{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:11:24Z","timestamp":1790770284556,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Therapies"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.therap.2018.02.007","type":"journal-article","created":{"date-parts":[[2018,3,3]],"date-time":"2018-03-03T11:54:32Z","timestamp":1520078072000},"page":"399-407","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["Birth defects in children of men exposed in utero to diethylstilbestrol (DES)"],"prefix":"10.1016","volume":"73","author":[{"given":"Michel","family":"Tournaire","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3987-1842","authenticated-orcid":false,"given":"Emmanuel","family":"Devouche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Epelboin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Cabau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2879-0820","authenticated-orcid":false,"given":"Annabel","family":"Dunbavand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Levadou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.therap.2018.02.007_bib0175","first-page":"353","article-title":"Genital tract anomalies associated with in utero exposure to diethylstilbestrol","volume":"14","author":"Kaufman","year":"1978","journal-title":"Isr J Med Sci"},{"key":"10.1016\/j.therap.2018.02.007_bib0180","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1056\/NEJM198003133021105","article-title":"Fertility and outcome of pregnancy in women exposed in utero to diethylstilbestrol","volume":"302","author":"Barnes","year":"1980","journal-title":"N Engl J Med"},{"key":"10.1016\/j.therap.2018.02.007_bib0185","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1056\/NEJM198702263160905","article-title":"Rates and risks of doethylstibestrol related clear cell adenocarcinoma of the vagina and cervix","volume":"316","author":"Melnick","year":"1987","journal-title":"NEJM"},{"key":"10.1016\/j.therap.2018.02.007_bib0190","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1158\/1055-9965.EPI-06-0109","article-title":"Prenatal diethylstilbestrol exposure and risk of breast cancer","volume":"15","author":"Palmer","year":"2006","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.therap.2018.02.007_bib0195","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1002\/ijc.22631","article-title":"Cancer risk in women prenatally exposed to diethylstilbestrol","volume":"121","author":"Troisi","year":"2007","journal-title":"Int J Cancer"},{"key":"10.1016\/j.therap.2018.02.007_bib0200","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1007\/s10552-010-9526-5","article-title":"Cancer risk in DES daughters","volume":"21","author":"Verloop","year":"2010","journal-title":"Cancer Causes Control"},{"key":"10.1016\/j.therap.2018.02.007_bib0205","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1056\/NEJMoa1013961","article-title":"Lifetime burden of adverse health outcomes among women exposed in-utero to Diethylstilbestrol (DES)","volume":"365","author":"Hoover","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1016\/j.therap.2018.02.007_bib0210","doi-asserted-by":"crossref","first-page":"101","DOI":"10.2515\/therapie\/2014012","article-title":"Diethylstilbestrol story","volume":"69","author":"Tournaire","year":"2014","journal-title":"Therapie"},{"key":"10.1016\/j.therap.2018.02.007_bib0215","doi-asserted-by":"crossref","first-page":"433","DOI":"10.2515\/therapie\/2015030","article-title":"Cancer risk in women exposed to diethylstilbestrol in utero","volume":"70","author":"Tournaire","year":"2015","journal-title":"Therapie"},{"key":"10.1016\/j.therap.2018.02.007_bib0220","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1476-069X-8-37","article-title":"Urogenital abnormalities in men exposed to diethylstilbestrol in utero","volume":"8","author":"Palmer","year":"2009","journal-title":"Environ Health"},{"key":"10.1016\/j.therap.2018.02.007_bib0225","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1016\/j.fertnstert.2005.05.062","article-title":"Reproductive outcomes in men with prenatal exposure to diethylstilbestrol","volume":"84","author":"Perez","year":"2005","journal-title":"Fertil Steril"},{"key":"10.1016\/j.therap.2018.02.007_bib0230","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1093\/jnci\/93.7.545","article-title":"Cancer risk in men exposed in utero to diethylstilbestrol","volume":"93","author":"Strohsnitter","year":"2001","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.therap.2018.02.007_bib0235","first-page":"249","article-title":"L\u2019administration de di\u00e9thylstilbestrol (DES) pendant la grossesse, un probl\u00e8me de sant\u00e9 publique","volume":"31","author":"Spira","year":"1983","journal-title":"Rev Epidemiol Sante Publ"},{"key":"10.1016\/j.therap.2018.02.007_bib0240","first-page":"658","article-title":"Pharmacovigilance et reproduction\u00a0: le mauvais exemple du Distilb\u00e8ne","volume":"21","author":"Epelboin","year":"1993","journal-title":"Contracep Fertil Sex"},{"key":"10.1016\/j.therap.2018.02.007_bib0245","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.diff.2014.09.005","article-title":"Prenatal diethylstilbestrol induces malformation of the external genitalia of male and female mice and persistent second-generation developmental abnormalities of the external genitalia in two mouse stains","volume":"88","author":"Mahawong","year":"2014","journal-title":"Differentiation"},{"key":"10.1016\/j.therap.2018.02.007_bib0250","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/ijc.2910500126","article-title":"Occurrence of tumours in the descendants of cba male mice prenatally treated with diethylstilbestrol","volume":"50","author":"Turusov","year":"1992","journal-title":"Int J Cancer"},{"key":"10.1016\/j.therap.2018.02.007_bib0255","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1093\/carcin\/19.9.1655","article-title":"Increased tumors but uncompromised fertility in the female descendants of mice exposed developmentally to diethylstilbestrol","volume":"19","author":"Newbold","year":"1998","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.therap.2018.02.007_bib0260","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1093\/carcin\/21.7.1355","article-title":"Proliferative lesions and reproductive tract tumors in male descendants of mice exposed developmentally to diethylstilbestrol","volume":"21","author":"Newbold","year":"2000","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.therap.2018.02.007_bib0265","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1111\/j.1365-2605.2009.01010.x","article-title":"Birth defects in the sons and daughters of women who were exposed in utero to Diethylstilbestrol (DES)","volume":"33","author":"Titus-Ernstoff","year":"2010","journal-title":"Int J Androl"},{"key":"10.1016\/j.therap.2018.02.007_bib0270","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.therap.2016.01.006","article-title":"Adverse health effects in children of women exposed in utero to DES","volume":"71","author":"Tournaire","year":"2016","journal-title":"Therapie"},{"key":"10.1016\/j.therap.2018.02.007_bib0275","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1016\/S0140-6736(02)08152-7","article-title":"Hypospadias in sons of women exposed to diethylstilbestrol in utero: a cohort study","volume":"359","author":"Klip","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.therap.2018.02.007_bib0280","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1097\/01.ede.0000164789.59728.6d","article-title":"Hypospadias in sons of women exposed to diethylstilbestrol in utero","volume":"16","author":"Palmer","year":"2005","journal-title":"Epidemiology"},{"key":"10.1016\/j.therap.2018.02.007_bib0285","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1002\/pd.1136","article-title":"Hypospadias in sons of women exposed to diethylstilbestrol in utero","volume":"25","author":"Pons","year":"2005","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.therap.2018.02.007_bib0290","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1093\/humrep\/dei398","article-title":"Hypospadias: a transgenerational effect of diethylstilbestrol?","volume":"21","author":"Brouwers","year":"2006","journal-title":"Hum Reprod"},{"key":"10.1016\/j.therap.2018.02.007_bib0295","author":"Epelboin","year":"2011"},{"key":"10.1016\/j.therap.2018.02.007_bib0300","doi-asserted-by":"crossref","first-page":"2574","DOI":"10.1016\/j.fertnstert.2011.02.047","article-title":"Prevalence of hypospadias in grandsons of women exposed to diethylstilbestrol during pregnancy: a multigenerational national cohort study","volume":"95","author":"Kalfa","year":"2011","journal-title":"Fertil Steril"},{"key":"10.1016\/j.therap.2018.02.007_bib0305","doi-asserted-by":"crossref","first-page":"38e1","DOI":"10.1016\/j.ajog.2007.02.036","article-title":"Esophageal atresia and tracheoesophageal fistula in children of women exposed to diehylstilbestrol in utero","volume":"197","author":"Felix","year":"2007","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.therap.2018.02.007_bib0310","series-title":"European Surveillance of Congenital Anomalies and Twins","author":"Eurocat","year":"2010"},{"key":"10.1016\/j.therap.2018.02.007_bib0315","unstructured":"ICD-10 International statistical classification of diseases and related health problems 10th revision. http:\/\/www.icd10data.com\/ICD10CM\/Codes [Accessed 27 February 2018]."},{"issue":"Suppl.\u00a01","key":"10.1016\/j.therap.2018.02.007_bib0320","first-page":"18","article-title":"Transgenerational effects of in utero exposure to diethylstilbestrol (DES): genital birth defects in \u201cDES grandsons\u201d Fund Clin Pharmacol","volume":"31","author":"Ferreira-De-Matos","year":"2017"},{"key":"10.1016\/j.therap.2018.02.007_bib0325","first-page":"595","article-title":"Exposure to diethylstilbestrol during a critical developmental period of the mouse reproductive tract leads to persistent induction of two estrogen-regulated genes","volume":"5","author":"Nelson","year":"1994","journal-title":"Cell Growth Differentiation"},{"key":"10.1016\/j.therap.2018.02.007_bib0330","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0378-4274(01)00295-8","article-title":"Gene imprinting in developmental toxicology: a possible interface between physiology and pathology","volume":"120","author":"McLachlan","year":"2001","journal-title":"Toxicol Lett"},{"issue":"6\u00a0Suppl.","key":"10.1016\/j.therap.2018.02.007_bib0335","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1210\/en.2005-1164","article-title":"Adverse effects of the model environmental estrogen diethylstilbestrol are transmitted to subsequent generations","volume":"147","author":"Newbold","year":"2006","journal-title":"Endocrinology"},{"key":"10.1016\/j.therap.2018.02.007_bib0340","first-page":"197","article-title":"Findings in female offspring of women exposed in-utero to diethylstilbestrol","volume":"99","author":"Kaufman","year":"2002","journal-title":"Obstet Gynecol"}],"container-title":["Therapies"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040595718300404?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040595718300404?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,3]],"date-time":"2019-04-03T08:20:00Z","timestamp":1554279600000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040595718300404"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["S0040595718300404"],"URL":"https:\/\/doi.org\/10.1016\/j.therap.2018.02.007","relation":{},"ISSN":["0040-5957"],"issn-type":[{"value":"0040-5957","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Birth defects in children of men exposed in utero to diethylstilbestrol (DES)","name":"articletitle","label":"Article Title"},{"value":"Therapies","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.therap.2018.02.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Soci\u00e9t\u00e9 fran\u00e7aise de pharmacologie et de th\u00e9rapeutique. Published by Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}