{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T07:19:36Z","timestamp":1790407176436,"version":"4.1.0"},"reference-count":103,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91957202"],"award-info":[{"award-number":["91957202"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82192870"],"award-info":[{"award-number":["82192870"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012152","name":"National Postdoctoral Program for Innovative Talents","doi-asserted-by":"publisher","award":["BX20240368"],"award-info":[{"award-number":["BX20240368"]}],"id":[{"id":"10.13039\/501100012152","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012165","name":"Key Technologies Research and Development Program","doi-asserted-by":"publisher","award":["2022YFA1103600"],"award-info":[{"award-number":["2022YFA1103600"]}],"id":[{"id":"10.13039\/501100012165","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012165","name":"Key Technologies Research and Development Program","doi-asserted-by":"publisher","award":["2019YFA0801700"],"award-info":[{"award-number":["2019YFA0801700"]}],"id":[{"id":"10.13039\/501100012165","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmn.com","cell.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Endocrinology &amp; Metabolism"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.tem.2024.07.011","type":"journal-article","created":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T16:07:36Z","timestamp":1723133256000},"page":"482-494","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Pregnancy-induced metabolic reprogramming and regenerative responses to pro-aging stresses"],"prefix":"10.1016","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5045-0304","authenticated-orcid":false,"given":"Dainan","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9753-9018","authenticated-orcid":false,"given":"Lanfang","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1603-4785","authenticated-orcid":false,"given":"Hongmei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3138-9525","authenticated-orcid":false,"given":"Ng","family":"Shyh-Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tem.2024.07.011_bb0005","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/6398520","article-title":"Association of oxidative stress on pregnancy","volume":"2020","author":"Tobo\u0142a-Wr\u00f3bel","year":"2020","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.tem.2024.07.011_bb0010","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1097\/GCO.0000000000000765","article-title":"Cellular aging and telomere dynamics in pregnancy","volume":"34","author":"Panelli","year":"2022","journal-title":"Curr. Opin. Obstet. Gynecol."},{"key":"10.1016\/j.tem.2024.07.011_bb0015","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1038\/s41569-020-0390-z","article-title":"Pregnancy and cardiovascular disease","volume":"17","author":"Ramlakhan","year":"2020","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.tem.2024.07.011_bb0020","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1038\/s41574-022-00734-y","article-title":"A global view of hypertensive disorders and diabetes mellitus during pregnancy","volume":"18","author":"Jiang","year":"2022","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.tem.2024.07.011_bb0025","article-title":"Progression to type 2 diabetes in women with a known history of gestational diabetes: systematic review and meta-analysis","volume":"369","author":"Vounzoulaki","year":"2020","journal-title":"BMJ"},{"key":"10.1016\/j.tem.2024.07.011_bb0030","article-title":"A dynamic peripheral immune landscape during human pregnancy","author":"Liu","year":"2022","journal-title":"Fundam. Res."},{"key":"10.1016\/j.tem.2024.07.011_bb0035","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.cell.2023.11.043","article-title":"A multi-tissue metabolome atlas of primate pregnancy","volume":"187","author":"Yu","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.tem.2024.07.011_bb0040","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.cell.2012.07.008","article-title":"Host remodeling of the gut microbiome and metabolic changes during pregnancy","volume":"150","author":"Koren","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.tem.2024.07.011_bb0045","first-page":"229","article-title":"Pregnancy-induced physiological hypertrophy protects against cardiac ischemia-reperfusion injury","volume":"7","author":"Xiao","year":"2014","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.tem.2024.07.011_bb0050","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1101\/gad.563110","article-title":"Pregnancy restores the regenerative capacity of the aged liver via activation of an mTORC1-controlled hyperplasia\/hypertrophy switch","volume":"24","author":"Gielchinsky","year":"2010","journal-title":"Genes Dev."},{"key":"10.1016\/j.tem.2024.07.011_bb0055","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.tics.2022.12.002","article-title":"Matrescence: lifetime impact of motherhood on cognition and the brain","volume":"27","author":"Orchard","year":"2023","journal-title":"Trends Cogn. Sci."},{"key":"10.1016\/j.tem.2024.07.011_bb0060","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1111\/acel.12286","article-title":"The rejuvenating effect of pregnancy on muscle regeneration","volume":"14","author":"Falick Michaeli","year":"2015","journal-title":"Aging Cell"},{"key":"10.1016\/j.tem.2024.07.011_bb0065","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1016\/j.jacc.2022.02.020","article-title":"Infertility and risk of heart failure in the Women\u2019s Health Initiative","volume":"79","author":"Lau","year":"2022","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.tem.2024.07.011_bb0070","doi-asserted-by":"crossref","first-page":"3418","DOI":"10.1007\/s12144-020-00826-w","article-title":"Assessment of attention in biological mothers using the Attention Network Test\u2013Revised","volume":"41","author":"Miller","year":"2020","journal-title":"Curr. Psychol."},{"key":"10.1016\/j.tem.2024.07.011_bb0075","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s12883-023-03108-7","article-title":"Associations between parenthood and dementia in men and women: biology or confounding?","volume":"23","author":"Basit","year":"2023","journal-title":"BMC Neurol."},{"key":"10.1016\/j.tem.2024.07.011_bb0080","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2019.19615","article-title":"Association of parity and breastfeeding with risk of early natural menopause","volume":"3","author":"Langton","year":"2020","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.tem.2024.07.011_bb0085","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1186\/s12889-022-13039-6","article-title":"Impact of fertility on the longevity of older rural Chinese women: an analysis of a longitudinal survey","volume":"22","author":"Zhou","year":"2022","journal-title":"BMC Public Health"},{"key":"10.1016\/j.tem.2024.07.011_bb0090","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1093\/gerona\/glu055","article-title":"Stress biology and aging mechanisms: toward understanding the deep connection between adaptation to stress and longevity","volume":"69","author":"Epel","year":"2014","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.tem.2024.07.011_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2020.101093","article-title":"Pregnancy as a model for aging","volume":"62","author":"Giller","year":"2020","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.tem.2024.07.011_bb0100","doi-asserted-by":"crossref","DOI":"10.1111\/aji.13229","article-title":"Immune epigenetic age in pregnancy and 1 year after birth: associations with weight change","volume":"83","author":"Ross","year":"2020","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.tem.2024.07.011_bb0105","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.cmet.2023.03.015","article-title":"Biological age is increased by stress and restored upon recovery","volume":"35","author":"Poganik","year":"2023","journal-title":"Cell Metab."},{"key":"10.1016\/j.tem.2024.07.011_bb0110","doi-asserted-by":"crossref","DOI":"10.1177\/2516865719867090","article-title":"DNA methylation trajectories during pregnancy","volume":"12","author":"Gruzieva","year":"2019","journal-title":"Epigenet. Insights"},{"key":"10.1016\/j.tem.2024.07.011_bb0115","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1080\/15592294.2017.1411444","article-title":"SLC9B1 methylation predicts fetal intolerance of labor","volume":"13","author":"Knight","year":"2018","journal-title":"Epigenetics"},{"key":"10.1016\/j.tem.2024.07.011_bb0120","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.cmet.2024.02.016","article-title":"The effects of pregnancy, its progression, and its cessation on human (maternal) biological aging","volume":"36","author":"Pham","year":"2024","journal-title":"Cell Metab."},{"key":"10.1016\/j.tem.2024.07.011_bb0125","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2317290121","article-title":"Pregnancy is linked to faster epigenetic aging in young women","volume":"121","author":"Ryan","year":"2024","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.tem.2024.07.011_bb0130","first-page":"7922","article-title":"Copy number variation as a tool for implementing pregnancy as an aging model","volume":"15","author":"Andrawus","year":"2023","journal-title":"Aging (Albany N.Y.)"},{"key":"10.1016\/j.tem.2024.07.011_bb0135","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/nyas.14529","article-title":"The cellular mechanobiology of aging: from biology to mechanics","volume":"1491","author":"Bajpai","year":"2021","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.tem.2024.07.011_bb0140","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.neuroscience.2018.07.006","article-title":"Potential brain age reversal after pregnancy: younger brains at 4-6\u202fweeks postpartum","volume":"386","author":"Luders","year":"2018","journal-title":"Neuroscience"},{"key":"10.1016\/j.tem.2024.07.011_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.repbio.2023.100734","article-title":"Cellular senescence in normal and adverse pregnancy","volume":"23","author":"Farf\u00e1n-Labonne","year":"2023","journal-title":"Reprod. Biol."},{"key":"10.1016\/j.tem.2024.07.011_bb0150","doi-asserted-by":"crossref","first-page":"559.e1","DOI":"10.1016\/j.ajog.2023.09.003","article-title":"Accelerated epigenetic clock aging in maternal peripheral blood and preterm birth","volume":"230","author":"Gascoigne","year":"2024","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.tem.2024.07.011_bb0155","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1146\/annurev-nutr-080508-141200","article-title":"Management of the metabolic syndrome and type 2 diabetes through lifestyle modification","volume":"29","author":"Magkos","year":"2009","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.tem.2024.07.011_bb0160","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1111\/aogs.14523","article-title":"Pregnancy complications and later life women\u2019s health","volume":"102","author":"McNestry","year":"2023","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"10.1016\/j.tem.2024.07.011_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101535","article-title":"Pregnancy, preeclampsia and maternal aging: from epidemiology to functional genomics","volume":"73","author":"Miller","year":"2022","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.tem.2024.07.011_bb0170","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.earlhumdev.2016.01.004","article-title":"Benefits of aerobic or resistance training during pregnancy on maternal health and perinatal outcomes: a systematic review","volume":"94","author":"Perales","year":"2016","journal-title":"Early Hum. Dev."},{"key":"10.1016\/j.tem.2024.07.011_bb0175","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s10522-013-9429-4","article-title":"Age-dependent alteration in muscle regeneration: the critical role of tissue niche","volume":"14","author":"Barberi","year":"2013","journal-title":"Biogerontology"},{"key":"10.1016\/j.tem.2024.07.011_bb0180","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1038\/nature03260","article-title":"Rejuvenation of aged progenitor cells by exposure to a young systemic environment","volume":"433","author":"Conboy","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.tem.2024.07.011_bb0185","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1007\/s00441-014-1900-2","article-title":"Testosterone is essential for skeletal muscle growth in aged mice in a heterochronic parabiosis model","volume":"357","author":"Sinha","year":"2014","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.tem.2024.07.011_bb0190","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202001914R","article-title":"Enhancement of myogenic potential of muscle progenitor cells and muscle healing during pregnancy","volume":"35","author":"Lu","year":"2021","journal-title":"FASEB J."},{"key":"10.1016\/j.tem.2024.07.011_bb0195","first-page":"1056","article-title":"The role of satellite cells in skeletal muscle regeneration-the effect of exercise and age","volume":"10","author":"Kaczmarek","year":"2021","journal-title":"Biology (Basel)"},{"key":"10.1016\/j.tem.2024.07.011_bb0200","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1126\/science.1087573","article-title":"Notch-mediated restoration of regenerative potential to aged muscle","volume":"302","author":"Conboy","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.tem.2024.07.011_bb0205","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1007\/s40279-013-0081-6","article-title":"How sex hormones promote skeletal muscle regeneration","volume":"43","author":"Velders","year":"2013","journal-title":"Sports Med."},{"key":"10.1016\/j.tem.2024.07.011_bb0210","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.3945\/ajcn.2009.28047","article-title":"Longitudinal study of muscle strength, quality, and adipose tissue infiltration","volume":"90","author":"Delmonico","year":"2009","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.tem.2024.07.011_bb0215","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.3389\/fphys.2019.01163","article-title":"Vastus lateralis architecture changes during pregnancy - a longitudinal study","volume":"10","author":"Bey","year":"2019","journal-title":"Front. Physiol."},{"key":"10.1016\/j.tem.2024.07.011_bb0220","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1093\/cvr\/cvu009","article-title":"Maternal cardiac metabolism in pregnancy","volume":"101","author":"Liu","year":"2014","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.tem.2024.07.011_bb0225","doi-asserted-by":"crossref","first-page":"273","DOI":"10.4037\/aacnacc2018911","article-title":"Physiologic and hemodynamic changes during pregnancy","volume":"29","author":"Troiano","year":"2018","journal-title":"AACN Adv. Crit. Care"},{"key":"10.1016\/j.tem.2024.07.011_bb0230","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1093\/cvr\/cvu013","article-title":"Pregnancy as a cardiac stress model","volume":"101","author":"Chung","year":"2014","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.tem.2024.07.011_bb0235","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1161\/HYPERTENSIONAHA.106.079426","article-title":"The fuzzy logic of physiological cardiac hypertrophy","volume":"49","author":"Dorn","year":"2007","journal-title":"Hypertension"},{"key":"10.1016\/j.tem.2024.07.011_bb0240","doi-asserted-by":"crossref","first-page":"H807","DOI":"10.1152\/ajpheart.00056.2016","article-title":"Pregnancy mitigates cardiac pathology in a mouse model of left ventricular pressure overload","volume":"311","author":"Xu","year":"2016","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.tem.2024.07.011_bb0245","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1161\/CIRCIMAGING.111.970012","article-title":"Morphological and functional adaptation of the maternal heart during pregnancy","volume":"5","author":"Savu","year":"2012","journal-title":"Circ. Cardiovasc. Imaging"},{"key":"10.1016\/j.tem.2024.07.011_bb0250","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1046\/j.1469-0705.2000.00135.x","article-title":"Maternal cardiac systolic and diastolic function: relationship with uteroplacental resistances. A Doppler and echocardiographic longitudinal study","volume":"15","author":"Valensise","year":"2000","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"10.1016\/j.tem.2024.07.011_bb0255","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1161\/CIRCRESAHA.117.311456","article-title":"PDK4 inhibits cardiac pyruvate oxidation in late pregnancy","volume":"121","author":"Liu","year":"2017","journal-title":"Circ. Res."},{"key":"10.1016\/j.tem.2024.07.011_bb0260","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1161\/CIRCRESAHA.118.312017","article-title":"Metabolic coordination of physiological and pathological cardiac remodeling","volume":"123","author":"Gibb","year":"2018","journal-title":"Circ. Res."},{"key":"10.1016\/j.tem.2024.07.011_bb0265","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1093\/cvr\/cvx088","article-title":"Fgf21 is required for cardiac remodeling in pregnancy","volume":"113","author":"Redondo-Angulo","year":"2017","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.tem.2024.07.011_bb0270","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1146\/annurev-physiol-020518-114435","article-title":"Plasticity of the maternal vasculature during pregnancy","volume":"81","author":"Osol","year":"2019","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.tem.2024.07.011_bb0275","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.jss.2013.05.084","article-title":"Cardioprotection by placenta-derived stromal cells in a murine myocardial infarction model","volume":"185","author":"Roy","year":"2013","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.tem.2024.07.011_bb0280","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.brainres.2009.12.029","article-title":"Pregnancy inhibits cell proliferation and neuroblast differentiation without neuronal damage in the hippocampal dentate gyrus in C57BL\/6N mice","volume":"1315","author":"Kim","year":"2010","journal-title":"Brain Res."},{"key":"10.1016\/j.tem.2024.07.011_bb0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2020.107950","article-title":"Effect of sertraline on central serotonin and hippocampal plasticity in pregnant and non-pregnant rats","volume":"166","author":"Pawluski","year":"2020","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.tem.2024.07.011_bb0290","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1126\/science.1076647","article-title":"Pregnancy-stimulated neurogenesis in the adult female forebrain mediated by prolactin","volume":"299","author":"Shingo","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.tem.2024.07.011_bb0295","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.brainresbull.2009.08.011","article-title":"Effects of maternal behavior induction and pup exposure on neurogenesis in adult, virgin female rats","volume":"80","author":"Furuta","year":"2009","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.tem.2024.07.011_bb0300","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1126\/science.abo5199","article-title":"Pregnancy-responsive pools of adult neural stem cells for transient neurogenesis in mothers","volume":"382","author":"Chaker","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.tem.2024.07.011_bb0305","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/j.neuroscience.2006.01.040","article-title":"The aging hippocampus: a multi-level analysis in the rat","volume":"139","author":"Driscoll","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.tem.2024.07.011_bb0310","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neurobiolaging.2019.01.021","article-title":"Early and late effects of maternal experience on hippocampal neurogenesis, microglia, and the circulating cytokine milieu","volume":"78","author":"Eid","year":"2019","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.tem.2024.07.011_bb0315","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jns.2009.06.040","article-title":"Pregnancy, prolactin and white matter regeneration","volume":"285","author":"Gregg","year":"2009","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.tem.2024.07.011_bb0320","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/s41572-018-0041-4","article-title":"Multiple sclerosis","volume":"4","author":"Filippi","year":"2018","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.tem.2024.07.011_bb0325","doi-asserted-by":"crossref","first-page":"e1939","DOI":"10.1212\/WNL.0000000000009374","article-title":"Pregnancy-related relapses and breastfeeding in a contemporary multiple sclerosis cohort","volume":"94","author":"Langer-Gould","year":"2020","journal-title":"Neurology"},{"key":"10.1016\/j.tem.2024.07.011_bb0330","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2023.103388","article-title":"Conceiving complexity: biological mechanisms underpinning the lasting effect of pregnancy on multiple sclerosis outcomes","volume":"22","author":"Campagna","year":"2023","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.tem.2024.07.011_bb0335","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/3651735","article-title":"Reproduction-associated hormones and adult hippocampal neurogenesis","volume":"2021","author":"Wan","year":"2021","journal-title":"Neural Plast."},{"key":"10.1016\/j.tem.2024.07.011_bb0340","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.neuroscience.2015.01.048","article-title":"Effects of stress early in gestation on hippocampal neurogenesis and glucocorticoid receptor density in pregnant rats","volume":"290","author":"Pawluski","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.tem.2024.07.011_bb0345","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3109\/03009734.2016.1165776","article-title":"Beta cell adaptation in pregnancy: a tribute to Claes Hellerstr\u00f6m","volume":"121","author":"Nielsen","year":"2016","journal-title":"Ups. J. Med. Sci."},{"key":"10.1016\/j.tem.2024.07.011_bb0350","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1038\/nature08894","article-title":"Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss","volume":"464","author":"Thorel","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.tem.2024.07.011_bb0355","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/nature13633","article-title":"Diabetes recovery by age-dependent conversion of pancreatic \u03b4-cells into insulin producers","volume":"514","author":"Chera","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.tem.2024.07.011_bb0360","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1007\/s00125-015-3670-0","article-title":"Prolactin-stimulated survivin induction is required for beta cell mass expansion during pregnancy in mice","volume":"58","author":"Xu","year":"2015","journal-title":"Diabetologia"},{"key":"10.1016\/j.tem.2024.07.011_bb0365","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1038\/nm.2173","article-title":"Serotonin regulates pancreatic beta cell mass during pregnancy","volume":"16","author":"Kim","year":"2010","journal-title":"Nat. Med."},{"key":"10.1016\/j.tem.2024.07.011_bb0370","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/nrendo.2016.147","article-title":"Impact of islet architecture on \u03b2-cell heterogeneity, plasticity and function","volume":"12","author":"Roscioni","year":"2016","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.tem.2024.07.011_bb0375","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.tem.2009.11.001","article-title":"Expansion of beta-cell mass in response to pregnancy","volume":"21","author":"Rieck","year":"2010","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.tem.2024.07.011_bb0380","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nature02520","article-title":"Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation","volume":"429","author":"Dor","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.tem.2024.07.011_bb0385","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1210\/en.2008-1003","article-title":"Prolactin receptor is required for normal glucose homeostasis and modulation of beta-cell mass during pregnancy","volume":"150","author":"Huang","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.tem.2024.07.011_bb0390","doi-asserted-by":"crossref","first-page":"125","DOI":"10.4161\/org.6.2.10374","article-title":"Non-\u03b2-cell progenitors of \u03b2-cells in pregnant mice","volume":"6","author":"Abouna","year":"2010","journal-title":"Organogenesis"},{"key":"10.1016\/j.tem.2024.07.011_bb0395","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1007\/s00125-010-1809-6","article-title":"Adaptive changes in pancreatic beta cell fractional area and beta cell turnover in human pregnancy","volume":"53","author":"Butler","year":"2010","journal-title":"Diabetologia"},{"key":"10.1016\/j.tem.2024.07.011_bb0400","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.cell.2014.09.040","article-title":"Generation of functional human pancreatic \u03b2 cells in vitro","volume":"159","author":"Pagliuca","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.tem.2024.07.011_bb0405","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.cell.2007.12.015","article-title":"Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas","volume":"132","author":"Xu","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.tem.2024.07.011_bb0410","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.cell.2016.11.002","article-title":"Long-term GABA administration induces alpha cell-mediated beta-like cell neogenesis","volume":"168","author":"Ben-Othman","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.tem.2024.07.011_bb0415","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/nature07314","article-title":"In vivo reprogramming of adult pancreatic exocrine cells to beta-cells","volume":"455","author":"Zhou","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.tem.2024.07.011_bb0420","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/nrendo.2015.9","article-title":"Diabetes mellitus \u2013 advances and challenges in human \u03b2-cell proliferation","volume":"11","author":"Wang","year":"2015","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.tem.2024.07.011_bb0425","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2107269118","article-title":"Pregnancy and weaning regulate human maternal liver size and function","volume":"118","author":"Bartlett","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.tem.2024.07.011_bb0430","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1258\/ebm.2011.011076","article-title":"Maternal hepatic growth response to pregnancy in the mouse","volume":"236","author":"Dai","year":"2011","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"10.1016\/j.tem.2024.07.011_bb0435","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2023.1165651","article-title":"Biomechanics in liver regeneration after partial hepatectomy","volume":"11","author":"Wu","year":"2023","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.tem.2024.07.011_bb0440","doi-asserted-by":"crossref","first-page":"G772","DOI":"10.1152\/ajpgi.00125.2019","article-title":"Pregnancy facilitates maternal liver regeneration after partial hepatectomy","volume":"318","author":"Lee","year":"2020","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.tem.2024.07.011_bb0445","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1159\/000374068","article-title":"Telocytes in pregnancy-induced physiological liver growth","volume":"36","author":"Wang","year":"2015","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.tem.2024.07.011_bb0450","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1016\/j.stem.2023.09.002","article-title":"Spatial-temporal proliferation of hepatocytes during pregnancy revealed by genetic lineage tracing","volume":"30","author":"He","year":"2023","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.tem.2024.07.011_bb0455","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.stem.2023.04.007","article-title":"IGFBP2 expressing midlobular hepatocytes preferentially contribute to liver homeostasis and regeneration","volume":"30","author":"Lin","year":"2023","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.tem.2024.07.011_bb0460","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1053\/j.gastro.2015.05.043","article-title":"Fibroblast growth factor signaling controls liver size in mice with humanized livers","volume":"149","author":"Naugler","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1016\/j.tem.2024.07.011_bb0465","doi-asserted-by":"crossref","first-page":"R720","DOI":"10.1152\/ajpregu.00282.2013","article-title":"Prolactin promotes normal liver growth, survival, and regeneration in rodents: effects on hepatic IL-6, suppressor of cytokine signaling-3, and angiogenesis","volume":"305","author":"Moreno-Carranza","year":"2013","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.tem.2024.07.011_bb0470","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1248\/bpb.b18-00712","article-title":"Human placenta hydrolysate promotes liver regeneration via activation of the cytokine\/growth factor-mediated pathway and anti-oxidative effect","volume":"42","author":"Lee","year":"2019","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.tem.2024.07.011_bb0475","doi-asserted-by":"crossref","first-page":"231","DOI":"10.4161\/isl.3.5.15940","article-title":"Histopathology and ex vivo insulin secretion of pancreatic islets in gestational diabetes: a case report","volume":"3","author":"Tancredi","year":"2011","journal-title":"Islets"},{"key":"10.1016\/j.tem.2024.07.011_bb0480","doi-asserted-by":"crossref","first-page":"64","DOI":"10.2337\/diab.30.1.64","article-title":"Responses of neonatal rat islets to streptozotocin: limited B-cell regeneration and hyperglycemia","volume":"30","author":"Bonner-Weir","year":"1981","journal-title":"Diabetes"},{"key":"10.1016\/j.tem.2024.07.011_bb0485","doi-asserted-by":"crossref","first-page":"5303","DOI":"10.3390\/jcm12165303","article-title":"Analysis of clinical profiles and echocardiographic cardiac outcomes in peripartum cardiomyopathy (PPCM) vs. PPCM with co-existing hypertensive pregnancy disorder (HPD-PPCM) patients: a systematic review and meta-analysis","volume":"12","author":"Nugrahani","year":"2023","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.tem.2024.07.011_bb0490","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1097\/GCO.0000000000000419","article-title":"Cardiovascular origins of preeclampsia","volume":"29","author":"Kalafat","year":"2017","journal-title":"Curr. Opin. Obstet. Gynecol."},{"key":"10.1016\/j.tem.2024.07.011_bb0495","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2020.147018","article-title":"Silencing of RGS2 enhances hippocampal neuron regeneration and rescues depression-like behavioral impairments through activation of cAMP pathway","volume":"1746","author":"Zhu","year":"2020","journal-title":"Brain Res."},{"key":"10.1016\/j.tem.2024.07.011_bb0500","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1089\/jwh.2020.8862","article-title":"Perinatal depression: challenges and opportunities","volume":"30","author":"Dagher","year":"2021","journal-title":"J. Women's Health (Larchmt)"},{"key":"10.1016\/j.tem.2024.07.011_bb0505","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1017\/S1092852914000480","article-title":"The role of reproductive hormones in postpartum depression","volume":"20","author":"Schiller","year":"2015","journal-title":"CNS Spectr."},{"key":"10.1016\/j.tem.2024.07.011_bb0510","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.neuron.2019.02.023","article-title":"Perinatal depression: embracing variability toward better treatment and outcomes","volume":"102","author":"Galea","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.tem.2024.07.011_bb0515","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.biopsych.2015.04.015","article-title":"Role of serotonin transporter changes in depressive responses to sex-steroid hormone manipulation: a positron emission tomography study","volume":"78","author":"Frokjaer","year":"2015","journal-title":"Biol. Psychiatry"}],"container-title":["Trends in Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043276024001929?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043276024001929?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T14:40:28Z","timestamp":1762353628000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043276024001929"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":103,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["S1043276024001929"],"URL":"https:\/\/doi.org\/10.1016\/j.tem.2024.07.011","relation":{},"ISSN":["1043-2760"],"issn-type":[{"value":"1043-2760","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pregnancy-induced metabolic reprogramming and regenerative responses to pro-aging stresses","name":"articletitle","label":"Article Title"},{"value":"Trends in Endocrinology & Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tem.2024.07.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}