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Rev."},{"key":"10.1016\/j.tem.2017.01.004_bib0370","doi-asserted-by":"crossref","first-page":"e00065","DOI":"10.1042\/BSR20130046","article-title":"Turning WAT into BAT: a review on regulators controlling the browning of white adipocytes","volume":"33","author":"Lo","year":"2013","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.tem.2017.01.004_bib0375","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1038\/nm.3361","article-title":"Brown and beige fat: development, function and therapeutic potential","volume":"19","author":"Harms","year":"2013","journal-title":"Nat. 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Med."},{"key":"10.1016\/j.tem.2017.01.004_bib0415","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/nature10986","article-title":"A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism","volume":"484","author":"Herman","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.tem.2017.01.004_bib0420","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.cell.2008.07.048","article-title":"Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism","volume":"134","author":"Cao","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.tem.2017.01.004_bib0425","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1038\/ncomms2537","article-title":"De novo lipogenesis in human fat and liver is linked to ChREBP-beta and metabolic health","volume":"4","author":"Eissing","year":"2013","journal-title":"Nat. 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Chem."},{"key":"10.1016\/j.tem.2017.01.004_bib0440","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1007\/s00125-013-2913-1","article-title":"Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding","volume":"56","author":"Turner","year":"2013","journal-title":"Diabetologia"},{"key":"10.1016\/j.tem.2017.01.004_bib0445","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.cmet.2005.09.005","article-title":"Full intracellular retention of GLUT4 requires AS160 Rab GTPase activating protein","volume":"2","author":"Eguez","year":"2005","journal-title":"Cell Metab."},{"key":"10.1016\/j.tem.2017.01.004_bib0450","doi-asserted-by":"crossref","first-page":"14599","DOI":"10.1074\/jbc.C300063200","article-title":"Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocation","volume":"278","author":"Sano","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tem.2017.01.004_bib0455","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0092-8674(04)00452-0","article-title":"FoxOs at the crossroads of cellular metabolism, differentiation, and transformation","volume":"117","author":"Accili","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.tem.2017.01.004_bib0460","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.cmet.2005.04.010","article-title":"Control of lipid metabolism by phosphorylation-dependent degradation of the SREBP family of transcription factors by SCF(Fbw7)","volume":"1","author":"Sundqvist","year":"2005","journal-title":"Cell Metab."},{"key":"10.1016\/j.tem.2017.01.004_bib0465","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/ncb1547","article-title":"Insulin signalling to mTOR mediated by the Akt\/PKB substrate PRAS40","volume":"9","author":"Vander Haar","year":"2007","journal-title":"Nat. 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Chem."},{"key":"10.1016\/j.tem.2017.01.004_bib0485","doi-asserted-by":"crossref","first-page":"20462","DOI":"10.1074\/jbc.R114.576355","article-title":"Pathway-selective insulin resistance and metabolic disease: the importance of nutrient flux","volume":"289","author":"Otero","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tem.2017.01.004_bib0490","doi-asserted-by":"crossref","first-page":"10162","DOI":"10.1073\/pnas.1019268108","article-title":"Hyperinsulinemia leads to uncoupled insulin regulation of the GLUT4 glucose transporter and the FoxO1 transcription factor","volume":"108","author":"Gonzalez","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tem.2017.01.004_bib0495","doi-asserted-by":"crossref","first-page":"362","DOI":"10.2337\/db12-0255","article-title":"A role for adipose tissue de novo lipogenesis in glucose homeostasis during catch-up growth: a Randle cycle favoring fat storage","volume":"62","author":"Marcelino","year":"2013","journal-title":"Diabetes"},{"key":"10.1016\/j.tem.2017.01.004_bib0500","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1083\/jcb.201403080","article-title":"Glucose uptake in brown fat cells is dependent on mTOR complex 2-promoted GLUT1 translocation","volume":"207","author":"Olsen","year":"2014","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.tem.2017.01.004_bib0505","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1084\/jem.20120988","article-title":"Unstressing intemperate models: how cold stress undermines mouse modeling","volume":"209","author":"Karp","year":"2012","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.tem.2017.01.004_bib0510","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.molmet.2015.03.001","article-title":"Integration of body temperature into the analysis of energy expenditure in the mouse","volume":"4","author":"Abreu-Vieira","year":"2015","journal-title":"Mol. Metab."},{"key":"10.1016\/j.tem.2017.01.004_bib0515","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.cmet.2008.12.014","article-title":"UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality","volume":"9","author":"Feldmann","year":"2009","journal-title":"Cell Metab."},{"key":"10.1016\/j.tem.2017.01.004_bib0520","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1242\/jeb.050989","article-title":"Nonshivering thermogenesis and its adequate measurement in metabolic studies","volume":"214","author":"Cannon","year":"2011","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.tem.2017.01.004_bib0525","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1242\/dev.127.2.319","article-title":"Myf5 is a novel early axonal marker in the mouse brain and is subjected to post-transcriptional regulation in neurons","volume":"127","author":"Daubas","year":"2000","journal-title":"Development."},{"key":"10.1016\/j.tem.2017.01.004_bib0530","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.devcel.2008.01.002","article-title":"Two cell lineages, myf5 and myf5-independent, participate in mouse skeletal myogenesis","volume":"14","author":"Haldar","year":"2008","journal-title":"Dev. Cell"},{"key":"10.1016\/j.tem.2017.01.004_bib0535","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1042\/BST0370289","article-title":"Rag proteins regulate amino acid-induced mTORC1 signaling","volume":"37","author":"Sancak","year":"2009","journal-title":"Biochem. Soc. 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Chem."},{"key":"10.1016\/j.tem.2017.01.004_bib0575","doi-asserted-by":"crossref","first-page":"E1552","DOI":"10.1152\/ajpendo.00134.2007","article-title":"Obesity-related elevations in plasma leucine are associated with alterations in enzymes involved in branched chain amino acid (BCAA) metabolism","volume":"293","author":"She","year":"2007","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2017.01.004_bib0580","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/nchembio.1961","article-title":"Branched-chain amino acid catabolism fuels adipocyte differentiation and lipogenesis","volume":"12","author":"Green","year":"2016","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.tem.2017.01.004_bib0585","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.cmet.2009.02.002","article-title":"A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance","volume":"9","author":"Newgard","year":"2009","journal-title":"Cell Metab."},{"key":"10.1016\/j.tem.2017.01.004_bib0590","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1097\/MCO.0b013e3283595cff","article-title":"Regulation of brown adipose tissue development and white fat reduction by L-arginine","volume":"15","author":"Wu","year":"2012","journal-title":"Curr. Opin. Clin. Nutr. Metab. 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