{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T20:10:36Z","timestamp":1786997436683,"version":"build-2736575974"},"reference-count":36,"publisher":"Elsevier BV","issue":"50","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tetrahedron"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1016\/j.tet.2012.09.084","type":"journal-article","created":{"date-parts":[[2012,9,25]],"date-time":"2012-09-25T15:18:20Z","timestamp":1348586300000},"page":"10360-10364","source":"Crossref","is-referenced-by-count":15,"title":["Improved synthesis of 3-aryl isoxazoles containing fused aromatic rings"],"prefix":"10.1016","volume":"68","author":[{"given":"Yousef R.","family":"Mirzaei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Weaver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott A.","family":"Steiger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison K.","family":"Kearns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariusz P.","family":"Gajewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin C.","family":"Rider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard D.","family":"Beall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.R.","family":"Natale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tet.2012.09.084_bib1a","doi-asserted-by":"crossref","first-page":"4001","DOI":"10.1016\/j.tetlet.2011.05.104","volume":"52","author":"Zhu","year":"2011","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.tet.2012.09.084_bib1b","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.bmcl.2009.11.070","volume":"20","author":"Nakamura","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.tet.2012.09.084_bib2_1","unstructured":"The Kurth group has provided a useful catalog of the bioactive isoxazole literature in their NOC synthesis papers over the years, the following are illustrative examples:"},{"key":"10.1016\/j.tet.2012.09.084_bib2a","first-page":"1063","author":"Yu","year":"2010","journal-title":"Synlett"},{"key":"10.1016\/j.tet.2012.09.084_bib2b","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1021\/cc900133k","volume":"12","author":"Meng","year":"2010","journal-title":"J. Comb. Chem."},{"key":"10.1016\/j.tet.2012.09.084_bib2c","doi-asserted-by":"crossref","first-page":"5110","DOI":"10.1016\/j.tetlet.2009.06.100","volume":"50","author":"Butler","year":"2009","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.tet.2012.09.084_bib2d","first-page":"3036","author":"Choung","year":"2008","journal-title":"Synlett"},{"key":"10.1016\/j.tet.2012.09.084_bib2e","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1021\/jo0352124","volume":"69","author":"Quan","year":"2004","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.tet.2012.09.084_bib2f","doi-asserted-by":"crossref","first-page":"6564","DOI":"10.1021\/jo016377k","volume":"67","author":"Hwang","year":"2002","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.tet.2012.09.084_bib3","series-title":"Glutamate and GABA Receptors and Transporters, Structure Function and Pharmacology","year":"2002"},{"key":"10.1016\/j.tet.2012.09.084_bib4","doi-asserted-by":"crossref","first-page":"925","DOI":"10.2174\/1385272054368420","volume":"9","author":"Pinho e Melo","year":"2005","journal-title":"Curr. Org. Chem."},{"key":"10.1016\/j.tet.2012.09.084_bib5","doi-asserted-by":"crossref","first-page":"5971","DOI":"10.1002\/ejoc.200900802","author":"Trogu","year":"2009","journal-title":"Eur. J. Org. Chem."},{"key":"10.1016\/j.tet.2012.09.084_bib6","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1021\/ol027283f","volume":"5","author":"Bode","year":"2003","journal-title":"Org. Lett."},{"key":"10.1016\/j.tet.2012.09.084_bib7","doi-asserted-by":"crossref","first-page":"3555","DOI":"10.1016\/S0040-4039(03)00614-2","volume":"44","author":"Bode","year":"2003","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.tet.2012.09.084_bib8","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1016\/j.bmc.2008.12.056","volume":"17","author":"Han","year":"2009","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.tet.2012.09.084_bib9","doi-asserted-by":"crossref","first-page":"4067","DOI":"10.1016\/j.bmcl.2009.06.019","volume":"19","author":"Gajewski","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.tet.2012.09.084_bib10a","doi-asserted-by":"crossref","first-page":"6882","DOI":"10.1158\/0008-5472.CAN-06-3948","volume":"67","author":"Veiseh","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.tet.2012.09.084_bib10b","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1021\/ol006825v","volume":"3","author":"Smeltzer","year":"2001","journal-title":"Org. Lett."},{"key":"10.1016\/j.tet.2012.09.084_bib10c","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/S0022-4804(03)00093-3","volume":"111","author":"McGreevy","year":"2003","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.tet.2012.09.084_bib11","series-title":"Nitrile Oxides, Nitrones and Nitronates in Organic Synthesis","author":"Feuer","year":"2008"},{"key":"10.1016\/j.tet.2012.09.084_bib12a","doi-asserted-by":"crossref","first-page":"5461","DOI":"10.1021\/ja00997a033","volume":"89","author":"Stork","year":"1967","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.tet.2012.09.084_bib12b","volume":"Collect. Vol. No. VI","author":"McMurry","year":"1988"},{"key":"10.1016\/j.tet.2012.09.084_bib13","doi-asserted-by":"crossref","first-page":"5660","DOI":"10.1021\/jo00350a047","volume":"50","author":"Natale","year":"1985","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.tet.2012.09.084_bib14","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1021\/jm020354w","volume":"46","author":"Zamponi","year":"2003","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.tet.2012.09.084_bib15","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1021\/ed062p1118","volume":"62","author":"Bowles","year":"1985","journal-title":"J. Chem. Educ."},{"key":"10.1016\/j.tet.2012.09.084_bib16a","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1002\/jhet.5570320314","volume":"32","author":"Mosher","year":"1995","journal-title":"J. Heterocycl. Chem."},{"key":"10.1016\/j.tet.2012.09.084_bib16b","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1002\/jhet.5570400321","volume":"40","author":"Han","year":"2003","journal-title":"J. Heterocycl. Chem."},{"key":"10.1016\/j.tet.2012.09.084_bib17","doi-asserted-by":"crossref","first-page":"2809","DOI":"10.1021\/jo01019a074","volume":"30","author":"Grundmann","year":"1965","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.tet.2012.09.084_bib18a","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1002\/prac.19813230222","volume":"323","author":"Beger","year":"1981","journal-title":"J. Prakt. Chem.\/Chem.-Ztg."},{"key":"10.1016\/j.tet.2012.09.084_bib18b","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1246\/cl.1982.71","volume":"1","author":"Fujisawa","year":"1982","journal-title":"Chem. Lett."},{"key":"10.1016\/j.tet.2012.09.084_bib19","doi-asserted-by":"crossref","first-page":"7673","DOI":"10.1016\/S0040-4039(02)01845-2","volume":"43","author":"Han","year":"2002","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.tet.2012.09.084_bib20a","first-page":"1478","volume":"95","author":"Renzi","year":"1965","journal-title":"Gazz. Chim. Ital."},{"key":"10.1016\/j.tet.2012.09.084_bib20b","first-page":"885","volume":"24","author":"Renzi","year":"1969","journal-title":"IL Farmaco Ed. Sci."},{"key":"10.1016\/j.tet.2012.09.084_bib21a","doi-asserted-by":"crossref","first-page":"5223","DOI":"10.1016\/j.bmcl.2004.06.060","volume":"14","author":"Liu","year":"2004","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.tet.2012.09.084_bib21b","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/j.bmcl.2004.11.075","volume":"15","author":"Xin","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.tet.2012.09.084_bib22","doi-asserted-by":"crossref","first-page":"9002","DOI":"10.1002\/chem.201001492","volume":"16","author":"Butler","year":"2010","journal-title":"Chem.\u2014Eur. J."}],"container-title":["Tetrahedron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040402012014743?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040402012014743?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T09:53:52Z","timestamp":1542707632000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040402012014743"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":36,"journal-issue":{"issue":"50","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["S0040402012014743"],"URL":"https:\/\/doi.org\/10.1016\/j.tet.2012.09.084","relation":{},"ISSN":["0040-4020"],"issn-type":[{"value":"0040-4020","type":"print"}],"subject":[],"published":{"date-parts":[[2012,12]]}}}