{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T08:53:24Z","timestamp":1789721604705,"version":"4.0.1"},"reference-count":86,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT-162343"],"award-info":[{"award-number":["PJT-162343"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP-133394"],"award-info":[{"award-number":["MOP-133394"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP-133557"],"award-info":[{"award-number":["MOP-133557"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008644","name":"Faculty of Medicine, McGill University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008644","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007921","name":"University of Pittsburgh","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007921","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Endocrinology &amp; Metabolism"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.tem.2019.08.014","type":"journal-article","created":{"date-parts":[[2019,10,22]],"date-time":"2019-10-22T00:12:31Z","timestamp":1571703151000},"page":"37-45","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["A Tale of Two Proteins: Betaglycan, IGSF1, and the Continuing Search for the Inhibin B Receptor"],"prefix":"10.1016","volume":"31","author":[{"given":"Daniel J.","family":"Bernard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney L.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Br\u00fbl\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tem.2019.08.014_bib1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1126\/science.76.1957.19","article-title":"Dual endocrine activity of the testes","volume":"76","author":"McCullagh","year":"1932","journal-title":"Science"},{"key":"10.1016\/j.tem.2019.08.014_bib2","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1210\/er.2014-1003","article-title":"Inhibin at 90: from discovery to clinical application, a historical review","volume":"35","author":"Makanji","year":"2014","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.tem.2019.08.014_bib3","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1677\/joe.0.1720199","article-title":"Production and purification of recombinant human inhibin and activin","volume":"172","author":"Pangas","year":"2002","journal-title":"J.\u00a0Endocrinol."},{"key":"10.1016\/j.tem.2019.08.014_bib4","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1210\/mend-1-8-561","article-title":"Rat inhibin: molecular cloning of alpha- and beta-subunit complementary deoxyribonucleic acids and expression in the ovary","volume":"1","author":"Woodruff","year":"1987","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.tem.2019.08.014_bib5","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1073\/pnas.85.1.247","article-title":"Gonadal and extragonadal expression of inhibin alpha, beta A, and beta B subunits in various tissues predicts diverse functions","volume":"85","author":"Meunier","year":"1988","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tem.2019.08.014_bib6","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1126\/science.3125611","article-title":"Dynamic changes in inhibin messenger RNAs in rat ovarian follicles during the reproductive cycle","volume":"239","author":"Woodruff","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.tem.2019.08.014_bib7","doi-asserted-by":"crossref","DOI":"10.1677\/joe.0.115R021","article-title":"Inhibin gene expression in\u00a0the human corpus luteum","volume":"115","author":"Davis","year":"1987","journal-title":"J.\u00a0Endocrinol."},{"key":"10.1016\/j.tem.2019.08.014_bib8","doi-asserted-by":"crossref","DOI":"10.1677\/joe.0.116R003","article-title":"The sheep corpus luteum secretes inhibin","volume":"116","author":"Tsonis","year":"1988","journal-title":"J.\u00a0Endocrinol."},{"key":"10.1016\/j.tem.2019.08.014_bib9","first-page":"3341","article-title":"Serum inhibin B levels reflect Sertoli cell function in normal men and men with testicular dysfunction","volume":"81","author":"Anawalt","year":"1996","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2019.08.014_bib10","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/0303-7207(87)90181-X","article-title":"Rapid and specific lowering of pituitary FSH beta mRNA levels by inhibin","volume":"53","author":"Mercer","year":"1987","journal-title":"Mol. Cell Endocrinol."},{"key":"10.1016\/j.tem.2019.08.014_bib11","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1210\/mend-3-2-280","article-title":"Rapid and profound suppression of messenger ribonucleic acid encoding follicle-stimulating hormone beta by inhibin from primate Sertoli cells","volume":"3","author":"Attardi","year":"1989","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.tem.2019.08.014_bib12","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/321776a0","article-title":"Purification and characterization of an FSH releasing protein from porcine ovarian follicular fluid","volume":"321","author":"Vale","year":"1986","journal-title":"Nature"},{"key":"10.1016\/j.tem.2019.08.014_bib13","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1038\/321779a0","article-title":"Pituitary FSH is released by a heterodimer of the beta-subunits from the two forms of inhibin","volume":"321","author":"Ling","year":"1986","journal-title":"Nature"},{"key":"10.1016\/j.tem.2019.08.014_bib14","doi-asserted-by":"crossref","first-page":"16385","DOI":"10.1016\/S0021-9258(18)42014-5","article-title":"Isolation and characterization of native activin B","volume":"267","author":"Nakamura","year":"1992","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.tem.2019.08.014_bib15","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1210\/endo-128-3-1682","article-title":"Evidence for an autocrine role of activin B within rat anterior pituitary cultures","volume":"128","author":"Corrigan","year":"1991","journal-title":"Endocrinology"},{"key":"10.1016\/j.tem.2019.08.014_bib16","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1210\/endo-124-1-552","article-title":"Production and regulation of inhibin subunits in pituitary gonadotropes","volume":"124","author":"Roberts","year":"1989","journal-title":"Endocrinology"},{"key":"10.1016\/j.tem.2019.08.014_bib17","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1210\/me.2015-1004","article-title":"Minireview: activin signaling in gonadotropes: what does the FOX say\u2026 to the SMAD?","volume":"29","author":"Fortin","year":"2015","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.tem.2019.08.014_bib18","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.1016\/j.cellsig.2013.09.002","article-title":"Activins bind and signal via bone morphogenetic protein receptor type II (BMPR2) in immortalized gonadotrope-like cells","volume":"25","author":"Rejon","year":"2013","journal-title":"Cell Signal."},{"key":"10.1016\/j.tem.2019.08.014_bib19","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/374356a0","article-title":"Different phenotypes for mice deficient in either activins or activin receptor type II","volume":"374","author":"Matzuk","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.tem.2019.08.014_bib20","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1128\/MCB.16.3.1066","article-title":"Activation of signalling by the activin receptor complex","volume":"16","author":"Attisano","year":"1996","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.tem.2019.08.014_bib21","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.mce.2004.03.009","article-title":"Activin isoforms signal through type I receptor serine\/threonine kinase ALK7","volume":"220","author":"Tsuchida","year":"2004","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.tem.2019.08.014_bib22","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/1477-7827-4-52","article-title":"Activin B can signal through both ALK4 and ALK7 in gonadotrope cells","volume":"4","author":"Bernard","year":"2006","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.tem.2019.08.014_bib23","doi-asserted-by":"crossref","first-page":"4966","DOI":"10.1096\/fj.11-199059","article-title":"Neuroendocrine control of female reproductive function by the activin receptor ALK7","volume":"26","author":"Sandoval-Guzman","year":"2012","journal-title":"FASEB J."},{"key":"10.1016\/j.tem.2019.08.014_bib24","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1210\/me.2004-0475","article-title":"Smad3 mediates activin-induced transcription of follicle-stimulating hormone beta-subunit gene","volume":"19","author":"Suszko","year":"2005","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.tem.2019.08.014_bib25","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1074\/jbc.M116.759167","article-title":"SMAD3 regulates follicle-stimulating hormone synthesis by pituitary gonadotrope cells in\u00a0vivo","volume":"292","author":"Li","year":"2017","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.tem.2019.08.014_bib26","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1210\/me.2010-0480","article-title":"SMADs and FOXL2 synergistically regulate murine FSHbeta transcription via a conserved proximal promoter element","volume":"25","author":"Tran","year":"2011","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.tem.2019.08.014_bib27","doi-asserted-by":"crossref","first-page":"5456","DOI":"10.1210\/en.2010-0605","article-title":"Activin A regulates porcine follicle-stimulating hormone beta-subunit transcription via cooperative actions of SMADs and FOXL2","volume":"151","author":"Lamba","year":"2010","journal-title":"Endocrinology"},{"key":"10.1016\/j.tem.2019.08.014_bib28","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1210\/me.2008-0324","article-title":"A novel role for the forkhead transcription factor FOXL2 in activin A-regulated follicle-stimulating hormone beta subunit transcription","volume":"23","author":"Lamba","year":"2009","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.tem.2019.08.014_bib29","doi-asserted-by":"crossref","first-page":"2641","DOI":"10.1210\/en.2018-00100","article-title":"Conditional deletion of FOXL2 and SMAD4 in gonadotropes of adult mice causes isolated FSH deficiency","volume":"159","author":"Li","year":"2018","journal-title":"Endocrinology"},{"key":"10.1016\/j.tem.2019.08.014_bib30","doi-asserted-by":"crossref","first-page":"3396","DOI":"10.1096\/fj.14-249532","article-title":"Follicle-stimulating hormone synthesis and fertility depend on SMAD4 and FOXL2","volume":"28","author":"Fortin","year":"2014","journal-title":"FASEB J."},{"key":"10.1016\/j.tem.2019.08.014_bib31","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1210\/me.2012-1286","article-title":"Impaired fertility and FSH synthesis in gonadotrope-specific Foxl2 knockout mice","volume":"27","author":"Tran","year":"2013","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.tem.2019.08.014_bib32","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/0092-8674(91)90549-E","article-title":"Expression cloning of an activin receptor, a predicted transmembrane serine kinase","volume":"65","author":"Mathews","year":"1991","journal-title":"Cell"},{"key":"10.1016\/j.tem.2019.08.014_bib33","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1126\/science.1313188","article-title":"Cloning of a second type of activin receptor and functional characterization in Xenopus embryos","volume":"255","author":"Mathews","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.tem.2019.08.014_bib34","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0092-8674(92)90209-U","article-title":"Novel activin receptors: distinct genes and alternative mRNA splicing generate a repertoire of serine\/threonine kinase receptors","volume":"68","author":"Attisano","year":"1992","journal-title":"Cell"},{"key":"10.1016\/j.tem.2019.08.014_bib35","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1093\/emboj\/cdg156","article-title":"Structures of an ActRIIB:activin a complex reveal a novel binding mode for TGF-beta ligand:receptor interactions","volume":"22","author":"Thompson","year":"2003","journal-title":"EMBO J."},{"key":"10.1016\/j.tem.2019.08.014_bib36","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.molcel.2004.07.011","article-title":"A flexible activin explains the membrane-dependent cooperative assembly of TGF-beta family receptors","volume":"15","author":"Greenwald","year":"2004","journal-title":"Mol. Cell."},{"key":"10.1016\/j.tem.2019.08.014_bib37","doi-asserted-by":"crossref","first-page":"6308","DOI":"10.1074\/jbc.270.11.6308","article-title":"Inhibin antagonizes inhibition of liver cell growth by activin by a dominant-negative mechanism","volume":"270","author":"Xu","year":"1995","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.tem.2019.08.014_bib38","doi-asserted-by":"crossref","first-page":"5463","DOI":"10.1210\/endo.137.12.8940372","article-title":"Inhibin A and inhibin B are inversely correlated to follicle-stimulating hormone, yet are discordant during the follicular phase of the rat estrous cycle, and inhibin A is expressed in a sexually dimorphic manner","volume":"137","author":"Woodruff","year":"1996","journal-title":"Endocrinology"},{"key":"10.1016\/j.tem.2019.08.014_bib39","doi-asserted-by":"crossref","first-page":"4784","DOI":"10.1210\/en.2008-1783","article-title":"Inhibin B is a more potent suppressor of rat follicle-stimulating hormone release than inhibin a in\u00a0vitro and in\u00a0vivo","volume":"150","author":"Makanji","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.tem.2019.08.014_bib40","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/35006129","article-title":"Betaglycan binds inhibin and can mediate functional antagonism of activin signalling","volume":"404","author":"Lewis","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.tem.2019.08.014_bib41","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1016\/0092-8674(93)90368-Z","article-title":"Betaglycan presents ligand to the TGF beta signaling receptor","volume":"73","author":"Lopez-Casillas","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.tem.2019.08.014_bib42","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/0092-8674(91)90074-9","article-title":"Expression cloning and characterization of the TGF-beta type III receptor","volume":"67","author":"Wang","year":"1991","journal-title":"Cell"},{"key":"10.1016\/j.tem.2019.08.014_bib43","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/0092-8674(91)90073-8","article-title":"Structure and expression of the membrane proteoglycan betaglycan, a component of the TGF-beta receptor system","volume":"67","author":"Lopez-Casillas","year":"1991","journal-title":"Cell"},{"key":"10.1016\/j.tem.2019.08.014_bib44","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1210\/endo.143.3.8707","article-title":"The distribution of betaglycan protein and mRNA in rat brain, pituitary, and gonads: implications for a role for betaglycan in inhibin-mediated reproductive functions","volume":"143","author":"MacConell","year":"2002","journal-title":"Endocrinology"},{"key":"10.1016\/j.tem.2019.08.014_bib45","doi-asserted-by":"crossref","first-page":"5640","DOI":"10.1210\/en.2003-0670","article-title":"Betaglycan localization in the female rat pituitary: implications for the regulation of follicle-stimulating hormone by inhibin","volume":"144","author":"Chapman","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.tem.2019.08.014_bib46","doi-asserted-by":"crossref","first-page":"17011","DOI":"10.1074\/jbc.M601459200","article-title":"Identification of distinct inhibin and transforming growth factor beta-binding sites on betaglycan: functional separation of betaglycan co-receptor actions","volume":"281","author":"Wiater","year":"2006","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.tem.2019.08.014_bib47","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1210\/me.2009-0021","article-title":"Endogenous betaglycan is essential for high-potency inhibin antagonism in gonadotropes","volume":"23","author":"Wiater","year":"2009","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.tem.2019.08.014_bib48","doi-asserted-by":"crossref","first-page":"4371","DOI":"10.1128\/MCB.23.12.4371-4385.2003","article-title":"Heart and liver defects and reduced transforming growth factor beta2 sensitivity in transforming growth factor beta type III receptor-deficient embryos","volume":"23","author":"Stenvers","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.tem.2019.08.014_bib49","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1210\/en.2018-01049","article-title":"Inhibin: to betaglycan, or not to betaglycan","volume":"160","author":"Walton","year":"2019","journal-title":"Endocrinology"},{"key":"10.1016\/j.tem.2019.08.014_bib50","doi-asserted-by":"crossref","first-page":"2600","DOI":"10.1210\/endo.141.7.7540","article-title":"Structure and expression of a membrane component of the inhibin receptor system","volume":"141","author":"Chong","year":"2000","journal-title":"Endocrinology"},{"key":"10.1016\/j.tem.2019.08.014_bib51","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1006\/geno.1997.5156","article-title":"Cloning and expression of an immunoglobulin superfamily gene (IGSF1) in Xq25","volume":"48","author":"Mazzarella","year":"1998","journal-title":"Genomics"},{"key":"10.1016\/j.tem.2019.08.014_bib52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-1119(98)00253-4","article-title":"Identification and genomic organization of a gene coding for a new member of the cell adhesion molecule family mapping to Xq25","volume":"214","author":"Frattini","year":"1998","journal-title":"Gene"},{"key":"10.1016\/j.tem.2019.08.014_bib53","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1210\/mend.15.4.0616","article-title":"Modulation of activin signal transduction by inhibin B and inhibin-binding protein (INhBP)","volume":"15","author":"Chapman","year":"2001","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.tem.2019.08.014_bib54","doi-asserted-by":"crossref","first-page":"42937","DOI":"10.1038\/srep42937","article-title":"The syndrome of central hypothyroidism and macroorchidism: IGSF1 controls TRHR and FSHB expression by differential modulation of pituitary TGFbeta and Activin pathways","volume":"7","author":"Garcia","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tem.2019.08.014_bib55","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0303-7207(02)00227-7","article-title":"Properties of inhibin binding to betaglycan, InhBP\/p120 and the activin type II receptors","volume":"196","author":"Chapman","year":"2002","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.tem.2019.08.014_bib56","doi-asserted-by":"crossref","first-page":"4882","DOI":"10.1128\/MCB.23.14.4882-4891.2003","article-title":"Normal reproductive function in InhBP\/p120-deficient mice","volume":"23","author":"Bernard","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.tem.2019.08.014_bib57","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1210\/en.2016-1788","article-title":"TRH action is impaired in pituitaries of male IGSF1-deficient mice","volume":"158","author":"Turgeon","year":"2017","journal-title":"Endocrinology"},{"key":"10.1016\/j.tem.2019.08.014_bib58","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1038\/ng.2453","article-title":"Loss-of-function mutations in IGSF1 cause an X-linked syndrome of central hypothyroidism and testicular enlargement","volume":"44","author":"Sun","year":"2012","journal-title":"Nat. Genet."},{"key":"10.1016\/j.tem.2019.08.014_bib59","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1530\/JOE-15-0204","article-title":"Spatial and temporal expression of immunoglobulin superfamily member 1 in the rat","volume":"226","author":"Joustra","year":"2015","journal-title":"J.\u00a0Endocrinol."},{"key":"10.1016\/j.tem.2019.08.014_bib60","doi-asserted-by":"crossref","first-page":"3910","DOI":"10.1210\/en.2018-00750","article-title":"Single-cell RNA sequencing reveals novel markers of male pituitary stem cells and hormone-producing cell types","volume":"159","author":"Cheung","year":"2018","journal-title":"Endocrinology"},{"key":"10.1016\/j.tem.2019.08.014_bib61","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1210\/en.2015-1836","article-title":"Molecular plasticity of male and female murine gonadotropes revealed by mRNA sequencing","volume":"157","author":"Qiao","year":"2016","journal-title":"Endocrinology"},{"key":"10.1016\/j.tem.2019.08.014_bib62","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1210\/jc.2015-3880","article-title":"IGSF1 deficiency: lessons from an extensive case series and recommendations for clinical management","volume":"101","author":"Joustra","year":"2016","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2019.08.014_bib63","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1159\/000439433","article-title":"Pituitary hormone secretion profiles in IGSF1 deficiency syndrome","volume":"103","author":"Joustra","year":"2016","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.tem.2019.08.014_bib64","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1210\/js.2017-00478","article-title":"From consternation to revelation: discovery of a role for IGSF1 in pituitary control of thyroid function","volume":"2","author":"Bernard","year":"2018","journal-title":"J.\u00a0Endocr. Soc."},{"key":"10.1016\/j.tem.2019.08.014_bib65","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.mce.2009.03.021","article-title":"Reducing betaglycan expression by RNA interference (RNAi) attenuates inhibin bioactivity in LbetaT2 gonadotropes","volume":"307","author":"Escalona","year":"2009","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.tem.2019.08.014_bib66","doi-asserted-by":"crossref","first-page":"16743","DOI":"10.1074\/jbc.M801045200","article-title":"Suppression of inhibin A biological activity by alterations in the binding site for betaglycan","volume":"283","author":"Makanji","year":"2008","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.tem.2019.08.014_bib67","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1210\/en.2006-1612","article-title":"Inhibin A and B in\u00a0vitro bioactivities are modified by their degree of glycosylation and their affinities to betaglycan","volume":"148","author":"Makanji","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.tem.2019.08.014_bib68","doi-asserted-by":"crossref","first-page":"53126","DOI":"10.1074\/jbc.M408090200","article-title":"Reconstitution and analysis of soluble inhibin and activin receptor complexes in a cell-free system","volume":"279","author":"del Re","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.tem.2019.08.014_bib69","doi-asserted-by":"crossref","first-page":"14588","DOI":"10.1074\/jbc.M008866200","article-title":"Ligand binding and functional properties of betaglycan, a co-receptor of the transforming growth factor-beta superfamily. Specialized binding regions for transforming growth factor-beta and inhibin A","volume":"276","author":"Esparza-Lopez","year":"2001","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.tem.2019.08.014_bib70","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1177\/42.8.8027530","article-title":"In situ hybridization analysis of anterior pituitary hormone gene expression during fetal mouse development","volume":"42","author":"Japon","year":"1994","journal-title":"J.\u00a0Histochem. Cytochem."},{"key":"10.1016\/j.tem.2019.08.014_bib71","doi-asserted-by":"crossref","first-page":"4077","DOI":"10.1210\/en.2018-00770","article-title":"Betaglycan (TGFBR3) functions as an inhibin A, but not inhibin B, coreceptor in pituitary gonadotrope cells in mice","volume":"159","author":"Li","year":"2018","journal-title":"Endocrinology"},{"key":"10.1016\/j.tem.2019.08.014_bib72","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1530\/eje.0.1450561","article-title":"Inhibin B in male reproduction: pathophysiology and clinical relevance","volume":"145","author":"Meachem","year":"2001","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.tem.2019.08.014_bib73","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0303-7207(01)00498-1","article-title":"Operation of the follicle-stimulating hormone (FSH)-inhibin B feedback loop in the control of primate spermatogenesis","volume":"180","author":"Ramaswamy","year":"2001","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.tem.2019.08.014_bib74","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1210\/endo-123-1-120","article-title":"Age-dependent changes in physiological action, content, and immunostaining of inhibin in male rats","volume":"123","author":"Rivier","year":"1988","journal-title":"Endocrinology"},{"key":"10.1016\/j.tem.2019.08.014_bib75","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3109\/01485019508987837","article-title":"Inhibin functions in male rats","volume":"34","author":"Saito","year":"1995","journal-title":"Arch. Androl."},{"key":"10.1016\/j.tem.2019.08.014_bib76","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0303-7207(88)90163-3","article-title":"Passive immunoneutralization of endogenous inhibin: sex-related differences in the role of inhibin during development","volume":"58","author":"Culler","year":"1988","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.tem.2019.08.014_bib77","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1210\/en.2019-00001","article-title":"Follicle-stimulating hormone glycobiology","volume":"160","author":"Bousfield","year":"2019","journal-title":"Endocrinology"},{"key":"10.1016\/j.tem.2019.08.014_bib78","doi-asserted-by":"crossref","DOI":"10.1210\/jc.2015-1317","article-title":"Hypoglycosylated hFSH has greater bioactivity than fully glycosylated recombinant hFSH in human granulosa cells","volume":"100","author":"Jiang","year":"2015","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2019.08.014_bib79","doi-asserted-by":"crossref","first-page":"12238","DOI":"10.1021\/bi700907k","article-title":"BMP-3 and BMP-6 structures illuminate the nature of binding specificity with receptors","volume":"46","author":"Allendorph","year":"2007","journal-title":"Biochemistry"},{"key":"10.1016\/j.tem.2019.08.014_bib80","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1038\/sj.emboj.7601000","article-title":"Structural basis for the inhibition of activin signalling by follistatin","volume":"25","author":"Harrington","year":"2006","journal-title":"EMBO J."},{"key":"10.1016\/j.tem.2019.08.014_bib81","doi-asserted-by":"crossref","first-page":"3065","DOI":"10.1074\/jbc.RA118.005210","article-title":"TGF-beta2 uses the concave surface of its extended finger region to bind betaglycan's ZP domain via three residues specific to TGF-beta and inhibin-alpha","volume":"294","author":"Henen","year":"2019","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.tem.2019.08.014_bib82","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1210\/endo.142.4.8108","article-title":"Identification of specific inhibin A-binding proteins on mouse Leydig (TM3) and sertoli (TM4) cell lines","volume":"142","author":"Harrison","year":"2001","journal-title":"Endocrinology"},{"key":"10.1016\/j.tem.2019.08.014_bib83","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/molehr\/gaw070","article-title":"Inhibin-B secretion and FSH isoform distribution may play an integral part of follicular selection in the natural menstrual cycle","volume":"23","author":"Yding Andersen","year":"2017","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.tem.2019.08.014_bib84","first-page":"1401","article-title":"Measurement of dimeric inhibin B throughout the human menstrual cycle","volume":"81","author":"Groome","year":"1996","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2019.08.014_bib85","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1210\/mend.15.4.0630","article-title":"Inhibin binding protein in rats: alternative transcripts and regulation in the pituitary across the estrous cycle","volume":"15","author":"Bernard","year":"2001","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.tem.2019.08.014_bib86","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2019.00623","article-title":"Cell type- and sex-dependent transcriptome profiles of rat anterior pituitary cells","author":"Fletcher","year":"2019","journal-title":"Front. Endocrinol."}],"container-title":["Trends in Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S104327601930181X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S104327601930181X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T21:39:35Z","timestamp":1778794775000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S104327601930181X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":86,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["S104327601930181X"],"URL":"https:\/\/doi.org\/10.1016\/j.tem.2019.08.014","relation":{},"ISSN":["1043-2760"],"issn-type":[{"value":"1043-2760","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A Tale of Two Proteins: Betaglycan, IGSF1, and the Continuing Search for the Inhibin B Receptor","name":"articletitle","label":"Article Title"},{"value":"Trends in Endocrinology & Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tem.2019.08.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}