{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T20:32:45Z","timestamp":1793219565210,"version":"4.5.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:00:00Z","timestamp":1773792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Therapies"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.therap.2026.03.001","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T09:20:52Z","timestamp":1773825652000},"page":"408-415","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Descriptive study of the effects of treprostinil and\/or epoprostenol in newborn infants with inhaled NO refractory persistent pulmonary hypertension of the newborn (PPHN)"],"prefix":"10.1016","volume":"81","author":[{"given":"Charlotte","family":"Mazepa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Mur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9raldine","family":"Gascoin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Storme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Joram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Viard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Dulac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marine","family":"Butin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Breinig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1 Pt 1","key":"10.1016\/j.therap.2026.03.001_bib0135","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1542\/peds.105.1.14","article-title":"Persistent pulmonary hypertension of the newborn in the era before nitric oxide: practice variation and outcomes","volume":"105","author":"Walsh-Sukys","year":"2000","journal-title":"Pediatrics"},{"key":"10.1016\/j.therap.2026.03.001_bib0140","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.arcped.2010.10.021","article-title":"Pulmonary hypertension in pediatric and neonatal intensive care unit. Part I: physiopathology","volume":"18","author":"Dumas de la Roque","year":"2011","journal-title":"Arch Pediatr"},{"key":"10.1016\/j.therap.2026.03.001_bib0145","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1002\/ppul.25073","article-title":"Persistent pulmonary hypertension of the newborn","volume":"56","author":"Mandell","year":"2021","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.therap.2026.03.001_bib0150","doi-asserted-by":"crossref","first-page":"e680","DOI":"10.1542\/neo.16-12-e680","article-title":"Persistent pulmonary hypertension of the newborn","volume":"16","author":"Lakshminrusimha","year":"2015","journal-title":"Neoreviews"},{"key":"10.1016\/j.therap.2026.03.001_bib0155","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.clp.2015.11.013","article-title":"Pulmonary hypertension and pulmonary vasodilators","volume":"43","author":"Keller","year":"2016","journal-title":"Clin Perinatol"},{"key":"10.1016\/j.therap.2026.03.001_bib0160","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1007\/s00134-003-2122-3","article-title":"Inhaled nitric oxide therapy in neonates and children: reaching a European consensus","volume":"30","author":"Macrae","year":"2004","journal-title":"Intensive Care Med"},{"issue":"2 Pt 2 Su","key":"10.1016\/j.therap.2026.03.001_bib0165","first-page":"S24","article-title":"Clinical pathophysiology of persistent pulmonary hypertension of the newborn and the role of inhaled nitric oxide therapy","volume":"16","author":"Kinsella","year":"1996","journal-title":"J Perinatol"},{"key":"10.1016\/j.therap.2026.03.001_bib0170","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.arcped.2010.11.001","article-title":"Pulmonary hypertension in pediatric and neonatal intensive care unit. Part II: diagnosis and treatment","volume":"18","author":"Dumas de la Roque","year":"2011","journal-title":"Arch Pediatr"},{"key":"10.1016\/j.therap.2026.03.001_bib0175","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jss.2012.07.058","article-title":"The use of ECMO for persistent pulmonary hypertension of the newborn: a decade of experience","volume":"177","author":"Lazar","year":"2012","journal-title":"J Surg Res"},{"key":"10.1016\/j.therap.2026.03.001_bib0180","unstructured":"ANSM. R\u00e9sum\u00e9 des caract\u00e9ristiques du produit. Flolan; 2008. http:\/\/agence-prd.ansm.sante.fr\/php\/ecodex\/rcp\/R0140592.htm. [Accessed 9 March 2026]"},{"key":"10.1016\/j.therap.2026.03.001_bib0185","unstructured":"ANSM. R\u00e9sum\u00e9 des caract\u00e9ristiques du produit. Remodulin; 2013. http:\/\/agence-prd.ansm.sante.fr\/php\/ecodex\/rcp\/R0221179.htm. [Accessed 9 March 2026]"},{"key":"10.1016\/j.therap.2026.03.001_bib0190","unstructured":"DrugBank. Epoprostenol. 2025. https:\/\/go.drugbank.com\/drugs\/DB01240. [Accessed 9 March 2026]"},{"key":"10.1016\/j.therap.2026.03.001_bib0195","unstructured":"DrugBank. Treprostinil. 2025. https:\/\/go.drugbank.com\/drugs\/DB00374. [Accessed 9 March 2026]"},{"key":"10.1016\/j.therap.2026.03.001_bib0200","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.jpeds.2015.06.016","article-title":"Short-term treprostinil use in infants with congenital diaphragmatic hernia following repairs","volume":"167","author":"Olson","year":"2015","journal-title":"J Pediatr"},{"key":"10.1016\/j.therap.2026.03.001_bib0205","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1038\/s41372-018-0179-7","article-title":"Intravenous epoprostenol improves oxygenation index in patients with persistent pulmonary hypertension of the newborn refractory to nitric oxide","volume":"38","author":"Ahmad","year":"2018","journal-title":"J Perinatol"},{"key":"10.1016\/j.therap.2026.03.001_bib0210","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1086\/674762","article-title":"Safety of epoprostenol and treprostinil in children less than 12 months of age","volume":"3","author":"McIntyre","year":"2013","journal-title":"Pulm Circ"},{"key":"10.1016\/j.therap.2026.03.001_bib0215","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.ijcard.2018.03.067","article-title":"Safety, efficacy and management of subcutaneous treprostinil infusions in the treatment of severe pediatric pulmonary hypertension","volume":"264","author":"Levy","year":"2018","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.therap.2026.03.001_bib0220","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1016\/j.jpedsurg.2017.03.058","article-title":"Safety and tolerability of subcutaneous treprostinil in newborns with congenital diaphragmatic hernia and life-threatening pulmonary hypertension","volume":"52","author":"Carpentier","year":"2017","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.therap.2026.03.001_bib0225","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.jpeds.2010.09.025","article-title":"Add-on therapy with subcutaneous treprostinil for refractory pediatric pulmonary hypertension","volume":"158","author":"Levy","year":"2011","journal-title":"J Pediatr"},{"key":"10.1016\/j.therap.2026.03.001_bib0230","first-page":"CD012963","article-title":"Prostanoids and their analogues for the treatment of pulmonary hypertension in neonates","volume":"10","author":"Shivanna","year":"2019","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.therap.2026.03.001_bib0235","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.jpedsurg.2003.11.010","article-title":"The relationship of pulmonary artery pressure and survival in congenital diaphragmatic hernia","volume":"39","author":"Dillon","year":"2004","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.therap.2026.03.001_bib0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpeds.2012.12.036","article-title":"Outcomes of congenital diaphragmatic hernia in the modern era of management","volume":"163","author":"Wynn","year":"2013","journal-title":"J Pediatr"},{"key":"10.1016\/j.therap.2026.03.001_bib0245","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1161\/CIR.0000000000000329","article-title":"Pediatric pulmonary hypertension: guidelines from the American Heart Association and American Thoracic Society","volume":"132","author":"Abman","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.therap.2026.03.001_bib0250","doi-asserted-by":"crossref","first-page":"2200879","DOI":"10.1183\/13993003.00879-2022","article-title":"2022 ESC\/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension","volume":"61","author":"Humbert","year":"2023","journal-title":"Eur Respir J"},{"key":"10.1016\/j.therap.2026.03.001_bib0255","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.clp.2021.05.009","article-title":"Pathophysiology and management of persistent pulmonary hypertension of the newborn","volume":"48","author":"Singh","year":"2021","journal-title":"Clin Perinatol"},{"key":"10.1016\/j.therap.2026.03.001_bib0260","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1097\/FJC.0000000000000674","article-title":"Subcutaneous and intravenous treprostinil pharmacokinetics in children with pulmonary vascular disease","volume":"73","author":"Hall","year":"2019","journal-title":"J Cardiovasc Pharmacol"}],"container-title":["Therapies"],"original-title":[],"language":"fr","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040595726000478?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040595726000478?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T19:50:23Z","timestamp":1793217023000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040595726000478"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S0040595726000478"],"URL":"https:\/\/doi.org\/10.1016\/j.therap.2026.03.001","relation":{},"ISSN":["0040-5957"],"issn-type":[{"value":"0040-5957","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Descriptive study of the effects of treprostinil and\/or epoprostenol in newborn infants with inhaled NO refractory persistent pulmonary hypertension of the newborn (PPHN)","name":"articletitle","label":"Article Title"},{"value":"Therapies","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.therap.2026.03.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Masson SAS on behalf of Soci\u00e9t\u00e9 fran\u00e7aise de pharmacologie et de th\u00e9rapeutique.","name":"copyright","label":"Copyright"}]}}