{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T15:12:34Z","timestamp":1788793954105,"version":"build-2803163510"},"reference-count":166,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,9,7]],"date-time":"2027-09-07T00:00:00Z","timestamp":1820275200000},"content-version":"am","delay-in-days":371,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 HD007505"],"award-info":[{"award-number":["T32 HD007505"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["F31 DK135181"],"award-info":[{"award-number":["F31 DK135181"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01 DK125513"],"award-info":[{"award-number":["R01 DK125513"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01 DK137798"],"award-info":[{"award-number":["R01 DK137798"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01 DK121759"],"award-info":[{"award-number":["R01 DK121759"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Endocrinology & Metabolism"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.tem.2026.01.010","type":"journal-article","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T13:37:11Z","timestamp":1773754631000},"page":"826-852","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Lamin A\/C in health, laminopathies, and familial partial lipodystrophy 2"],"prefix":"10.1016","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4289-0614","authenticated-orcid":false,"given":"Jessica N.","family":"Maung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9171-1144","authenticated-orcid":false,"given":"Elif A.","family":"Oral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6907-7960","authenticated-orcid":false,"given":"Ormond A.","family":"MacDougald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tem.2026.01.010_bb0005","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/6799","article-title":"Mutations in the gene encoding lamin A\/C cause autosomal dominant Emery\u2013Dreifuss muscular dystrophy","volume":"21","author":"Bonne","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.tem.2026.01.010_bb0010","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1093\/hmg\/9.1.109","article-title":"Nuclear lamin A\/C R482Q mutation in Canadian kindreds with Dunnigan-type familial partial lipodystrophy","volume":"9","author":"Cao","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.tem.2026.01.010_bb0015","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/72807","article-title":"LMNA, encoding lamin A\/C, is mutated in partial lipodystrophy","volume":"24","author":"Shackleton","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.tem.2026.01.010_bb0020","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/nature01629","article-title":"Recurrent de novo point mutations in lamin A cause Hutchinson\u2013Gilford progeria syndrome","volume":"423","author":"Eriksson","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.tem.2026.01.010_bb0025","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1056\/NEJM199912023412302","article-title":"Missense mutations in the rod domain of the lamin A\/C gene as causes of dilated cardiomyopathy and conduction-system disease","volume":"341","author":"Fatkin","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.tem.2026.01.010_bb0030","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1086\/341908","article-title":"Mandibuloacral dysplasia is caused by a mutation in LMNA-encoding lamin A\/C","volume":"71","author":"Novelli","year":"2002","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.tem.2026.01.010_bb0035","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1086\/339274","article-title":"Homozygous defects in LMNA, encoding lamin A\/C nuclear-envelope proteins, cause autosomal recessive axonal neuropathy in human (Charcot\u2013Marie\u2013Tooth disorder type 2) and mouse","volume":"70","author":"Sandre-Giovannoli","year":"2002","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.tem.2026.01.010_bb0040","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1016\/j.yexcr.2007.03.028","article-title":"\u201cLaminopathies\u201d: a wide spectrum of human diseases","volume":"313","author":"Worman","year":"2007","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.tem.2026.01.010_bb0045","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1038\/s41586-020-03086-7","article-title":"In vivo base editing rescues Hutchinson\u2013Gilford progeria syndrome in mice","volume":"589","author":"Koblan","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.tem.2026.01.010_bb0050","first-page":"907","article-title":"Lipodystrophy: a paradigm for understanding the consequences of \u201coverloading\u201d adipose tissue","volume":"101","author":"Lim","year":"2021","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.tem.2026.01.010_bb0055","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1186\/gb-2011-12-5-222","article-title":"The lamin protein family","volume":"12","author":"Dittmer","year":"2011","journal-title":"Genome Biol."},{"key":"10.1016\/j.tem.2026.01.010_bb0060","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.864191","article-title":"Post-translational modification of lamins: mechanisms and functions","volume":"10","author":"Zheng","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.tem.2026.01.010_bb0065","series-title":"Genetic Disorders","first-page":"27","article-title":"Laminopathies","author":"McKenna","year":"2013"},{"key":"10.1016\/j.tem.2026.01.010_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.ceb.2023.102267","article-title":"Lamins as structural nuclear elements through evolution","volume":"85","author":"Odell","year":"2023","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.tem.2026.01.010_bb0075","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1210\/jcem.87.2.8256","article-title":"Lamin expression in human adipose cells in relation to anatomical site and differentiation state","volume":"87","author":"Lelliott","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2026.01.010_bb0080","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1007\/s00018-021-04084-2","article-title":"The wide and growing range of lamin B-related diseases: from laminopathies to cancer","volume":"79","author":"Evangelisti","year":"2022","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.tem.2026.01.010_bb0085","doi-asserted-by":"crossref","first-page":"16321","DOI":"10.1016\/S0021-9258(19)85424-8","article-title":"Structural organization of the human gene encoding nuclear lamin A and nuclear lamin C","volume":"268","author":"Lin","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tem.2026.01.010_bb0090","doi-asserted-by":"crossref","first-page":"66","DOI":"10.4161\/nucl.28068","article-title":"Nuclear localization signal deletion mutants of lamin A and progerin reveal insights into lamin A processing and emerin targeting","volume":"5","author":"Wu","year":"2014","journal-title":"Nucleus"},{"key":"10.1016\/j.tem.2026.01.010_bb0095","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1242\/jcs.107.1.61","article-title":"The processing pathway of prelamin A","volume":"107","author":"Sinensky","year":"1994","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.tem.2026.01.010_bb0100","doi-asserted-by":"crossref","first-page":"2791","DOI":"10.1002\/1873-3468.14750","article-title":"Scaffold, mechanics and functions of nuclear lamins","volume":"597","author":"Buxboim","year":"2023","journal-title":"FEBS Lett."},{"key":"10.1016\/j.tem.2026.01.010_bb0105","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1080\/19491034.2017.1337622","article-title":"The structure of lamin filaments in somatic cells as revealed by cryo-electron tomography","volume":"8","author":"Turgay","year":"2017","journal-title":"Nucleus"},{"key":"10.1016\/j.tem.2026.01.010_bb0110","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/nature21382","article-title":"The molecular architecture of lamins in somatic cells","volume":"543","author":"Turgay","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.tem.2026.01.010_bb0115","first-page":"52","article-title":"Expression of emerin and lamins in muscle of patients with different forms of Emery\u2013Dreifuss muscular dystrophy","volume":"22","author":"Niebroj-Dobosz","year":"2003","journal-title":"Acta Myol."},{"key":"10.1016\/j.tem.2026.01.010_bb0120","doi-asserted-by":"crossref","first-page":"3409","DOI":"10.1101\/gad.1735208","article-title":"The A- and B-type nuclear lamin networks: microdomains involved in chromatin organization and transcription","volume":"22","author":"Shimi","year":"2008","journal-title":"Genes Dev."},{"key":"10.1016\/j.tem.2026.01.010_bb0125","doi-asserted-by":"crossref","first-page":"4075","DOI":"10.1091\/mbc.E15-07-0461","article-title":"Structural organization of nuclear lamins A, C, B1, and B2 revealed by superresolution microscopy","volume":"26","author":"Shimi","year":"2015","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.tem.2026.01.010_bb0130","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1242\/jcs.108.2.635","article-title":"Lamin proteins form an internal nucleoskeleton as well as a peripheral lamina in human cells","volume":"108","author":"Hoz\u00e1k","year":"1995","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.tem.2026.01.010_bb0135","doi-asserted-by":"crossref","first-page":"552","DOI":"10.4161\/nucl.22257","article-title":"The nuclear envelope proteome differs notably between tissues","volume":"3","author":"Korfali","year":"2012","journal-title":"Nucleus"},{"key":"10.1016\/j.tem.2026.01.010_bb0140","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1016\/j.cell.2013.02.031","article-title":"Nuclear positioning","volume":"152","author":"Gundersen","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.tem.2026.01.010_bb0145","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s13036-019-0197-9","article-title":"The LINC complex, mechanotransduction, and mesenchymal stem cell function and fate","volume":"13","author":"Bouzid","year":"2019","journal-title":"J. Biol. Eng."},{"key":"10.1016\/j.tem.2026.01.010_bb0150","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1080\/19491034.2022.2118418","article-title":"A-type lamins involvement in transport and implications in cancer?","volume":"13","author":"Scott","year":"2022","journal-title":"Nucleus"},{"key":"10.1016\/j.tem.2026.01.010_bb0155","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1038\/nature06947","article-title":"Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions","volume":"453","author":"Guelen","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.tem.2026.01.010_bb0160","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s13059-020-02003-5","article-title":"Lamina-associated domains: peripheral matters and internal affairs","volume":"21","author":"Briand","year":"2020","journal-title":"Genome Biol."},{"key":"10.1016\/j.tem.2026.01.010_bb0165","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/s41598-017-00176-x","article-title":"Identifying novel transcriptional and epigenetic features of nuclear lamina-associated genes","volume":"7","author":"Wu","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tem.2026.01.010_bb0170","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1101\/gr.141028.112","article-title":"Constitutive nuclear lamina\u2013genome interactions are highly conserved and associated with A\/T-rich sequence","volume":"23","author":"Meuleman","year":"2013","journal-title":"Genome Res."},{"key":"10.1016\/j.tem.2026.01.010_bb0175","doi-asserted-by":"crossref","first-page":"30","DOI":"10.4161\/19491034.2014.990855","article-title":"Distinct features of lamin A-interacting chromatin domains mapped by ChIP-sequencing from sonicated or micrococcal nuclease-digested chromatin","volume":"6","author":"Lund","year":"2015","journal-title":"Nucleus"},{"key":"10.1016\/j.tem.2026.01.010_bb0180","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gku324","article-title":"Enriched domain detector: a program for detection of wide genomic enrichment domains robust against local variations","volume":"42","author":"Lund","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.tem.2026.01.010_bb0185","doi-asserted-by":"crossref","first-page":"3473","DOI":"10.1242\/jcs.113.19.3473","article-title":"Lamina-associated polypeptide 2\u03b1 binds intranuclear A-type lamins","volume":"113","author":"Dechat","year":"2000","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.tem.2026.01.010_bb0190","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1101\/gr.196220.115","article-title":"A-type lamins bind both hetero- and euchromatin, the latter being regulated by lamina-associated polypeptide 2\u03b1","volume":"26","author":"Gesson","year":"2016","journal-title":"Genome Res."},{"key":"10.1016\/j.tem.2026.01.010_bb0195","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.761469","article-title":"Diversity of nuclear lamin A\/C action as a key to tissue-specific regulation of cellular identity in health and disease","volume":"9","author":"Malashicheva","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.tem.2026.01.010_bb0200","doi-asserted-by":"crossref","first-page":"3990","DOI":"10.1172\/JCI129187","article-title":"Altered adipose tissue and adipocyte function in the pathogenesis of metabolic syndrome","volume":"129","author":"Kahn","year":"2019","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tem.2026.01.010_bb0205","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1194\/jlr.R094060","article-title":"Beyond adiponectin and leptin: adipose tissue-derived mediators of inter-organ communication","volume":"60","author":"Funcke","year":"2019","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.tem.2026.01.010_bb0210","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1161\/CIRCULATIONAHA.111.087213","article-title":"Energy balance and obesity","volume":"126","author":"Hill","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.tem.2026.01.010_bb0215","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1123\/ijsn.6.2.80","article-title":"Physical activity, fat balance, and energy balance","volume":"6","author":"Hill","year":"1996","journal-title":"Int. J. Sport Nutr."},{"key":"10.1016\/j.tem.2026.01.010_bb0220","first-page":"1515","article-title":"Study: waist-to-hip ratio might predict mortality better than BMI","volume":"330","author":"Harris","year":"2023","journal-title":"Jama"},{"key":"10.1016\/j.tem.2026.01.010_bb0225","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1016\/j.mayocp.2023.05.026","article-title":"Obesity: a review of pathophysiology and classification","volume":"98","author":"Busebee","year":"2023","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.tem.2026.01.010_bb0230","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.bbalip.2009.12.006","article-title":"Adipose tissue expandability, lipotoxicity and the metabolic syndrome\u2014an allostatic perspective","volume":"1801","author":"Virtue","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.tem.2026.01.010_bb0235","series-title":"Obesity and Lipotoxicity","first-page":"391","article-title":"Insulin resistance, obesity, and lipotoxicity","author":"Yaz\u0131c\u0131","year":"2024"},{"key":"10.1016\/j.tem.2026.01.010_bb0240","doi-asserted-by":"crossref","first-page":"249","DOI":"10.2337\/db19-0447","article-title":"Clinical and molecular prevalence of lipodystrophy in an unascertained large clinical care cohort","volume":"69","author":"Gonzaga-Jauregui","year":"2020","journal-title":"Diabetes"},{"key":"10.1016\/j.tem.2026.01.010_bb0245","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.2337\/dbi24-0018","article-title":"Lipodystrophy prevalence, \u201clipodystrophy-like phenotypes,\u201d and diagnostic challenges","volume":"73","author":"Akinci","year":"2024","journal-title":"Diabetes"},{"key":"10.1016\/j.tem.2026.01.010_bb0250","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s11892-018-1099-9","article-title":"Phenotypic and genetic characteristics of lipodystrophy: pathophysiology, metabolic abnormalities, and comorbidities","volume":"18","author":"Akinci","year":"2018","journal-title":"Curr. Diab. Rep."},{"key":"10.1016\/j.tem.2026.01.010_bb0255","doi-asserted-by":"crossref","first-page":"e1204","DOI":"10.1210\/clinem\/dgad606","article-title":"Deciphering the clinical presentations in LMNA-related lipodystrophy: report of 115 cases and a systematic review","volume":"109","author":"Besci","year":"2024","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2026.01.010_bb0260","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1007\/s11892-025-01602-5","article-title":"Lipodystrophy syndromes: one name but many diseases highlighting the importance of adipose tissue in metabolism","volume":"25","author":"Foss-Freitas","year":"2025","journal-title":"Curr. Diab. Rep."},{"key":"10.1016\/j.tem.2026.01.010_bb0265","doi-asserted-by":"crossref","first-page":"725","DOI":"10.3390\/cells12050725","article-title":"Clinical spectrum of LMNA-associated type 2 familial partial lipodystrophy: a systematic review","volume":"12","author":"Fernandez-Pombo","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.tem.2026.01.010_bb0270","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1210\/jc.2018-01922","article-title":"Regional body fat changes and metabolic complications in children with Dunnigan lipodystrophy-causing LMNA variants","volume":"104","author":"Patni","year":"2019","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2026.01.010_bb0275","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1159\/000533992","article-title":"A very-low-calorie diet can cause remission of diabetes mellitus and hypertriglyceridemia in familial partial lipodystrophy","volume":"17","author":"Foss-Freitas","year":"2023","journal-title":"Obes. Facts"},{"key":"10.1016\/j.tem.2026.01.010_bb0280","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1080\/17446651.2025.2574318","article-title":"Advances of pharmacological therapies in lipodystrophy syndromes: current evidence and future directions","volume":"20","author":"Besci","year":"2025","journal-title":"Expert Rev. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2026.01.010_bb0285","first-page":"756","article-title":"Metabolic improvements with tirzepatide in lipodystrophy: a novel option?","volume":"48","author":"Meral","year":"2025","journal-title":"Diabetes Care"},{"key":"10.1016\/j.tem.2026.01.010_bb0290","doi-asserted-by":"crossref","DOI":"10.1210\/jendso\/bvaf067","article-title":"Changes after leptin administration in partial lipodystrophy and factors associated with hepatic and metabolic response","volume":"9","author":"Akinci","year":"2025","journal-title":"J. Endocr. Soc."},{"key":"10.1016\/j.tem.2026.01.010_bb0295","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.cmet.2017.03.005","article-title":"FGF21 regulates metabolism through adipose-dependent and -independent mechanisms","volume":"25","author":"BonDurant","year":"2017","journal-title":"Cell Metab."},{"key":"10.1016\/j.tem.2026.01.010_bb0300","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.194882","article-title":"Effects of FGF21, soluble TGFBR2, and environmental temperature on metabolic dysfunction in lipodystrophic mice","volume":"10","author":"Maung","year":"2025","journal-title":"JCI Insight"},{"key":"10.1016\/j.tem.2026.01.010_bb0305","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.omtm.2022.09.014","article-title":"Gene therapy restores adipose tissue and metabolic health in a pre-clinical mouse model of lipodystrophy","volume":"27","author":"Sommer","year":"2022","journal-title":"Mol. Ther. Methods Clin. Dev."},{"key":"10.1016\/j.tem.2026.01.010_bb0310","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2406946121","article-title":"Progerin forms an abnormal meshwork and has a dominant-negative effect on the nuclear lamina","volume":"121","author":"Kim","year":"2024","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tem.2026.01.010_bb0315","doi-asserted-by":"crossref","first-page":"4084","DOI":"10.1093\/hmg\/dds233","article-title":"Human ZMPSTE24 disease mutations: residual proteolytic activity correlates with disease severity","volume":"21","author":"Barrowman","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.tem.2026.01.010_bb0320","series-title":"GeneReviews\u00ae","article-title":"Emery\u2013Dreifuss muscular dystrophy","author":"Bonne","year":"1993"},{"key":"10.1016\/j.tem.2026.01.010_bb0325","doi-asserted-by":"crossref","first-page":"3027","DOI":"10.1242\/jcs.00599","article-title":"Effect of pathogenic missense mutations in lamin A on its interaction with emerin in vivo","volume":"116","author":"Holt","year":"2003","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.tem.2026.01.010_bb0330","doi-asserted-by":"crossref","first-page":"4447","DOI":"10.1242\/jcs.114.24.4447","article-title":"Nuclear envelope defects associated with LMNA mutations cause dilated cardiomyopathy and Emery\u2013Dreifuss muscular dystrophy","volume":"114","author":"Raharjo","year":"2001","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.tem.2026.01.010_bb0335","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.devcel.2013.08.012","article-title":"Lamina-associated polypeptide-1 interacts with the muscular dystrophy protein emerin and is essential for skeletal muscle maintenance","volume":"26","author":"Shin","year":"2013","journal-title":"Dev. Cell"},{"key":"10.1016\/j.tem.2026.01.010_bb0340","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1083\/jcb.147.5.913","article-title":"Loss of A-type lamin expression compromises nuclear envelope integrity leading to muscular dystrophy","volume":"147","author":"Sullivan","year":"1999","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.tem.2026.01.010_bb0345","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.ahj.2008.01.026","article-title":"Lamin A\/C mutation analysis in a cohort of 324 unrelated patients with idiopathic or familial dilated cardiomyopathy","volume":"156","author":"Parks","year":"2008","journal-title":"Am. Heart J."},{"key":"10.1016\/j.tem.2026.01.010_bb0350","series-title":"GeneReviews\u00ae","article-title":"LMNA-related dilated cardiomyopathy","author":"Hershberger","year":"1993"},{"key":"10.1016\/j.tem.2026.01.010_bb0355","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1016\/j.jacbts.2022.06.015","article-title":"Genetic ablation of the DNA damage response pathway attenuates lamin-associated dilated cardiomyopathy in mice","volume":"7","author":"Cheedipudi","year":"2022","journal-title":"JACC Basic Transl. Sci."},{"key":"10.1016\/j.tem.2026.01.010_bb0360","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.1002\/ajmg.a.33005","article-title":"Mandibuloacral dysplasia type A in childhood","volume":"149A","author":"Garavelli","year":"2009","journal-title":"Am. J. Med. Genet. A."},{"key":"10.1016\/j.tem.2026.01.010_bb0365","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1038\/ng1872","article-title":"Lamin B1 duplications cause autosomal dominant leukodystrophy","volume":"38","author":"Padiath","year":"2006","journal-title":"Nat. Genet."},{"key":"10.1016\/j.tem.2026.01.010_bb0370","doi-asserted-by":"crossref","first-page":"5337","DOI":"10.1210\/jc.2003-031658","article-title":"Patients with familial partial lipodystrophy of the Dunnigan type due to a LMNA R482W mutation show muscular and cardiac abnormalities","volume":"89","author":"Vantyghem","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.tem.2026.01.010_bb0375","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/S0969-2126(02)00777-3","article-title":"(2002) The Ig-like structure of the C-terminal domain of lamin A\/C, mutated in muscular dystrophies, cardiomyopathy, and partial lipodystrophy","volume":"10","author":"Krimm","year":"1993","journal-title":"Structure"},{"key":"10.1016\/j.tem.2026.01.010_bb0380","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1107\/S1744309109020302","article-title":"Structure of the lamin A\/C R482W mutant responsible for dominant familial partial lipodystrophy (FPLD)","volume":"65","author":"Magracheva","year":"2009","journal-title":"Acta Crystallograph. Sect. F Struct. Biol. Cryst. Commun."},{"key":"10.1016\/j.tem.2026.01.010_bb0385","doi-asserted-by":"crossref","first-page":"4819","DOI":"10.1021\/bi020704g","article-title":"The carboxyl-terminal region common to lamins A and C contains a DNA-binding domain","volume":"42","author":"Stierl\u00e9","year":"2003","journal-title":"Biochemistry"},{"key":"10.1016\/j.tem.2026.01.010_bb0390","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/s42003-022-03212-3","article-title":"Crystal structure of progeria mutant S143F lamin A\/C reveals increased hydrophobicity driving nuclear deformation","volume":"5","author":"Ahn","year":"2022","journal-title":"Commun. Biol."},{"key":"10.1016\/j.tem.2026.01.010_bb0395","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/s41525-021-00265-x","article-title":"Most myopathic lamin variants aggregate: a functional genomics approach for assessing variants of uncertain significance","volume":"6","author":"Anderson","year":"2021","journal-title":"NPJ Genomic Med."},{"key":"10.1016\/j.tem.2026.01.010_bb0400","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1093\/hmg\/ddi480","article-title":"Nuclear lamin A inhibits adipocyte differentiation: implications for Dunnigan-type familial partial lipodystrophy","volume":"15","author":"Boguslavsky","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.tem.2026.01.010_bb0405","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1083\/jcb.201707090","article-title":"Lipodystrophic laminopathy: lamin A mutation relaxes chromatin architecture to impair adipogenesis","volume":"216","author":"Elzeneini","year":"2017","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.tem.2026.01.010_bb0410","doi-asserted-by":"crossref","first-page":"25768","DOI":"10.1074\/jbc.M513511200","article-title":"Lamins A and C but not lamin B1 regulate nuclear mechanics","volume":"281","author":"Lammerding","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tem.2026.01.010_bb0415","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.cell.2012.01.059","article-title":"Accumulation of the inner nuclear envelope protein Sun1 is pathogenic in progeric and dystrophic laminopathies","volume":"149","author":"Chen","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.tem.2026.01.010_bb0420","doi-asserted-by":"crossref","DOI":"10.1080\/19491034.2023.2262308","article-title":"Revisiting the truncated lamin A produced by a commonly used strain of Lmna knockout mice","volume":"14","author":"Kim","year":"2023","journal-title":"Nucleus"},{"key":"10.1016\/j.tem.2026.01.010_bb0425","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1172\/JCI200419670","article-title":"Lamin A\/C deficiency causes defective nuclear mechanics and mechanotransduction","volume":"113","author":"Lammerding","year":"2004","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tem.2026.01.010_bb0430","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1093\/hmg\/ddh295","article-title":"Decreased mechanical stiffness in LMNA\u2212\/\u2212 cells is caused by defective nucleo-cytoskeletal integrity: implications for the development of laminopathies","volume":"13","author":"Broers","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.tem.2026.01.010_bb0435","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1529\/biophysj.106.102426","article-title":"Nuclear lamin A\/C deficiency induces defects in cell mechanics, polarization, and migration","volume":"93","author":"Lee","year":"2007","journal-title":"Biophys. J."},{"key":"10.1016\/j.tem.2026.01.010_bb0440","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1039\/C7IB00069C","article-title":"Lmna knockout mouse embryonic fibroblasts are less contractile than their wild-type counterparts","volume":"9","author":"van Loosdregt","year":"2017","journal-title":"Integr. Biol. (Camb)"},{"key":"10.1016\/j.tem.2026.01.010_bb0445","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2121816119","article-title":"Nuclear lamin isoforms differentially contribute to LINC complex-dependent nucleo-cytoskeletal coupling and whole-cell mechanics","volume":"119","author":"Vahabikashi","year":"2022","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tem.2026.01.010_bb0450","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1038\/s41594-025-01622-5","article-title":"The molecular basis of lamin-specific chromatin interactions","volume":"32","author":"Wang","year":"2025","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.tem.2026.01.010_bb0455","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1038\/emboj.2009.196","article-title":"Novel roles for A-type lamins in telomere biology and the DNA damage response pathway","volume":"28","author":"Gonzalez-Suarez","year":"2009","journal-title":"EMBO J."},{"key":"10.1016\/j.tem.2026.01.010_bb0460","doi-asserted-by":"crossref","first-page":"9948","DOI":"10.1093\/nar\/gkac741","article-title":"Lamin A\/C impairments cause mitochondrial dysfunction by attenuating PGC1\u03b1 and the NAMPT\u2013NAD+ pathway","volume":"50","author":"Maynard","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.tem.2026.01.010_bb0465","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202007082","article-title":"Computational analyses reveal spatial relationships between nuclear pore complexes and specific lamins","volume":"220","author":"Kittisopikul","year":"2021","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.tem.2026.01.010_bb0470","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0057891","article-title":"Lamin A\/C haploinsufficiency modulates the differentiation potential of mouse embryonic stem cells","volume":"8","author":"Sehgal","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.tem.2026.01.010_bb0475","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1038\/cr.2013.118","article-title":"Proliferation and differentiation of mouse embryonic stem cells lacking all lamins","volume":"23","author":"Kim","year":"2013","journal-title":"Cell Res."},{"key":"10.1016\/j.tem.2026.01.010_bb0480","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.molcel.2018.05.017","article-title":"Lamins organize the global three-dimensional genome from the nuclear periphery","volume":"71","author":"Zheng","year":"2018","journal-title":"Mol. Cell"},{"key":"10.1016\/j.tem.2026.01.010_bb0485","doi-asserted-by":"crossref","first-page":"6663","DOI":"10.1038\/s41467-022-34366-7","article-title":"Lamin A\/C-dependent chromatin architecture safeguards na\u00efve pluripotency to prevent aberrant cardiovascular cell fate and function","volume":"13","author":"Wang","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tem.2026.01.010_bb0490","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.2337\/db20-1001","article-title":"Adipocyte-specific deletion of lamin A\/C largely models human familial partial lipodystrophy type 2","volume":"70","author":"Corsa","year":"2021","journal-title":"Diabetes"},{"key":"10.1016\/j.tem.2026.01.010_bb0495","doi-asserted-by":"crossref","first-page":"3988","DOI":"10.3390\/cells11243988","article-title":"Loss of mature lamin A\/C triggers a shift in intracellular metabolic homeostasis via AMPK\u03b1 activation","volume":"11","author":"Zhou","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.tem.2026.01.010_bb0500","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1083\/jcb.136.6.1201","article-title":"Disruption of nuclear lamin organization alters the distribution of replication factors and inhibits DNA synthesis","volume":"136","author":"Spann","year":"1997","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.tem.2026.01.010_bb0505","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1083\/jcb.200112047","article-title":"Alteration of nuclear lamin organization inhibits RNA polymerase II-dependent transcription","volume":"156","author":"Spann","year":"2002","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.tem.2026.01.010_bb0510","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/s41420-024-01998-1","article-title":"Eliminating elevated p53 signaling fails to rescue skeletal muscle defects or extend survival in lamin A\/C-deficient mice","volume":"10","author":"Kirby","year":"2024","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.tem.2026.01.010_bb0515","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1016\/j.celrep.2016.10.040","article-title":"Rapamycin reverses metabolic deficits in lamin A\/C-deficient mice","volume":"17","author":"Liao","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.tem.2026.01.010_bb0520","doi-asserted-by":"crossref","first-page":"195","DOI":"10.4161\/nucl.2.3.15731","article-title":"Postnatal myogenic and adipogenic developmental: defects and metabolic impairment upon loss of A-type lamins","volume":"2","author":"Kubben","year":"2011","journal-title":"Nucleus"},{"key":"10.1016\/j.tem.2026.01.010_bb0525","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1006\/bbrc.2002.6466","article-title":"Characterization of adiposity and metabolism in Lmna-deficient mice","volume":"291","author":"Cutler","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.tem.2026.01.010_bb0530","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1172\/JCI27125","article-title":"Prelamin A and lamin A appear to be dispensable in the nuclear lamina","volume":"116","author":"Fong","year":"2006","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tem.2026.01.010_bb0535","doi-asserted-by":"crossref","first-page":"20818","DOI":"10.1074\/jbc.M110.128835","article-title":"Direct synthesis of lamin A, bypassing prelamin A processing, causes misshapen nuclei in fibroblasts but no detectable pathology in mice","volume":"285","author":"Coffinier","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tem.2026.01.010_bb0540","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adh0798","article-title":"Perinuclear damage from nuclear envelope deterioration elicits stress responses that contribute to LMNA cardiomyopathy","volume":"10","author":"Sikder","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.tem.2026.01.010_bb0545","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.jcmgh.2017.06.005","article-title":"Hepatocyte-specific deletion of mouse lamin A\/C leads to male-selective steatohepatitis","volume":"4","author":"Kwan","year":"2017","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.tem.2026.01.010_bb0550","article-title":"Altered lipid metabolism and inflammatory programs associate with adipocyte loss in familial partial lipodystrophy 2","volume":"136","author":"Maung","year":"2025","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tem.2026.01.010_bb0555","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1002\/mc.23147","article-title":"Loss of myeloid-specific lamin A\/C drives lung metastasis through Gfi-1- and C\/EBP\u03b5-mediated granulocytic differentiation","volume":"59","author":"Ishii","year":"2020","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.tem.2026.01.010_bb0560","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.diff.2014.12.002","article-title":"Tissue specific loss of A-type lamins in the gastrointestinal epithelium can enhance polyp size","volume":"89","author":"Wang","year":"2015","journal-title":"Differentiation"},{"key":"10.1016\/j.tem.2026.01.010_bb0565","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1053\/j.gastro.2018.01.024","article-title":"Lamin A\/C maintains exocrine pancreas homeostasis by regulating stability of RB and activity of E2F","volume":"154","author":"Elenbaas","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1016\/j.tem.2026.01.010_bb0570","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-019-0289-0","article-title":"Altered adipocyte differentiation and unbalanced autophagy in type 2 familial partial lipodystrophy: an in vitro and in vivo study of adipose tissue browning","volume":"51","author":"Pellegrini","year":"2019","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.tem.2026.01.010_bb0575","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1093\/hmg\/11.7.769","article-title":"A novel interaction between lamin A and SREBP1: implications for partial lipodystrophy and other laminopathies","volume":"11","author":"Lloyd","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.tem.2026.01.010_bb0580","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1161\/ATVBAHA.113.301933","article-title":"Lipodystrophy-linked LMNA p.R482W mutation induces clinical early atherosclerosis and in vitro endothelial dysfunction","volume":"33","author":"Bidault","year":"2013","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.tem.2026.01.010_bb0585","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1093\/hmg\/ddt509","article-title":"Deregulation of fragile X-related protein 1 by the lipodystrophic lamin A p.R482W mutation elicits a myogenic gene expression program in preadipocytes","volume":"23","author":"Oldenburg","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.tem.2026.01.010_bb0590","doi-asserted-by":"crossref","first-page":"4459","DOI":"10.1242\/jcs.114.24.4459","article-title":"Nuclear envelope disorganization in fibroblasts from lipodystrophic patients with heterozygous R482Q\/W mutations in the lamin A\/C gene","volume":"114","author":"Vigouroux","year":"2001","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.tem.2026.01.010_bb0595","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1006\/excr.2002.5669","article-title":"Expression of lamin A mutated in the carboxyl-terminal tail generates an aberrant nuclear phenotype similar to that observed in cells from patients with Dunnigan-type partial lipodystrophy and Emery\u2013Dreifuss muscular dystrophy","volume":"282","author":"Favreau","year":"2003","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.tem.2026.01.010_bb0600","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1083\/jcb.201701043","article-title":"A lipodystrophy-causing lamin A mutant alters conformation and epigenetic regulation of the antiadipogenic MIR335 locus","volume":"216","author":"Oldenburg","year":"2017","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.tem.2026.01.010_bb0605","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.bbrc.2017.11.008","article-title":"FPLD2 LMNA mutation R482W dysregulates iPSC-derived adipocyte function and lipid metabolism","volume":"495","author":"Friesen","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.tem.2026.01.010_bb0610","doi-asserted-by":"crossref","DOI":"10.2337\/db24-1470-P","article-title":"1470-P: modeling familial partial lipodystrophy type 2 (LMNA p.R482W) utilizing iPSC-derived adipocytes","volume":"73","author":"Borrego Alvarez","year":"2024","journal-title":"Diabetes"},{"key":"10.1016\/j.tem.2026.01.010_bb0615","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1093\/hmg\/ddi158","article-title":"Altered pre-lamin A processing is a common mechanism leading to lipodystrophy","volume":"14","author":"Capanni","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.tem.2026.01.010_bb0620","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1139\/bcb-2017-0210","article-title":"Lamin A\/C mutation associated with lipodystrophy influences adipogenic differentiation of stem cells through interaction with Notch signaling","volume":"96","author":"Perepelina","year":"2018","journal-title":"Biochem. Cell Biol."},{"key":"10.1016\/j.tem.2026.01.010_bb0625","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1111\/j.1582-4934.2009.00690.x","article-title":"The R439C mutation in LMNA causes lamin oligomerization and susceptibility to oxidative stress","volume":"13","author":"Verstraeten","year":"2009","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.tem.2026.01.010_bb0630","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1091\/mbc.e12-07-0527","article-title":"Lamin A tail modification by SUMO1 is disrupted by familial partial lipodystrophy-causing mutations","volume":"24","author":"Simon","year":"2013","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.tem.2026.01.010_bb0635","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.3390\/jcm10071497","article-title":"Variable expressivity and allelic heterogeneity in type 2 familial partial lipodystrophy: the p.(Thr528Met) LMNA variant","volume":"10","author":"Ara\u00fajo-Vilar","year":"2021","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.tem.2026.01.010_bb0640","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1080\/21623945.2019.1640007","article-title":"A new laminopathy caused by an Arg133\/Leu mutation in lamin A\/C and the effects thereof on adipocyte differentiation and the transcriptome","volume":"8","author":"Wang","year":"2019","journal-title":"Adipocyte"},{"key":"10.1016\/j.tem.2026.01.010_bb0645","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/j.stem.2020.12.016","article-title":"Pathogenic LMNA variants disrupt cardiac lamina\u2013chromatin interactions and de-repress alternative fate genes","volume":"28","author":"Shah","year":"2021","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.tem.2026.01.010_bb0650","doi-asserted-by":"crossref","DOI":"10.1091\/mbc.E21-10-0527","article-title":"Nuclear damage in LMNA mutant iPSC-derived cardiomyocytes is associated with impaired lamin localization to the nuclear envelope","volume":"34","author":"Wallace","year":"2023","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.tem.2026.01.010_bb0655","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1016\/j.yexcr.2008.04.017","article-title":"Specific contribution of lamin A and lamin C in the development of laminopathies","volume":"314","author":"Sylvius","year":"2008","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.tem.2026.01.010_bb0660","doi-asserted-by":"crossref","first-page":"7000","DOI":"10.1038\/s41467-024-51318-5","article-title":"Lamin A\/C deficiency-mediated ROS elevation contributes to pathogenic phenotypes of dilated cardiomyopathy in iPSC model","volume":"15","author":"Qiu","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tem.2026.01.010_bb0665","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/s41563-019-0563-5","article-title":"Mutant lamins cause nuclear envelope rupture and DNA damage in skeletal muscle cells","volume":"19","author":"Earle","year":"2020","journal-title":"Nat. Mater."},{"key":"10.1016\/j.tem.2026.01.010_bb0670","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.nmd.2024.03.006","article-title":"Proteomic characterization of human LMNA-related congenital muscular dystrophy muscle cells","volume":"38","author":"Storey","year":"2024","journal-title":"Neuromuscul. Disord."},{"key":"10.1016\/j.tem.2026.01.010_bb0675","doi-asserted-by":"crossref","first-page":"816","DOI":"10.3390\/cells9040816","article-title":"Lamin mutations cause increased YAP nuclear entry in muscle stem cells","volume":"9","author":"Owens","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.tem.2026.01.010_bb0680","doi-asserted-by":"crossref","first-page":"3997","DOI":"10.1093\/hmg\/ddr327","article-title":"The accumulation of un-repairable DNA damage in laminopathy progeria fibroblasts is caused by ROS generation and is prevented by treatment with N-acetylcysteine","volume":"20","author":"Richards","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.tem.2026.01.010_bb0685","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.devcel.2020.02.011","article-title":"Phosphorylated lamin A\/C in the nuclear interior binds active enhancers associated with abnormal transcription in progeria","volume":"52","author":"Ikegami","year":"2020","journal-title":"Dev. Cell"},{"key":"10.1016\/j.tem.2026.01.010_bb0690","article-title":"Hutchinson\u2013Gilford progeria syndrome: a literature review","volume":"14","author":"Lamis","year":"2022","journal-title":"Cureus"},{"key":"10.1016\/j.tem.2026.01.010_bb0695","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1194\/jlr.M800491-JLR200","article-title":"The role of LMNA in adipose: a novel mouse model of lipodystrophy based on the Dunnigan-type familial partial lipodystrophy mutation","volume":"50","author":"Wojtanik","year":"2009","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.tem.2026.01.010_bb0700","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1194\/jlr.M071381","article-title":"Extracellular matrix remodeling and transforming growth factor-\u03b2 signaling abnormalities induced by lamin A\/C variants that cause lipodystrophy","volume":"58","author":"Le Dour","year":"2017","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.tem.2026.01.010_bb0705","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1093\/hmg\/ddr534","article-title":"DelK32-lamin A\/C has abnormal location and induces incomplete tissue maturation and severe metabolic defects leading to premature death","volume":"21","author":"Bertrand","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.tem.2026.01.010_bb0710","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1093\/hmg\/ddl170","article-title":"Pathology and nuclear abnormalities in hearts of transgenic mice expressing M371K lamin A encoded by an LMNA mutation causing Emery\u2013Dreifuss muscular dystrophy","volume":"15","author":"Wang","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.tem.2026.01.010_bb0715","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/nature01631","article-title":"A progeroid syndrome in mice is caused by defects in A-type lamins","volume":"423","author":"Mounkes","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.tem.2026.01.010_bb0720","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1093\/hmg\/ddi221","article-title":"Expression of an LMNA-N195K variant of A-type lamins results in cardiac conduction defects and death in mice","volume":"14","author":"Mounkes","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.tem.2026.01.010_bb0725","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.ijcard.2022.06.038","article-title":"The LMNA p.R541C mutation causes dilated cardiomyopathy in human and mice","volume":"363","author":"Yang","year":"2022","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.tem.2026.01.010_bb0730","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.jacbts.2023.11.002","article-title":"Primate model carrying LMNA mutation develops dilated cardiomyopathy","volume":"9","author":"Luo","year":"2024","journal-title":"JACC Basic Transl. Sci."},{"key":"10.1016\/j.tem.2026.01.010_bb0735","article-title":"CRISPR\/Cas9-mediated elimination of the LMNA c.745C>G pathogenic mutation enhances survival and cardiac function in LMNA-associated congenital muscular dystrophy","author":"G\u00f3mez-Dom\u00ednguez","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.tem.2026.01.010_bb0740","doi-asserted-by":"crossref","first-page":"10291","DOI":"10.1073\/pnas.0504641102","article-title":"Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson\u2013Gilford progeria syndrome mutation","volume":"102","author":"Yang","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tem.2026.01.010_bb0745","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3002847","article-title":"Splicing-directed therapy in a new mouse model of human accelerated aging","volume":"3","author":"Osorio","year":"2011","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.tem.2026.01.010_bb0750","doi-asserted-by":"crossref","first-page":"3291","DOI":"10.1172\/JCI35876","article-title":"Progerin elicits disease phenotypes of progeria in mice whether or not it is farnesylated","volume":"118","author":"Yang","year":"2008","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tem.2026.01.010_bb0755","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s12017-012-8168-z","article-title":"Behavioral and molecular exploration of the AR-CMT2A mouse model Lmna R298C\/R298C","volume":"14","author":"Poitelon","year":"2012","journal-title":"NeuroMolecular Med."},{"key":"10.1016\/j.tem.2026.01.010_bb0760","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.ajpath.2012.05.031","article-title":"Pathological features in the LmnaDhe\/+ mutant mouse provide a novel model of human otitis media and laminopathies","volume":"181","author":"Zhang","year":"2012","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.tem.2026.01.010_bb0765","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1002\/1873-3468.13070","article-title":"Of mice and men\u2014environmental temperature, body temperature, and treatment of obesity","volume":"592","author":"Reitman","year":"2018","journal-title":"FEBS Lett."},{"key":"10.1016\/j.tem.2026.01.010_bb0770","doi-asserted-by":"crossref","first-page":"10428","DOI":"10.1073\/pnas.0401424101","article-title":"Lamin B1 is required for mouse development and nuclear integrity","volume":"101","author":"Vergnes","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tem.2026.01.010_bb0775","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1016\/j.bpj.2014.01.045","article-title":"Adipocyte stiffness increases with accumulation of lipid droplets","volume":"106","author":"Shoham","year":"2014","journal-title":"Biophys. J."},{"key":"10.1016\/j.tem.2026.01.010_bb0780","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202208123","article-title":"Small lipid droplets are rigid enough to indent a nucleus, dilute the lamina, and cause rupture","volume":"222","author":"Ivanovska","year":"2023","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.tem.2026.01.010_bb0785","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1111\/cen.13311","article-title":"Spectrum of disease associated with partial lipodystrophy: lessons from a trial cohort","volume":"86","author":"Ajluni","year":"2017","journal-title":"Clin. Endocrinol. (Oxf)"},{"key":"10.1016\/j.tem.2026.01.010_bb0790","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s40842-018-0058-3","article-title":"Potential association of LMNA-associated generalized lipodystrophy with juvenile dermatomyositis","volume":"4","author":"Sahinoz","year":"2018","journal-title":"Clin. Diabetes Endocrinol."},{"key":"10.1016\/j.tem.2026.01.010_bb0795","doi-asserted-by":"crossref","first-page":"844","DOI":"10.3390\/cells9040844","article-title":"Lamin A\/C assembly defects in LMNA-congenital muscular dystrophy is responsible for the increased severity of the disease compared with Emery\u2013Dreifuss muscular dystrophy","volume":"9","author":"Bertrand","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.tem.2026.01.010_bb0800","doi-asserted-by":"crossref","first-page":"12888","DOI":"10.1074\/jbc.M413788200","article-title":"The fatty acid-binding protein, aP2, coordinates macrophage cholesterol trafficking and inflammatory activity. Macrophage expression of aP2 impacts peroxisome proliferator-activated receptor \u03b3 and IkappaB kinase activities","volume":"280","author":"Makowski","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tem.2026.01.010_bb0805","doi-asserted-by":"crossref","first-page":"864","DOI":"10.2337\/db12-1089","article-title":"Lessons on conditional gene targeting in mouse adipose tissue","volume":"62","author":"Lee","year":"2013","journal-title":"Diabetes"},{"key":"10.1016\/j.tem.2026.01.010_bb0810","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/nature06902","article-title":"Dynamics of fat cell turnover in humans","volume":"453","author":"Spalding","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.tem.2026.01.010_bb0815","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.56189","article-title":"Dynamic control of adipose tissue development and adult tissue homeostasis by platelet-derived growth factor receptor \u03b1","volume":"9","author":"Shin","year":"2020","journal-title":"ELife"},{"key":"10.1016\/j.tem.2026.01.010_bb0820","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1136\/jmg.2008.059485","article-title":"Site-dependent differences in both prelamin A and adipogenic genes in subcutaneous adipose tissue of patients with type 2 familial partial lipodystrophy","volume":"46","author":"Ara\u00fajo-Vilar","year":"2009","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.tem.2026.01.010_bb0825","doi-asserted-by":"crossref","first-page":"3182","DOI":"10.1101\/gad.12.20.3182","article-title":"Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy","volume":"12","author":"Shimomura","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/j.tem.2026.01.010_bb0830","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1016\/j.ajpath.2011.07.049","article-title":"LMNA mutations induce a noninflammatory fibrosis and a brown fat-like dystrophy of enlarged cervical adipose tissue","volume":"179","author":"B\u00e9r\u00e9ziat","year":"2011","journal-title":"Am. J. Pathol."}],"container-title":["Trends in Endocrinology & Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S104327602600010X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S104327602600010X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T15:06:17Z","timestamp":1788793577000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S104327602600010X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":166,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S104327602600010X"],"URL":"https:\/\/doi.org\/10.1016\/j.tem.2026.01.010","relation":{},"ISSN":["1043-2760"],"issn-type":[{"value":"1043-2760","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lamin A\/C in health, laminopathies, and familial partial lipodystrophy 2","name":"articletitle","label":"Article Title"},{"value":"Trends in Endocrinology & Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tem.2026.01.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}