{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T09:52:53Z","timestamp":1791021173611,"version":"4.1.0"},"reference-count":79,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"NSFC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Endocrinology & Metabolism"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.tem.2026.09.008","type":"journal-article","created":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T04:26:39Z","timestamp":1790915199000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Isoform usage dynamics in metabolic adaptation"],"prefix":"10.1016","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-2841-6363","authenticated-orcid":false,"given":"Yadanar T.","family":"Naing","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1388-3129","authenticated-orcid":false,"given":"Xianli","family":"Ju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8360-3912","authenticated-orcid":false,"given":"Jia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3937-941X","authenticated-orcid":false,"given":"Lei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tem.2026.09.008_bb0005","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1038\/s12276-023-01006-z","article-title":"Nutrient sensors and their crosstalk","volume":"55","author":"Sung","year":"2023","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.tem.2026.09.008_bb0010","article-title":"Post-ingestive systemic nutrient sensing for whole-body homeostasis","volume":"48","author":"Lee","year":"2025","journal-title":"Mol. Cell"},{"key":"10.1016\/j.tem.2026.09.008_bb0015","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1038\/s41576-022-00514-4","article-title":"Alternative splicing as a source of phenotypic diversity","volume":"23","author":"Wright","year":"2022","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.tem.2026.09.008_bb0020","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.cmet.2025.01.009","article-title":"Isoform usage as a distinct regulatory layer driving nutrient-responsive metabolic adaptation","volume":"37","author":"Li","year":"2025","journal-title":"Cell Metab."},{"key":"10.1016\/j.tem.2026.09.008_bb0025","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.tcb.2024.02.002","article-title":"Metabolic regulation of mRNA splicing","volume":"34","author":"Cui","year":"2024","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.tem.2026.09.008_bb0030","article-title":"Unveiling tissue-specific RNA landscapes in mouse organs during fasting and feeding using nanopore direct RNA sequencing","volume":"12","author":"Jiang","year":"2025","journal-title":"Adv. Sci.(Weinh)"},{"key":"10.1016\/j.tem.2026.09.008_bb0035","doi-asserted-by":"crossref","first-page":"4558","DOI":"10.1016\/j.molcel.2024.10.037","article-title":"Nutrient control of growth and metabolism through mTORC1 regulation of mRNA splicing","volume":"84","author":"Ogawa","year":"2024","journal-title":"Mol. Cell"},{"key":"10.1016\/j.tem.2026.09.008_bb0040","article-title":"Isoform age splice isoform profiling using long-read technologies","volume":"8","author":"De Paoli-Iseppi","year":"2021","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.tem.2026.09.008_bb0045","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1038\/s41592-024-02298-3","article-title":"Systematic assessment of long-read RNA-seq methods for transcript identification and quantification","volume":"21","author":"Pardo-Palacios","year":"2024","journal-title":"Nat. Methods"},{"key":"10.1016\/j.tem.2026.09.008_bb0050","doi-asserted-by":"crossref","first-page":"18779","DOI":"10.1074\/jbc.272.30.18779","article-title":"The organization, promoter analysis, and expression of the human PPAR\u03b3 gene","volume":"272","author":"Fajas","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tem.2026.09.008_bb0055","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1172\/JCI119424","article-title":"Peroxisome proliferator-activated receptor gene expression in human tissues: effects of obesity, weight loss, and regulation by insulin and glucocorticoids","volume":"99","author":"Vidal-Puig","year":"1997","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tem.2026.09.008_bb0060","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.0030064","article-title":"PPAR\u03b32 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism","volume":"3","author":"Medina-Gomez","year":"2007","journal-title":"PLoS Genet."},{"key":"10.1016\/j.tem.2026.09.008_bb0065","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1016\/j.celrep.2018.07.063","article-title":"Peroxisome proliferator-activated receptor \u03b32 controls the rate of adipose tissue lipid storage and determines metabolic flexibility","volume":"24","author":"Virtue","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.tem.2026.09.008_bb0070","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1101\/gad.349232.121","article-title":"Isoform-specific functions of PPAR\u03b3 in gene regulation and metabolism","volume":"36","author":"Hu","year":"2022","journal-title":"Genes Dev."},{"key":"10.1016\/j.tem.2026.09.008_bb0075","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/3099","article-title":"A Pro12Ala substitution in PPAR\u03b32 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity","volume":"20","author":"Deeb","year":"1998","journal-title":"Nat. Genet."},{"key":"10.1016\/j.tem.2026.09.008_bb0080","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1093\/aje\/kwp450","article-title":"The association between the peroxisome proliferator-activated receptor-gamma2 (PPARG2) Pro12Ala gene variant and type 2 diabetes mellitus: a HuGE review and meta-analysis","volume":"171","author":"Gouda","year":"2010","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.tem.2026.09.008_bb0085","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.3390\/ijms25021109","article-title":"The role of SCAP\/SREBP as central regulators of lipid metabolism in hepatic steatosis","volume":"25","author":"Chandrasekaran","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tem.2026.09.008_bb0090","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1172\/JCI119247","article-title":"Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells","volume":"99","author":"Shimomura","year":"1997","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tem.2026.09.008_bb0095","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1172\/JCI119248","article-title":"Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells","volume":"99","author":"Shimano","year":"1997","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tem.2026.09.008_bb0100","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1172\/JCI118951","article-title":"Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a","volume":"98","author":"Shimano","year":"1996","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tem.2026.09.008_bb0105","doi-asserted-by":"crossref","first-page":"4864","DOI":"10.1128\/MCB.00553-09","article-title":"Sterol regulatory element binding protein 1a regulates hepatic fatty acid partitioning by activating acetyl coenzyme A carboxylase 2","volume":"29","author":"Im","year":"2009","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.tem.2026.09.008_bb0110","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.cmet.2011.04.001","article-title":"Linking lipid metabolism to the innate immune response in macrophages through sterol regulatory element binding protein-1a","volume":"13","author":"Im","year":"2011","journal-title":"Cell Metab."},{"key":"10.1016\/j.tem.2026.09.008_bb0115","doi-asserted-by":"crossref","first-page":"G627","DOI":"10.1152\/ajpgi.00090.2022","article-title":"Hepatocyte- or macrophage-specific SREBP-1a deficiency in mice exacerbates methionine- and choline-deficient diet-induced nonalcoholic fatty liver disease","volume":"323","author":"Araki","year":"2022","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.tem.2026.09.008_bb0120","doi-asserted-by":"crossref","first-page":"12737","DOI":"10.1073\/pnas.96.22.12737","article-title":"Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes","volume":"96","author":"Foretz","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tem.2026.09.008_bb0125","doi-asserted-by":"crossref","first-page":"3760","DOI":"10.1128\/MCB.19.5.3760","article-title":"ADD1\/SREBP-1c is required in the activation of hepatic lipogenic gene expression by glucose","volume":"19","author":"Foretz","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.tem.2026.09.008_bb0130","doi-asserted-by":"crossref","first-page":"9520","DOI":"10.1074\/jbc.M111421200","article-title":"Diminished hepatic response to fasting\/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c","volume":"277","author":"Liang","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tem.2026.09.008_bb0135","doi-asserted-by":"crossref","first-page":"3594","DOI":"10.1210\/en.2009-0377","article-title":"Differential signaling activation by insulin and insulin-like growth factors I and II upon binding to insulin receptor isoform A","volume":"150","author":"Sacco","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.tem.2026.09.008_bb0140","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1210\/er.2017-00073","article-title":"Insulin receptor isoforms in physiology and disease: an updated view","volume":"38","author":"Belfiore","year":"2017","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.tem.2026.09.008_bb0145","doi-asserted-by":"crossref","first-page":"3278","DOI":"10.1128\/MCB.19.5.3278","article-title":"Insulin receptor isoform A, a newly recognized, high-affinity insulin-like growth factor II receptor in fetal and cancer cells","volume":"19","author":"Frasca","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.tem.2026.09.008_bb0150","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1210\/mend-3-8-1263","article-title":"Tissue-specific expression of two alternatively spliced insulin receptor mRNAs in man","volume":"3","author":"Moller","year":"1989","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.tem.2026.09.008_bb0155","doi-asserted-by":"crossref","first-page":"31222","DOI":"10.1038\/srep31222","article-title":"Insulin receptor alternative splicing is regulated by insulin signalling and modulates beta cell survival","volume":"6","author":"Malakar","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tem.2026.09.008_bb0160","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1677\/jme.1.01635","article-title":"Differential gene expression of insulin receptor isoforms A and B and insulin receptor substrates 1, 2 and 3 in rat tissues: modulation by aging and differentiation in rat adipose tissue","volume":"34","author":"Serrano","year":"2005","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.tem.2026.09.008_bb0165","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1007\/s00125-010-1760-6","article-title":"Insulin analogues differently activate insulin receptor isoforms and post-receptor signalling","volume":"53","author":"Sciacca","year":"2010","journal-title":"Diabetologia"},{"key":"10.1016\/j.tem.2026.09.008_bb0170","doi-asserted-by":"crossref","first-page":"2650","DOI":"10.1210\/en.2002-0136","article-title":"Signalling differences from the A and B isoforms of the insulin receptor (IR) in 32D cells in the presence or absence of IR substrate-1","volume":"144","author":"Sciacca","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.tem.2026.09.008_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.110017","article-title":"Insulin receptor isoform B is required for efficient proinsulin processing in pancreatic \u03b2 cells","volume":"27","author":"Jiang","year":"2024","journal-title":"iScience"},{"key":"10.1016\/j.tem.2026.09.008_bb0180","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2210434119","article-title":"Phosphorylation of RXR\u03b1 mediates the effect of JNK to suppress hepatic FGF21 expression and promote metabolic syndrome","volume":"119","author":"Vernia","year":"2022","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tem.2026.09.008_bb0185","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2527162123","article-title":"Mutually exclusive alternative pre-mRNA splicing promotes adaptive metabolic stress signaling by JNK","volume":"123","author":"Lee","year":"2026","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tem.2026.09.008_bb0190","doi-asserted-by":"crossref","first-page":"3450","DOI":"10.1074\/jbc.M610745200","article-title":"Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns","volume":"282","author":"Donkor","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tem.2026.09.008_bb0195","doi-asserted-by":"crossref","first-page":"32883","DOI":"10.1074\/jbc.M503885200","article-title":"Alternatively spliced lipin isoforms exhibit distinct expression pattern, subcellular localization, and role in adipogenesis","volume":"280","author":"P\u00e9terfy","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tem.2026.09.008_bb0200","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1074\/jbc.M209505200","article-title":"Natural structural variants of the nuclear receptor farnesoid X receptor affect transcriptional activation","volume":"278","author":"Zhang","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tem.2026.09.008_bb0205","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1053\/j.gastro.2020.07.036","article-title":"FXR isoforms control different metabolic functions in liver cells via binding to specific DNA motifs","volume":"159","author":"Pittol","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.tem.2026.09.008_bb0210","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0115028","article-title":"Hepatic farnesoid X-receptor isoforms \u03b12 and \u03b14 differentially modulate bile salt and lipoprotein metabolism in mice","volume":"9","author":"Boesjes","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.tem.2026.09.008_bb0215","doi-asserted-by":"crossref","first-page":"15241","DOI":"10.1074\/jbc.273.24.15241","article-title":"SR-BII, an isoform of the scavenger receptor BI containing an alternate cytoplasmic tail, mediates lipid transfer between high-density lipoprotein and cells","volume":"273","author":"Webb","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tem.2026.09.008_bb0220","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1038\/s42255-022-00681-y","article-title":"Liver RBFOX2 regulates cholesterol homeostasis via Scarb1 alternative splicing in mice","volume":"4","author":"Paterson","year":"2022","journal-title":"Nat. Metab."},{"key":"10.1016\/j.tem.2026.09.008_bb0225","doi-asserted-by":"crossref","first-page":"4348","DOI":"10.1074\/jbc.M513154200","article-title":"High-density lipoprotein endocytosis by scavenger receptor SR-BII is clathrin-dependent and requires a carboxyl-terminal dileucine motif","volume":"281","author":"Eckhardt","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tem.2026.09.008_bb0230","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/j.cell.2017.10.037","article-title":"Post-transcriptional regulation of de novo lipogenesis by mTORC1-S6K1-SRPK2 signaling","volume":"171","author":"Lee","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.tem.2026.09.008_bb0235","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1053\/j.gastro.2006.04.019","article-title":"S-adenosylmethionine regulates cytoplasmic HuR via AMP-activated kinase","volume":"131","author":"Mart\u00ednez-Chantar","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.tem.2026.09.008_bb0240","doi-asserted-by":"crossref","first-page":"3425","DOI":"10.1128\/MCB.22.10.3425-3436.2002","article-title":"AMP-activated kinase regulates cytoplasmic HuR","volume":"22","author":"Wang","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.tem.2026.09.008_bb0245","doi-asserted-by":"crossref","first-page":"48376","DOI":"10.1074\/jbc.M409014200","article-title":"AMP-activated protein kinase-regulated phosphorylation and acetylation of importin \u03b11: involvement in the nuclear import of RNA-binding protein HuR","volume":"279","author":"Wang","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tem.2026.09.008_bb0250","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/s41467-019-14001-8","article-title":"The RNA-binding protein HuR is a negative regulator in adipogenesis","volume":"11","author":"Siang","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tem.2026.09.008_bb0255","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1038\/s41467-019-10348-0","article-title":"Adipose HuR protects against diet-induced obesity and insulin resistance","volume":"10","author":"Li","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tem.2026.09.008_bb0260","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.cmet.2017.12.010","article-title":"The RNA-binding protein NONO coordinates hepatic adaptation to feeding","volume":"27","author":"Benegiamo","year":"2018","journal-title":"Cell Metab."},{"key":"10.1016\/j.tem.2026.09.008_bb0265","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1128\/MCB.01674-13","article-title":"SRSF10 regulates alternative splicing and is required for adipocyte differentiation","volume":"34","author":"Li","year":"2014","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.tem.2026.09.008_bb0270","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1016\/j.celrep.2015.10.038","article-title":"SRSF10 plays a role in myoblast differentiation and glucose production via regulation of alternative splicing","volume":"13","author":"Wei","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.tem.2026.09.008_bb0275","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1097\/HEP.0000000000000433","article-title":"Targeting hepatic serine-arginine protein kinase 2 ameliorates alcohol-associated liver disease by alternative splicing control of lipogenesis","volume":"78","author":"Li","year":"2023","journal-title":"Hepatology"},{"key":"10.1016\/j.tem.2026.09.008_bb0280","doi-asserted-by":"crossref","first-page":"3379","DOI":"10.1093\/nar\/gkac165","article-title":"Dysregulated RNA polyadenylation contributes to metabolic impairment in non-alcoholic fatty liver disease","volume":"50","author":"Jobbins","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.tem.2026.09.008_bb0285","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.cell.2022.12.004","article-title":"Glucose dissociates DDX21 dimers to regulate mRNA splicing and tissue differentiation","volume":"186","author":"Miao","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.tem.2026.09.008_bb0290","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.cmet.2011.06.007","article-title":"Expression of the splicing factor gene SFRS10 is reduced in human obesity and contributes to enhanced lipogenesis","volume":"14","author":"Pihlajam\u00e4ki","year":"2011","journal-title":"Cell Metab."},{"key":"10.1016\/j.tem.2026.09.008_bb0295","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1016\/j.cmet.2025.07.007","article-title":"HNF1A and A1CF coordinate a beta cell transcription-splicing axis that is disrupted in type 2 diabetes","volume":"37","author":"Bernardo","year":"2025","journal-title":"Cell Metab."},{"key":"10.1016\/j.tem.2026.09.008_bb0300","first-page":"219","article-title":"Pancreatic microexons regulate islet function and glucose homeostasis","volume":"5","author":"Juan-Mateu","year":"2023","journal-title":"Nat. Metab."},{"key":"10.1016\/j.tem.2026.09.008_bb0305","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.2337\/db07-0156","article-title":"Genes involved in fatty acid partitioning and binding, lipolysis, monocyte\/macrophage recruitment, and inflammation are overexpressed in the human fatty liver of insulin-resistant subjects","volume":"56","author":"Westerbacka","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.tem.2026.09.008_bb0310","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1038\/ncomms2537","article-title":"De novo lipogenesis in human fat and liver is linked to ChREBP-\u03b2 and metabolic health","volume":"4","author":"Eissing","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tem.2026.09.008_bb0315","doi-asserted-by":"crossref","first-page":"2500","DOI":"10.1038\/s41598-024-52237-7","article-title":"Dysregulation of RNA splicing in early non-alcoholic fatty liver disease through hepatocellular carcinoma","volume":"14","author":"Webster","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tem.2026.09.008_bb0320","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/S2468-1253(20)30077-7","article-title":"Global prevalence, incidence, and outcomes of non-obese or lean non-alcoholic fatty liver disease: a systematic review and meta-analysis","volume":"5","author":"Ye","year":"2020","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"10.1016\/j.tem.2026.09.008_bb0325","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1038\/s42003-024-06475-0","article-title":"Regulation of endocrine cell alternative splicing revealed by single-cell RNA sequencing in type 2 diabetes pathogenesis","volume":"7","author":"Wang","year":"2024","journal-title":"Commun. Biol."},{"key":"10.1016\/j.tem.2026.09.008_bb0330","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1186\/s13059-022-02757-0","article-title":"Genetic regulation of RNA splicing in human pancreatic islets","volume":"23","author":"Atla","year":"2022","journal-title":"Genome Biol."},{"key":"10.1016\/j.tem.2026.09.008_bb0335","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ajhg.2021.11.019","article-title":"Subcutaneous adipose tissue splice quantitative trait loci reveal differences in isoform usage associated with cardiometabolic traits","volume":"109","author":"Brotman","year":"2022","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.tem.2026.09.008_bb0340","doi-asserted-by":"crossref","DOI":"10.1172\/JCI163464","article-title":"A splice-switching oligonucleotide treatment ameliorates glycogen storage disease type 1a in mice with G6PC c.648G>T","volume":"133","author":"Ito","year":"2023","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tem.2026.09.008_bb0345","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/j.cmet.2024.04.003","article-title":"TM7SF3 controls TEAD1 splicing to prevent MASH-induced liver fibrosis","volume":"36","author":"Isaac","year":"2024","journal-title":"Cell Metab."},{"key":"10.1016\/j.tem.2026.09.008_bb0350","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1016\/j.cmet.2021.09.008","article-title":"DRAK2 aggravates nonalcoholic fatty liver disease progression through SRSF6-associated RNA alternative splicing","volume":"33","author":"Li","year":"2021","journal-title":"Cell Metab."},{"key":"10.1016\/j.tem.2026.09.008_bb0355","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/nrm.2017.103","article-title":"Functional 5\u2032 UTR mRNA structures in eukaryotic translation regulation and how to find them","volume":"19","author":"Leppek","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.tem.2026.09.008_bb0360","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1101\/gr.279176.124","article-title":"Long-read Ribo-STAMP simultaneously measures transcription and translation with isoform resolution","volume":"34","author":"Jagannatha","year":"2024","journal-title":"Genome Res."},{"key":"10.1016\/j.tem.2026.09.008_bb0365","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.tcb.2015.10.012","article-title":"Evolution and biological roles of alternative 3\u2032UTRs","volume":"26","author":"Mayr","year":"2016","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.tem.2026.09.008_bb0370","doi-asserted-by":"crossref","first-page":"6916","DOI":"10.1038\/s41467-024-51252-6","article-title":"Single-cell long-read targeted sequencing reveals transcriptional variation in ovarian cancer","volume":"15","author":"Byrne","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tem.2026.09.008_bb0375","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1126\/science.1184208","article-title":"Regulation of alternative splicing by histone modifications","volume":"327","author":"Luco","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.tem.2026.09.008_bb0380","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.molcel.2016.01.012","article-title":"Nuclear m6A reader YTHDC1 regulates mRNA splicing","volume":"61","author":"Xiao","year":"2016","journal-title":"Mol. Cell"},{"key":"10.1016\/j.tem.2026.09.008_bb0385","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1016\/j.molcel.2021.03.010","article-title":"mTORC1 promotes cell growth via m6A-dependent mRNA degradation","volume":"81","author":"Cho","year":"2021","journal-title":"Mol. Cell"},{"key":"10.1016\/j.tem.2026.09.008_bb0390","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1016\/j.molcel.2021.03.009","article-title":"mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis","volume":"81","author":"Villa","year":"2021","journal-title":"Mol. Cell"},{"key":"10.1016\/j.tem.2026.09.008_bb0395","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1038\/cr.2014.151","article-title":"FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis","volume":"24","author":"Zhao","year":"2014","journal-title":"Cell Res."}],"container-title":["Trends in Endocrinology & Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S104327602600247X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S104327602600247X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T08:55:28Z","timestamp":1791017728000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S104327602600247X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":79,"alternative-id":["S104327602600247X"],"URL":"https:\/\/doi.org\/10.1016\/j.tem.2026.09.008","relation":{},"ISSN":["1043-2760"],"issn-type":[{"value":"1043-2760","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Isoform usage dynamics in metabolic adaptation","name":"articletitle","label":"Article Title"},{"value":"Trends in Endocrinology & Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tem.2026.09.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}