{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T03:08:54Z","timestamp":1790046534727,"version":"4.0.1"},"reference-count":128,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T00:00:00Z","timestamp":1758326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"NHLBI","doi-asserted-by":"publisher","award":["R01 HL159461"],"award-info":[{"award-number":["R01 HL159461"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"NIA","doi-asserted-by":"publisher","award":["R01AG082801"],"award-info":[{"award-number":["R01AG082801"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"NIA","doi-asserted-by":"publisher","award":["P30AG024827"],"award-info":[{"award-number":["P30AG024827"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"NIA","doi-asserted-by":"publisher","award":["1R01AG082696"],"award-info":[{"award-number":["1R01AG082696"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"NIA","doi-asserted-by":"publisher","award":["R03CA286521"],"award-info":[{"award-number":["R03CA286521"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000915","name":"Richard King Mellon Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000915","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"NIH NIGMS","doi-asserted-by":"publisher","award":["R35GM146869"],"award-info":[{"award-number":["R35GM146869"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Endocrinology & Metabolism"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.tem.2025.09.006","type":"journal-article","created":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T23:09:57Z","timestamp":1759792197000},"page":"550-565","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Methionine restriction and mimetics to ameliorate human aging and disease"],"prefix":"10.1016","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9852-8329","authenticated-orcid":false,"given":"Andrey A.","family":"Parkhitko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8447-0439","authenticated-orcid":false,"given":"Sudipta","family":"Pathak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1267-7575","authenticated-orcid":false,"given":"Jay E.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0049-2677","authenticated-orcid":false,"given":"Bettina","family":"Mittendorfer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5287-9246","authenticated-orcid":false,"given":"Matthew L.","family":"Steinhauser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tem.2025.09.006_bb0005","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.ads1532","article-title":"Dietary methionine restriction started late in life promotes healthy aging in a sex-specific manner","volume":"11","author":"Hernandez-Arciga","year":"2025","journal-title":"Sci. Adv."},{"key":"10.1016\/j.tem.2025.09.006_bb0010","doi-asserted-by":"crossref","DOI":"10.1111\/acel.14277","article-title":"Unique tau- and synuclein-dependent metabolic reprogramming in neurons distinct from normal aging","volume":"23","author":"Yadav","year":"2024","journal-title":"Aging Cell"},{"key":"10.1016\/j.tem.2025.09.006_bb0015","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1101\/gad.282277.116","article-title":"Tissue-specific down-regulation of S-adenosyl-homocysteine via suppression of dAhcyL1\/dAhcyL2 extends health span and life span in Drosophila","volume":"30","author":"Parkhitko","year":"2016","journal-title":"Genes Dev."},{"key":"10.1016\/j.tem.2025.09.006_bb0020","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.cmet.2015.07.005","article-title":"Organization of the mammalian metabolome according to organ function, lineage specialization, and longevity","volume":"22","author":"Ma","year":"2015","journal-title":"Cell Metab."},{"key":"10.1016\/j.tem.2025.09.006_bb0025","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.58053","article-title":"Downregulation of the tyrosine degradation pathway extends Drosophila lifespan","volume":"9","author":"Parkhitko","year":"2020","journal-title":"Elife"},{"key":"10.1016\/j.tem.2025.09.006_bb0030","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.mad.2006.01.001","article-title":"Methionine flux to transsulfuration is enhanced in the long living Ames dwarf mouse","volume":"127","author":"Uthus","year":"2006","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.tem.2025.09.006_bb0035","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1111\/acel.12266","article-title":"Methionine restriction slows down senescence in human diploid fibroblasts","volume":"13","author":"Koziel","year":"2014","journal-title":"Aging Cell"},{"key":"10.1016\/j.tem.2025.09.006_bb0040","doi-asserted-by":"crossref","first-page":"3592","DOI":"10.1038\/ncomms4592","article-title":"Methionine restriction extends lifespan of Drosophila melanogaster under conditions of low amino-acid status","volume":"5","author":"Lee","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tem.2025.09.006_bb0045","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1093\/jn\/123.2.269","article-title":"Low methionine ingestion by rats extends life span","volume":"123","author":"Orentreich","year":"1993","journal-title":"J. Nutr."},{"key":"10.1016\/j.tem.2025.09.006_bb0050","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.1474-9726.2005.00152.x","article-title":"Methionine-deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF-I and insulin levels, and increases hepatocyte MIF levels and stress resistance","volume":"4","author":"Miller","year":"2005","journal-title":"Aging Cell"},{"key":"10.1016\/j.tem.2025.09.006_bb0055","doi-asserted-by":"crossref","first-page":"116","DOI":"10.3390\/nu15010116","article-title":"The association between methionine intake and diabetes in Chinese adults \u2013 results from the China Health and Nutrition Survey","volume":"15","author":"Sun","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.tem.2025.09.006_bb0060","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.numecd.2005.05.005","article-title":"High dietary methionine intake increases the risk of acute coronary events in middle-aged men","volume":"16","author":"Virtanen","year":"2006","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"10.1016\/j.tem.2025.09.006_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102595","article-title":"Effects of methionine intake on cognitive function in mild cognitive impairment patients and APP\/PS1 Alzheimer's disease model mice: role of the cystathionine-beta-synthase\/H(2)S pathway","volume":"59","author":"Xi","year":"2023","journal-title":"Redox Biol."},{"key":"10.1016\/j.tem.2025.09.006_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103192","article-title":"Dietary sulfur amino acid restriction in humans with overweight and obesity: evidence of an altered plasma and urine sulfurome, and a novel metabolic signature that correlates with loss of fat mass and adipose tissue gene expression","volume":"73","author":"Olsen","year":"2024","journal-title":"Redox Biol."},{"key":"10.1016\/j.tem.2025.09.006_bb0075","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s12967-023-04833-w","article-title":"Dietary sulfur amino acid restriction in humans with overweight and obesity: a translational randomized controlled trial","volume":"22","author":"Olsen","year":"2024","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.tem.2025.09.006_bb0080","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s12603-023-1883-3","article-title":"Dietary methionine and total sulfur amino acid restriction in healthy adults","volume":"27","author":"Richie","year":"2023","journal-title":"J. Nutr. Health Aging"},{"key":"10.1016\/j.tem.2025.09.006_bb0085","doi-asserted-by":"crossref","first-page":"E836","DOI":"10.1210\/jc.2010-2493","article-title":"Dietary methionine restriction increases fat oxidation in obese adults with metabolic syndrome","volume":"96","author":"Plaisance","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2025.09.006_bb0090","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/jcb.25604","article-title":"Methionine-restricted diet increases miRNAs that can target RUNX2 expression and alters bone structure in young mice","volume":"118","author":"Plummer","year":"2017","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.tem.2025.09.006_bb0095","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.bonr.2016.02.002","article-title":"Methionine restriction alters bone morphology and affects osteoblast differentiation","volume":"5","author":"Ouattara","year":"2016","journal-title":"Bone Rep."},{"key":"10.1016\/j.tem.2025.09.006_bb0100","doi-asserted-by":"crossref","first-page":"621","DOI":"10.3945\/jn.113.187922","article-title":"A methionine-restricted diet and endurance exercise decrease bone mass and extrinsic strength but increase intrinsic strength in growing male rats","volume":"144","author":"Huang","year":"2014","journal-title":"J. Nutr."},{"key":"10.1016\/j.tem.2025.09.006_bb0105","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0051357","article-title":"Methionine-restricted C57BL\/6J mice are resistant to diet-induced obesity and insulin resistance but have low bone density","volume":"7","author":"Ables","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.tem.2025.09.006_bb0110","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13629","article-title":"Intermittent methionine restriction reduces IGF-1 levels and produces similar healthspan benefits to continuous methionine restriction","volume":"21","author":"Plummer","year":"2022","journal-title":"Aging Cell"},{"key":"10.1016\/j.tem.2025.09.006_bb0115","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1126\/science.aao3265","article-title":"SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway","volume":"358","author":"Gu","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.tem.2025.09.006_bb0120","first-page":"R728","article-title":"Dietary methionine restriction enhances metabolic flexibility and increases uncoupled respiration in both fed and fasted states","volume":"299","author":"Hasek","year":"2010","journal-title":"Am. J. Phys. Regul. Integr. Comp. Phys."},{"key":"10.1016\/j.tem.2025.09.006_bb0125","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.2337\/db15-1324","article-title":"Role of GCN2-independent signaling through a noncanonical PERK\/NRF2 pathway in the physiological responses to dietary methionine restriction","volume":"65","author":"Wanders","year":"2016","journal-title":"Diabetes"},{"key":"10.1016\/j.tem.2025.09.006_bb0130","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1002\/oby.22763","article-title":"Weight loss and concomitant adipose autophagy in methionine-restricted obese mice is not dependent on adiponectin or FGF21","volume":"28","author":"Cooke","year":"2020","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.tem.2025.09.006_bb0135","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1096\/fj.14-270348","article-title":"UCP1 is an essential mediator of the effects of methionine restriction on energy balance but not insulin sensitivity","volume":"29","author":"Wanders","year":"2015","journal-title":"FASEB J."},{"key":"10.1016\/j.tem.2025.09.006_bb0140","doi-asserted-by":"crossref","first-page":"3003","DOI":"10.1007\/s11357-023-00857-8","article-title":"Sexually dimorphic effects of methionine sulfoxide reductase A (MsrA) on murine longevity and health span during methionine restriction","volume":"45","author":"Thyne","year":"2023","journal-title":"Geroscience"},{"key":"10.1016\/j.tem.2025.09.006_bb0145","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aba1306","article-title":"Life span extension by glucose restriction is abrogated by methionine supplementation: cross-talk between glucose and methionine and implication of methionine as a key regulator of life span","volume":"6","author":"Zou","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.tem.2025.09.006_bb0150","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1038\/nature08619","article-title":"Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila","volume":"462","author":"Grandison","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.tem.2025.09.006_bb0155","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.tips.2024.03.002","article-title":"Targeting methionine metabolism in cancer: opportunities and challenges","volume":"45","author":"Bin","year":"2024","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.tem.2025.09.006_bb0160","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.tem.2024.01.009","article-title":"Dietary methionine restriction in cancer development and antitumor immunity","volume":"35","author":"Ji","year":"2024","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.tem.2025.09.006_bb0165","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1517\/14712598.2015.963050","article-title":"Development of recombinant methioninase to target the general cancer-specific metabolic defect of methionine dependence: a 40-year odyssey","volume":"15","author":"Hoffman","year":"2015","journal-title":"Expert. Opin. Biol. Ther."},{"key":"10.1016\/j.tem.2025.09.006_bb0170","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1006\/prep.1996.0700","article-title":"Overexpression and large-scale production of recombinant L-methionine-alpha-deamino-gamma-mercaptomethane-lyase for novel anticancer therapy","volume":"9","author":"Tan","year":"1997","journal-title":"Protein Expr. Purif."},{"key":"10.1016\/j.tem.2025.09.006_bb0175","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1073\/pnas.73.5.1523","article-title":"High in vivo rates of methionine biosynthesis in transformed human and malignant rat cells auxotrophic for methionine","volume":"73","author":"Hoffman","year":"1976","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tem.2025.09.006_bb0180","doi-asserted-by":"crossref","first-page":"3857","DOI":"10.21873\/anticanres.15877","article-title":"Long-term stable disease in a rectal-cancer patient treated by methionine restriction with oral recombinant methioninase and a low-methionine diet","volume":"42","author":"Kubota","year":"2022","journal-title":"Anticancer Res."},{"key":"10.1016\/j.tem.2025.09.006_bb0185","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.21873\/invivo.12488","article-title":"Chronic treatment of an advanced prostate-cancer patient with oral methioninase resulted in long-term stabilization of rapidly rising PSA levels","volume":"35","author":"Han","year":"2021","journal-title":"In Vivo"},{"key":"10.1016\/j.tem.2025.09.006_bb0190","first-page":"717","article-title":"Human tumors are methionine dependent in vivo","volume":"15","author":"Hoshiya","year":"1995","journal-title":"Anticancer Res."},{"key":"10.1016\/j.tem.2025.09.006_bb0195","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1038\/s42255-023-00854-3","article-title":"Methionine restriction-induced sulfur deficiency impairs antitumour immunity partially through gut microbiota","volume":"5","author":"Ji","year":"2023","journal-title":"Nat. Metab."},{"key":"10.1016\/j.tem.2025.09.006_bb0200","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/s41586-020-2682-1","article-title":"Cancer SLC43A2 alters T cell methionine metabolism and histone methylation","volume":"585","author":"Bian","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.tem.2025.09.006_bb0205","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.44210","article-title":"Antigen receptor control of methionine metabolism in T cells","volume":"8","author":"Sinclair","year":"2019","journal-title":"Elife"},{"key":"10.1016\/j.tem.2025.09.006_bb0210","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1038\/s41467-023-38316-9","article-title":"Methionine consumption by cancer cells drives a progressive upregulation of PD-1 expression in CD4 T cells","volume":"14","author":"Pandit","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tem.2025.09.006_bb0215","first-page":"1862","article-title":"Isolation and purification of L-methionine-alpha-deamino-gamma-mercaptomethane-lyase (L-methioninase) from Clostridium sporogenes","volume":"33","author":"Kreis","year":"1973","journal-title":"Cancer Res."},{"key":"10.1016\/j.tem.2025.09.006_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbapap.2023.140991","article-title":"Methionine gamma lyase: Structure\u2013activity relationships and therapeutic applications","volume":"1872","author":"Raboni","year":"2024","journal-title":"Biochim. Biophys. Acta, Proteins Proteomics"},{"key":"10.1016\/j.tem.2025.09.006_bb0225","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1002\/iub.255","article-title":"Methionine gamma-lyase: the unique reaction mechanism, physiological roles, and therapeutic applications against infectious diseases and cancers","volume":"61","author":"Sato","year":"2009","journal-title":"IUBMB Life"},{"key":"10.1016\/j.tem.2025.09.006_bb0230","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adu1710","article-title":"Xenotopic synthetic biology: prospective tools for delaying aging and age-related diseases","volume":"11","author":"Parkhitko","year":"2025","journal-title":"Sci. Adv."},{"key":"10.1016\/j.tem.2025.09.006_bb0235","doi-asserted-by":"crossref","first-page":"301","DOI":"10.3389\/fcell.2019.00301","article-title":"Extension of cellular lifespan by methionine restriction involves alterations in central carbon metabolism and is mitophagy-dependent","volume":"7","author":"Plummer","year":"2019","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.tem.2025.09.006_bb0240","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2110387118","article-title":"A genetic model of methionine restriction extends Drosophila health- and lifespan","volume":"118","author":"Parkhitko","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tem.2025.09.006_bb0245","doi-asserted-by":"crossref","first-page":"973","DOI":"10.21873\/invivo.11865","article-title":"Oral recombinant methioninase inhibits diabetes onset in mice on a high-fat diet","volume":"34","author":"Tashiro","year":"2020","journal-title":"In Vivo"},{"key":"10.1016\/j.tem.2025.09.006_bb0250","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1158\/1078-0432.CCR-03-0068","article-title":"Pharmacokinetics, methionine depletion, and antigenicity of recombinant methioninase in primates","volume":"10","author":"Yang","year":"2004","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.tem.2025.09.006_bb0255","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/978-1-4939-8796-2_17","article-title":"Pilot Phase I clinical trial of methioninase on high-stage cancer patients: rapid depletion of circulating methionine","volume":"1866","author":"Hoffman","year":"2019","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.tem.2025.09.006_bb0260","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1517\/14712598.2012.636349","article-title":"Targeting methionine auxotrophy in cancer: discovery & exploration","volume":"12","author":"Agrawal","year":"2012","journal-title":"Expert. Opin. Biol. Ther."},{"key":"10.1016\/j.tem.2025.09.006_bb0265","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.bcp.2018.05.003","article-title":"Exploiting methionine restriction for cancer treatment","volume":"154","author":"Chaturvedi","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.tem.2025.09.006_bb0270","first-page":"17141","article-title":"Depletion of L-methionine in foods with an engineered thermophilic methionine gamma-lyase efficiently inhibits tumor growth","volume":"71","author":"Hu","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.tem.2025.09.006_bb0275","doi-asserted-by":"crossref","first-page":"13000","DOI":"10.1073\/pnas.1917362117","article-title":"Enzyme-mediated depletion of serum l-Met abrogates prostate cancer growth via multiple mechanisms without evidence of systemic toxicity","volume":"117","author":"Lu","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tem.2025.09.006_bb0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2021.102470","article-title":"Implementation of dietary methionine restriction using casein after selective, oxidative deletion of methionine","volume":"24","author":"Fang","year":"2021","journal-title":"iScience"},{"key":"10.1016\/j.tem.2025.09.006_bb0285","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1146\/annurev.bi.44.070175.002251","article-title":"Biological methylation: selected aspects","volume":"44","author":"Cantoni","year":"1975","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.tem.2025.09.006_bb0290","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13034","article-title":"Methionine metabolism and methyltransferases in the regulation of aging and lifespan extension across species","volume":"18","author":"Parkhitko","year":"2019","journal-title":"Aging Cell"},{"key":"10.1016\/j.tem.2025.09.006_bb0295","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/0955-2863(90)90070-2","article-title":"Methionine metabolism in mammals","volume":"1","author":"Finkelstein","year":"1990","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.tem.2025.09.006_bb0300","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1177\/1535370217740860","article-title":"Methionine adenosyltransferases in cancers: mechanisms of dysregulation and implications for therapy","volume":"243","author":"Maldonado","year":"2018","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"10.1016\/j.tem.2025.09.006_bb0305","doi-asserted-by":"crossref","first-page":"9531","DOI":"10.1021\/acs.jmedchem.2c00395","article-title":"Overview of methionine adenosyltransferase 2A (MAT2A) as an anticancer target: structure, function, and inhibitors","volume":"65","author":"Li","year":"2022","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.tem.2025.09.006_bb0310","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/s41467-024-55316-5","article-title":"MAT2A inhibitor AG-270\/S095033 in patients with advanced malignancies: a phase I trial","volume":"16","author":"Gounder","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tem.2025.09.006_bb0315","doi-asserted-by":"crossref","first-page":"4600","DOI":"10.1021\/acs.jmedchem.1c01595","article-title":"Leveraging structure-based drug design to identify next-generation MAT2A inhibitors, including brain-penetrant and peripherally efficacious leads","volume":"65","author":"Li","year":"2022","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.tem.2025.09.006_bb0320","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.tips.2021.07.004","article-title":"Targeting methionine aminopeptidase 2 in cancer, obesity, and autoimmunity","volume":"42","author":"Goya Grocin","year":"2021","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.tem.2025.09.006_bb0325","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/S0300-9084(01)01344-X","article-title":"Protection of translation initiation factor eIF2 phosphorylation correlates with eIF2-associated glycoprotein p67 levels and requires the lysine-rich domain I of p67","volume":"83","author":"Datta","year":"2001","journal-title":"Biochimie"},{"key":"10.1016\/j.tem.2025.09.006_bb0330","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1002\/oby.20356","article-title":"Ascending dose-controlled trial of beloranib, a novel obesity treatment for safety, tolerability, and weight loss in obese women","volume":"21","author":"Hughes","year":"2013","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.tem.2025.09.006_bb0335","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1038\/oby.2012.87","article-title":"The angiogenic inhibitor TNP-470 decreases caloric intake and weight gain in high-fat fed mice","volume":"20","author":"White","year":"2012","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.tem.2025.09.006_bb0340","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1677\/jme.1.02165","article-title":"Assessment of the anti-obesity effects of the TNP-470 analog, CKD-732","volume":"38","author":"Kim","year":"2007","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.tem.2025.09.006_bb0345","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.clinthera.2023.06.003","article-title":"Pharmaceutical therapies for the treatment of obesity: a network meta-analysis","volume":"45","author":"Morsali","year":"2023","journal-title":"Clin. Ther."},{"key":"10.1016\/j.tem.2025.09.006_bb0350","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.chom.2024.01.005","article-title":"The live biotherapeutic SYNB1353 decreases plasma methionine via directed degradation in animal models and healthy volunteers","volume":"32","author":"Perreault","year":"2024","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.tem.2025.09.006_bb0355","article-title":"Targeted deprivation of methionine with engineered Salmonella leads to oncolysis and suppression of metastasis in broad types of animal tumor models","volume":"4","author":"Zhou","year":"2023","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.tem.2025.09.006_bb0360","first-page":"4642","article-title":"Old-age-induced obesity reversed by a methionine-deficient diet or oral administration of recombinant methioninase-producing Escherichia coli in C57BL\/6 mice","volume":"15","author":"Kubota","year":"2023","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.tem.2025.09.006_bb0365","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1200\/JCO.2002.20.1.142","article-title":"Phase I study of the intravenous administration of attenuated Salmonella typhimurium to patients with metastatic melanoma","volume":"20","author":"Toso","year":"2002","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.tem.2025.09.006_bb0370","doi-asserted-by":"crossref","first-page":"247","DOI":"10.21873\/cgp.20499","article-title":"Engineered methioninase-expressing tumor-targeting Salmonella typhimurium A1-R inhibits syngeneic-cancer mouse models by depleting tumor methionine","volume":"22","author":"Kubota","year":"2025","journal-title":"Cancer Genomics Proteomics"},{"key":"10.1016\/j.tem.2025.09.006_bb0375","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/j.1474-9726.2006.00220.x","article-title":"Methionine restriction decreases visceral fat mass and preserves insulin action in aging male Fischer 344 rats independent of energy restriction","volume":"5","author":"Malloy","year":"2006","journal-title":"Aging Cell"},{"key":"10.1016\/j.tem.2025.09.006_bb0380","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1111\/acel.12269","article-title":"Growth hormone signaling is necessary for lifespan extension by dietary methionine","volume":"13","author":"Brown-Borg","year":"2014","journal-title":"Aging Cell"},{"key":"10.1016\/j.tem.2025.09.006_bb0385","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/nyas.13687","article-title":"Metabolic adaptation of short-living growth hormone transgenic mice to methionine restriction and supplementation","volume":"1418","author":"Brown-Borg","year":"2018","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.tem.2025.09.006_bb0390","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1011640","article-title":"An insulin-sensitive Drosophila insulin-like receptor mutant remodels methionine metabolism to extend lifespan","volume":"21","author":"Tatar","year":"2025","journal-title":"PLoS Genet."},{"key":"10.1016\/j.tem.2025.09.006_bb0395","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1210\/endo-120-2-659","article-title":"Evidence that selenium induces growth retardation through reduced growth hormone and somatomedin C production","volume":"120","author":"Thorlacius-Ussing","year":"1987","journal-title":"Endocrinology"},{"key":"10.1016\/j.tem.2025.09.006_bb0400","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.62483","article-title":"Selenium supplementation inhibits IGF-1 signaling and confers methionine restriction-like healthspan benefits to mice","volume":"10","author":"Plummer","year":"2021","journal-title":"Elife"},{"key":"10.1016\/j.tem.2025.09.006_bb0405","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s12950-025-00451-z","article-title":"Intermittent methionine restriction and selenium supplementation protect against inflammation and the development of dermatitis","volume":"22","author":"Plummer","year":"2025","journal-title":"J. Inflamm. (Lond)"},{"key":"10.1016\/j.tem.2025.09.006_bb0410","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1007633","article-title":"Glycine promotes longevity in Caenorhabditis elegans in a methionine cycle-dependent fashion","volume":"15","author":"Liu","year":"2019","journal-title":"PLoS Genet."},{"key":"10.1016\/j.tem.2025.09.006_bb0415","doi-asserted-by":"crossref","DOI":"10.1111\/acel.12953","article-title":"Glycine supplementation extends lifespan of male and female mice","volume":"18","author":"Miller","year":"2019","journal-title":"Aging Cell"},{"key":"10.1016\/j.tem.2025.09.006_bb0420","doi-asserted-by":"crossref","first-page":"528.2","DOI":"10.1096\/fasebj.25.1_supplement.528.2","article-title":"Dietary glycine supplementation mimics lifespan extension by dietary methionine restriction in Fisher 344 rats","volume":"25","author":"Brind","year":"2011","journal-title":"FASEB J."},{"key":"10.1016\/j.tem.2025.09.006_bb0425","doi-asserted-by":"crossref","first-page":"8332","DOI":"10.1038\/ncomms9332","article-title":"Enhancing S-adenosyl-methionine catabolism extends Drosophila lifespan","volume":"6","author":"Obata","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tem.2025.09.006_bb0430","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1007\/s11357-024-01326-6","article-title":"An antireductant approach ameliorates misfolded proinsulin-induced hyperglycemia and glucose intolerance in male Akita mice","volume":"47","author":"Mattocks","year":"2024","journal-title":"Geroscience"},{"key":"10.1016\/j.tem.2025.09.006_bb0435","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2019.110712","article-title":"The effect of short-term methionine restriction on glutathione synthetic capacity and antioxidant responses at the whole tissue and mitochondrial level in the rat liver","volume":"127","author":"Tamanna","year":"2019","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.tem.2025.09.006_bb0440","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1111\/nyas.13556","article-title":"Sulfur amino acid restriction-induced changes in redox-sensitive proteins are associated with slow protein synthesis rates","volume":"1418","author":"Nichenametla","year":"2018","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.tem.2025.09.006_bb0445","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/2046-2395-3-10","article-title":"Altered dietary methionine differentially impacts glutathione and methionine metabolism in long-living growth hormone-deficient Ames dwarf and wild-type mice","volume":"3","author":"Brown-Borg","year":"2014","journal-title":"Longev. Healthspan"},{"key":"10.1016\/j.tem.2025.09.006_bb0450","doi-asserted-by":"crossref","first-page":"7832","DOI":"10.1038\/s41467-023-43550-2","article-title":"Early-adult methionine restriction reduces methionine sulfoxide and extends lifespan in Drosophila","volume":"14","author":"Kosakamoto","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tem.2025.09.006_bb0455","article-title":"Intermittent methionine restriction reduces marrow fat accumulation and preserves more bone mass than continuous methionine restriction","volume":"2","author":"Plummer","year":"2024","journal-title":"Aging Biol."},{"key":"10.1016\/j.tem.2025.09.006_bb0460","doi-asserted-by":"crossref","DOI":"10.1126\/science.abn9257","article-title":"Taurine deficiency as a driver of aging","volume":"380","author":"Singh","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.tem.2025.09.006_bb0465","doi-asserted-by":"crossref","DOI":"10.1126\/science.adl2116","article-title":"Is taurine an aging biomarker?","volume":"388","author":"Fernandez","year":"2025","journal-title":"Science"},{"key":"10.1016\/j.tem.2025.09.006_bb0470","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1038\/ncb1975","article-title":"Induction of autophagy by spermidine promotes longevity","volume":"11","author":"Eisenberg","year":"2009","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.tem.2025.09.006_bb0475","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1038\/nm.4222","article-title":"Cardioprotection and lifespan extension by the natural polyamine spermidine","volume":"22","author":"Eisenberg","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.tem.2025.09.006_bb0480","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1038\/s41556-024-01468-x","article-title":"Spermidine is essential for fasting-mediated autophagy and longevity","volume":"26","author":"Hofer","year":"2024","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.tem.2025.09.006_bb0485","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.cell.2014.11.048","article-title":"Endogenous hydrogen sulfide production is essential for dietary restriction benefits","volume":"160","author":"Hine","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.tem.2025.09.006_bb0490","doi-asserted-by":"crossref","first-page":"16831","DOI":"10.1073\/pnas.1102008108","article-title":"Increased transsulfuration mediates longevity and dietary restriction in Drosophila","volume":"108","author":"Kabil","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tem.2025.09.006_bb0495","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2020.101188","article-title":"Targeting metabolic pathways for extension of lifespan and healthspan across multiple species","volume":"64","author":"Parkhitko","year":"2020","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.tem.2025.09.006_bb0500","first-page":"1187","article-title":"Combinatorial interventions in aging. Nat","volume":"3","author":"Parkhitko","year":"2023","journal-title":"Aging"},{"key":"10.1016\/j.tem.2025.09.006_bb0505","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1038\/s42255-025-01297-8","article-title":"Cysteine depletion triggers adipose tissue thermogenesis and weight loss","volume":"7","author":"Lee","year":"2025","journal-title":"Nat. Metab."},{"key":"10.1016\/j.tem.2025.09.006_bb0510","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/s41586-025-08996-y","article-title":"Unravelling cysteine-deficiency-associated rapid weight loss","volume":"643","author":"Varghese","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.tem.2025.09.006_bb0515","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/j.cmet.2024.01.018","article-title":"Methionine secreted by tumor-associated pericytes supports cancer stem cells in clear cell renal carcinoma","volume":"36","author":"Zhang","year":"2024","journal-title":"Cell Metab."},{"key":"10.1016\/j.tem.2025.09.006_bb0520","doi-asserted-by":"crossref","first-page":"8388","DOI":"10.1038\/s41467-024-52527-8","article-title":"The role of forkhead box M1-methionine adenosyltransferase 2 A\/2B axis in liver inflammation and fibrosis","volume":"15","author":"Yang","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tem.2025.09.006_bb0525","doi-asserted-by":"crossref","first-page":"5038","DOI":"10.1038\/s41467-023-39786-7","article-title":"Challenges in developing geroscience trials","volume":"14","author":"Rolland","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tem.2025.09.006_bb0530","doi-asserted-by":"crossref","first-page":"3978","DOI":"10.1172\/JCI129186","article-title":"Metabolically healthy obesity: facts and fantasies","volume":"129","author":"Smith","year":"2019","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tem.2025.09.006_bb0535","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1749-6632.1999.tb07784.x","article-title":"Insulin resistance: a chicken that has come to roost","volume":"892","author":"Reaven","year":"1999","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.tem.2025.09.006_bb0540","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/ncb3107","article-title":"Tipping the metabolic scales towards increased longevity in mammals","volume":"17","author":"Riera","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.tem.2025.09.006_bb0545","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102213","article-title":"Pharmacological interventions in human aging","volume":"95","author":"Petr","year":"2024","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.tem.2025.09.006_bb0550","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.cmet.2023.12.007","article-title":"Human trials exploring anti-aging medicines","volume":"36","author":"Guarente","year":"2024","journal-title":"Cell Metab."},{"key":"10.1016\/j.tem.2025.09.006_bb0555","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1093\/jn\/nxac172","article-title":"Cumulative consumption of sulfur amino acids and risk of diabetes: a prospective cohort study","volume":"152","author":"Dong","year":"2022","journal-title":"J. Nutr."},{"key":"10.1016\/j.tem.2025.09.006_bb0560","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s00394-021-02641-w","article-title":"Association of dietary sulfur amino acid intake with mortality from diabetes and other causes","volume":"61","author":"Dong","year":"2022","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.tem.2025.09.006_bb0565","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2019.100248","article-title":"Association of sulfur amino acid consumption with cardiometabolic risk factors: cross-sectional findings from NHANES III","volume":"19","author":"Dong","year":"2020","journal-title":"EClinicalMedicine"},{"key":"10.1016\/j.tem.2025.09.006_bb0570","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1159\/000501745","article-title":"Aging is a powerful risk factor for type 2 diabetes mellitus independent of body mass index","volume":"66","author":"Fazeli","year":"2020","journal-title":"Gerontology"},{"key":"10.1016\/j.tem.2025.09.006_bb0575","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.2337\/diacare.22.9.1462","article-title":"Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp","volume":"22","author":"Matsuda","year":"1999","journal-title":"Diabetes Care"},{"key":"10.1016\/j.tem.2025.09.006_bb0580","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1002\/oby.21806","article-title":"Concentration-dependent linkage of dietary methionine restriction to the components of its metabolic phenotype","volume":"25","author":"Forney","year":"2017","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.tem.2025.09.006_bb0585","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.177997","article-title":"Methionine as a regulator of bone remodeling with fasting","volume":"9","author":"Amorim","year":"2024","journal-title":"JCI Insight"},{"key":"10.1016\/j.tem.2025.09.006_bb0590","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1038\/s41467-023-36483-3","article-title":"Methionine adenosyltransferase2A inhibition restores metabolism to improve regenerative capacity and strength of aged skeletal muscle","volume":"14","author":"Rajabian","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tem.2025.09.006_bb0595","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.ebiom.2019.03.058","article-title":"TGF-beta1\/p65\/MAT2A pathway regulates liver fibrogenesis via intracellular SAM","volume":"42","author":"Wang","year":"2019","journal-title":"EBioMedicine"},{"key":"10.1016\/j.tem.2025.09.006_bb0600","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202101205RR","article-title":"Inhibition of MAT2A suppresses osteoclastogenesis and prevents ovariectomy-induced bone loss","volume":"36","author":"Kang","year":"2022","journal-title":"FASEB J."},{"key":"10.1016\/j.tem.2025.09.006_bb0605","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/nm.3774","article-title":"DNA methyltransferase 3a regulates osteoclast differentiation by coupling to an S-adenosylmethionine-producing metabolic pathway","volume":"21","author":"Nishikawa","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.tem.2025.09.006_bb0610","first-page":"629","article-title":"Loss of MAT2A compromises methionine metabolism and represents a vulnerability in H3K27M mutant glioma by modulating the epigenome","volume":"3","author":"Golbourn","year":"2022","journal-title":"Nat. Can."},{"key":"10.1016\/j.tem.2025.09.006_bb0615","first-page":"131","article-title":"Blocking methionine catabolism induces senescence and confers vulnerability to GSK3 inhibition in liver cancer","volume":"5","author":"Li","year":"2024","journal-title":"Nat. Can."},{"key":"10.1016\/j.tem.2025.09.006_bb0620","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.tibs.2024.12.009","article-title":"Mechanisms and rationales of SAM homeostasis","volume":"50","author":"Xing","year":"2025","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.tem.2025.09.006_bb0625","doi-asserted-by":"crossref","first-page":"1694S","DOI":"10.1093\/jn\/136.6.1694S","article-title":"Adequate range for sulfur-containing amino acids and biomarkers for their excess: lessons from enteral and parenteral nutrition","volume":"136","author":"van de Poll","year":"2006","journal-title":"J. Nutr."},{"key":"10.1016\/j.tem.2025.09.006_bb0630","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1016\/S0002-8223(02)90346-9","article-title":"Dietary reference intakes for energy, carbohydrate, fiber, fat, fatty acids, cholesterol, protein and amino acids","volume":"102","author":"Trumbo","year":"2002","journal-title":"J. Am. Diet. Assoc."},{"key":"10.1016\/j.tem.2025.09.006_bb0635","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1093\/ajcn\/74.6.761","article-title":"Dietary cysteine reduces the methionine requirement in men","volume":"74","author":"Di Buono","year":"2001","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.tem.2025.09.006_bb0640","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.tjnut.2023.01.012","article-title":"Amino acid intake and conformance with the dietary reference intakes in the United States: analysis of the national health and nutrition examination survey, 2001\u20132018","volume":"153","author":"Berryman","year":"2023","journal-title":"J. Nutr."}],"container-title":["Trends in Endocrinology & Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043276025001985?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043276025001985?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T15:21:53Z","timestamp":1780327313000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043276025001985"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":128,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S1043276025001985"],"URL":"https:\/\/doi.org\/10.1016\/j.tem.2025.09.006","relation":{},"ISSN":["1043-2760"],"issn-type":[{"value":"1043-2760","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Methionine restriction and mimetics to ameliorate human aging and disease","name":"articletitle","label":"Article Title"},{"value":"Trends in Endocrinology & Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tem.2025.09.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}