{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T18:11:29Z","timestamp":1771611089298,"version":"3.50.1"},"reference-count":41,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Therapies"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.therap.2025.11.012","type":"journal-article","created":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T00:07:04Z","timestamp":1766534824000},"page":"10-18","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pharmaco-metabolomics and metabolomics: A new tool in precision medicine?"],"prefix":"10.1016","volume":"81","author":[{"given":"Antonin","family":"Lamazi\u00e8re","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erwan","family":"Werner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Barau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Fran\u00e7ois","family":"Benoist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9l\u00e8ne","family":"Blasco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Bonnel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abd El Kader","family":"Ait Tayeb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florence","family":"Castelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Guiot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Najiba","family":"Lahlou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magali","family":"Sarafian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Blin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9line","family":"Verstuyft","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.therap.2025.11.012_bib0210","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s40271-025-00765-3","article-title":"Evaluation tools for patient and public involvement (PPI) in health research: a scoping review","volume":"19","author":"Nissen","year":"2026","journal-title":"Patient"},{"key":"10.1016\/j.therap.2025.11.012_bib0215","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1007\/s00216-021-03586-z","article-title":"Metabolomics for personalized medicine: the input of analytical chemistry from biomarker discovery to point-of-care tests","volume":"414","author":"Castelli","year":"2022","journal-title":"Anal Bioanal Chem"},{"key":"10.1016\/j.therap.2025.11.012_bib0220","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.cell.2008.08.026","article-title":"Metabolic phenotyping in health and disease","volume":"134","author":"Holmes","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.therap.2025.11.012_bib0225","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.therap.2024.11.010","article-title":"How to facilitate the wider use of pharmacogenetic tests?","volume":"80","author":"Verstuyft","year":"2025","journal-title":"Therapie"},{"key":"10.1016\/j.therap.2025.11.012_bib0230","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s13059-017-1215-1","article-title":"Multi-omics approaches to disease","volume":"18","author":"Hasin","year":"2017","journal-title":"Genome Biol"},{"key":"10.1016\/j.therap.2025.11.012_bib0235","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/nrd.2016.32","article-title":"Emerging applications of metabolomics in drug discovery and precision medicine","volume":"15","author":"Wishart","year":"2016","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.therap.2025.11.012_bib0240","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/nrm3314","article-title":"Metabolomics: the apogee of the omics trilogy","volume":"13","author":"Patti","year":"2012","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.therap.2025.11.012_bib0245","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/nrg.2018.4","article-title":"Integrative omics for health and disease","volume":"19","author":"Karczewski","year":"2018","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.therap.2025.11.012_bib0250","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1007\/s13361-016-1469-y","article-title":"Untargeted metabolomics strategies-challenges and emerging directions","volume":"27","author":"Schrimpe-Rutledge","year":"2016","journal-title":"J Am Soc Mass Spectrom"},{"key":"10.1016\/j.therap.2025.11.012_bib0255","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s11306-007-0082-2","article-title":"Proposed minimum reporting standards for chemical analysis Chemical Analysis Working Group (CAWG) Metabolomics Standards Initiative (MSI)","volume":"3","author":"Sumner","year":"2007","journal-title":"Metabolomics"},{"key":"10.1016\/j.therap.2025.11.012_bib0260","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/s11306-025-02259-7","article-title":"Recommendations for sample selection, collection and preparation for NMR-based metabolomics studies of blood","volume":"21","author":"Emwas","year":"2025","journal-title":"Metabolomics"},{"key":"10.1016\/j.therap.2025.11.012_bib0265","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1093\/humrep\/deac254","article-title":"Combining metabolomics and machine learning models as a tool to distinguish non-classic 21-hydroxylase deficiency from polycystic ovary syndrome without adrenocorticotropic hormone testing","volume":"38","author":"Bachelot","year":"2023","journal-title":"Hum Reprod"},{"key":"10.1016\/j.therap.2025.11.012_bib0270","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1007\/s11306-018-1460-7","article-title":"Towards quality assurance and quality control in untargeted metabolomics studies","volume":"15","author":"Beger","year":"2019","journal-title":"Metabolomics"},{"key":"10.1016\/j.therap.2025.11.012_bib0275","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s11306-024-02135-w","article-title":"Metabolomics 2023 workshop report: moving toward consensus on best QA\/QC practices in LC-MS-based untargeted metabolomics","volume":"20","author":"Mosley","year":"2024","journal-title":"Metabolomics"},{"key":"10.1016\/j.therap.2025.11.012_bib0280","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.1007\/s00216-018-0964-3","article-title":"MALDI imaging facilitates new topical drug development process by determining quantitative skin distribution profiles","volume":"410","author":"Bonnel","year":"2018","journal-title":"Anal Bioanal Chem"},{"key":"10.1016\/j.therap.2025.11.012_bib0285","doi-asserted-by":"crossref","first-page":"106085","DOI":"10.1016\/j.jsbmb.2022.106085","article-title":"A proof of concept of a machine learning algorithm to predict late-onset 21-hydroxylase deficiency in children with premature pubic hair","volume":"220","author":"Agnani","year":"2022","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1016\/j.therap.2025.11.012_bib0290","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/clpt.2014.83","article-title":"Geneva cocktail for cytochrome p450 and P-glycoprotein activity assessment using dried blood spots","volume":"96","author":"Bosilkovska","year":"2014","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.therap.2025.11.012_bib0295","doi-asserted-by":"crossref","first-page":"62","DOI":"10.3390\/ijns8040062","article-title":"Liquid chromatography-tandem mass spectrometry in newborn screening laboratories","volume":"8","author":"Gelb","year":"2022","journal-title":"Int J Neonatal Screen"},{"key":"10.1016\/j.therap.2025.11.012_bib0300","doi-asserted-by":"crossref","first-page":"6563","DOI":"10.1021\/acs.analchem.4c06061","article-title":"Beyond targeted newborn screening: a nontargeted metabolomics workflow to investigate birthweight\u2013metabolome correlations","volume":"97","author":"Asef","year":"2025","journal-title":"Anal Chem"},{"key":"10.1016\/j.therap.2025.11.012_bib0305","doi-asserted-by":"crossref","first-page":"e100","DOI":"10.1542\/neo.26-2-011","article-title":"Applications of metabolomics and lipidomics in the neonatal intensive care unit","volume":"26","author":"Reiss","year":"2025","journal-title":"Neoreviews"},{"key":"10.1016\/j.therap.2025.11.012_bib0310","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1080\/15622975.2024.2366235","article-title":"Optimisation of pharmacotherapy in psychiatry through therapeutic drug monitoring, molecular brain imaging and pharmacogenetic tests: focus on antipsychotics","volume":"25","author":"Hart","year":"2024","journal-title":"World J Biol Psychiatry"},{"key":"10.1016\/j.therap.2025.11.012_bib0315","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1002\/cpt.3502","article-title":"French-Speaking Network of Pharmacogenetics (RNPGx) recommendations for clinical use of mavacamten","volume":"117","author":"Lebreton","year":"2025","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.therap.2025.11.012_bib0320","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.therap.2017.01.005","article-title":"Pharmacogenetics of anti-cancer drugs: state of the art and implementation\u00a0\u2013\u00a0recommendations of the French National Network of Pharmacogenetics","volume":"72","author":"Quaranta","year":"2017","journal-title":"Therapie"},{"key":"10.1016\/j.therap.2025.11.012_bib0325","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.therap.2016.09.016","article-title":"Pharmacogenetics of immunosuppressants: state of the art and clinical implementation\u00a0\u2013\u00a0recommendations from the French National Network of Pharmacogenetics (RNPGx)","volume":"72","author":"Woillard","year":"2017","journal-title":"Therapie"},{"key":"10.1016\/j.therap.2025.11.012_bib0330","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1177\/03063127231162629","article-title":"Infrastructuring European scientific integration: heterogeneous meanings of the European biobanking infrastructure BBMRI\u2013ERIC","volume":"53","author":"Aarden","year":"2023","journal-title":"Soc Stud Sci"},{"key":"10.1016\/j.therap.2025.11.012_bib0335","doi-asserted-by":"crossref","first-page":"1045843","DOI":"10.3389\/fphar.2022.1045843","article-title":"Plasma metabolomic profiling reveals factors associated with dose-adjusted trough concentration of tacrolimus in liver transplant recipients","volume":"13","author":"Zhu","year":"2022","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.therap.2025.11.012_bib0340","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1093\/ajcn\/nqab263","article-title":"Erythrocyte fatty acid membrane composition in children on long-term parenteral nutrition enriched with \u03c9-3 fatty acids","volume":"115","author":"Goulet","year":"2022","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.therap.2025.11.012_bib0345","unstructured":"FrBioNet. France Biobank Network. 2025. https:\/\/www.frbionet.fr\/ [Accessed 24 November 2025]."},{"key":"10.1016\/j.therap.2025.11.012_bib0350","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1038\/nprot.2011.335","article-title":"Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry","volume":"6","author":"Dunn","year":"2011","journal-title":"Nat Protoc"},{"key":"10.1016\/j.therap.2025.11.012_bib0355","doi-asserted-by":"crossref","first-page":"100954","DOI":"10.1016\/j.jpha.2024.02.008","article-title":"Signal interference between drugs and metabolites in LC-ESI-MS quantitative analysis and its evaluation strategy","volume":"14","author":"Jiang","year":"2024","journal-title":"J Pharm Anal"},{"key":"10.1016\/j.therap.2025.11.012_bib0360","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1093\/ejendo\/lvaf208","article-title":"Advances in congenital adrenal hyperplasia newborn screening: 11-ketotestosterone and 21-deoxycortisone as additional discriminatory biomarkers","volume":"193","author":"Sow","year":"2025","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.therap.2025.11.012_bib0365","doi-asserted-by":"crossref","first-page":"105726","DOI":"10.1016\/j.puhe.2025.105726","article-title":"AI and omics technologies in biobanking: applications and challenges for public health","volume":"243","author":"Venturini","year":"2025","journal-title":"Public Health"},{"key":"10.1016\/j.therap.2025.11.012_bib0370","doi-asserted-by":"crossref","first-page":"706","DOI":"10.3390\/molecules30030706","article-title":"Development and validation of targeted metabolomics methods using liquid chromatography-tandem mass spectrometry (LC-MS\/MS) for the quantification of 235 plasma metabolites","volume":"30","author":"Xu","year":"2025","journal-title":"Molecules"},{"key":"10.1016\/j.therap.2025.11.012_bib0375","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1038\/s41596-022-00801-8","article-title":"A proposed framework to evaluate the quality and reliability of targeted metabolomics assays from the UK Consortium on Metabolic Phenotyping (MAP\/UK)","volume":"18","author":"Sarmad","year":"2023","journal-title":"Nat Protoc"},{"key":"10.1016\/j.therap.2025.11.012_bib0380","unstructured":"Cofrac\u00a0\u2013\u00a0Comit\u00e9 fran\u00e7ais d\u2019accr\u00e9ditation. 2025. https:\/\/tools.cofrac.fr\/ [Accessed 24 November 2025]."},{"key":"10.1016\/j.therap.2025.11.012_bib0385","doi-asserted-by":"crossref","first-page":"3818","DOI":"10.1021\/bi301519p","article-title":"Matrix-assisted laser desorption ionization imaging mass spectrometry: in situ molecular mapping","volume":"52","author":"Angel","year":"2013","journal-title":"Biochemistry"},{"key":"10.1016\/j.therap.2025.11.012_bib0390","doi-asserted-by":"crossref","first-page":"5934","DOI":"10.3390\/molecules29245934","article-title":"Advancements in mass spectrometry-based targeted metabolomics and lipidomics: implications for clinical research","volume":"29","author":"Anh","year":"2024","journal-title":"Molecules"},{"key":"10.1016\/j.therap.2025.11.012_bib0395","unstructured":"LIPID MAPS. 2025. https:\/\/lipidmaps.org\/ [Accessed 24 November 2025]."},{"key":"10.1016\/j.therap.2025.11.012_bib0400","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s40900-024-00642-7","article-title":"Patient and public involvement in the design of an international clinical trial: real world experience","volume":"10","author":"Simons","year":"2024","journal-title":"Res Involv Engagem"},{"key":"10.1016\/j.therap.2025.11.012_bib0405","doi-asserted-by":"crossref","first-page":"e83","DOI":"10.1016\/S2666-7568(24)00010-2","article-title":"Increasing patient and public involvement in clinical research","volume":"5","year":"2024","journal-title":"Lancet Healthy Longev"},{"key":"10.1016\/j.therap.2025.11.012_bib0410","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1186\/s12874-024-02323-1","article-title":"Is this really empowerment? Enhancing our understanding of empowerment in patient and public involvement within clinical research","volume":"24","author":"Schilling","year":"2024","journal-title":"BMC Med Res Methodol"}],"container-title":["Therapies"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040595725001635?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040595725001635?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T17:26:47Z","timestamp":1771608407000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040595725001635"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["S0040595725001635"],"URL":"https:\/\/doi.org\/10.1016\/j.therap.2025.11.012","relation":{},"ISSN":["0040-5957"],"issn-type":[{"value":"0040-5957","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pharmaco-metabolomics and metabolomics: A new tool in precision medicine?","name":"articletitle","label":"Article Title"},{"value":"Therapies","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.therap.2025.11.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.therap.2025.12.001","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Masson SAS on behalf of Soci\u00e9t\u00e9 fran\u00e7aise de pharmacologie et de th\u00e9rapeutique.","name":"copyright","label":"Copyright"}]}}