{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T03:56:58Z","timestamp":1793159818804,"version":"4.5.0"},"reference-count":187,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100004410","name":"European Molecular Biology Organization","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmn.com","cell.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Endocrinology &amp; Metabolism"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.tem.2023.10.002","type":"journal-article","created":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T16:10:02Z","timestamp":1699287002000},"page":"107-124","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":98,"title":["Mechanisms of hepatic fatty acid oxidation and ketogenesis during fasting"],"prefix":"10.1016","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4488-7734","authenticated-orcid":false,"given":"Philip M.M.","family":"Ruppert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4028-8200","authenticated-orcid":false,"given":"Sander","family":"Kersten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tem.2023.10.002_bb0005","doi-asserted-by":"crossref","first-page":"464","DOI":"10.3945\/ajcn.115.109553","article-title":"Health effects of intermittent fasting: hormesis or harm? A systematic review","volume":"102","author":"Horne","year":"2015","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.tem.2023.10.002_bb0010","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.mad.2005.03.018","article-title":"Starvation in humans: evolutionary background and contemporary implications","volume":"126","author":"Prentice","year":"2005","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.tem.2023.10.002_bb0015","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1079\/PNS2005421","article-title":"Insights from the developing world: thrifty genotypes and thrifty phenotypes","volume":"64","author":"Prentice","year":"2005","journal-title":"Proc. Nutr. Soc."},{"key":"10.1016\/j.tem.2023.10.002_bb0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev.nutr.26.061505.111258","article-title":"Fuel metabolism in starvation","volume":"26","author":"Cahill","year":"2006","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.tem.2023.10.002_bb0025","article-title":"The impact of fasting on adipose tissue metabolism","volume":"1868","author":"Kersten","year":"2023","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"10.1016\/j.tem.2023.10.002_bb0030","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1038\/jcbfm.2013.128","article-title":"Why does brain metabolism not favor burning of fatty acids to provide energy? Reflections on disadvantages of the use of free fatty acids as fuel for brain","volume":"33","author":"Schonfeld","year":"2013","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.tem.2023.10.002_bb0035","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1002\/pmic.200701001","article-title":"A proteomic approach to identify differentially expressed plasma proteins between the fed and prolonged fasted states","volume":"9","author":"Bertile","year":"2009","journal-title":"Proteomics"},{"key":"10.1016\/j.tem.2023.10.002_bb0040","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1515\/hsz-2019-0184","article-title":"Alterations in rat adipose tissue transcriptome and proteome in response to prolonged fasting","volume":"401","author":"Ibrahim","year":"2020","journal-title":"Biol. Chem."},{"key":"10.1016\/j.tem.2023.10.002_bb0045","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1126\/science.1948033","article-title":"Quantitation of hepatic glycogenolysis and gluconeogenesis in fasting humans with 13C NMR","volume":"254","author":"Rothman","year":"1991","journal-title":"Science"},{"key":"10.1016\/j.tem.2023.10.002_bb0050","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1172\/JCI105650","article-title":"Brain metabolism during fasting","volume":"46","author":"Owen","year":"1967","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tem.2023.10.002_bb0055","doi-asserted-by":"crossref","first-page":"252","DOI":"10.3389\/fendo.2020.00252","article-title":"Causes and consequences of hypertriglyceridemia","volume":"11","author":"Packard","year":"2020","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.tem.2023.10.002_bb0060","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1152\/physiolgenomics.00117.2020","article-title":"Probing metabolic memory in the hepatic response to fasting","volume":"52","author":"Defour","year":"2020","journal-title":"Physiol. Genomics"},{"key":"10.1016\/j.tem.2023.10.002_bb0065","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1172\/JCI6223","article-title":"Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting","volume":"103","author":"Kersten","year":"1999","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tem.2023.10.002_bb0070","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1177\/1756283X11430859","article-title":"Secondary causes of nonalcoholic fatty liver disease","volume":"5","author":"Kneeman","year":"2012","journal-title":"Ther. Adv. Gastroenterol."},{"key":"10.1016\/j.tem.2023.10.002_bb0075","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1042\/CS20070217","article-title":"Fasting in healthy subjects is associated with intrahepatic accumulation of lipids as assessed by 1H-magnetic resonance spectroscopy","volume":"114","author":"Moller","year":"2008","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.tem.2023.10.002_bb0080","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.mito.2018.02.009","article-title":"Mitochondrial beta-oxidation of saturated fatty acids in humans","volume":"46","author":"Adeva-Andany","year":"2019","journal-title":"Mitochondrion"},{"key":"10.1016\/j.tem.2023.10.002_bb0085","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1096\/fj.08-119420","article-title":"Metabolic profiling of PPARalpha-\/- mice reveals defects in carnitine and amino acid homeostasis that are partially reversed by oral carnitine supplementation","volume":"23","author":"Makowski","year":"2009","journal-title":"FASEB J."},{"key":"10.1016\/j.tem.2023.10.002_bb0090","first-page":"E409","article-title":"Carnitine metabolism in normal-weight and obese human subjects during fasting","volume":"238","author":"Hoppel","year":"1980","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.tem.2023.10.002_bb0095","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1006\/bbrc.1996.1244","article-title":"Acylcarnitine metabolism during fasting and after refeeding","volume":"225","author":"Yamaguti","year":"1996","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.tem.2023.10.002_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2021.101269","article-title":"Diminished ketone interconversion, hepatic TCA cycle flux, and glucose production in D-beta-hydroxybutyrate dehydrogenase hepatocyte-deficient mice","volume":"53","author":"Stagg","year":"2021","journal-title":"Mol. Metab."},{"key":"10.1016\/j.tem.2023.10.002_bb0105","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.cmet.2016.12.022","article-title":"Multi-dimensional roles of ketone bodies in fuel metabolism, signaling, and therapeutics","volume":"25","author":"Puchalska","year":"2017","journal-title":"Cell Metab."},{"key":"10.1016\/j.tem.2023.10.002_bb0110","doi-asserted-by":"crossref","first-page":"E1724","DOI":"10.1152\/ajpendo.00717.2006","article-title":"A high-fat, ketogenic diet induces a unique metabolic state in mice","volume":"292","author":"Kennedy","year":"2007","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2023.10.002_bb0115","doi-asserted-by":"crossref","first-page":"104","DOI":"10.3945\/ajcn.111.012369","article-title":"Genetic variation in PNPLA3 (adiponutrin) confers sensitivity to weight loss-induced decrease in liver fat in humans","volume":"94","author":"Sevastianova","year":"2011","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.tem.2023.10.002_bb0120","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1203\/00006450-199707000-00017","article-title":"The effect of carnitine on ketogenesis in perfused livers from juvenile visceral steatosis mice with systemic carnitine deficiency","volume":"42","author":"Nakajima","year":"1997","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.tem.2023.10.002_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.plefa.2020.102236","article-title":"The effect of a 6-month ketogenic medium-chain triglyceride supplement on plasma cardiometabolic and inflammatory markers in mild cognitive impairment","volume":"169","author":"Myette-Cote","year":"2021","journal-title":"Prostaglandins Leukot. Essent. Fat. Acids"},{"key":"10.1016\/j.tem.2023.10.002_bb0130","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.2147\/DMSO.S209938","article-title":"Characterization of variable presentations of diabetic ketoacidosis based on blood ketone levels and major society diagnostic criteria: a new viewpoint on the assessment of diabetic ketoacidosis","volume":"12","author":"Lee","year":"2019","journal-title":"Diabetes Metab. Syndr. Obes."},{"key":"10.1016\/j.tem.2023.10.002_bb0135","first-page":"E1161","article-title":"Blood-brain barrier permeability of glucose and ketone bodies during short-term starvation in humans","volume":"268","author":"Hasselbalch","year":"1995","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.tem.2023.10.002_bb0140","doi-asserted-by":"crossref","first-page":"E805","DOI":"10.1152\/ajpendo.1989.256.6.E805","article-title":"Generalized decrease in brain glucose metabolism during fasting in humans studied by PET","volume":"256","author":"Redies","year":"1989","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2023.10.002_bb0145","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.tem.2013.09.002","article-title":"Ketone bodies as signaling metabolites","volume":"25","author":"Newman","year":"2014","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.tem.2023.10.002_bb0150","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1146\/annurev-nutr-111120-111518","article-title":"Metabolic and signaling roles of ketone bodies in health and disease","volume":"41","author":"Puchalska","year":"2021","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.tem.2023.10.002_bb0155","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1006\/bbrc.1995.2232","article-title":"Fatty acid beta-oxidation in peroxisomes and mitochondria: the first, unequivocal evidence for the involvement of carnitine in shuttling propionyl-CoA from peroxisomes to mitochondria","volume":"213","author":"Jakobs","year":"1995","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.tem.2023.10.002_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2020.165720","article-title":"Metabolic interactions between peroxisomes and mitochondria with a special focus on acylcarnitine metabolism","volume":"1866","author":"Houten","year":"2020","journal-title":"Biochim. Biophys. Acta Mol. basis Dis."},{"key":"10.1016\/j.tem.2023.10.002_bb0165","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1016\/0026-0495(91)90207-D","article-title":"Effect of physiological concentrations of insulin and glucagon on the relationship between nonesterified fatty acids availability and ketone body production in humans","volume":"40","author":"Beylot","year":"1991","journal-title":"Metabolism"},{"key":"10.1016\/j.tem.2023.10.002_bb0170","doi-asserted-by":"crossref","first-page":"326","DOI":"10.2337\/diab.34.4.326","article-title":"Ketone body production and disposal in diabetic ketosis. A comparison with fasting ketosis","volume":"34","author":"Fery","year":"1985","journal-title":"Diabetes"},{"key":"10.1016\/j.tem.2023.10.002_bb0175","doi-asserted-by":"crossref","first-page":"10","DOI":"10.2337\/diab.24.1.10","article-title":"Physiologic mechanisms in the development of starvation ketosis in man","volume":"24","author":"Grey","year":"1975","journal-title":"Diabetes"},{"key":"10.1016\/j.tem.2023.10.002_bb0180","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1677\/joe.0.1200337","article-title":"The effect of a 72-h fast on plasma levels of pituitary, adrenal, thyroid, pancreatic and gastrointestinal hormones in healthy men and women","volume":"120","author":"Beer","year":"1989","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.tem.2023.10.002_bb0185","first-page":"692","article-title":"Fasting as a metabolic stress paradigm selectively amplifies cortisol secretory burst mass and delays the time of maximal nyctohemeral cortisol concentrations in healthy men","volume":"81","author":"Bergendahl","year":"1996","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2023.10.002_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2020.101033","article-title":"Fasting induces ANGPTL4 and reduces LPL activity in human adipose tissue","volume":"40","author":"Ruppert","year":"2020","journal-title":"Mol. Metab."},{"key":"10.1016\/j.tem.2023.10.002_bb0195","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1172\/JCI113450","article-title":"Fasting enhances growth hormone secretion and amplifies the complex rhythms of growth hormone secretion in man","volume":"81","author":"Ho","year":"1988","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tem.2023.10.002_bb0200","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1172\/JCI106445","article-title":"Glucagon levels and metabolic effects in fasting man","volume":"49","author":"Marliss","year":"1970","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tem.2023.10.002_bb0205","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1172\/JCI104788","article-title":"The effects of total starvation upon the levels of circulating glucagon and insulin in man","volume":"42","author":"Unger","year":"1963","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tem.2023.10.002_bb0210","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1210\/jcem-27-1-130","article-title":"Urinary excretion of catecholamines in fasting obese subjects","volume":"27","author":"Januszewicz","year":"1967","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2023.10.002_bb0215","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.domaniend.2004.02.003","article-title":"The role of insulin, glucagon, dexamethasone, and leptin in the regulation of ketogenesis and glycogen storage in primary cultures of porcine hepatocytes prepared from 60 kg pigs","volume":"27","author":"Fernandez-Figares","year":"2004","journal-title":"Domest. Anim. Endocrinol."},{"key":"10.1016\/j.tem.2023.10.002_bb0220","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1093\/oxfordjournals.jbchem.a133866","article-title":"Regulatory mechanism of ketogenesis by glucagon and insulin in isolated and cultured hepatocytes","volume":"91","author":"Harano","year":"1982","journal-title":"J. Biochem."},{"key":"10.1016\/j.tem.2023.10.002_bb0225","first-page":"156","article-title":"Hormonal control of fatty acid oxidation during the neonatal period","volume":"18","author":"Pegorier","year":"1992","journal-title":"Diabete Metab."},{"key":"10.1016\/j.tem.2023.10.002_bb0230","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1002\/hep.1840130620","article-title":"Regulation of fatty-acid metabolism by pancreatic hormones in cultured human hepatocytes","volume":"13","author":"Vons","year":"1991","journal-title":"Hepatology"},{"key":"10.1016\/j.tem.2023.10.002_bb0235","first-page":"111","article-title":"Genomics of lipid-laden human hepatocyte cultures enables drug target screening for the treatment of non-alcoholic fatty liver disease","volume":"11","author":"Breher-Esch","year":"2018","journal-title":"BMC Med. Genet."},{"key":"10.1016\/j.tem.2023.10.002_bb0240","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1111\/j.1432-1033.1996.00789.x","article-title":"Cyclic AMP and fatty acids increase carnitine palmitoyltransferase I gene transcription in cultured fetal rat hepatocytes","volume":"235","author":"Chatelain","year":"1996","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.tem.2023.10.002_bb0245","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0248-4900(05)80176-5","article-title":"Positive regulation of the peroxisomal beta-oxidation pathway by fatty acids through activation of peroxisome proliferator-activated receptors (PPAR)","volume":"77","author":"Dreyer","year":"1993","journal-title":"Biol. Cell."},{"key":"10.1016\/j.tem.2023.10.002_bb0250","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/S0300-9084(00)88874-4","article-title":"Transcriptional regulation of mitochondrial HMG-CoA synthase in the control of ketogenesis","volume":"80","author":"Hegardt","year":"1998","journal-title":"Biochimie"},{"key":"10.1016\/j.tem.2023.10.002_bb0255","doi-asserted-by":"crossref","first-page":"18767","DOI":"10.1016\/S0021-9258(17)32234-2","article-title":"Peroxisome proliferator-activated receptor mediates induction of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene by fatty acids","volume":"269","author":"Rodriguez","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tem.2023.10.002_bb0260","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1210\/endo.137.1.8536636","article-title":"Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat","volume":"137","author":"Braissant","year":"1996","journal-title":"Endocrinology"},{"key":"10.1016\/j.tem.2023.10.002_bb0265","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/35013000","article-title":"Roles of PPARs in health and disease","volume":"405","author":"Kersten","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.tem.2023.10.002_bb0270","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1146\/annurev.med.53.082901.104018","article-title":"The mechanisms of action of PPARs","volume":"53","author":"Berger","year":"2002","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.tem.2023.10.002_bb0275","doi-asserted-by":"crossref","first-page":"28918","DOI":"10.1074\/jbc.M910350199","article-title":"Defect in peroxisome proliferator-activated receptor alpha-inducible fatty acid oxidation determines the severity of hepatic steatosis in response to fasting","volume":"275","author":"Hashimoto","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tem.2023.10.002_bb0280","doi-asserted-by":"crossref","first-page":"7473","DOI":"10.1073\/pnas.96.13.7473","article-title":"A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: the PPARalpha-null mouse as a model of fatty acid oxidation disorders","volume":"96","author":"Leone","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tem.2023.10.002_bb0285","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.mce.2017.07.035","article-title":"Insights into the role of hepatocyte PPARalpha activity in response to fasting","volume":"471","author":"Regnier","year":"2017","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.tem.2023.10.002_bb0290","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1152\/physiolgenomics.00127.2009","article-title":"Transcriptional profiling reveals divergent roles of PPARalpha and PPARbeta\/delta in regulation of gene expression in mouse liver","volume":"41","author":"Sanderson","year":"2010","journal-title":"Physiol. Genomics"},{"key":"10.1016\/j.tem.2023.10.002_bb0295","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.molmet.2014.02.002","article-title":"Integrated physiology and systems biology of PPARalpha","volume":"3","author":"Kersten","year":"2014","journal-title":"Mol. Metab."},{"key":"10.1016\/j.tem.2023.10.002_bb0300","doi-asserted-by":"crossref","first-page":"26839","DOI":"10.1155\/2007\/26839","article-title":"Comprehensive analysis of PPARalpha-dependent regulation of hepatic lipid metabolism by expression profiling","volume":"2007","author":"Rakhshandehroo","year":"2007","journal-title":"PPAR Res."},{"key":"10.1016\/j.tem.2023.10.002_bb0305","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1042\/BJ20050636","article-title":"The G0\/G1 switch gene 2 is a novel PPAR target gene","volume":"392","author":"Zandbergen","year":"2005","journal-title":"Biochem. J."},{"key":"10.1016\/j.tem.2023.10.002_bb0310","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1186\/s12864-018-4834-3","article-title":"The whole transcriptome effects of the PPARalpha agonist fenofibrate on livers of hepatocyte humanized mice","volume":"19","author":"de la Rosa Rodriguez","year":"2018","journal-title":"BMC Genomics"},{"key":"10.1016\/j.tem.2023.10.002_bb0315","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1186\/s12864-015-1969-3","article-title":"The impact of PPARalpha activation on whole genome gene expression in human precision cut liver slices","volume":"16","author":"Janssen","year":"2015","journal-title":"BMC Genomics"},{"key":"10.1016\/j.tem.2023.10.002_bb0320","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0006796","article-title":"Comparative analysis of gene regulation by the transcription factor PPARalpha between mouse and human","volume":"4","author":"Rakhshandehroo","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.tem.2023.10.002_bb0325","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110910","article-title":"ATGL-dependent white adipose tissue lipolysis controls hepatocyte PPARalpha activity","volume":"39","author":"Fougerat","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.tem.2023.10.002_bb0330","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.jhep.2015.02.035","article-title":"Fasting-induced G0\/G1 switch gene 2 and FGF21 expression in the liver are under regulation of adipose tissue derived fatty acids","volume":"63","author":"Jaeger","year":"2015","journal-title":"J. Hepatol."},{"key":"10.1016\/j.tem.2023.10.002_bb0335","article-title":"Acute activation of adipocyte lipolysis reveals dynamic lipid remodeling of the hepatic lipidome","author":"Zhang","year":"2023","journal-title":"J. Lipid. Res."},{"key":"10.1016\/j.tem.2023.10.002_bb0340","doi-asserted-by":"crossref","first-page":"6257","DOI":"10.1128\/MCB.00370-09","article-title":"Peroxisome proliferator-activated receptor b\/d (PPARb\/d) but not PPARa serves as a plasma free fatty acid sensor in liver","volume":"29","author":"Sanderson","year":"2009","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.tem.2023.10.002_bb0345","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.cmet.2005.04.002","article-title":"\u201cNew\u201d hepatic fat activates PPARalpha to maintain glucose, lipid, and cholesterol homeostasis","volume":"1","author":"Chakravarthy","year":"2005","journal-title":"Cell Metab."},{"key":"10.1016\/j.tem.2023.10.002_bb0350","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0001681","article-title":"Effect of synthetic dietary triglycerides: a novel research paradigm for nutrigenomics","volume":"3","author":"Sanderson","year":"2008","journal-title":"PLoS ONE"},{"key":"10.1016\/j.tem.2023.10.002_bb0355","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1038\/nm.2439","article-title":"ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-alpha and PGC-1","volume":"17","author":"Haemmerle","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.tem.2023.10.002_bb0360","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1002\/hep.24006","article-title":"Adipose triglyceride lipase is a major hepatic lipase that regulates triacylglycerol turnover and fatty acid signaling and partitioning","volume":"53","author":"Ong","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.tem.2023.10.002_bb0365","doi-asserted-by":"crossref","first-page":"24527","DOI":"10.1016\/S0021-9258(17)31420-5","article-title":"Regulation of the peroxisome proliferator-activated receptor alpha gene by glucocorticoids","volume":"269","author":"Lemberger","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tem.2023.10.002_bb0370","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1128\/MCB.20.5.1868-1876.2000","article-title":"The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes","volume":"20","author":"Vega","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.tem.2023.10.002_bb0375","doi-asserted-by":"crossref","first-page":"4012","DOI":"10.1073\/pnas.0730870100","article-title":"Regulation of hepatic fasting response by PPARgamma coactivator-1alpha (PGC-1): requirement for hepatocyte nuclear factor 4alpha in gluconeogenesis","volume":"100","author":"Rhee","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tem.2023.10.002_bb0380","doi-asserted-by":"crossref","first-page":"39182","DOI":"10.1038\/srep39182","article-title":"CREB3L3 controls fatty acid oxidation and ketogenesis in synergy with PPARalpha","volume":"6","author":"Nakagawa","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tem.2023.10.002_bb0385","doi-asserted-by":"crossref","first-page":"4706","DOI":"10.1210\/en.2014-1113","article-title":"Hepatic CREB3L3 controls whole-body energy homeostasis and improves obesity and diabetes","volume":"155","author":"Nakagawa","year":"2014","journal-title":"Endocrinology"},{"key":"10.1016\/j.tem.2023.10.002_bb0390","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.cell.2005.11.040","article-title":"Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response","volume":"124","author":"Zhang","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.tem.2023.10.002_bb0395","doi-asserted-by":"crossref","first-page":"4121","DOI":"10.1128\/MCB.00665-15","article-title":"Lysine acetylation of CREBH regulates fasting-induced hepatic lipid metabolism","volume":"35","author":"Kim","year":"2015","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.tem.2023.10.002_bb0400","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1097\/MOL.0b013e3283508fed","article-title":"The role of CREB-H transcription factor in triglyceride metabolism","volume":"23","author":"Lee","year":"2012","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/j.tem.2023.10.002_bb0410","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.cmet.2010.02.016","article-title":"Regulation of hepatic gluconeogenesis by an ER-bound transcription factor, CREBH","volume":"11","author":"Lee","year":"2010","journal-title":"Cell Metab."},{"key":"10.1016\/j.tem.2023.10.002_bb0415","doi-asserted-by":"crossref","DOI":"10.1128\/MCB.00048-17","article-title":"CREBH maintains circadian glucose homeostasis by regulating hepatic glycogenolysis and gluconeogenesis","volume":"37","author":"Kim","year":"2017","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.tem.2023.10.002_bb0420","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1038\/nm.2347","article-title":"The transcription factor cyclic AMP-responsive element-binding protein H regulates triglyceride metabolism","volume":"17","author":"Lee","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.tem.2023.10.002_bb0425","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1002\/hep.27371","article-title":"Transcriptional activation of Fsp27 by the liver-enriched transcription factor CREBH promotes lipid droplet growth and hepatic steatosis","volume":"61","author":"Xu","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.tem.2023.10.002_bb0430","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1016\/j.bbrc.2009.12.046","article-title":"The liver-enriched transcription factor CREBH is nutritionally regulated and activated by fatty acids and PPARalpha","volume":"391","author":"Danno","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.tem.2023.10.002_bb0435","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1210\/en.2013-1490","article-title":"Liver-enriched transcription factor CREBH interacts with peroxisome proliferator-activated receptor alpha to regulate metabolic hormone FGF21","volume":"155","author":"Kim","year":"2014","journal-title":"Endocrinology"},{"key":"10.1016\/j.tem.2023.10.002_bb0440","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1016\/j.bbalip.2017.07.007","article-title":"Regulation of lipid droplet-associated proteins by peroxisome proliferator-activated receptors","volume":"1862","author":"de la Rosa Rodriguez","year":"2017","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.tem.2023.10.002_bb0445","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1186\/s12864-019-5563-y","article-title":"Transcriptional profiling of PPARalpha-\/- and CREB3L3-\/- livers reveals disparate regulation of hepatoproliferative and metabolic functions of PPARalpha","volume":"20","author":"Ruppert","year":"2019","journal-title":"BMC Genomics"},{"key":"10.1016\/j.tem.2023.10.002_bb0450","doi-asserted-by":"crossref","first-page":"27938","DOI":"10.1038\/srep27938","article-title":"CREBH-FGF21 axis improves hepatic steatosis by suppressing adipose tissue lipolysis","volume":"6","author":"Park","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tem.2023.10.002_bb0455","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.cmet.2007.05.002","article-title":"Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states","volume":"5","author":"Badman","year":"2007","journal-title":"Cell Metab."},{"key":"10.1016\/j.tem.2023.10.002_bb0460","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.cmet.2007.05.003","article-title":"Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21","volume":"5","author":"Inagaki","year":"2007","journal-title":"Cell Metab."},{"key":"10.1016\/j.tem.2023.10.002_bb0465","doi-asserted-by":"crossref","first-page":"4931","DOI":"10.1210\/en.2009-0532","article-title":"Fibroblast growth factor 21-deficient mice demonstrate impaired adaptation to ketosis","volume":"150","author":"Badman","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.tem.2023.10.002_bb0470","doi-asserted-by":"crossref","first-page":"4625","DOI":"10.1210\/en.2009-0119","article-title":"Fibroblast growth factor 21 regulates lipolysis in white adipose tissue but is not required for ketogenesis and triglyceride clearance in liver","volume":"150","author":"Hotta","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.tem.2023.10.002_bb0475","doi-asserted-by":"crossref","first-page":"2566","DOI":"10.3390\/cells9122566","article-title":"Comparative transcriptomics analyses in livers of mice, humans, and humanized mice define human-specific gene networks","volume":"9","author":"Jiang","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.tem.2023.10.002_bb0480","doi-asserted-by":"crossref","first-page":"4601","DOI":"10.1172\/JCI83349","article-title":"FGF21 and the late adaptive response to starvation in humans","volume":"125","author":"Fazeli","year":"2015","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tem.2023.10.002_bb0485","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.cmet.2008.06.014","article-title":"The circulating metabolic regulator FGF21 is induced by prolonged fasting and PPARalpha activation in man","volume":"8","author":"Galman","year":"2008","journal-title":"Cell Metab."},{"key":"10.1016\/j.tem.2023.10.002_bb0490","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1530\/JOE-18-0002","article-title":"Fasting decreases plasma FGF21 in obese subjects and the expression of FGF21 receptors in adipose tissue in both lean and obese subjects","volume":"239","author":"Nygaard","year":"2018","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.tem.2023.10.002_bb0495","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.cmet.2013.01.014","article-title":"Glucagon-induced acetylation of Foxa2 regulates hepatic lipid metabolism","volume":"17","author":"von Meyenn","year":"2013","journal-title":"Cell Metab."},{"key":"10.1016\/j.tem.2023.10.002_bb0500","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1038\/nature03047","article-title":"Foxa2 regulates lipid metabolism and ketogenesis in the liver during fasting and in diabetes","volume":"432","author":"Wolfrum","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.tem.2023.10.002_bb0505","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1007\/s00018-006-6095-6","article-title":"The Foxa family of transcription factors in development and metabolism","volume":"63","author":"Friedman","year":"2006","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.tem.2023.10.002_bb0510","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.cmet.2005.07.002","article-title":"Foxa2 integrates the transcriptional response of the hepatocyte to fasting","volume":"2","author":"Zhang","year":"2005","journal-title":"Cell Metab."},{"key":"10.1016\/j.tem.2023.10.002_bb0515","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0167-4781(93)90064-K","article-title":"Induction of peroxisomal acyl-CoA oxidase by 3-thia fatty acid, in hepatoma cells and hepatocytes in culture is modified by dexamethasone and insulin","volume":"1171","author":"Sorensen","year":"1993","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.tem.2023.10.002_bb0520","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1101\/gr.212175.116","article-title":"Transcription factor assisted loading and enhancer dynamics dictate the hepatic fasting response","volume":"27","author":"Goldstein","year":"2017","journal-title":"Genome Res."},{"key":"10.1016\/j.tem.2023.10.002_bb0525","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1074\/jbc.271.3.1764","article-title":"Expression of the peroxisome proliferator-activated receptor alpha gene is stimulated by stress and follows a diurnal rhythm","volume":"271","author":"Lemberger","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tem.2023.10.002_bb0530","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.11853","article-title":"Glucocorticoid receptor-PPARalpha axis in fetal mouse liver prepares neonates for milk lipid catabolism","volume":"5","author":"Rando","year":"2016","journal-title":"eLife"},{"key":"10.1016\/j.tem.2023.10.002_bb0535","doi-asserted-by":"crossref","first-page":"7397","DOI":"10.1073\/pnas.0806742106","article-title":"PPARalpha blocks glucocorticoid receptor alpha-mediated transactivation but cooperates with the activated glucocorticoid receptor alpha for transrepression on NF-kappaB","volume":"106","author":"Bougarne","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tem.2023.10.002_bb0540","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.molcel.2019.10.007","article-title":"Cistromic reprogramming of the diurnal glucocorticoid hormone response by high-fat diet","volume":"76","author":"Quagliarini","year":"2019","journal-title":"Mol. Cell"},{"key":"10.1016\/j.tem.2023.10.002_bb0545","doi-asserted-by":"crossref","first-page":"10539","DOI":"10.1093\/nar\/gkw742","article-title":"Chromatin recruitment of activated AMPK drives fasting response genes co-controlled by GR and PPARalpha","volume":"44","author":"Ratman","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.tem.2023.10.002_bb0550","first-page":"G1141","article-title":"Glucocorticoids inhibit mitochondrial matrix acyl-CoA dehydrogenases and fatty acid beta-oxidation","volume":"272","author":"Letteron","year":"1997","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.tem.2023.10.002_bb0555","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2020.572981","article-title":"Multifaceted control of GR signaling and its impact on hepatic transcriptional networks and metabolism","volume":"11","author":"Praestholm","year":"2020","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.tem.2023.10.002_bb0560","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1210\/me.2003-0283","article-title":"Inactivation of the glucocorticoid receptor in hepatocytes leads to fasting hypoglycemia and ameliorates hyperglycemia in streptozotocin-induced diabetes mellitus","volume":"18","author":"Opherk","year":"2004","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.tem.2023.10.002_bb0565","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.cmet.2022.01.004","article-title":"A macrophage-hepatocyte glucocorticoid receptor axis coordinates fasting ketogenesis","volume":"34","author":"Loft","year":"2022","journal-title":"Cell Metab."},{"key":"10.1016\/j.tem.2023.10.002_bb0570","doi-asserted-by":"crossref","first-page":"3528","DOI":"10.1038\/ncomms4528","article-title":"Hepatic IRE1alpha regulates fasting-induced metabolic adaptive programs through the XBP1s-PPARalpha axis signalling","volume":"5","author":"Shao","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tem.2023.10.002_bb0575","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1016\/j.molmet.2017.09.006","article-title":"Induction of fibroblast growth factor 21 does not require activation of the hepatic X-box binding protein 1 in mice","volume":"6","author":"Olivares","year":"2017","journal-title":"Mol. Metab."},{"key":"10.1016\/j.tem.2023.10.002_bb0580","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1172\/JCI88893","article-title":"Nutrient-sensing nuclear receptors PPARalpha and FXR control liver energy balance","volume":"127","author":"Preidis","year":"2017","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tem.2023.10.002_bb0585","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.molmet.2015.09.005","article-title":"Bioenergetic cues shift FXR splicing towards FXRalpha2 to modulate hepatic lipolysis and fatty acid metabolism","volume":"4","author":"Correia","year":"2015","journal-title":"Mol. Metab."},{"key":"10.1016\/j.tem.2023.10.002_bb0590","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0115028","article-title":"Hepatic farnesoid X-receptor isoforms alpha2 and alpha4 differentially modulate bile salt and lipoprotein metabolism in mice","volume":"9","author":"Boesjes","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.tem.2023.10.002_bb0595","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1053\/j.gastro.2020.07.036","article-title":"FXR isoforms control different metabolic functions in liver cells via binding to specific DNA motifs","volume":"159","author":"Ramos Pittol","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.tem.2023.10.002_bb0600","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.cmet.2008.09.008","article-title":"The glucagon receptor is required for the adaptive metabolic response to fasting","volume":"8","author":"Longuet","year":"2008","journal-title":"Cell Metab."},{"key":"10.1016\/j.tem.2023.10.002_bb0605","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1006\/abbi.1996.0077","article-title":"Regulation of peroxisome proliferator-activated receptor-alpha mRNA in rat liver","volume":"326","author":"Sterchele","year":"1996","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.tem.2023.10.002_bb0610","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1530\/JOE-16-0649","article-title":"Glucagon-induced extracellular cAMP regulates hepatic lipid metabolism","volume":"234","author":"Lv","year":"2017","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.tem.2023.10.002_bb0615","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1194\/jlr.M080382","article-title":"HDAC5 integrates ER stress and fasting signals to regulate hepatic fatty acid oxidation","volume":"59","author":"Qiu","year":"2018","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.tem.2023.10.002_bb0620","doi-asserted-by":"crossref","DOI":"10.1016\/j.peptides.2022.170906","article-title":"A reappraisal of the role of cyclic AMP in the physiological action of glucagon","volume":"159","author":"Rodgers","year":"2023","journal-title":"Peptides"},{"key":"10.1016\/j.tem.2023.10.002_bb0625","doi-asserted-by":"crossref","first-page":"882","DOI":"10.2337\/db19-1216","article-title":"The limited role of glucagon for ketogenesis during fasting or in response to SGLT2 inhibition","volume":"69","author":"Capozzi","year":"2020","journal-title":"Diabetes"},{"key":"10.1016\/j.tem.2023.10.002_bb0630","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1038\/nature09584","article-title":"mTORC1 controls fasting-induced ketogenesis and its modulation by ageing","volume":"468","author":"Sengupta","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.tem.2023.10.002_bb0635","doi-asserted-by":"crossref","first-page":"4207","DOI":"10.1172\/JCI96036","article-title":"mTORC1 stimulates phosphatidylcholine synthesis to promote triglyceride secretion","volume":"127","author":"Quinn","year":"2017","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tem.2023.10.002_bb0640","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.100884","article-title":"mTORC1 activation is not sufficient to suppress hepatic PPAR\u03b1 signaling or ketogenesis","volume":"297","author":"Selen","year":"2021","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tem.2023.10.002_bb0645","doi-asserted-by":"crossref","first-page":"4107","DOI":"10.1038\/s41467-022-31803-5","article-title":"Hepatic non-parenchymal S100A9-TLR4-mTORC1 axis normalizes diabetic ketogenesis","volume":"13","author":"Ursino","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tem.2023.10.002_bb0650","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1139\/apnm-2018-0635","article-title":"Sex-based differences in hepatic and skeletal muscle triglyceride storage and metabolism (1)","volume":"44","author":"Beaudry","year":"2019","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"10.1016\/j.tem.2023.10.002_bb0655","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3389\/fendo.2015.00061","article-title":"Sexual dimorphism in glucose and lipid metabolism during fasting, hypoglycemia, and exercise","volume":"6","author":"Hedrington","year":"2015","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.tem.2023.10.002_bb0660","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.ogc.2009.03.001","article-title":"Gender differences in lipid metabolism and the effect of obesity","volume":"36","author":"Magkos","year":"2009","journal-title":"Obstet. Gynecol. Clin. N. Am."},{"key":"10.1016\/j.tem.2023.10.002_bb0665","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1016\/0026-0495(94)90008-6","article-title":"Sex differences in the adaptation of glucose metabolism to short-term fasting: effects of oral contraceptives","volume":"43","author":"Corssmit","year":"1994","journal-title":"Metabolism"},{"key":"10.1016\/j.tem.2023.10.002_bb0670","first-page":"527","article-title":"Metabolic differences between males and females and between normal and obese subjects during total fast","volume":"54","author":"Goschke","year":"1976","journal-title":"Klin. Wochenschr."},{"key":"10.1016\/j.tem.2023.10.002_bb0675","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0026-0495(82)90024-5","article-title":"Differences in circulating gluconeogenic substrates during short-term fasting in men, women, and children","volume":"31","author":"Haymond","year":"1982","journal-title":"Metabolism"},{"key":"10.1016\/j.tem.2023.10.002_bb0680","doi-asserted-by":"crossref","first-page":"E411","DOI":"10.1152\/ajpendo.2000.279.2.E411","article-title":"Short-term fasting abolishes the sex-related difference in GH and leptin secretion in humans","volume":"279","author":"Maccario","year":"2000","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2023.10.002_bb0685","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1017\/S0007114510004472","article-title":"Young women partition fatty acids towards ketone body production rather than VLDL-TAG synthesis, compared with young men","volume":"105","author":"Marinou","year":"2011","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.tem.2023.10.002_bb0690","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1210\/jcem-37-5-698","article-title":"Homeostasis during fasting. II. Hormone substrate differences between men and women","volume":"37","author":"Merimee","year":"1973","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2023.10.002_bb0700","first-page":"3188","article-title":"Gender factors affect fatty acids-induced insulin resistance in nonobese humans: effects of oral steroidal contraception","volume":"86","author":"Perseghin","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2023.10.002_bb0705","doi-asserted-by":"crossref","first-page":"3646","DOI":"10.1210\/jc.2007-0552","article-title":"Gender-related differences in the metabolic response to fasting","volume":"92","author":"Soeters","year":"2007","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2023.10.002_bb0710","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1210\/jcem-46-3-414","article-title":"Sex variations in free fatty acids and ketones during fasting: evidence for a role of glucagon","volume":"46","author":"Merimee","year":"1978","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2023.10.002_bb0715","doi-asserted-by":"crossref","first-page":"4425","DOI":"10.1210\/jc.2015-2649","article-title":"Sex-specific differences in hepatic fat oxidation and synthesis may explain the higher propensity for NAFLD in men","volume":"100","author":"Pramfalk","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2023.10.002_bb0720","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1194\/jlr.P020867","article-title":"The effect of short-term fasting on liver and skeletal muscle lipid, glucose, and energy metabolism in healthy women and men","volume":"53","author":"Browning","year":"2012","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.tem.2023.10.002_bb0725","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.2337\/db07-0654","article-title":"The contribution of splanchnic fat to VLDL triglyceride is greater in insulin-resistant than insulin-sensitive men and women: studies in the postprandial state","volume":"56","author":"Hodson","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.tem.2023.10.002_bb0730","doi-asserted-by":"crossref","first-page":"E1333","DOI":"10.1152\/ajpendo.2001.281.6.E1333","article-title":"Gender differences in lipid and glucose kinetics during short-term fasting","volume":"281","author":"Mittendorfer","year":"2001","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2023.10.002_bb0735","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1210\/jc.2006-2215","article-title":"Women produce fewer but triglyceride-richer very low-density lipoproteins than men","volume":"92","author":"Magkos","year":"2007","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2023.10.002_bb0740","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/S0015-0282(01)01686-7","article-title":"Endocrine and chronobiological effects of fasting in women","volume":"75","author":"Berga","year":"2001","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.tem.2023.10.002_bb0745","doi-asserted-by":"crossref","first-page":"E224","DOI":"10.1152\/ajpendo.00464.2015","article-title":"Differential regulation of lipid and protein metabolism in obese vs. lean subjects before and after a 72-h fast","volume":"311","author":"Bak","year":"2016","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2023.10.002_bb0750","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0200817","article-title":"Prolonged fasting-induced metabolic signatures in human skeletal muscle of lean and obese men","volume":"13","author":"Bak","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.tem.2023.10.002_bb0755","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/0026-0495(89)90047-4","article-title":"Accelerated decline in hepatic glucose production during fasting in normal women compared with men","volume":"38","author":"Clore","year":"1989","journal-title":"Metabolism"},{"key":"10.1016\/j.tem.2023.10.002_bb0760","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/j.1748-1716.2007.01740.x","article-title":"Effects of a 3-day fast on regional lipid and glucose metabolism in human skeletal muscle and adipose tissue","volume":"191","author":"Gjedsted","year":"2007","journal-title":"Acta Physiol."},{"key":"10.1016\/j.tem.2023.10.002_bb0765","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1210\/jcem.74.4.1548337","article-title":"Augmented growth hormone (GH) secretory burst frequency and amplitude mediate enhanced GH secretion during a two-day fast in normal men","volume":"74","author":"Hartman","year":"1992","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2023.10.002_bb0770","first-page":"E278","article-title":"Effect of short-term fasting on lipid kinetics in lean and obese women","volume":"276","author":"Horowitz","year":"1999","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.tem.2023.10.002_bb0775","doi-asserted-by":"crossref","first-page":"4671","DOI":"10.1172\/JCI129913","article-title":"Regulation of hepatic mitochondrial oxidation by glucose-alanine cycling during starvation in humans","volume":"129","author":"Petersen","year":"2019","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tem.2023.10.002_bb0780","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1016\/j.metabol.2010.01.024","article-title":"Extended metabolic evaluation of suspected symptomatic hypoglycemia: the prolonged fast and beyond","volume":"59","author":"Soeters","year":"2010","journal-title":"Metabolism"},{"key":"10.1016\/j.tem.2023.10.002_bb0785","doi-asserted-by":"crossref","first-page":"2900","DOI":"10.1210\/jc.2008-0250","article-title":"Muscle adaptation to short-term fasting in healthy lean humans","volume":"93","author":"Soeters","year":"2008","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2023.10.002_bb0790","doi-asserted-by":"crossref","first-page":"E885","DOI":"10.1152\/ajpendo.00215.2014","article-title":"Regulation of skeletal muscle energy\/nutrient-sensing pathways during metabolic adaptation to fasting in healthy humans","volume":"307","author":"Wijngaarden","year":"2014","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2023.10.002_bb0795","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1093\/ajcn\/46.4.557","article-title":"Leucine, glucose, and energy metabolism after 3 days of fasting in healthy human subjects","volume":"46","author":"Nair","year":"1987","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.tem.2023.10.002_bb0800","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1161\/01.ATV.0000092326.00725.ED","article-title":"Gender differences in postprandial ketone bodies in normolipidemic subjects and in untreated patients with familial combined hyperlipidemia","volume":"23","author":"Halkes","year":"2003","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.tem.2023.10.002_bb0805","doi-asserted-by":"crossref","first-page":"5523","DOI":"10.1113\/JP280412","article-title":"Sex differences in the effect of acute fasting on excitatory and inhibitory synapses onto ventral tegmental area dopamine neurons","volume":"598","author":"Godfrey","year":"2020","journal-title":"J. Physiol."},{"key":"10.1016\/j.tem.2023.10.002_bb0810","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1136\/gutjnl-2020-323323","article-title":"Integrative study of diet-induced mouse models of NAFLD identifies PPARalpha as a sexually dimorphic drug target","volume":"71","author":"Smati","year":"2022","journal-title":"Gut"},{"key":"10.1016\/j.tem.2023.10.002_bb0815","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.eplepsyres.2017.11.005","article-title":"Ketogenic diet-induced extension of longevity in epileptic Kcna1-null mice is influenced by gender and age at treatment onset","volume":"140","author":"Chun","year":"2018","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.tem.2023.10.002_bb0820","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1210\/jcem-23-11-1080","article-title":"Sex difference in serum-free fatty acid levels in diabetic subjects","volume":"23","author":"Moorhouse","year":"1963","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2023.10.002_bb0825","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1038\/oby.2009.224","article-title":"Relationship between body fat mass and free fatty acid kinetics in men and women","volume":"17","author":"Mittendorfer","year":"2009","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.tem.2023.10.002_bb0830","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s41574-020-00431-8","article-title":"Sexual dimorphism in cardiometabolic health: the role of adipose tissue, muscle and liver","volume":"17","author":"Goossens","year":"2021","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.tem.2023.10.002_bb0835","doi-asserted-by":"crossref","first-page":"2654","DOI":"10.1007\/s00125-016-4105-2","article-title":"A beta cell ATGL-lipolysis\/adipose tissue axis controls energy homeostasis and body weight via insulin secretion in mice","volume":"59","author":"Attane","year":"2016","journal-title":"Diabetologia"},{"key":"10.1016\/j.tem.2023.10.002_bb0840","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.molmet.2016.12.004","article-title":"Kinase Suppressor of Ras 2 (KSR2) expression in the brain regulates energy balance and glucose homeostasis","volume":"6","author":"Guo","year":"2017","journal-title":"Mol. Metab."},{"key":"10.1016\/j.tem.2023.10.002_bb0845","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.812802","article-title":"Loss of adipocyte STAT5 confers increased depot-specific adiposity in male and female mice that is not associated with altered adipose tissue lipolysis","volume":"13","author":"Richard","year":"2022","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.tem.2023.10.002_bb0850","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.3390\/cells8121529","article-title":"Sex differences in liver, adipose tissue, and muscle transcriptional response to fasting and refeeding in mice","volume":"8","author":"Bazhan","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.tem.2023.10.002_bb0855","doi-asserted-by":"crossref","first-page":"R1528","DOI":"10.1152\/ajpregu.00018.2007","article-title":"Metabolic homeostasis in mice with disrupted Clock gene expression in peripheral tissues","volume":"293","author":"Kennaway","year":"2007","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.tem.2023.10.002_bb0860","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.cmet.2018.05.021","article-title":"Short-term fasting reveals amino acid metabolism as a major sex-discriminating factor in the liver","volume":"28","author":"Della Torre","year":"2018","journal-title":"Cell Metab."},{"key":"10.1016\/j.tem.2023.10.002_bb0865","first-page":"76","article-title":"Effects of fasting on neuroendocrine function and follicle development in lean women","volume":"83","author":"Alvero","year":"1998","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2023.10.002_bb0870","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/978-3-319-70178-3_12","article-title":"Role of estrogens in the regulation of liver lipid metabolism","volume":"1043","author":"Palmisano","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.tem.2023.10.002_bb0875","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1210\/jcem.74.4.1548345","article-title":"Free fatty acid metabolism in the follicular and luteal phases of the menstrual cycle","volume":"74","author":"Heiling","year":"1992","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2023.10.002_bb0880","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/0010-7824(87)90038-2","article-title":"Metabolic effects of combined oral contraceptive preparations","volume":"36","author":"Singh","year":"1987","journal-title":"Contraception"},{"key":"10.1016\/j.tem.2023.10.002_bb0890","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1111\/j.1365-2265.1989.tb01428.x","article-title":"Use of combined oral contraceptive preparations alters the insulin sensitivity of fatty acid and ketone metabolism","volume":"30","author":"Singh","year":"1989","journal-title":"Clin. Endocrinol. (Oxf)"},{"key":"10.1016\/j.tem.2023.10.002_bb0895","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/0026-0495(81)90150-5","article-title":"Metabolic response to starvation. I. Relative effects of pregnancy and sex steroid administration in the rat","volume":"30","author":"Morrow","year":"1981","journal-title":"Metabolism"},{"key":"10.1016\/j.tem.2023.10.002_bb0900","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2022.869799","article-title":"Environmental enrichment and estrogen upregulate beta-hydroxybutyrate underlying functional improvement","volume":"15","author":"Pyo","year":"2022","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.tem.2023.10.002_bb0905","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1210\/jcem-53-2-258","article-title":"Reproductive function during fasting in men","volume":"53","author":"Klibanski","year":"1981","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2023.10.002_bb0910","first-page":"1967","article-title":"Fasting suppresses pulsatile luteinizing hormone (LH) secretion and enhances orderliness of LH release in young but not older men","volume":"83","author":"Bergendahl","year":"1998","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2023.10.002_bb0915","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1530\/EJE-14-0006","article-title":"Effect of testosterone on markers of mitochondrial oxidative phosphorylation and lipid metabolism in muscle of aging men with subnormal bioavailable testosterone","volume":"171","author":"Petersson","year":"2014","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.tem.2023.10.002_bb0920","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1056\/NEJM199607043350101","article-title":"The effects of supraphysiologic doses of testosterone on muscle size and strength in normal men","volume":"335","author":"Bhasin","year":"1996","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.tem.2023.10.002_bb0925","doi-asserted-by":"crossref","first-page":"E1172","DOI":"10.1152\/ajpendo.2001.281.6.E1172","article-title":"Testosterone dose-response relationships in healthy young men","volume":"281","author":"Bhasin","year":"2001","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2023.10.002_bb0930","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1007\/s00125-003-1324-0","article-title":"Effect of testosterone on lipolysis in human pre-adipocytes from different fat depots","volume":"47","author":"Dicker","year":"2004","journal-title":"Diabetologia"},{"key":"10.1016\/j.tem.2023.10.002_bb0935","doi-asserted-by":"crossref","first-page":"29577","DOI":"10.1074\/jbc.273.45.29577","article-title":"Peroxisome proliferator-activated receptor alpha-isoform deficiency leads to progressive dyslipidemia with sexually dimorphic obesity and steatosis","volume":"273","author":"Costet","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tem.2023.10.002_bb0940","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2020.115204","article-title":"Perfluorooctanoic acid activates multiple nuclear receptor pathways and skews expression of genes regulating cholesterol homeostasis in liver of humanized PPARalpha mice fed an American diet","volume":"405","author":"Schlezinger","year":"2020","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tem.2023.10.002_bb0945","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1172\/JCI3949","article-title":"A gender-related defect in lipid metabolism and glucose homeostasis in peroxisome proliferator-activated receptor alpha-deficient mice","volume":"102","author":"Djouadi","year":"1998","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tem.2023.10.002_bb0950","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1210\/en.2002-220630","article-title":"Sex difference in hepatic peroxisome proliferator-activated receptor alpha expression: influence of pituitary and gonadal hormones","volume":"144","author":"Jalouli","year":"2003","journal-title":"Endocrinology"}],"container-title":["Trends in Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043276023002151?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043276023002151?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T20:45:56Z","timestamp":1760906756000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043276023002151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":187,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["S1043276023002151"],"URL":"https:\/\/doi.org\/10.1016\/j.tem.2023.10.002","relation":{},"ISSN":["1043-2760"],"issn-type":[{"value":"1043-2760","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mechanisms of hepatic fatty acid oxidation and ketogenesis during fasting","name":"articletitle","label":"Article Title"},{"value":"Trends in Endocrinology & Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tem.2023.10.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}