/nature04480","article-title":"Lymphangiogenesis in development and human disease","volume":"438","author":"Alitalo","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.tem.2016.12.002_bib0080","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1161\/CIRCRESAHA.116.306170","article-title":"Nonvenous origin of dermal lymphatic vasculature","volume":"116","author":"Martinez-Corral","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.tem.2016.12.002_bib0085","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1016\/j.celrep.2015.02.026","article-title":"cKit lineage hemogenic endothelium-derived cells contribute to mesenteric lymphatic vessels","volume":"10","author":"Stanczuk","year":"2015","journal-title":"Cell. Rep."},{"key":"10.1016\/j.tem.2016.12.002_bib0090","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1002\/dvg.22939","article-title":"Pdgfrb\u2013Cre targets lymphatic endothelial cells of both venous and non-venous origins","volume":"54","author":"Ulvmar","year":"2016","journal-title":"Genesis"},{"key":"10.1016\/j.tem.2016.12.002_bib0095","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/nature07391","article-title":"Sox18 induces development of the lymphatic vasculature in mice","volume":"456","author":"Francois","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.tem.2016.12.002_bib0100","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1101\/gad.1859310","article-title":"The nuclear hormone receptor Coup-TFII is required for the initiation and early maintenance of Prox1 expression in lymphatic endothelial cells","volume":"24","author":"Srinivasan","year":"2010","journal-title":"Genes Dev."},{"key":"10.1016\/j.tem.2016.12.002_bib0105","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1152\/physiol.00053.2010","article-title":"The transcriptional control of lymphatic vascular development","volume":"26","author":"Francois","year":"2011","journal-title":"Physiology"},{"key":"10.1016\/j.tem.2016.12.002_bib0110","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1242\/jcs.116293","article-title":"COUP-TFII orchestrates venous and lymphatic endothelial identity by homo- or hetero-dimerisation with PROX1","volume":"126","author":"Aranguren","year":"2013","journal-title":"J. Cell. Sci."},{"key":"10.1016\/j.tem.2016.12.002_bib0115","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1101\/gad.216226.113","article-title":"The Prox1\u2013Vegfr3 feedback loop maintains the identity and the number of lymphatic endothelial cell progenitors","volume":"28","author":"Srinivasan","year":"2014","journal-title":"Genes Dev."},{"key":"10.1016\/j.tem.2016.12.002_bib0120","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/ni1013","article-title":"Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins","volume":"5","author":"Karkkainen","year":"2004","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.tem.2016.12.002_bib0125","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.15252\/emmm.201505731","article-title":"VEGF-C is required for intestinal lymphatic vessel maintenance and lipid absorption","volume":"7","author":"Nurmi","year":"2015","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.tem.2016.12.002_bib0130","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1128\/MCB.25.6.2441-2449.2005","article-title":"Vascular endothelial growth factor D is dispensable for development of the lymphatic system","volume":"25","author":"Baldwin","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.tem.2016.12.002_bib0135","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1161\/CIRCRESAHA.111.250738","article-title":"CCBE1 is essential for mammalian lymphatic vascular development and enhances the lymphangiogenic effect of vascular endothelial growth factor-C in vivo","volume":"109","author":"Bos","year":"2011","journal-title":"Circ. Res."},{"key":"10.1016\/j.tem.2016.12.002_bib0140","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1161\/CIRCULATIONAHA.113.002779","article-title":"CCBE1 enhances lymphangiogenesis via A disintegrin and metalloprotease with thrombospondin motifs-3-mediated vascular endothelial growth factor-C activation","volume":"129","author":"Jeltsch","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.tem.2016.12.002_bib0145","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1172\/JCI83967","article-title":"Proteolytic activation defines distinct lymphangiogenic mechanisms for VEGFC and VEGFD","volume":"126","author":"Bui","year":"2016","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.tem.2016.12.002_bib0410","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1083\/jcb.200903137","article-title":"Neuropilin-2 mediates VEGF-C-induced lymphatic sprouting together with VEGFR3","volume":"188","author":"Xu","year":"2010","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.tem.2016.12.002_bib0155","doi-asserted-by":"crossref","first-page":"3546","DOI":"10.1093\/emboj\/cdg342","article-title":"T1alpha\/podoplanin deficiency disrupts normal lymphatic vasculature formation and causes lymphedema","volume":"22","author":"Schacht","year":"2003","journal-title":"EMBO J."},{"key":"10.1016\/j.tem.2016.12.002_bib0160","doi-asserted-by":"crossref","first-page":"3997","DOI":"10.1182\/blood-2009-04-216069","article-title":"Novel function for blood platelets and podoplanin in developmental separation of blood and lymphatic circulation","volume":"115","author":"Uhrin","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.tem.2016.12.002_bib0165","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/nature12501","article-title":"Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2","volume":"502","author":"Herzog","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.tem.2016.12.002_bib0170","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1172\/JCI71609","article-title":"Development of the mammalian lymphatic vasculature","volume":"124","author":"Yang","year":"2014","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tem.2016.12.002_bib0175","doi-asserted-by":"crossref","first-page":"3861","DOI":"10.1172\/JCI80454","article-title":"FOXC2 and fluid shear stress stabilize postnatal lymphatic vasculature","volume":"125","author":"Sabine","year":"2015","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tem.2016.12.002_bib0180","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.1172\/JCI80465","article-title":"Foxc1 and Foxc2 deletion causes abnormal lymphangiogenesis and correlates with ERK hyperactivation","volume":"126","author":"Fatima","year":"2016","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tem.2016.12.002_bib0185","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1002\/ar.22912","article-title":"Cardiac mouse lymphatics: developmental and anatomical update","volume":"297","author":"Flaht-Zabost","year":"2014","journal-title":"Anat. Rec."},{"key":"10.1016\/j.tem.2016.12.002_bib0190","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1002\/dvdy.23827","article-title":"Cellular phenotypes and spatio-temporal patterns of lymphatic vessel development in embryonic mouse hearts","volume":"241","author":"Flaht","year":"2012","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.tem.2016.12.002_bib0195","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/j.1365-2362.2010.02431.x","article-title":"Lymphatic vasculature is increased in heart valves, ischaemic and inflamed hearts and in cholesterol-rich and calcified atherosclerotic lesions","volume":"41","author":"Kholova","year":"2011","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.tem.2016.12.002_bib0200","doi-asserted-by":"crossref","first-page":"183170","DOI":"10.1155\/2014\/183170","article-title":"Comparative and developmental anatomy of cardiac lymphatics","volume":"2014","author":"Ratajska","year":"2014","journal-title":"ScientificWorldJournal"},{"key":"10.1016\/j.tem.2016.12.002_bib0205","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/j.1445-2197.2008.04802.x","article-title":"Aortic fat pad and atrial fibrillation: cardiac lymphatics revisited","volume":"79","author":"Lupinski","year":"2009","journal-title":"ANZ J. Surg."},{"key":"10.1016\/j.tem.2016.12.002_bib0210","series-title":"GeneReviews","article-title":"Milroy disease","author":"Brice","year":"1993"},{"key":"10.1016\/j.tem.2016.12.002_bib0215","series-title":"GeneReviews","article-title":"Lymphedema-distichiasis syndrome","author":"Mansour","year":"1993"},{"key":"10.1016\/j.tem.2016.12.002_bib0220","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1542\/peds.2009-3207","article-title":"Noonan syndrome: clinical features, diagnosis, and management guidelines","volume":"126","author":"Romano","year":"2010","journal-title":"Pediatrics"},{"key":"10.1016\/j.tem.2016.12.002_bib0225","doi-asserted-by":"crossref","first-page":"2696","DOI":"10.1093\/eurheartj\/ehv428","article-title":"Cardiovascular disease in Europe \u2013 epidemiological update 2015","volume":"36","author":"Townsend","year":"2015","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.tem.2016.12.002_bib0230","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1161\/CIRCRESAHA.114.301174","article-title":"Mechanisms that regulate macrophage burden in atherosclerosis","volume":"114","author":"Randolph","year":"2014","journal-title":"Circ. Res."},{"key":"10.1016\/j.tem.2016.12.002_bib0235","doi-asserted-by":"crossref","first-page":"3251","DOI":"10.1093\/eurheartj\/eht301","article-title":"Stabilization of atherosclerotic plaques: an update","volume":"34","author":"Yla-Herttuala","year":"2013","journal-title":"Eur. Heart J."},{"issue":"Suppl.","key":"10.1016\/j.tem.2016.12.002_bib0240","doi-asserted-by":"crossref","first-page":"S189","DOI":"10.1194\/jlr.R800088-JLR200","article-title":"The role of reverse cholesterol transport in animals and humans and relationship to atherosclerosis","volume":"50","author":"Rader","year":"2009","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.tem.2016.12.002_bib0245","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/0002-9343(77)90874-9","article-title":"High density lipoprotein as a protective factor against coronary heart disease. The Framingham Study","volume":"62","author":"Gordon","year":"1977","journal-title":"Am. J. Med."},{"key":"10.1016\/j.tem.2016.12.002_bib0250","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.cmet.2013.04.002","article-title":"Lymphatic vessels are essential for the removal of cholesterol from peripheral tissues by SR-BI-mediated transport of HDL","volume":"17","author":"Lim","year":"2013","journal-title":"Cell. Metab."},{"key":"10.1016\/j.tem.2016.12.002_bib0255","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1161\/ATVBAHA.114.302528","article-title":"Lymphatic vessel insufficiency in hypercholesterolemic mice alters lipoprotein levels and promotes atherogenesis","volume":"34","author":"Vuorio","year":"2014","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.tem.2016.12.002_bib0260","doi-asserted-by":"crossref","first-page":"27862","DOI":"10.1038\/srep27862","article-title":"Effects of LDL receptor modulation on lymphatic function","volume":"6","author":"Milasan","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tem.2016.12.002_bib0265","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1161\/01.ATV.7.4.333","article-title":"Glycosaminoglycans and apolipoproteins B and A-I in human aortas. Chemical and immunological analysis of lesion-free aortas from children and adults","volume":"7","author":"Yla-Herttuala","year":"1987","journal-title":"Arteriosclerosis"},{"key":"10.1016\/j.tem.2016.12.002_bib0270","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1056\/NEJMoa1206797","article-title":"Effects of dalcetrapib in patients with a recent acute coronary syndrome","volume":"367","author":"Schwartz","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.tem.2016.12.002_bib0275","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1194\/jlr.R024075","article-title":"Cholesteryl ester transfer protein inhibition as a strategy to reduce cardiovascular risk","volume":"53","author":"Barter","year":"2012","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.tem.2016.12.002_bib0280","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1038\/nrcardio.2012.122","article-title":"Third universal definition of myocardial infarction","volume":"9","author":"Thygesen","year":"2012","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.tem.2016.12.002_bib0285","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1161\/CIRCRESAHA.111.243162","article-title":"Regulation of the inflammatory response in cardiac repair","volume":"110","author":"Frangogiannis","year":"2012","journal-title":"Circ. Res."},{"key":"10.1016\/j.tem.2016.12.002_bib0290","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/j.1549-8719.2000.tb00127.x","article-title":"Effects of myocardial edema on the development of myocardial interstitial fibrosis","volume":"7","author":"Davis","year":"2000","journal-title":"Microcirculation"},{"key":"10.1016\/j.tem.2016.12.002_bib0295","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/j.1365-2559.2007.02785.x","article-title":"Lymphangiogenesis in myocardial remodelling after infarction","volume":"51","author":"Ishikawa","year":"2007","journal-title":"Histopathology"},{"key":"10.1016\/j.tem.2016.12.002_bib0300","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S0002-9440(10)65582-4","article-title":"Vascular endothelial growth factor-C (VEGF-C\/VEGF-2) promotes angiogenesis in the setting of tissue ischemia","volume":"153","author":"Witzenbichler","year":"1998","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.tem.2016.12.002_bib0305","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1089\/hum.2006.100","article-title":"Adenovirus-mediated gene transfer of human vascular endothelial growth factor-d induces transient angiogenic effects in mouse hind limb muscle","volume":"18","author":"Kholova","year":"2007","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.tem.2016.12.002_bib0310","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1161\/01.RES.0000073584.46059.E3","article-title":"VEGF-D is the strongest angiogenic and lymphangiogenic effector among VEGFs delivered into skeletal muscle via adenoviruses","volume":"92","author":"Rissanen","year":"2003","journal-title":"Circ. Res."},{"key":"10.1016\/j.tem.2016.12.002_bib0315","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1161\/01.CIR.0000115519.03688.A2","article-title":"Adenoviral catheter-mediated intramyocardial gene transfer using the mature form of vascular endothelial growth factor-D induces transmural angiogenesis in porcine heart","volume":"109","author":"Rutanen","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.tem.2016.12.002_bib0320","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1161\/01.CIR.0000015982.70785.B7","article-title":"Phase 1\/2 placebo-controlled, double-blind, dose-escalating trial of myocardial vascular endothelial growth factor 2 gene transfer by catheter delivery in patients with chronic myocardial ischemia","volume":"105","author":"Losordo","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.tem.2016.12.002_bib0325","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1540-8183.2005.04026.x","article-title":"Long-term (2-year) clinical events following transthoracic intramyocardial gene transfer of VEGF-2 in no-option patients","volume":"18","author":"Reilly","year":"2005","journal-title":"J. Interv. Cardiol."},{"key":"10.1016\/j.tem.2016.12.002_bib0330","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.atherosclerosis.2011.12.034","article-title":"Lymphangiogenesis in aortic valve stenosis \u2013 novel regulatory roles for valvular myofibroblasts and mast cells","volume":"221","author":"Syvaranta","year":"2012","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.tem.2016.12.002_bib0335","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.ijcard.2016.06.049","article-title":"Lymphangiogenesis is increased in heart valve endocarditis","volume":"219","author":"Niinimaki","year":"2016","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.tem.2016.12.002_bib0340","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.it.2012.03.006","article-title":"Regulation and implications of inflammatory lymphangiogenesis","volume":"33","author":"Kim","year":"2012","journal-title":"Trends Immunol."},{"key":"10.1016\/j.tem.2016.12.002_bib0345","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1111\/ajt.13564","article-title":"Ischemia\u2013reperfusion injury enhances lymphatic endothelial VEGFR3 and rejection in cardiac allografts","volume":"16","author":"Dashkevich","year":"2016","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.tem.2016.12.002_bib0350","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.celrep.2016.04.007","article-title":"Targeted delivery of immunomodulators to lymph nodes","volume":"15","author":"Azzi","year":"2016","journal-title":"Cell. Rep."},{"key":"10.1016\/j.tem.2016.12.002_bib0355","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1097\/SLA.0b013e31826ed043","article-title":"Lymph node transfer and perinodal lymphatic growth factor treatment for lymphedema","volume":"257","author":"Honkonen","year":"2013","journal-title":"Ann. Surg."},{"key":"10.1016\/j.tem.2016.12.002_bib0360","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s10456-015-9469-2","article-title":"VEGF-C and VEGF-C156S in the pro-lymphangiogenic growth factor therapy of lymphedema: a large animal study","volume":"18","author":"Visuri","year":"2015","journal-title":"Angiogenesis"},{"key":"10.1016\/j.tem.2016.12.002_bib0365","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1161\/CIRCULATIONAHA.110.965384","article-title":"Growth factor therapy and autologous lymph node transfer in lymphedema","volume":"123","author":"Lahteenvuo","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.tem.2016.12.002_bib0370","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1089\/hum.2016.131","article-title":"Intramyocardial gene therapy directed to hibernating heart muscle using a combination of electromechanical mapping and positron emission tomography","volume":"27","author":"Hassinen","year":"2016","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.tem.2016.12.002_bib0375","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1136\/heartjnl-2016-309373","article-title":"AdVEGF-B186 and AdVEGF-D\u0394N\u0394C induce angiogenesis and increase perfusion in porcine myocardium","volume":"102","author":"Nurro","year":"2016","journal-title":"Heart"},{"key":"10.1016\/j.tem.2016.12.002_bib0380","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1089\/hum.2015.095","article-title":"Recent advancements in cardiovascular gene therapy and vascular biology","volume":"26","author":"Laakkonen","year":"2015","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.tem.2016.12.002_bib0385","doi-asserted-by":"crossref","first-page":"27265","DOI":"10.1074\/jbc.M116.736801","article-title":"Differential receptor binding and regulatory mechanisms for the lymphangiogenic growth factors VEGF-C and VEGF-D","volume":"291","author":"Davydova","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tem.2016.12.002_bib0390","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1038\/ng1642","article-title":"Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity","volume":"37","author":"Harvey","year":"2005","journal-title":"Nat. Genet."},{"key":"10.1016\/j.tem.2016.12.002_bib0395","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1089\/lrb.2008.1022","article-title":"Breast cancer-related chronic arm lymphedema is associated with excess adipose and muscle tissue","volume":"7","author":"Brorson","year":"2009","journal-title":"Lymphat Res. Biol."},{"key":"10.1016\/j.tem.2016.12.002_bib0400","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.healun.2005.08.013","article-title":"Vascular endothelial growth factor C-induced collateral formation in a model of myocardial ischemia","volume":"25","author":"Patila","year":"2006","journal-title":"J. Heart Lung Transplant."}],"container-title":["Trends in Endocrinology & Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043276016301710?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043276016301710?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T00:41:13Z","timestamp":1658364073000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043276016301710"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":80,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["S1043276016301710"],"URL":"https:\/\/doi.org\/10.1016\/j.tem.2016.12.002","relation":{},"ISSN":["1043-2760"],"issn-type":[{"value":"1043-2760","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cardiac Lymphatics \u2013 A New Avenue for Therapeutics?","name":"articletitle","label":"Article Title"},{"value":"Trends in Endocrinology & Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tem.2016.12.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}