{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T03:40:27Z","timestamp":1767843627371,"version":"3.49.0"},"reference-count":131,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","cell.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","bmn.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Endocrinology & Metabolism"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1016\/j.tem.2018.04.009","type":"journal-article","created":{"date-parts":[[2018,5,11]],"date-time":"2018-05-11T22:21:05Z","timestamp":1526077265000},"page":"510-523","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Molecular Mechanisms Governing Embryonic Differentiation of Pituitary Somatotropes"],"prefix":"10.1016","volume":"29","author":[{"given":"Buffy S.","family":"Ellsworth","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caitlin E.","family":"Stallings","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tem.2018.04.009_bib0005","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.ydbio.2011.01.010","article-title":"Birthdating studies reshape models for pituitary gland cell specification","volume":"352","author":"Davis","year":"2011","journal-title":"Dev. Biol."},{"key":"10.1016\/j.tem.2018.04.009_bib0010","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1177\/42.8.8027530","article-title":"In situ hybridization analysis of anterior pituitary hormone gene expression during fetal mouse development","volume":"42","author":"Japon","year":"1994","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.tem.2018.04.009_bib0015","doi-asserted-by":"crossref","first-page":"4351","DOI":"10.1210\/en.2016-1372","article-title":"Foxo1 is required for normal somatotrope differentiation","volume":"157","author":"Kapali","year":"2016","journal-title":"Endocrinology"},{"key":"10.1016\/j.tem.2018.04.009_bib0020","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s11102-007-0051-9","article-title":"Pituitary development and physiology","volume":"10","author":"Cheung","year":"2007","journal-title":"Pituitary"},{"key":"10.1016\/j.tem.2018.04.009_bib0025","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1210\/edrv-12-4-337","article-title":"Mammosomatotropes: presence and functions in normal and neoplastic pituitary tissue","volume":"12","author":"Frawley","year":"1991","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.tem.2018.04.009_bib0030","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1677\/JOE-09-0414","article-title":"Use of a prolactin-Cre\/ROSA-YFP transgenic mouse provides no evidence for lactotroph transdifferentiation after weaning, or increase in lactotroph\/somatotroph proportion in lactation","volume":"205","author":"Castrique","year":"2010","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.tem.2018.04.009_bib0035","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1210\/en.2006-1542","article-title":"Reporter expression, induced by a growth hormone promoter-driven Cre recombinase (rGHp-Cre) transgene, questions the developmental relationship between somatotropes and lactotropes in the adult mouse pituitary gland","volume":"148","author":"Luque","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.tem.2018.04.009_bib0040","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1677\/JOE-08-0447","article-title":"The role of SOX proteins in normal pituitary development","volume":"200","author":"Alatzoglou","year":"2009","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.tem.2018.04.009_bib0045","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.ghir.2017.10.005","article-title":"Progression from isolated growth hormone deficiency to combined pituitary hormone deficiency","volume":"37","author":"Cerbone","year":"2017","journal-title":"Growth Horm. IGF Res."},{"key":"10.1016\/j.tem.2018.04.009_bib0050","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1210\/er.2016-1101","article-title":"Genetics of combined pituitary hormone deficiency: roadmap into the genome era","volume":"37","author":"Fang","year":"2016","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.tem.2018.04.009_bib0055","doi-asserted-by":"crossref","first-page":"3306","DOI":"10.1210\/jc.2003-031601","article-title":"Malignant disease and cardiovascular morbidity in hypopituitary adults with or without growth hormone replacement therapy","volume":"89","author":"Svensson","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2018.04.009_bib0060","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0925-4773(99)00116-1","article-title":"Comparative expression of the mouse Sox1, Sox2 and Sox3 genes from pre-gastrulation to early somite stages","volume":"86","author":"Wood","year":"1999","journal-title":"Mech. Dev."},{"key":"10.1016\/j.tem.2018.04.009_bib0065","doi-asserted-by":"crossref","first-page":"2907","DOI":"10.1073\/pnas.0707886105","article-title":"SOX2-expressing progenitor cells generate all of the major cell types in the adult mouse pituitary gland","volume":"105","author":"Fauquier","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tem.2018.04.009_bib0070","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.stem.2013.07.006","article-title":"Mobilized adult pituitary stem cells contribute to endocrine regeneration in response to physiological demand","volume":"13","author":"Rizzoti","year":"2013","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.tem.2018.04.009_bib0075","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.stem.2013.07.004","article-title":"Sox2+ stem\/progenitor cells in the adult mouse pituitary support organ homeostasis and have tumor-inducing potential","volume":"13","author":"Andoniadou","year":"2013","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.tem.2018.04.009_bib0080","doi-asserted-by":"crossref","first-page":"3635","DOI":"10.1172\/JCI64311","article-title":"SOX2 regulates the hypothalamic\u2013pituitary axis at multiple levels","volume":"122","author":"Jayakody","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tem.2018.04.009_bib0085","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1242\/dev.02829","article-title":"Lack of the murine homeobox gene Hesx1 leads to a posterior transformation of the anterior forebrain","volume":"134","author":"Andoniadou","year":"2007","journal-title":"Development"},{"key":"10.1016\/j.tem.2018.04.009_bib0090","doi-asserted-by":"crossref","first-page":"3289","DOI":"10.1242\/dev.153387","article-title":"Hypothalamic Sonic hedgehog is required for cell specification and proliferation of LHX3\/LHX4 pituitary embryonic precursors","volume":"144","author":"Carreno","year":"2017","journal-title":"Development"},{"key":"10.1016\/j.tem.2018.04.009_bib0095","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1093\/hmg\/6.3.457","article-title":"Pituitary homeobox 2, a novel member of the bicoid-related family of homeobox genes, is a potential regulator of anterior structure formation","volume":"6","author":"Gage","year":"1997","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.tem.2018.04.009_bib0100","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/ng1296-392","article-title":"Cloning and characterization of a novel bicoid-related homeobox transcription factor gene, RIEG, involved in Rieger syndrome","volume":"14","author":"Semina","year":"1996","journal-title":"Nat. Genet."},{"key":"10.1016\/j.tem.2018.04.009_bib0105","doi-asserted-by":"crossref","first-page":"4573","DOI":"10.1073\/pnas.95.8.4573","article-title":"Identification and characterization of the ARP1 gene, a target for the human acute leukemia ALL1 gene","volume":"95","author":"Arakawa","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tem.2018.04.009_bib0110","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0925-4773(97)00110-X","article-title":"Expression patterns of Brx1 (Rieg gene), Sonic hedgehog, Nkx2.2, Dlx1 and Arx during zona limitans intrathalamica and embryonic ventral lateral geniculate nuclear formation","volume":"67","author":"Kitamura","year":"1997","journal-title":"Mech. Dev."},{"key":"10.1016\/j.tem.2018.04.009_bib0115","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1006\/mcne.1996.0062","article-title":"Otlx2, an Otx-related homeobox gene expressed in the pituitary gland and in a restricted pattern in the forebrain","volume":"8","author":"Muccielli","year":"1996","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.tem.2018.04.009_bib0120","doi-asserted-by":"crossref","first-page":"7706","DOI":"10.1073\/pnas.93.15.7706","article-title":"P-OTX: a PIT-1-interacting homeodomain factor expressed during anterior pituitary gland development","volume":"93","author":"Szeto","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tem.2018.04.009_bib0125","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/S0022-3476(74)80507-X","article-title":"Autosomal dominant transmission of isolated growth hormone deficiency in iris\u2013dental dysplasia (Rieger\u2019s syndrome)","volume":"85","author":"Sadeghi-Nejad","year":"1974","journal-title":"J. Pediatr."},{"key":"10.1016\/j.tem.2018.04.009_bib0130","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1542\/peds.44.4.564","article-title":"Rieger\u2019s syndrome","volume":"44","author":"Feingold","year":"1969","journal-title":"Pediatrics"},{"key":"10.1016\/j.tem.2018.04.009_bib0135","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1034\/j.1600-0420.1998.760424.x","article-title":"Cardiovascular anomaly in Rieger syndrome: heterogeneity or contiguity?","volume":"76","author":"Mammi","year":"1998","journal-title":"Acta Ophthalmol. Scand."},{"key":"10.1016\/j.tem.2018.04.009_bib0140","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S0092-8674(02)01084-X","article-title":"Identification of a Wnt\/Dvl\/\u03b2-catenin\u2192Pitx2 pathway mediating cell-type-specific proliferation during development","volume":"111","author":"Kioussi","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.tem.2018.04.009_bib0145","doi-asserted-by":"crossref","first-page":"4643","DOI":"10.1242\/dev.126.20.4643","article-title":"Dosage requirement of Pitx2 for development of multiple organs","volume":"126","author":"Gage","year":"1999","journal-title":"Development"},{"key":"10.1016\/j.tem.2018.04.009_bib0150","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1242\/dev.129.2.329","article-title":"Pitx2 is required at multiple stages of pituitary organogenesis: pituitary primordium formation and cell specification","volume":"129","author":"Suh","year":"2002","journal-title":"Development"},{"key":"10.1016\/j.tem.2018.04.009_bib0155","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1210\/me.2005-0052","article-title":"PITX genes are required for cell survival and Lhx3 activation","volume":"19","author":"Charles","year":"2005","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.tem.2018.04.009_bib0160","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.1210\/endo.143.8.8962","article-title":"Regulation of prolactin, GH, and Pit-1 gene expression in anterior pituitary by Pitx2: An approach using Pitx2 mutants","volume":"143","author":"Quentien","year":"2002","journal-title":"Endocrinology"},{"key":"10.1016\/j.tem.2018.04.009_bib0165","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0092-8674(02)00823-1","article-title":"LIM factor Lhx3 contributes to the specification of motor neuron and interneuron identity through cell-type-specific protein\u2013protein interactions","volume":"110","author":"Thaler","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.tem.2018.04.009_bib0170","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1126\/science.272.5264.1004","article-title":"Specification of pituitary cell lineages by the LIM homeobox gene Lhx3","volume":"272","author":"Sheng","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.tem.2018.04.009_bib0175","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.ydbio.2007.10.006","article-title":"Mechanisms underlying pituitary hypoplasia and failed cell specification in Lhx3-deficient mice","volume":"313","author":"Ellsworth","year":"2008","journal-title":"Dev. Biol."},{"key":"10.1016\/j.tem.2018.04.009_bib0180","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.mod.2006.06.005","article-title":"Reduced expression of the LIM-homeobox gene Lhx3 impairs growth and differentiation of Rathke\u2019s pouch and increases cell apoptosis during mouse pituitary development","volume":"123","author":"Zhao","year":"2006","journal-title":"Mech. Dev."},{"key":"10.1016\/j.tem.2018.04.009_bib0185","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/nrendo.2011.119","article-title":"The role of homeodomain transcription factors in heritable pituitary disease","volume":"7","author":"Prince","year":"2011","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.tem.2018.04.009_bib0190","doi-asserted-by":"crossref","first-page":"2720","DOI":"10.1073\/pnas.92.7.2720","article-title":"P-Lim, a LIM homeodomain factor, is expressed during pituitary organ and cell commitment and synergizes with Pit-1","volume":"92","author":"Bach","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tem.2018.04.009_bib0195","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1210\/mend.13.12.0395","article-title":"Differential activation of pituitary hormone genes by human Lhx3 isoforms with distinct DNA binding properties","volume":"13","author":"Sloop","year":"1999","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.tem.2018.04.009_bib0200","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1096\/fj.08-125971","article-title":"Structure, expression, and biological function of INSM1 transcription factor in neuroendocrine differentiation","volume":"23","author":"Lan","year":"2009","journal-title":"FASEB J."},{"key":"10.1016\/j.tem.2018.04.009_bib0205","doi-asserted-by":"crossref","first-page":"4947","DOI":"10.1242\/dev.097642","article-title":"Insm1 controls development of pituitary endocrine cells and requires a SNAG domain for function and for recruitment of histone-modifying factors","volume":"140","author":"Welcker","year":"2013","journal-title":"Development"},{"key":"10.1016\/j.tem.2018.04.009_bib0210","first-page":"1570","article-title":"The Ames dwarf gene, df, is required early in pituitary ontogeny for the extinction of Rpx transcription and initiation of lineage-specific cell proliferation","volume":"10","author":"Gage","year":"1996","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.tem.2018.04.009_bib0215","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/384327a0","article-title":"Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism","volume":"384","author":"Sornson","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.tem.2018.04.009_bib0220","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1006\/dbio.1995.8040","article-title":"The Ames dwarf gene is required for Pit-1 gene activation","volume":"172","author":"Andersen","year":"1995","journal-title":"Dev. Biol."},{"key":"10.1016\/j.tem.2018.04.009_bib0225","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1210\/en.2015-1862","article-title":"All hormone-producing cell types of the pituitary intermediate and anterior lobes derive from Prop1-expressing progenitors","volume":"157","author":"Davis","year":"2016","journal-title":"Endocrinology"},{"key":"10.1016\/j.tem.2018.04.009_bib0230","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/S0014-5793(98)01234-4","article-title":"Human Prop-1: cloning, mapping, genomic structure. Mutations in familial combined pituitary hormone deficiency","volume":"437","author":"Duquesnoy","year":"1998","journal-title":"FEBS Lett."},{"key":"10.1016\/j.tem.2018.04.009_bib0235","doi-asserted-by":"crossref","first-page":"5256","DOI":"10.1210\/jc.2004-0661","article-title":"PROP1 mutations cause progressive deterioration of anterior pituitary function including adrenal insufficiency: a longitudinal analysis","volume":"89","author":"Bottner","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2018.04.009_bib0240","doi-asserted-by":"crossref","first-page":"2727","DOI":"10.1093\/hmg\/ddh311","article-title":"Pituitary hypoplasia and respiratory distress syndrome in Prop1 knockout mice","volume":"13","author":"Nasonkin","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.tem.2018.04.009_bib0245","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1095\/biolreprod49.2.346","article-title":"Gonadotropin secretion, synthesis, and gene expression in two types of bovine growth hormone transgenic mice","volume":"49","author":"Tang","year":"1993","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.tem.2018.04.009_bib0250","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.14470","article-title":"PROP1 triggers epithelial\u2013mesenchymal transition-like process in pituitary stem cells","volume":"5","author":"Perez Millan","year":"2016","journal-title":"Elife"},{"key":"10.1016\/j.tem.2018.04.009_bib0255","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/347528a0","article-title":"Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1","volume":"347","author":"Li","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.tem.2018.04.009_bib0260","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1101\/gad.4.5.695","article-title":"Pituitary cell phenotypes involve cell-specific Pit-1 mRNA translation and synergistic interactions with other classes of transcription factors","volume":"4","author":"Simmons","year":"1990","journal-title":"Genes Dev."},{"key":"10.1016\/j.tem.2018.04.009_bib0265","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1007\/s10142-016-0518-8","article-title":"Genomic analyses identify agents regulating somatotroph and lactotroph functions","volume":"16","author":"Fan","year":"2016","journal-title":"Funct. Integr. Genomics"},{"key":"10.1016\/j.tem.2018.04.009_bib0270","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0120010","article-title":"Dose-dependent dual role of PIT-1 (POU1F1) in somatolactotroph cell proliferation and apoptosis","volume":"10","author":"Jullien","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.tem.2018.04.009_bib0275","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1038\/sj.emboj.7601636","article-title":"The dependence receptor Ret induces apoptosis in somatotrophs through a Pit-1\/p53 pathway, preventing tumor growth","volume":"26","author":"Canibano","year":"2007","journal-title":"EMBO J."},{"key":"10.1016\/j.tem.2018.04.009_bib0280","doi-asserted-by":"crossref","first-page":"4329","DOI":"10.1210\/en.2014-1034","article-title":"Somatotropinomas, but not nonfunctioning pituitary adenomas, maintain a functional apoptotic RET\/Pit1\/ARF\/p53 pathway that is blocked by excess GDNF","volume":"155","author":"Diaz-Rodriguez","year":"2014","journal-title":"Endocrinology"},{"key":"10.1016\/j.tem.2018.04.009_bib0285","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1089\/hum.2011.105","article-title":"Inactivation of transcription factor pit-1 to target tumoral somatolactotroph cells","volume":"23","author":"Roche","year":"2012","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.tem.2018.04.009_bib0290","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1101\/gad.7.9.1674","article-title":"Identification of a novel zinc finger protein binding a conserved element critical for Pit-1-dependent growth hormone gene expression","volume":"7","author":"Lipkin","year":"1993","journal-title":"Genes Dev."},{"key":"10.1016\/j.tem.2018.04.009_bib0295","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S1043-2760(99)00189-7","article-title":"Genealogy of the anterior pituitary gland: tracing a family tree","volume":"10","author":"Burrows","year":"1999","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.tem.2018.04.009_bib0300","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1530\/JOE-12-0229","article-title":"Pituitary development: a complex, temporal regulated process dependent on specific transcriptional factors","volume":"215","author":"de Moraes","year":"2012","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.tem.2018.04.009_bib0305","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1111\/apm.12545","article-title":"Frameshift mutations of a tumor suppressor gene ZNF292 in gastric and colorectal cancers with high microsatellite instability","volume":"124","author":"Lee","year":"2016","journal-title":"APMIS"},{"key":"10.1016\/j.tem.2018.04.009_bib0310","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1385\/ENDO:18:1:67","article-title":"Transcript abundance in mouse pituitaries with altered growth hormone expression quantified by reverse transcriptase polymerase chain reaction implicates transcription factor Zn-16 in gene regulation in vivo","volume":"18","author":"Wojtkiewicz","year":"2002","journal-title":"Endocrine"},{"key":"10.1016\/j.tem.2018.04.009_bib0315","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0303-7207(99)00200-2","article-title":"Mouse growth hormone transcription factor Zn-16: unique bipartite structure containing tandemly repeated zinc finger domains not reported in rat Zn-15","volume":"159","author":"VanderHeyden","year":"2000","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.tem.2018.04.009_bib0320","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1101\/gad.1444706","article-title":"Sustained Notch signaling in progenitors is required for sequential emergence of distinct cell lineages during organogenesis","volume":"20","author":"Zhu","year":"2006","journal-title":"Genes Dev."},{"key":"10.1016\/j.tem.2018.04.009_bib0325","doi-asserted-by":"crossref","first-page":"5460","DOI":"10.1093\/emboj\/19.20.5460","article-title":"Mammalian achaete\u2013scute and atonal homologs regulate neuronal versus glial fate determination in the central nervous system","volume":"19","author":"Tomita","year":"2000","journal-title":"EMBO J."},{"key":"10.1016\/j.tem.2018.04.009_bib0330","doi-asserted-by":"crossref","first-page":"28545","DOI":"10.1074\/jbc.273.44.28545","article-title":"Biological role of the CCAAT\/enhancer-binding protein family of transcription factors","volume":"273","author":"Lekstrom-Himes","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tem.2018.04.009_bib0335","doi-asserted-by":"crossref","first-page":"21484","DOI":"10.1074\/jbc.271.35.21484","article-title":"CCAAT\/enhancer-binding protein alpha activation of the rat growth hormone promoter in pituitary progenitor GHFT1-5 cells","volume":"271","author":"Schaufele","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tem.2018.04.009_bib0340","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1101\/gad.7.4.683","article-title":"GHF-1-promoter-targeted immortalization of a somatotropic progenitor cell results in dwarfism in transgenic mice","volume":"7","author":"Lew","year":"1993","journal-title":"Genes Dev."},{"key":"10.1016\/j.tem.2018.04.009_bib0345","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1210\/me.2011-1075","article-title":"CEBPD suppresses prolactin expression and prolactinoma cell proliferation","volume":"25","author":"Tong","year":"2011","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.tem.2018.04.009_bib0350","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.molmed.2008.03.002","article-title":"OutFOXOing disease and disability: the therapeutic potential of targeting FoxO proteins","volume":"14","author":"Maiese","year":"2008","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.tem.2018.04.009_bib0355","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0052136","article-title":"Forkhead box O1 is present in quiescent pituitary cells during development and is increased in the absence of p27 Kip1","volume":"7","author":"Majumdar","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.tem.2018.04.009_bib0360","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s00441-006-0345-7","article-title":"Expression of retinaldehyde dehydrogenase (RALDH)2 and RALDH3 but not RALDH1 in the developing anterior pituitary glands of rats","volume":"328","author":"Fujiwara","year":"2007","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.tem.2018.04.009_bib0365","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1507\/endocrj.K10E-315","article-title":"Retinoic acid and dexamethasone induce differentiation and maturation of somatotroph cells at different stages in vitro","volume":"58","author":"Cheng","year":"2011","journal-title":"Endocr. J."},{"key":"10.1016\/j.tem.2018.04.009_bib0370","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1159\/000078787","article-title":"Effects of hormones targeting nuclear receptors on transcriptional regulation of the growth hormone gene in the MtT\/S rat somatotrope cell line","volume":"79","author":"Iwasaki","year":"2004","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.tem.2018.04.009_bib0375","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.domaniend.2005.04.004","article-title":"Regulation of pituitary somatotroph differentiation by hormones of peripheral endocrine glands","volume":"29","author":"Porter","year":"2005","journal-title":"Domest. Anim. Endocrinol."},{"key":"10.1016\/j.tem.2018.04.009_bib0380","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1210\/endo-123-3-1230","article-title":"Differentiation of fetal rat somatotropes in vitro: effects of cortisol, 3,5,3\u2032-triiodothyronine, and glucagon, a light microscopic and radioimmunological study","volume":"123","author":"Hemming","year":"1988","journal-title":"Endocrinology"},{"key":"10.1016\/j.tem.2018.04.009_bib0385","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1210\/endo-114-6-2107","article-title":"Fetal rat somatotropes in vitro: effects of insulin, cortisol, and growth hormone-releasing factor on their differentiation: a light and electron microscopic study","volume":"114","author":"Hemming","year":"1984","journal-title":"Endocrinology"},{"key":"10.1016\/j.tem.2018.04.009_bib0390","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1210\/endo.140.3.6586","article-title":"Regulation of somatotroph differentiation and growth hormone (GH) secretion by corticosterone and GH-releasing hormone during embryonic development","volume":"140","author":"Dean","year":"1999","journal-title":"Endocrinology"},{"key":"10.1016\/j.tem.2018.04.009_bib0395","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1679\/aohc.61.75","article-title":"Corticosteroids stimulate the differentiation of growth hormone cells but suppress that of prolactin cells in the fetal rat pituitary","volume":"61","author":"Sato","year":"1998","journal-title":"Arch. Histol. Cytol."},{"key":"10.1016\/j.tem.2018.04.009_bib0400","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1210\/endo.138.5.5124","article-title":"Involvement of glucocorticoid-induced factor(s) in the stimulation of growth hormone expression in the fetal rat pituitary gland in vitro","volume":"138","author":"Nogami","year":"1997","journal-title":"Endocrinology"},{"key":"10.1016\/j.tem.2018.04.009_bib0405","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1210\/endo.132.2.7678792","article-title":"Dexamethasone induces advanced growth hormone expression in the fetal rat pituitary gland in vivo","volume":"132","author":"Nogami","year":"1993","journal-title":"Endocrinology"},{"key":"10.1016\/j.tem.2018.04.009_bib0410","article-title":"Regulation of growth hormone expression in fetal rat pituitary gland by thyroid or glucocorticoid hormone","volume":"268","author":"Nogami","year":"1995","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.tem.2018.04.009_bib0415","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1210\/en.2003-1064","article-title":"Glucocorticoid induction of lactotrophs and prolactin gene expression in chicken embryonic pituitary cells: a delayed response relative to stimulated growth hormone production","volume":"145","author":"Fu","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.tem.2018.04.009_bib0420","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s11010-014-1988-4","article-title":"Role of Ras, ERK, and Akt in glucocorticoid-induced differentiation of embryonic rat somatotropes in vitro","volume":"391","author":"Lv","year":"2014","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.tem.2018.04.009_bib0425","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-1119(03)00804-7","article-title":"Transcriptional control during mammalian anterior pituitary development","volume":"319","author":"Savage","year":"2003","journal-title":"Gene"},{"key":"10.1016\/j.tem.2018.04.009_bib0430","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1210\/en.2014-1686","article-title":"Mechanisms involved in glucocorticoid induction of pituitary GH expression during embryonic development","volume":"156","author":"Ellestad","year":"2015","journal-title":"Endocrinology"},{"key":"10.1016\/j.tem.2018.04.009_bib0435","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1159\/000125043","article-title":"Maturation of the pituitary\u2013adrenal function in rat fetuses","volume":"48","author":"Boudouresque","year":"1988","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.tem.2018.04.009_bib0440","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/s00418-007-0364-9","article-title":"Hypophyseal corticosteroids stimulate somatotrope differentiation in the embryonic chicken pituitary gland","volume":"129","author":"Zheng","year":"2008","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.tem.2018.04.009_bib0445","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms10351","article-title":"Functional anterior pituitary generated in self-organizing culture of human embryonic stem cells","volume":"7","author":"Ozone","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tem.2018.04.009_bib0450","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature10637","article-title":"Self-formation of functional adenohypophysis in three-dimensional culture","volume":"480","author":"Suga","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.tem.2018.04.009_bib0455","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s004410100442","article-title":"Effects of diethylstilbestrol on the cytogenesis of prolactin cells in the pars distalis of the pituitary gland of the mouse","volume":"306","author":"Matsubara","year":"2001","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.tem.2018.04.009_bib0460","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S1043-2760(02)00613-6","article-title":"Growth hormone-releasing hormone and pituitary development, hyperplasia and tumorigenesis","volume":"13","author":"Frohman","year":"2002","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.tem.2018.04.009_bib0465","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1159\/000122709","article-title":"Growth hormone and ACTH in the pituitary of normal and anencephalic human fetuses: immunocytochemical evidence for hypothalamic influences during development","volume":"24","author":"Begeot","year":"1977","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.tem.2018.04.009_bib0470","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1210\/endo-98-5-1123","article-title":"Growth hormone in encephalectomized rat fetuses, with comments on the effects of anesthetics","volume":"98","author":"Rieutort","year":"1976","journal-title":"Endocrinology"},{"key":"10.1016\/j.tem.2018.04.009_bib0475","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1038\/364208a0","article-title":"Molecular basis of the little mouse phenotype and implications for cell type-specific growth","volume":"364","author":"Lin","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.tem.2018.04.009_bib0480","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1101\/gad.12.11.1691","article-title":"Multistep signaling requirements for pituitary organogenesis in vivo","volume":"12","author":"Treier","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/j.tem.2018.04.009_bib0485","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/j.stemcr.2016.05.005","article-title":"Derivation of diverse hormone-releasing pituitary cells from human pluripotent stem cells","volume":"6","author":"Zimmer","year":"2016","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.tem.2018.04.009_bib0490","doi-asserted-by":"crossref","first-page":"15982","DOI":"10.1074\/jbc.274.23.15982","article-title":"Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway","volume":"274","author":"Nakae","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tem.2018.04.009_bib0495","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1210\/me.2013-1425","article-title":"Notch signaling in postnatal pituitary expansion: proliferation, progenitors, and cell specification","volume":"28","author":"Nantie","year":"2014","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.tem.2018.04.009_bib0500","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.ydbio.2006.11.010","article-title":"Hes1 is required for pituitary growth and melanotrope specification","volume":"304","author":"Raetzman","year":"2007","journal-title":"Dev. Biol."},{"key":"10.1016\/j.tem.2018.04.009_bib0505","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1111\/jne.12010","article-title":"Pituitary phenotypes of mice lacking the Notch signalling ligand delta-like 1 homologue","volume":"25","author":"Cheung","year":"2013","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.tem.2018.04.009_bib0510","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1111\/j.1365-2826.2011.02189.x","article-title":"Role of the non-canonical Notch ligand delta-like protein 1 in hormone-producing cells of the adult male mouse pituitary","volume":"23","author":"Puertas-Avendano","year":"2011","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.tem.2018.04.009_bib0515","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1002\/dvdy.21511","article-title":"WNT signaling affects gene expression in the ventral diencephalon and pituitary gland growth","volume":"237","author":"Potok","year":"2008","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.tem.2018.04.009_bib0520","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.cell.2006.02.046","article-title":"Homeodomain-mediated \u03b2-catenin-dependent switching events dictate cell-lineage determination","volume":"125","author":"Olson","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.tem.2018.04.009_bib0525","doi-asserted-by":"crossref","first-page":"3339","DOI":"10.1210\/en.2017-00581","article-title":"Canonical WNT signaling regulates the pituitary organizer and pituitary gland formation","volume":"158","author":"Osmundsen","year":"2017","journal-title":"Endocrinology"},{"key":"10.1016\/j.tem.2018.04.009_bib0530","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1242\/dev.128.3.377","article-title":"Hedgehog signaling is required for pituitary gland development","volume":"128","author":"Treier","year":"2001","journal-title":"Development"},{"key":"10.1016\/j.tem.2018.04.009_bib0535","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1242\/dev.127.8.1593","article-title":"Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation","volume":"127","author":"Park","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.tem.2018.04.009_bib0540","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/S0002-9297(07)62934-6","article-title":"The Sonic hedgehog\u2013Patched\u2013Gli pathway in human development and disease","volume":"67","author":"Villavicencio","year":"2000","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.tem.2018.04.009_bib0545","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.ydbio.2010.09.024","article-title":"Direct and indirect requirements of Shh\/Gli signaling in early pituitary development","volume":"348","author":"Wang","year":"2010","journal-title":"Dev. Biol."},{"key":"10.1016\/j.tem.2018.04.009_bib0550","doi-asserted-by":"crossref","first-page":"R141","DOI":"10.1530\/JME-15-0009","article-title":"Role of GLI2 in hypopituitarism phenotype","volume":"54","author":"Arnhold","year":"2015","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.tem.2018.04.009_bib0555","doi-asserted-by":"crossref","DOI":"10.1038\/srep24928","article-title":"Hedgehog signaling activation induces stem cell proliferation and hormone release in the adult pituitary gland","volume":"6","author":"Pyczek","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tem.2018.04.009_bib0560","doi-asserted-by":"crossref","first-page":"16880","DOI":"10.1073\/pnas.0508202102","article-title":"Revealing the large-scale network organization of growth hormone-secreting cells","volume":"102","author":"Bonnefont","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tem.2018.04.009_bib0565","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.mce.2013.08.018","article-title":"Pituitary stem cells: where do we stand?","volume":"385","author":"Vankelecom","year":"2014","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.tem.2018.04.009_bib0570","doi-asserted-by":"crossref","first-page":"3224","DOI":"10.1210\/en.2012-1152","article-title":"The adult pituitary shows stem\/progenitor cell activation in response to injury and is capable of regeneration","volume":"153","author":"Fu","year":"2012","journal-title":"Endocrinology"},{"key":"10.1016\/j.tem.2018.04.009_bib0575","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1210\/en.2015-1741","article-title":"Regeneration in the pituitary after cell-ablation injury: time-related aspects and molecular analysis","volume":"157","author":"Willems","year":"2016","journal-title":"Endocrinology"},{"key":"10.1016\/j.tem.2018.04.009_bib0580","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1210\/en.2015-2059","article-title":"Pituitary regeneration: it\u2019ll knock your SOX off!","volume":"157","author":"Ellsworth","year":"2016","journal-title":"Endocrinology"},{"key":"10.1016\/j.tem.2018.04.009_bib0585","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-16796-2","article-title":"Major depletion of SOX2+ stem cells in the adult pituitary is not restored which does not affect hormonal cell homeostasis and remodelling","volume":"7","author":"Roose","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tem.2018.04.009_bib0590","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1016\/j.celrep.2013.10.048","article-title":"Specification of functional cranial placode derivatives from human pluripotent stem cells","volume":"5","author":"Dincer","year":"2013","journal-title":"Cell Rep."},{"key":"10.1016\/j.tem.2018.04.009_bib0595","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0378-1119(02)00393-1","article-title":"Characterization of cis-regulatory elements of the homeobox gene Xanf-1","volume":"285","author":"Eroshkin","year":"2002","journal-title":"Gene"},{"key":"10.1016\/j.tem.2018.04.009_bib0600","first-page":"2442","article-title":"Mutations within Sox2\/SOX2 are associated with abnormalities in the hypothalamo-pituitary\u2013gonadal axis in mice and humans","volume":"116","author":"Kelberman","year":"2006","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tem.2018.04.009_bib0605","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.mce.2007.10.003","article-title":"Smad3 and Pitx2 cooperate in stimulation of FSH\u03b2 gene transcription","volume":"281","author":"Suszko","year":"2008","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.tem.2018.04.009_bib0610","doi-asserted-by":"crossref","first-page":"4866","DOI":"10.1210\/en.2004-0598","article-title":"Regulation of the follicle-stimulating hormone beta gene by the LHX3 LIM-homeodomain transcription factor","volume":"145","author":"West","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.tem.2018.04.009_bib0615","doi-asserted-by":"crossref","first-page":"36311","DOI":"10.1074\/jbc.M103888200","article-title":"An isoform-specific inhibitory domain regulates the LHX3 LIM homeodomain factor holoprotein and the production of a functional alternate translation form","volume":"276","author":"Sloop","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tem.2018.04.009_bib0620","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1126\/science.278.5344.1809","article-title":"Multistep control of pituitary organogenesis","volume":"278","author":"Sheng","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.tem.2018.04.009_bib0625","doi-asserted-by":"crossref","first-page":"4229","DOI":"10.1242\/dev.129.18.4229","article-title":"Lhx4 and Prop1 are required for cell survival and expansion of the pituitary primordia","volume":"129","author":"Raetzman","year":"2002","journal-title":"Development"},{"key":"10.1016\/j.tem.2018.04.009_bib0630","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1210\/me.2004-0341","article-title":"Role of PROP1 in pituitary gland growth","volume":"19","author":"Ward","year":"2005","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.tem.2018.04.009_bib0635","doi-asserted-by":"crossref","first-page":"4542","DOI":"10.1210\/endo.140.10.7076","article-title":"CCAAT\/enhancer-binding protein alpha is a physiological regulator of prolactin gene expression","volume":"140","author":"Jacob","year":"1999","journal-title":"Endocrinology"},{"key":"10.1016\/j.tem.2018.04.009_bib0640","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1210\/me.2002-0136","article-title":"Imaging the localized protein interactions between Pit-1 and the CCAAT\/enhancer binding protein alpha in the living pituitary cell nucleus","volume":"17","author":"Day","year":"2003","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.tem.2018.04.009_bib0645","doi-asserted-by":"crossref","first-page":"33424","DOI":"10.1074\/jbc.M112.362103","article-title":"FOXO1 transcription factor inhibits luteinizing hormone beta gene expression in pituitary gonadotrope cells","volume":"287","author":"Arriola","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tem.2018.04.009_bib0650","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1210\/me.2013-1185","article-title":"Forkhead box O1 is a repressor of basal and GnRH-induced Fshb transcription in gonadotropes","volume":"27","author":"Skarra","year":"2013","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.tem.2018.04.009_bib0655","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1007\/s11102-014-0610-9","article-title":"Frequent development of combined pituitary hormone deficiency in patients initially diagnosed as isolated growth hormone deficiency: a long term follow-up of patients from a single center","volume":"18","author":"Otto","year":"2015","journal-title":"Pituitary"}],"container-title":["Trends in Endocrinology & Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043276018300924?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043276018300924?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T15:14:28Z","timestamp":1661267668000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043276018300924"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":131,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["S1043276018300924"],"URL":"https:\/\/doi.org\/10.1016\/j.tem.2018.04.009","relation":{},"ISSN":["1043-2760"],"issn-type":[{"value":"1043-2760","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular Mechanisms Governing Embryonic Differentiation of Pituitary Somatotropes","name":"articletitle","label":"Article Title"},{"value":"Trends in Endocrinology & Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tem.2018.04.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}