{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T16:44:12Z","timestamp":1788281052373,"version":"build-2803163510"},"reference-count":50,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Theriogenology"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.theriogenology.2016.04.005","type":"journal-article","created":{"date-parts":[[2016,4,13]],"date-time":"2016-04-13T15:24:26Z","timestamp":1460561066000},"page":"1156-1164","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["Serum levels of mitochondrial uncoupling protein 1, leptin, and lipids during late pregnancy and the early postpartum period in mares"],"prefix":"10.1016","volume":"86","author":[{"given":"F.","family":"Arfuso","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Giannetto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Rizzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Fazio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Giudice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1736-3006","authenticated-orcid":false,"given":"G.","family":"Piccione","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.theriogenology.2016.04.005_bib1","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.siny.2008.09.004","article-title":"Normal and abnormal maternal metabolism during pregnancy","volume":"14","author":"Hadden","year":"2009","journal-title":"Semin Fetal Neonatal Med"},{"key":"10.1016\/j.theriogenology.2016.04.005_bib2","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1111\/j.1939-165X.2005.tb00049.x","article-title":"Clinical biochemistry of pregnant and nursing mares","volume":"34","author":"Harvey","year":"2005","journal-title":"Vet Clin Pathol"},{"key":"10.1016\/j.theriogenology.2016.04.005_bib3","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.jevs.2011.08.015","article-title":"Hematological and biochemical profiles in peripartum mares and neonatal foals (heavy draft horse)","volume":"32","author":"Aoki","year":"2012","journal-title":"J Equine Vet Sci"},{"key":"10.1016\/j.theriogenology.2016.04.005_bib4","first-page":"427","article-title":"Concentrations of plasma leptin, ghrelin and parameters of lipid metabolism in purebred Arabian and pony mares during the periparturient period","volume":"64","author":"K\u0119dzierski","year":"2008","journal-title":"Med Weter"},{"key":"10.1016\/j.theriogenology.2016.04.005_bib5","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/387206a0","article-title":"Crystal structure of the obese protein leptin E-100","volume":"387","author":"Zhang","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.theriogenology.2016.04.005_bib6","doi-asserted-by":"crossref","first-page":"2942","DOI":"10.2527\/2002.80112942x","article-title":"Leptin in horses: tissue localization and relationship between peripheral concentrations in leptin and body condition","volume":"80","author":"Buff","year":"2002","journal-title":"J Anim Sci"},{"key":"10.1016\/j.theriogenology.2016.04.005_bib7","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.2460\/ajvr.70.10.1250","article-title":"Effects of diet-induced gain on insulin sensitivity and plasma hormone and lipid concentrations in horses","volume":"70","author":"Carter","year":"2009","journal-title":"Am J Vet Res"},{"key":"10.1016\/j.theriogenology.2016.04.005_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0739-7240(00)00061-8","article-title":"Effects of a single day of feed restriction on changes in serum leptin, gonadotropins, prolactin and metabolites in aged and young mares","volume":"19","author":"McManus","year":"2000","journal-title":"Domest Anim Endocrinol"},{"key":"10.1016\/j.theriogenology.2016.04.005_bib9","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.2527\/2005.8351023x","article-title":"Effects of short-term feed deprivation and melatonin implants on circadian patterns of leptin in the horse","volume":"83","author":"Buff","year":"2005","journal-title":"J Anim Sci"},{"key":"10.1016\/j.theriogenology.2016.04.005_bib10","first-page":"282","article-title":"Leptin: from a signal of adiposity to a hormonal mediator in peripheral tissues","volume":"8","author":"Baratta","year":"2002","journal-title":"Med Sci Monit"},{"key":"10.1016\/j.theriogenology.2016.04.005_bib11","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1038\/nm0997-1029","article-title":"Nonadipose tissue production of leptin: leptin as a novel placenta derived hormone in humans","volume":"3","author":"Masuzaki","year":"1997","journal-title":"Nat Med"},{"key":"10.1016\/j.theriogenology.2016.04.005_bib12","doi-asserted-by":"crossref","first-page":"11073","DOI":"10.1073\/pnas.94.20.11073","article-title":"Leptin and leptin receptor mRNA and protein expression in the murine fetus and placenta","volume":"94","author":"Hoggard","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.theriogenology.2016.04.005_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1439-0531.2007.00963.x","article-title":"Serum leptin concentrations in Lipizzan fillies","volume":"44","author":"Cebulj-Kadunc","year":"2009","journal-title":"Reprod Domest Anim"},{"key":"10.1016\/j.theriogenology.2016.04.005_bib14","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.anireprosci.2009.03.002","article-title":"Relation between leptin and estradiol levels in Egyptian lactating Arab mares during foaling heat","volume":"117","author":"El-Maaty","year":"2010","journal-title":"Anim Reprod Sci"},{"key":"10.1016\/j.theriogenology.2016.04.005_bib15","doi-asserted-by":"crossref","first-page":"5259","DOI":"10.1210\/endo.139.12.6523","article-title":"Leptin is not necessary for gestation and parturition but regulates maternal nutrition via a leptin resistence state","volume":"139","author":"Mounzih","year":"1998","journal-title":"Endocrinology"},{"key":"10.1016\/j.theriogenology.2016.04.005_bib16","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/35007534","article-title":"Central nervous system control of food intake","volume":"404","author":"Schwartz","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.theriogenology.2016.04.005_bib17","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1111\/j.1749-6632.2002.tb04295.x","article-title":"Uncoupling proteins, leptin, and obesity: an updated review","volume":"967","author":"Giacobino","year":"2002","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.theriogenology.2016.04.005_bib18","doi-asserted-by":"crossref","first-page":"E312","DOI":"10.1152\/ajpendo.00037.2001","article-title":"Accelerated substrate cycling: a new energy-wasting role for leptin in\u00a0vivo","volume":"282","author":"Reidy","year":"2002","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.theriogenology.2016.04.005_bib19","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1590\/S0004-27302012000400001","article-title":"The role of the uncoupling protein 1 (UCP1) on the development of obesity and type 2 diabetes mellitus","volume":"56","author":"Brondani","year":"2012","journal-title":"Arq Bras Endocrinol Metabol"},{"key":"10.1016\/j.theriogenology.2016.04.005_bib20","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.theriogenology.2013.12.003","article-title":"Hemostatic profile during late pregnancy and early postpartum period in mares","volume":"81","author":"Bazzano","year":"2014","journal-title":"Theriogenology"},{"key":"10.1016\/j.theriogenology.2016.04.005_bib21","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.anireprosci.2014.07.005","article-title":"Physiological adjustments of haematological profile during the last trimester of pregnancy and the early post partum period in mares","volume":"149","author":"Bazzano","year":"2014","journal-title":"Anim Reprod Sci"},{"key":"10.1016\/j.theriogenology.2016.04.005_bib22","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1111\/rda.12411","article-title":"Metabolic profile of broodmares during late pregnancy and early post-partum","volume":"49","author":"Bazzano","year":"2014","journal-title":"Reprod Domest Anim"},{"key":"10.1016\/j.theriogenology.2016.04.005_bib23","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s00580-011-1375-4","article-title":"Plasma biochemistry in pregnant Spanish purebred broodmares","volume":"22","author":"Satu\u00e9","year":"2013","journal-title":"Comp Clin Pathol"},{"key":"10.1016\/j.theriogenology.2016.04.005_bib24","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.theriogenology.2013.11.001","article-title":"Hematological and biochemical profiles in Standardbred mares during peripartum","volume":"81","author":"Mariella","year":"2014","journal-title":"Theriogenology"},{"key":"10.1016\/j.theriogenology.2016.04.005_bib25","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/j.2042-3306.1983.tb01826.x","article-title":"Relationship between condition score, physical measurement and body fat percentage in mares","volume":"15","author":"Henneke","year":"1983","journal-title":"Equine Vet J"},{"key":"10.1016\/j.theriogenology.2016.04.005_bib26","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/clinchem\/18.6.499","article-title":"Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without the use of the preparative ultracentrifuge","volume":"18","author":"Friedewald","year":"1972","journal-title":"Clin Chem"},{"key":"10.1016\/j.theriogenology.2016.04.005_bib27","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/nrn3856","article-title":"The neuroprotective actions of oestradiol and oestrogen receptors","volume":"16","author":"Arevalo","year":"2015","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.theriogenology.2016.04.005_bib28","doi-asserted-by":"crossref","first-page":"4923","DOI":"10.1210\/en.2003-0537","article-title":"Direct effects of testosterone, 17 beta\u2013estradiol, and progesterone on adrenergic regulation in cultured brown adipocytes: potential mechanism for gender-dependent thermogenesis","volume":"144","author":"Monjo","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.theriogenology.2016.04.005_bib29","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/j.1467-789X.2008.00529.x","article-title":"Sex differences in obesity and the regulation of energy homeostasis","volume":"10","author":"Lovejoy","year":"2009","journal-title":"Obes Rev"},{"key":"10.1016\/j.theriogenology.2016.04.005_bib30","doi-asserted-by":"crossref","first-page":"150","DOI":"10.3109\/07853890.2014.919727","article-title":"The brain and brown fat","volume":"47","author":"Contreras","year":"2015","journal-title":"Ann Med"},{"key":"10.1016\/j.theriogenology.2016.04.005_bib31","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.cmet.2014.02.007","article-title":"Central neural regulation of brown adipose tissue thermogenesis and energy expenditure","volume":"19","author":"Morrison","year":"2014","journal-title":"Cell Metab"},{"key":"10.1016\/j.theriogenology.2016.04.005_bib32","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1210\/en.2014-1611","article-title":"Pregnancy induces resistance to the anorectic effect of hypothalamic malonyl\u2013CoA and the thermogenic effect of hypothalamic AMPK inhibition in female rats","volume":"156","author":"Martinez de Morentin","year":"2015","journal-title":"Endocrinology"},{"key":"10.1016\/j.theriogenology.2016.04.005_bib33","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.tem.2015.06.003","article-title":"Estrogens and the control of energy homeostasis: a brain perspective","volume":"26","author":"Lopez","year":"2015","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.theriogenology.2016.04.005_bib34","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1095\/biolreprod63.5.1219","article-title":"Leptin in pregnancy","volume":"63","author":"Henson","year":"2000","journal-title":"Biol Reprod"},{"key":"10.1016\/j.theriogenology.2016.04.005_bib35","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0739-7240(01)00108-4","article-title":"Maternal leptin is elevated during pregnancy in sheep","volume":"21","author":"Ehrhardt","year":"2001","journal-title":"Domest Anim Endocrinol"},{"key":"10.1016\/j.theriogenology.2016.04.005_bib36","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1016\/S0024-3205(98)00405-6","article-title":"Concentrations of leptin in the serum of pregnant, lactating, and cycling rats and of leptin messenger ribonucleic acid in rat placental tissue","volume":"63","author":"Amico","year":"1998","journal-title":"Life Sci"},{"key":"10.1016\/j.theriogenology.2016.04.005_bib37","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1017\/S1751731108001638","article-title":"Plasma concentration of leptin and ghrelin in Standardbred foals as related to the age, sex, exercise and training","volume":"2","author":"K\u0119dzierski","year":"2008","journal-title":"Animal"},{"key":"10.1016\/j.theriogenology.2016.04.005_bib38","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.2527\/2005.83102365x","article-title":"Diurnal variation of ghrelin, leptin, and adiponectin in Standardbred mares","volume":"83","author":"Gordon","year":"2005","journal-title":"J Anim Sci"},{"key":"10.1016\/j.theriogenology.2016.04.005_bib39","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/j.1439-0531.2010.01658.x","article-title":"Plasma leptin level in hyperlipidemic mares and their newborn foals","volume":"46","author":"K\u0119dzierski","year":"2011","journal-title":"Reprod Domest Anim"},{"key":"10.1016\/j.theriogenology.2016.04.005_bib40","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.2527\/jas.2006-771","article-title":"Endocrine profiles of periparturient mares and their foals","volume":"85","author":"Berg","year":"2007","journal-title":"J Anim Sci"},{"key":"10.1016\/j.theriogenology.2016.04.005_bib41","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0739-7240(03)00044-4","article-title":"Effects of lactation on metabolic and reproductive hormones in Lipizzaner mares","volume":"25","author":"Heidler","year":"2003","journal-title":"Domest Anim Endocrinol"},{"key":"10.1016\/j.theriogenology.2016.04.005_bib42","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1677\/joe.0.1690465","article-title":"Circulating leptin during ovine pregnancy in relation to maternal nutrition, body composition, and pregnancy outcome","volume":"169","author":"Thomas","year":"2001","journal-title":"J Endocrinol"},{"key":"10.1016\/j.theriogenology.2016.04.005_bib43","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1080\/gye.17.4.311.316","article-title":"Leptin messenger ribonucleic acid (mRNA) content in the human placenta at term: relationship to levels of leptin in cord blood and placental weight","volume":"17","author":"Jakimiuk","year":"2003","journal-title":"Gynecol Endocrinol"},{"key":"10.1016\/j.theriogenology.2016.04.005_bib44","doi-asserted-by":"crossref","first-page":"3008","DOI":"10.2527\/2003.81123008x","article-title":"Porcine leptin inhibits lipogenesis in porcine adipocytes","volume":"81","author":"Ramsay","year":"2003","journal-title":"J Anim Sci"},{"key":"10.1016\/j.theriogenology.2016.04.005_bib45","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1016\/S0022-2275(20)32479-2","article-title":"Effect of pregnancy and lactation on lipoprotein and cholesterol metabolism in the rat","volume":"39","author":"Smith","year":"1998","journal-title":"J Lipid Res"},{"key":"10.1016\/j.theriogenology.2016.04.005_bib46","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1042\/bst0270097","article-title":"Maternal nutrient restriction and endocrine programming of fetal adipose tissue development","volume":"27","author":"Symonds","year":"1999","journal-title":"Biochem Soc Trans"},{"key":"10.1016\/j.theriogenology.2016.04.005_bib47","series-title":"Clinical biochemistry of domestic animals","author":"Kaneko","year":"1997"},{"key":"10.1016\/j.theriogenology.2016.04.005_bib48","series-title":"Reproduction in domestic animals","author":"Cupps","year":"1991"},{"key":"10.1016\/j.theriogenology.2016.04.005_bib49","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1002\/mnfr.200700311","article-title":"Analysis of major proteins and fat fractions associated with mare's milk fat globules","volume":"52","author":"Barello","year":"2008","journal-title":"Mol Nutr Food Res"},{"key":"10.1016\/j.theriogenology.2016.04.005_bib50","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1080\/15216540152845966","article-title":"The mitochondrial uncoupling protein UCP1: a gated pore","volume":"52","author":"Arechaga","year":"2001","journal-title":"IUBMB Life"}],"container-title":["Theriogenology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0093691X16300334?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0093691X16300334?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T15:44:04Z","timestamp":1655480644000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0093691X16300334"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":50,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["S0093691X16300334"],"URL":"https:\/\/doi.org\/10.1016\/j.theriogenology.2016.04.005","relation":{},"ISSN":["0093-691X"],"issn-type":[{"value":"0093-691X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Serum levels of mitochondrial uncoupling protein 1, leptin, and lipids during late pregnancy and the early postpartum period in mares","name":"articletitle","label":"Article Title"},{"value":"Theriogenology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.theriogenology.2016.04.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}