{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T06:28:16Z","timestamp":1792477696610,"version":"4.5.0"},"reference-count":9,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R33ES025606"],"award-info":[{"award-number":["R33ES025606"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","cell.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","bmn.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Endocrinology & Metabolism"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.tem.2019.07.019","type":"journal-article","created":{"date-parts":[[2019,8,6]],"date-time":"2019-08-06T21:41:40Z","timestamp":1565127700000},"page":"575-577","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Huntington\u2019s Disease: Astrocytes Shift to Fatty Acid Metabolism"],"prefix":"10.1016","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4009-2478","authenticated-orcid":false,"given":"Bennett","family":"Van Houten","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tem.2019.07.019_bb0005","doi-asserted-by":"crossref","first-page":"16804","DOI":"10.1074\/jbc.R117.789271","article-title":"Production of superoxide and hydrogen peroxide from specific mitochondrial sites under different bioenergetic conditions","volume":"292","author":"Wong","year":"2017","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tem.2019.07.019_bb0010","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.dnarep.2005.03.002","article-title":"Role of mitochondrial DNA in toxic responses to oxidative stress","volume":"5","author":"Van Houten","year":"2006","journal-title":"DNA Repair"},{"key":"10.1016\/j.tem.2019.07.019_bb0015","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1002\/em.20575","article-title":"Mitochondrial dysfunction in neurodegenerative diseases and cancer","volume":"51","author":"de Moura","year":"2010","journal-title":"Environ. Mol. Mutagen"},{"key":"10.1016\/j.tem.2019.07.019_bb0020","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.tibs.2013.05.003","article-title":"Huntington\u2019s disease: underlying molecular mechanisms and emerging concepts","volume":"38","author":"Labbadia","year":"2013","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.tem.2019.07.019_bb0025","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1016\/j.cmet.2019.03.004","article-title":"Metabolic reprogramming in astrocytes distinguishes region-specific neuronal susceptibility in Huntington mice","volume":"29","author":"Polyzos","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.tem.2019.07.019_bb0030","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1073\/pnas.89.4.1271","article-title":"Fluorescence lifetime imaging of free and protein-bound NADH","volume":"89","author":"Lakowicz","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tem.2019.07.019_bb0035","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1002\/cyto.a.23597","article-title":"NADH autofluorescence: a marker on its way to boost bioenergetic research","volume":"95","author":"Schaefer","year":"2019","journal-title":"Cytometry A"},{"key":"10.1016\/j.tem.2019.07.019_bb0040","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1093\/hmg\/ddw051","article-title":"Mitochondrial targeting of XJB-5-131 attenuates or improves pathophysiology in HdhQ150 animals with well-developed disease phenotypes","volume":"25","author":"Polyzos","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.tem.2019.07.019_bb0045","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/j.celrep.2012.10.001","article-title":"Targeting of XJB-5-131 to mitochondria suppresses oxidative DNA damage and motor decline in a mouse model of Huntington\u2019s disease","volume":"2","author":"Xun","year":"2012","journal-title":"Cell Rep."}],"container-title":["Trends in Endocrinology & Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043276019301511?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043276019301511?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T21:53:48Z","timestamp":1695074028000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043276019301511"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":9,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["S1043276019301511"],"URL":"https:\/\/doi.org\/10.1016\/j.tem.2019.07.019","relation":{},"ISSN":["1043-2760"],"issn-type":[{"value":"1043-2760","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Huntington\u2019s Disease: Astrocytes Shift to Fatty Acid Metabolism","name":"articletitle","label":"Article Title"},{"value":"Trends in Endocrinology & Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tem.2019.07.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}