{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:38:50Z","timestamp":1758587930898,"version":"3.44.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Therapies"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.therap.2021.12.017","type":"journal-article","created":{"date-parts":[[2021,12,30]],"date-time":"2021-12-30T00:16:02Z","timestamp":1640823362000},"page":"549-559","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hypersensibilit\u00e9 m\u00e9dicamenteuse multiple chez des patients ayant une allergie aux antibiotiques"],"prefix":"10.1016","volume":"77","author":[{"given":"Lobna","family":"Ben Mahmoud","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariam","family":"Ammar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Najla","family":"Bahloul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Hakim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanen","family":"Ghozzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nihel","family":"Lefi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zouheir","family":"Sahnoun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khaled","family":"Zeghal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.therap.2021.12.017_bib0145","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00105-016-3908-x","article-title":"Diagnostics of drug hypersensitivity reactions","volume":"68","author":"M\u00f6bs","year":"2017","journal-title":"Hautarzt Z Dermatol Venerol Verwandte Geb"},{"key":"10.1016\/j.therap.2021.12.017_bib0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/bcp.12297","article-title":"Immediate-type hypersensitivity drug reactions","volume":"78","author":"Stone","year":"2014","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.therap.2021.12.017_bib0155","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.mcna.2019.09.003","article-title":"Drug hypersensitivity reactions","volume":"104","author":"Dykewicz","year":"2020","journal-title":"Med Clin North Am"},{"key":"10.1016\/j.therap.2021.12.017_bib0160","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1159\/000458725","article-title":"Multiple drug hypersensitivity","volume":"172","author":"Pichler","year":"2017","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.therap.2021.12.017_bib0165","doi-asserted-by":"crossref","first-page":"72e1","DOI":"10.1016\/j.jaip.2017.08.027","article-title":"Cross-reactivity in \u03b2-Lactam allergy","volume":"6","author":"Zagursky","year":"2018","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.therap.2021.12.017_bib0170","doi-asserted-by":"crossref","first-page":"258e1","DOI":"10.1016\/j.jaip.2019.06.009","article-title":"Multiple drug hypersensitivity syndrome in a large database","volume":"8","author":"Landry","year":"2020","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.therap.2021.12.017_bib0175","first-page":"293","article-title":"Multiple drug hypersensitivity\u00a0\u2013\u00a0proof of multiple drug hypersensitivity by patch and lymphocyte transformation tests","volume":"15","author":"Gex-Collet","year":"2005","journal-title":"J Investig Allergol Clin Immunol"},{"key":"10.1016\/j.therap.2021.12.017_bib0180","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.anai.2011.11.006","article-title":"Multiple drug intolerance syndrome: prevalence, clinical characteristics, and management","volume":"108","author":"Macy","year":"2012","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.therap.2021.12.017_bib0185","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/S0091-6749(96)70172-0","article-title":"The multiple drug allergy syndrome: a matched-control retrospective study in patients allergic to penicillin","volume":"98","author":"Khoury","year":"1996","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.therap.2021.12.017_bib0190","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.iac.2004.03.002","article-title":"Multiple antibiotic allergy syndrome","volume":"24","author":"Macy","year":"2004","journal-title":"Immunol Allergy Clin North Am"},{"key":"10.1016\/j.therap.2021.12.017_bib0195","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.therap.2019.09.004","article-title":"Pharmacovigilance\u00a0\u2013\u00a0The next chapter","volume":"74","author":"Moore","year":"2019","journal-title":"Therapie"},{"key":"10.1016\/j.therap.2021.12.017_bib0200","first-page":"323","article-title":"Les conditions de s\u00e9curit\u00e9 pour la r\u00e9alisation des tests de provocation en allergologie","volume":"47","author":"Bousquet","year":"2007","journal-title":"Rev Fr Allergol Immunol Clin"},{"key":"10.1016\/j.therap.2021.12.017_bib0205","first-page":"494","article-title":"Diagnostic des allergies m\u00e9dicamenteuses\u00a0: questionnaire europ\u00e9en","volume":"40","author":"Demoly","year":"2000","journal-title":"Rev Fr Allergol Immunol Clin"},{"key":"10.1016\/j.therap.2021.12.017_bib0210","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1111\/j.1398-9995.2008.01944.x","article-title":"Pharmacovigilance of drug allergy and hypersensitivity using the ENDA-DAHD database and the GALEN platform. The Galenda project","volume":"64","author":"Bousquet","year":"2009","journal-title":"Allergy"},{"key":"10.1016\/j.therap.2021.12.017_bib0215","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/S0140-6736(77)91953-5","article-title":"Incidence and severity of anaphylactoid reactions to colloid volume substitutes","volume":"1","author":"Ring","year":"1977","journal-title":"Lancet"},{"key":"10.1016\/j.therap.2021.12.017_bib0220","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1051\/medsci\/2003193327","article-title":"Identifier et comprendre les allergies m\u00e9dicamenteuses","volume":"19","author":"Demoly","year":"2003","journal-title":"Med Sci (Paris)"},{"key":"10.1016\/j.therap.2021.12.017_bib0225","first-page":"865","article-title":"Multiple drug allergy in patients with cutaneous adverse drug reactions diagnosed by in vitro drug-induced interferon-gamma release","volume":"10","author":"Halevy","year":"2008","journal-title":"Isr Med Assoc J"},{"key":"10.1016\/j.therap.2021.12.017_bib0230","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1111\/all.13440","article-title":"Multiple drug intolerance syndrome and multiple drug allergy syndrome: epidemiology and associations with anxiety and depression","volume":"73","author":"Blumenthal","year":"2018","journal-title":"Allergy"},{"key":"10.1016\/j.therap.2021.12.017_bib0235","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/s11882-017-0725-y","article-title":"Update on quinolone allergy","volume":"17","author":"Do\u00f1a","year":"2017","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1016\/j.therap.2021.12.017_bib0240","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1111\/cea.12099","article-title":"Hypersensitivity reactions to fluoroquinolones: analysis of the factors involved","volume":"43","author":"Blanca-L\u00f3pez","year":"2013","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.therap.2021.12.017_bib0245","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/S1081-1206(10)60637-0","article-title":"Multiple-drug intolerance syndrome: clinical findings and usefulness of challenge tests","volume":"99","author":"Schiavino","year":"2007","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.therap.2021.12.017_bib0250","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1034\/j.1398-9995.2000.00698.x","article-title":"Multiple sensitivity to NSAID","volume":"55","author":"Asero","year":"2000","journal-title":"Allergy"},{"key":"10.1016\/j.therap.2021.12.017_bib0255","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1111\/j.1365-2133.2007.07807.x","article-title":"The diagnosis of a DRESS syndrome has been sufficiently established on the basis of typical clinical features and viral reactivations","volume":"156","author":"Shiohara","year":"2007","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.therap.2021.12.017_bib0260","first-page":"62","article-title":"Phenobarbital-induced DiHS and ceftriaxone hypersensitivity reaction: a case of multiple drug allergy","volume":"41","author":"Voltolini","year":"2009","journal-title":"Eur Ann Allergy Clin Immunol"},{"key":"10.1016\/j.therap.2021.12.017_bib0265","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1021\/tx400124m","article-title":"\u03b2-lactam antibiotics form distinct haptenic structures on albumin and activate drug-specific T-lymphocyte responses in multiallergic patients with cystic fibrosis","volume":"26","author":"Jenkins","year":"2013","journal-title":"Chem Res Toxicol"},{"key":"10.1016\/j.therap.2021.12.017_bib0270","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1111\/j.1346-8138.2010.01142.x","article-title":"Drug hypersensitivity: flare-up reactions, cross-reactivity and multiple drug hypersensitivity","volume":"38","author":"Pichler","year":"2011","journal-title":"J Dermatol"},{"key":"10.1016\/j.therap.2021.12.017_bib0275","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/j.1398-9995.2011.02720.x","article-title":"Multiple drug hypersensitivity: normal Treg cell function but enhanced in vivo activation of drug-specific T cells","volume":"67","author":"Daubner","year":"2012","journal-title":"Allergy"},{"key":"10.1016\/j.therap.2021.12.017_bib0140","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1097\/01.meg.0000252631.03668.26","article-title":"Sulphasalazine-induced hypersensitivity syndrome: a relapsing disorder and the role of human herpes virus-6","volume":"19","author":"Short","year":"2007","journal-title":"Eur J Gastroenterol Hepatol"}],"container-title":["Therapies"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040595721002699?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040595721002699?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T18:55:18Z","timestamp":1758567318000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040595721002699"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["S0040595721002699"],"URL":"https:\/\/doi.org\/10.1016\/j.therap.2021.12.017","relation":{},"ISSN":["0040-5957"],"issn-type":[{"type":"print","value":"0040-5957"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hypersensibilit\u00e9 m\u00e9dicamenteuse multiple chez des patients ayant une allergie aux antibiotiques","name":"articletitle","label":"Article Title"},{"value":"Therapies","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.therap.2021.12.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Soci\u00e9t\u00e9 fran\u00e7aise de pharmacologie et de th\u00e9rapeutique. Published by Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}