{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T01:44:27Z","timestamp":1790300667520,"version":"4.1.0"},"reference-count":90,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T00:00:00Z","timestamp":1751932800000},"content-version":"am","delay-in-days":372,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","bmn.com","cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Endocrinology & Metabolism"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.tem.2024.02.005","type":"journal-article","created":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T00:19:26Z","timestamp":1709165966000},"page":"648-660","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Parathyroid hormone\u2013PTH1R signaling in cardiovascular disease and homeostasis"],"prefix":"10.1016","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2107-7923","authenticated-orcid":false,"given":"Dwight A.","family":"Towler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tem.2024.02.005_bb0005","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1515\/cclm-2022-0942","article-title":"Determination of parathyroid hormone: from radioimmunoassay to LCMS\/MS","volume":"61","author":"Cavalier","year":"2023","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.tem.2024.02.005_bb0010","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1002\/jbmr.4665","article-title":"Epidemiology, pathophysiology, and genetics of primary hyperparathyroidism","volume":"37","author":"Minisola","year":"2022","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.tem.2024.02.005_bb0015","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.endonu.2015.05.006","article-title":"Prevalence of secondary hyperparathyroidism in patients with stage 3 and 4 chronic kidney disease seen in internal medicine","volume":"62","author":"Bureo","year":"2015","journal-title":"Endocrinol. Nutr."},{"key":"10.1016\/j.tem.2024.02.005_bb0020","series-title":"USRDS annual data report: epidemiology of kidney disease in the United States","author":"United States Renal Data System","year":"2022"},{"key":"10.1016\/j.tem.2024.02.005_bb0025","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S0021-9258(18)84940-7","article-title":"Further studies on the physiological action of a parathyroid hormone","volume":"64","author":"Collip","year":"1925","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tem.2024.02.005_bb0030","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1126\/science.1658941","article-title":"A G protein-linked receptor for parathyroid hormone and parathyroid hormone-related peptide","volume":"254","author":"Juppner","year":"1991","journal-title":"Science"},{"key":"10.1016\/j.tem.2024.02.005_bb0035","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1210\/endo.138.1.4845","article-title":"Cell-specific expression of the parathyroid hormone (PTH)\/PTH-related peptide receptor gene in kidney from kidney-specific and ubiquitous promoters","volume":"138","author":"Amizuka","year":"1997","journal-title":"Endocrinology"},{"key":"10.1016\/j.tem.2024.02.005_bb0040","first-page":"110","article-title":"Regional and systemic hemodynamic effects of parathyroid hormone-related protein: preservation of cardiac function and coronary and renal flow with reduced blood pressure","volume":"256","author":"Roca-Cusachs","year":"1991","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.tem.2024.02.005_bb0045","doi-asserted-by":"crossref","first-page":"3024","DOI":"10.1210\/endo.136.7.7789328","article-title":"The hemodynamic basis for the cardiac effects of parathyroid hormone (PTH) and PTH-related protein","volume":"136","author":"Ogino","year":"1995","journal-title":"Endocrinology"},{"key":"10.1016\/j.tem.2024.02.005_bb0050","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1001\/jamasurg.2019.3950","article-title":"Parathyroidectomy for patients with primary hyperparathyroidism and associations with hypertension","volume":"155","author":"Graff-Baker","year":"2020","journal-title":"JAMA Surg."},{"key":"10.1016\/j.tem.2024.02.005_bb0055","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1210\/endo.136.6.7750471","article-title":"Desensitization of vascular tissue to parathyroid hormone and parathyroid hormone-related protein","volume":"136","author":"Nyby","year":"1995","journal-title":"Endocrinology"},{"key":"10.1016\/j.tem.2024.02.005_bb0060","doi-asserted-by":"crossref","first-page":"F333","DOI":"10.1152\/ajprenal.00503.2012","article-title":"Knockdown of parathyroid hormone related protein in smooth muscle cells alters renal hemodynamics but not blood pressure","volume":"305","author":"Raison","year":"2013","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.tem.2024.02.005_bb0065","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1002\/jbmr.4682","article-title":"Management of primary hyperparathyroidism","volume":"37","author":"Bilezikian","year":"2022","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.tem.2024.02.005_bb0070","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/j.1365-2265.2009.03766.x","article-title":"Increased mortality and morbidity in mild primary hyperparathyroid patients. The Parathyroid Epidemiology and Audit Research Study (PEARS)","volume":"73","author":"Yu","year":"2010","journal-title":"Clin. Endocrinol."},{"key":"10.1016\/j.tem.2024.02.005_bb0075","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1161\/CIRCULATIONAHA.111.081307","article-title":"Coronary microvascular dysfunction induced by primary hyperparathyroidism is restored after parathyroidectomy","volume":"126","author":"Osto","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.tem.2024.02.005_bb0080","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/S0008-6363(00)00130-9","article-title":"Impaired flow-mediated vasodilation of the brachial artery in patients with primary hyperparathyroidism improves after parathyroidectomy","volume":"47","author":"Kosch","year":"2000","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.tem.2024.02.005_bb0085","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2022.15396","article-title":"Analysis of comorbidities, clinical outcomes, and parathyroidectomy in adults with primary hyperparathyroidism","volume":"5","author":"Axelsson","year":"2022","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.tem.2024.02.005_bb0090","doi-asserted-by":"crossref","first-page":"e302","DOI":"10.1097\/SLA.0000000000005691","article-title":"Adverse cardiovascular outcomes among older adults with primary hyperparathyroidism treated with parathyroidectomy versus nonoperative management","volume":"278","author":"Seib","year":"2023","journal-title":"Ann. Surg."},{"key":"10.1016\/j.tem.2024.02.005_bb0095","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1097\/SLA.0000000000005999","article-title":"Parathyroidectomy and the risk of major cerebrovascular and cardiovascular events in the elderly","volume":"278","author":"Grant","year":"2023","journal-title":"Ann. Surg."},{"key":"10.1016\/j.tem.2024.02.005_bb0100","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/cen.12206","article-title":"What predicts adverse outcomes in untreated primary hyperparathyroidism? The Parathyroid Epidemiology and Audit Research Study (PEARS)","volume":"79","author":"Yu","year":"2013","journal-title":"Clin. Endocrinol."},{"key":"10.1016\/j.tem.2024.02.005_bb0105","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.1161\/CIRCULATIONAHA.106.678276","article-title":"Brachial flow-mediated dilation predicts incident cardiovascular events in older adults: the Cardiovascular Health Study","volume":"115","author":"Yeboah","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.tem.2024.02.005_bb0110","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1093\/eurheartj\/ehab775","article-title":"Coronary flow reserve and cardiovascular outcomes: a systematic review and meta-analysis","volume":"43","author":"Kelshiker","year":"2022","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.tem.2024.02.005_bb0115","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1007\/s00259-010-1599-6","article-title":"Reduced coronary flow reserve in patients with primary hyperparathyroidism: a study by G-SPECT myocardial perfusion imaging","volume":"37","author":"Marini","year":"2010","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"10.1016\/j.tem.2024.02.005_bb0120","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1093\/eurheartj\/ehac001","article-title":"Coronary flow reserve: a versatile tool for interrogating pathophysiology, and a reliable marker of cardiovascular outcomes and mortality","volume":"43","author":"Taqueti","year":"2022","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.tem.2024.02.005_bb0125","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s40618-021-01645-x","article-title":"Cardiac structural and functional abnormalities in primary hyperparathyroidism","volume":"45","author":"Purra","year":"2022","journal-title":"J. Endocrinol. Investig."},{"key":"10.1016\/j.tem.2024.02.005_bb0130","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/S0002-9149(02)02708-X","article-title":"Coronary flow reserve and myocardial diastolic dysfunction in arterial hypertension","volume":"90","author":"Galderisi","year":"2002","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.tem.2024.02.005_bb0135","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1210\/jc.2011-2107","article-title":"Aortic valve calcification in mild primary hyperparathyroidism","volume":"97","author":"Iwata","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2024.02.005_bb0140","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1038\/ki.2008.64","article-title":"Secondary hyperparathyroidism is associated with higher mortality in men with moderate to severe chronic kidney disease","volume":"73","author":"Kovesdy","year":"2008","journal-title":"Kidney Int."},{"key":"10.1016\/j.tem.2024.02.005_bb0145","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/ki.2015.72","article-title":"Parathyroidectomy and survival among Japanese hemodialysis patients with secondary hyperparathyroidism","volume":"88","author":"Komaba","year":"2015","journal-title":"Kidney Int."},{"key":"10.1016\/j.tem.2024.02.005_bb0150","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.34067\/KID.0000772020","article-title":"Parathyroid hormone serum levels and mortality among hemodialysis patients in the Gulf Cooperation Council countries: results from the DOPPS (2012\u20132018)","volume":"1","author":"Al Salmi","year":"2020","journal-title":"Kidney360"},{"key":"10.1016\/j.tem.2024.02.005_bb0155","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1210\/en.2002-221026","article-title":"Administration of PTH-(7-84) antagonizes the effects of PTH-(1-84) on bone in rats with moderate renal failure","volume":"144","author":"Langub","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.tem.2024.02.005_bb0160","doi-asserted-by":"crossref","first-page":"2772","DOI":"10.1210\/jc.2009-1909","article-title":"The calcemic response to continuous parathyroid hormone (PTH)(1-34) infusion in end-stage kidney disease varies according to bone turnover: a potential role for PTH(7-84)","volume":"95","author":"Wesseling-Perry","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2024.02.005_bb0165","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jbmr.2691","article-title":"Xeno-Klotho inhibits parathyroid hormone signaling","volume":"31","author":"Takenaka","year":"2016","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.tem.2024.02.005_bb0170","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1210\/me.2009-0098","article-title":"Endogenous parathyroid hormone-related protein regulates the expression of PTH type 1 receptor and proliferation of vascular smooth muscle cells","volume":"23","author":"Song","year":"2009","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.tem.2024.02.005_bb0175","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/nrendo.2012.36","article-title":"Arterial calcification and bone physiology: role of the bone\u2013vascular axis","volume":"8","author":"Thompson","year":"2012","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.tem.2024.02.005_bb0180","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1681\/ASN.2008070692","article-title":"Vascular calcification: the killer of patients with chronic kidney disease","volume":"20","author":"Mizobuchi","year":"2009","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.tem.2024.02.005_bb0185","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1359\/JBMR.041221","article-title":"Decrease in thoracic vertebral bone attenuation with calcium-based phosphate binders in hemodialysis","volume":"20","author":"Raggi","year":"2005","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.tem.2024.02.005_bb0190","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1681\/ASN.2014020169","article-title":"Ankle\u2013brachial index and bone turnover in patients on dialysis","volume":"26","author":"London","year":"2015","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.tem.2024.02.005_bb0195","doi-asserted-by":"crossref","first-page":"952","DOI":"10.2215\/CJN.10390917","article-title":"Parathyroidectomy in the management of secondary hyperparathyroidism","volume":"13","author":"Lau","year":"2018","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"10.1016\/j.tem.2024.02.005_bb0200","doi-asserted-by":"crossref","DOI":"10.1038\/srep19150","article-title":"Parathyroidectomy associates with reduced mortality in Taiwanese dialysis patients with hyperparathyroidism: evidence for the controversy of current guidelines","volume":"6","author":"Ho","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tem.2024.02.005_bb0205","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1111\/cen.12333","article-title":"Parathyroidectomy improves cardiovascular outcome in nondiabetic dialysis patients with secondary hyperparathyroidism","volume":"80","author":"Lin","year":"2014","journal-title":"Clin. Endocrinol."},{"key":"10.1016\/j.tem.2024.02.005_bb0210","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1038\/s41569-023-00845-7","article-title":"Calcific aortic valve disease: mechanisms, prevention and treatment","volume":"20","author":"Moncla","year":"2023","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.tem.2024.02.005_bb0215","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1161\/ATVBAHA.122.317332","article-title":"Molecular mechanisms of vascular health: insights from vascular aging and calcification","volume":"43","author":"Sutton","year":"2023","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.tem.2024.02.005_bb0220","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1093\/cvr\/cvad062","article-title":"Lipoprotein(a) and calcific aortic valve disease initiation and progression: a systematic review and meta-analysis","volume":"119","author":"Pantelidis","year":"2023","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.tem.2024.02.005_bb0225","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1016\/j.jacc.2019.02.039","article-title":"Lp(a) oxyphospholipids: markers and mediators of vascular mineral metabolism in calcific aortic valve disease","volume":"73","author":"Towler","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.tem.2024.02.005_bb0230","doi-asserted-by":"crossref","first-page":"3776","DOI":"10.3390\/ijms23073776","article-title":"Parathyroid hormone induces human valvular endothelial cells dysfunction that impacts the osteogenic phenotype of valvular interstitial cells","volume":"23","author":"Vadana","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tem.2024.02.005_bb0235","first-page":"182","article-title":"Pathophysiology of aortic valve stenosis: is it both fibrocalcific and sex specific?","volume":"32","author":"Sritharen","year":"2017","journal-title":"Physiology (Bethesda)"},{"key":"10.1016\/j.tem.2024.02.005_bb0240","doi-asserted-by":"crossref","first-page":"D831","DOI":"10.1093\/nar\/gkaa793","article-title":"The Bgee suite: integrated curated expression atlas and comparative transcriptomics in animals","volume":"49","author":"Bastian","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.tem.2024.02.005_bb0245","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.atherosclerosis.2022.04.004","article-title":"Lipoprotein(a): an underestimated inflammatory mastermind","volume":"349","author":"Dzobo","year":"2022","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.tem.2024.02.005_bb0250","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1161\/CIRCRESAHA.112.281048","article-title":"Smooth muscle cell plasticity: fact or fiction?","volume":"112","author":"Nguyen","year":"2013","journal-title":"Circ. Res."},{"key":"10.1016\/j.tem.2024.02.005_bb0255","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1161\/CIRCRESAHA.108.183053","article-title":"Smooth muscle cells give rise to osteochondrogenic precursors and chondrocytes in calcifying arteries","volume":"104","author":"Speer","year":"2009","journal-title":"Circ. Res."},{"key":"10.1016\/j.tem.2024.02.005_bb0260","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1161\/01.CIR.0000096485.64373.C5","article-title":"Multilineage potential of cells from the artery wall","volume":"108","author":"Tintut","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.tem.2024.02.005_bb0265","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.139445","article-title":"Smooth muscle-derived progenitor cell myofibroblast differentiation through KLF4 downregulation promotes arterial remodeling and fibrosis","volume":"5","author":"Lu","year":"2020","journal-title":"JCI Insight"},{"key":"10.1016\/j.tem.2024.02.005_bb0270","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1161\/01.ATV.17.6.1135","article-title":"Parathyroid hormone-related peptide as a local regulator of vascular calcification. Its inhibitory action on in vitro calcification by bovine vascular smooth muscle cells","volume":"17","author":"Jono","year":"1997","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.tem.2024.02.005_bb0275","doi-asserted-by":"crossref","first-page":"50195","DOI":"10.1074\/jbc.M308825200","article-title":"Teriparatide (human parathyroid hormone (1\u201334)) inhibits osteogenic vascular calcification in diabetic low density lipoprotein receptor-deficient mice","volume":"278","author":"Shao","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tem.2024.02.005_bb0280","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1172\/JCI24140","article-title":"Msx2 promotes cardiovascular calcification by activating paracrine Wnt signals","volume":"115","author":"Shao","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tem.2024.02.005_bb0285","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.bone.2008.07.250","article-title":"Differential effects of intermittent PTH(1-34) and PTH(7-34) on bone microarchitecture and aortic calcification in experimental renal failure","volume":"43","author":"Sebastian","year":"2008","journal-title":"Bone"},{"key":"10.1016\/j.tem.2024.02.005_bb0290","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1161\/CIRCRESAHA.110.219899","article-title":"Activation of vascular smooth muscle parathyroid hormone receptor inhibits Wnt\/beta-catenin signaling and aortic fibrosis in diabetic arteriosclerosis","volume":"107","author":"Cheng","year":"2010","journal-title":"Circ. Res."},{"key":"10.1016\/j.tem.2024.02.005_bb0295","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1161\/CIRCRESAHA.119.316141","article-title":"PTH\/PTHrP receptor signaling restricts arterial fibrosis in diabetic LDLR-\/- mice by inhibiting myocardin-related transcription factor relays","volume":"126","author":"Behrmann","year":"2020","journal-title":"Circ. Res."},{"key":"10.1016\/j.tem.2024.02.005_bb0300","doi-asserted-by":"crossref","first-page":"2488","DOI":"10.1158\/1078-0432.CCR-21-4176","article-title":"FDA approval summary: belumosudil for adult and pediatric patients 12 years and older with chronic GvHD after two or more prior lines of systemic therapy","volume":"28","author":"Przepiorka","year":"2022","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.tem.2024.02.005_bb0305","doi-asserted-by":"crossref","first-page":"G1006","DOI":"10.1152\/ajpgi.00465.2002","article-title":"Inhibition of sustained smooth muscle contraction by PKA and PKG preferentially mediated by phosphorylation of RhoA","volume":"284","author":"Murthy","year":"2003","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.tem.2024.02.005_bb0310","doi-asserted-by":"crossref","first-page":"15818","DOI":"10.1073\/pnas.2006348117","article-title":"Clonally expanding smooth muscle cells promote atherosclerosis by escaping efferocytosis and activating the complement cascade","volume":"117","author":"Wang","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.tem.2024.02.005_bb0315","doi-asserted-by":"crossref","first-page":"H659","DOI":"10.1152\/ajpheart.00333.2022","article-title":"Cardiac micro-RNA and transcriptomic profile of a novel swine model of chronic kidney disease and left ventricular diastolic dysfunction","volume":"323","author":"Chade","year":"2022","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.tem.2024.02.005_bb0320","doi-asserted-by":"crossref","first-page":"F364","DOI":"10.1152\/ajprenal.00063.2018","article-title":"A translational model of chronic kidney disease in swine","volume":"315","author":"Chade","year":"2018","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.tem.2024.02.005_bb0325","doi-asserted-by":"crossref","first-page":"3384","DOI":"10.1210\/clinem\/dgaa450","article-title":"Cardiovascular safety of abaloparatide in postmenopausal women with osteoporosis: analysis from the ACTIVE Phase 3 trial","volume":"105","author":"Cosman","year":"2020","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2024.02.005_bb0330","first-page":"2548","article-title":"Hemodynamic effects of parathyroid hormone-related peptide-(1\u201334) in humans","volume":"82","author":"Wolzt","year":"1997","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2024.02.005_bb0335","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1111\/j.1476-5381.1996.tb15635.x","article-title":"Effect of intrarenally infused parathyroid hormone-related protein on renal blood flow and glomerular filtration rate in the anaesthetized rat","volume":"118","author":"Massfelder","year":"1996","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.tem.2024.02.005_bb0340","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1172\/JCI111035","article-title":"Rapid development of renal resistance to low doses of synthetic bovine parathyroid hormone fragment 1\u201334. Dissociation of urinary cyclic adenosine monophosphate, phosphaturic, and calciuric responses","volume":"72","author":"Law","year":"1983","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tem.2024.02.005_bb0345","first-page":"F240","article-title":"Tachyphylaxis to PTH in the isolated perfused rat kidney: resistance of anticalciuria","volume":"247","author":"Besarab","year":"1984","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.tem.2024.02.005_bb0350","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/ki.1994.79","article-title":"The renal PTH\/PTHrP receptor is down-regulated in rats with chronic renal failure","volume":"45","author":"Urena","year":"1994","journal-title":"Kidney Int."},{"key":"10.1016\/j.tem.2024.02.005_bb0355","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1046\/j.1523-1755.2000.00306.x","article-title":"Down-regulation of human osteoblast PTH\/PTHrP receptor mRNA in end-stage renal failure","volume":"58","author":"Picton","year":"2000","journal-title":"Kidney Int."},{"key":"10.1016\/j.tem.2024.02.005_bb0360","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1210\/endrev\/bnac032","article-title":"Molecular mechanisms of PTH\/PTHrP class B GPCR signaling and pharmacological implications","volume":"44","author":"Vilardaga","year":"2023","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.tem.2024.02.005_bb0365","doi-asserted-by":"crossref","first-page":"7455","DOI":"10.1073\/pnas.1918158117","article-title":"Gq\/11-dependent regulation of endosomal cAMP generation by parathyroid hormone class B GPCR","volume":"117","author":"White","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.tem.2024.02.005_bb0370","doi-asserted-by":"crossref","first-page":"3294","DOI":"10.1073\/pnas.1814670116","article-title":"Ca2+ allostery in PTH-receptor signaling","volume":"116","author":"White","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.tem.2024.02.005_bb0375","doi-asserted-by":"crossref","first-page":"5110","DOI":"10.1021\/acs.jcim.1c00471","article-title":"Molecular mechanism of Ca2+ in the allosteric regulation of human parathyroid hormone receptor-1","volume":"62","author":"Li","year":"2022","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.tem.2024.02.005_bb0380","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1210\/endo-129-2-848","article-title":"Acute phosphate depletion dissociates hormonal stimulated second messengers in osteoblast-like cells","volume":"129","author":"Green","year":"1991","journal-title":"Endocrinology"},{"key":"10.1016\/j.tem.2024.02.005_bb0385","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2022.101945","article-title":"Cellular abundance of sodium phosphate cotransporter SLC20A1\/PiT1 and phosphate uptake are controlled post-transcriptionally by ESCRT","volume":"298","author":"Zechner","year":"2022","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tem.2024.02.005_bb0390","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1002\/jbmr.2532","article-title":"A homozygous [Cys25]PTH(1-84) mutation that impairs PTH\/PTHrP receptor activation defines a novel form of hypoparathyroidism","volume":"30","author":"Lee","year":"2015","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.tem.2024.02.005_bb0395","doi-asserted-by":"crossref","first-page":"3884","DOI":"10.1210\/endo.136.9.7649096","article-title":"Parathyroid hormone (PTH)\/PTH-related peptide receptor density modulates activation of phospholipase C and phosphate transport by PTH in LLC-PK1 cells","volume":"136","author":"Guo","year":"1995","journal-title":"Endocrinology"},{"key":"10.1016\/j.tem.2024.02.005_bb0400","doi-asserted-by":"crossref","first-page":"2693","DOI":"10.1161\/ATVBAHA.121.316600","article-title":"Six shades of vascular smooth muscle cells illuminated by KLF4 (Kruppel-like factor 4)","volume":"41","author":"Yap","year":"2021","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.tem.2024.02.005_bb0405","doi-asserted-by":"crossref","first-page":"2765","DOI":"10.1016\/j.devcel.2021.09.001","article-title":"H3K4 di-methylation governs smooth muscle lineage identity and promotes vascular homeostasis by restraining plasticity","volume":"56","author":"Liu","year":"2021","journal-title":"Dev. Cell"},{"key":"10.1016\/j.tem.2024.02.005_bb0410","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/nbt1281","article-title":"Therapeutic targeting of a stem cell niche","volume":"25","author":"Adams","year":"2007","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.tem.2024.02.005_bb0415","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/ncpcardio1214","article-title":"Therapeutic targeting of the stem cell niche in experimental hindlimb ischemia","volume":"5","author":"Napoli","year":"2008","journal-title":"Nat. Clin. Pract. Cardiovasc. Med."},{"key":"10.1016\/j.tem.2024.02.005_bb0420","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1002\/jbmr.2171","article-title":"Teriparatide (PTH 1-34) treatment increases peripheral hematopoietic stem cells in postmenopausal women","volume":"29","author":"Yu","year":"2014","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.tem.2024.02.005_bb0425","doi-asserted-by":"crossref","first-page":"689","DOI":"10.2174\/1381612013397825","article-title":"Molecular mechanisms of ligand recognition by parathyroid hormone 1 (PTH1) and PTH2 receptors","volume":"7","author":"Hoare","year":"2001","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.tem.2024.02.005_bb0430","series-title":"Principles of bone biology","first-page":"623","article-title":"Cardiovascular actions of parathyroid hormone\/parathyroid hormone-related protein signaling","author":"Mirfakhraee","year":"2020"},{"key":"10.1016\/j.tem.2024.02.005_bb0435","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.1002\/jbmr.4716","article-title":"Management of hypoparathyroidism","volume":"37","author":"Khan","year":"2022","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.tem.2024.02.005_bb0440","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2022.116610","article-title":"Evidence for the cardiovascular effects of osteoporosis treatments in randomized trials of post-menopausal women: a systematic review and Bayesian network meta-analysis","volume":"167","author":"Seeto","year":"2023","journal-title":"Bone"},{"key":"10.1016\/j.tem.2024.02.005_bb0445","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1038\/nature02040","article-title":"Osteoblastic cells regulate the haematopoietic stem cell niche","volume":"425","author":"Calvi","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.tem.2024.02.005_bb0450","doi-asserted-by":"crossref","first-page":"e1117","DOI":"10.1210\/clinem\/dgad201","article-title":"Stable incidence and increasing prevalence of primary hyperparathyroidism in a population-based study in Scotland","volume":"108","author":"Soto-Pedre","year":"2023","journal-title":"J. Clin. Endocrinol. Metab."}],"container-title":["Trends in Endocrinology & Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043276024000341?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043276024000341?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T19:59:17Z","timestamp":1720468757000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043276024000341"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":90,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["S1043276024000341"],"URL":"https:\/\/doi.org\/10.1016\/j.tem.2024.02.005","relation":{},"ISSN":["1043-2760"],"issn-type":[{"value":"1043-2760","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Parathyroid hormone\u2013PTH1R signaling in cardiovascular disease and homeostasis","name":"articletitle","label":"Article Title"},{"value":"Trends in Endocrinology & Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tem.2024.02.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}