{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T12:56:06Z","timestamp":1761742566902},"reference-count":52,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thrombosis Research"],"published-print":{"date-parts":[[2006,1]]},"DOI":"10.1016\/j.thromres.2005.03.010","type":"journal-article","created":{"date-parts":[[2005,5,12]],"date-time":"2005-05-12T11:44:59Z","timestamp":1115898299000},"page":"271-277","source":"Crossref","is-referenced-by-count":7,"title":["Relationship between soluble thrombomodulin in patients with intermittent claudication and critical ischemia"],"prefix":"10.1016","volume":"117","author":[{"given":"M.","family":"Nasser","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Wolosker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Uint","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.A.","family":"Rosoky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Lobato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Wajngarten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Puech-Leao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"21","key":"10.1016\/j.thromres.2005.03.010_bib1","doi-asserted-by":"crossref","first-page":"2617","DOI":"10.1161\/01.CIR.0000128520.37674.EF","article-title":"Atherosclerotic vascular disease conference: writing group: III. Pathophysiology","volume":"109","author":"Faxon","year":"2004","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.thromres.2005.03.010_bib2","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0002-9343(99)00153-9","article-title":"Cellular cules and atherogenesis","volume":"107","author":"Price","year":"1999","journal-title":"Am J Med"},{"issue":"9","key":"10.1016\/j.thromres.2005.03.010_bib3","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1161\/hc0902.104353","article-title":"Inflammation and atherosclerosis","volume":"105","author":"Libby","year":"2002","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.thromres.2005.03.010_bib4","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/j.1365-2141.1995.tb05143.x","article-title":"A reliable marker of endothelial cell dysfunction: does it exist?","volume":"90","author":"Blann","year":"1995","journal-title":"Br J Haematol"},{"issue":"1","key":"10.1016\/j.thromres.2005.03.010_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0049-3848(93)90221-9","article-title":"The hemostatic system and coronary heart disease","volume":"70","author":"Hamsten","year":"1993","journal-title":"Thromb Res"},{"issue":"4","key":"10.1016\/j.thromres.2005.03.010_bib6","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1093\/oxfordjournals.bmb.a072925","article-title":"Vessel wall interactions regulating thrombosis","volume":"50","author":"Pearson","year":"1994","journal-title":"Br Med Bull"},{"issue":"9166","key":"10.1016\/j.thromres.2005.03.010_bib7","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1016\/S0140-6736(98)09057-6","article-title":"Soluble thrombomodulin as a predictor of incident coronary heart disease and symptomless carotid artery atherosclerosis in the Atherosclerosis Risk in Communities (ARIC) Study: a case-cohort study","volume":"353","author":"Salomaa","year":"1999","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.thromres.2005.03.010_bib8","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/S0021-9258(19)68276-1","article-title":"Isolation of a membrane-bound cofactor for thrombin-catalyzed activation of protein C","volume":"257","author":"Esmon","year":"1982","journal-title":"J Biol Chem"},{"issue":"11","key":"10.1016\/j.thromres.2005.03.010_bib9","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1046\/j.1365-2362.1997.2180766.x","article-title":"Circulating endothelial cell markers in peripheral vascular disease: relationship to the location and extent of atherosclerotic disease","volume":"27","author":"Blann","year":"1997","journal-title":"Eur J Clin Invest"},{"issue":"6","key":"10.1016\/j.thromres.2005.03.010_bib10","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1177\/000331979604700602","article-title":"Evaluation of the coagulation and fibrinolytic systems in men with intermittent claudication","volume":"47","author":"Handa","year":"1996","journal-title":"Angiology"},{"issue":"2","key":"10.1016\/j.thromres.2005.03.010_bib11","first-page":"112","article-title":"Evidence of elevated soluble plasma thrombomodulin in atherosclerosis","volume":"18","author":"Conri","year":"1993","journal-title":"J Mal Vasc"},{"issue":"Suppl 2","key":"10.1016\/j.thromres.2005.03.010_bib12","doi-asserted-by":"crossref","first-page":"S120","DOI":"10.1177\/096120339800700227","article-title":"Thrombomodulin: an overview and potential implications in vascular disorders","volume":"7","author":"Boffa","year":"1998","journal-title":"Lupus"},{"key":"10.1016\/j.thromres.2005.03.010_bib13","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1096\/fasebj.9.10.7615164","article-title":"Thrombomodulin as a model of molecular mechanisms that modulate protease specificity and function at the vessel surface","volume":"9","author":"Esmon","year":"1995","journal-title":"FASEB J"},{"issue":"6","key":"10.1016\/j.thromres.2005.03.010_bib14","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/0049-3848(93)90116-6","article-title":"Levels of plasma thrombomodulin are increased in atheromatous arterial disease","volume":"71","author":"Seigneur","year":"1993","journal-title":"Thromb Res"},{"issue":"4","key":"10.1016\/j.thromres.2005.03.010_bib15","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0049-3848(99)00156-5","article-title":"Relationship between endothelial cell markers and arterial stenosis in peripheral and carotid artery disease","volume":"97","author":"Blann","year":"2000","journal-title":"Thromb Res"},{"issue":"9190","key":"10.1016\/j.thromres.2005.03.010_bib16","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1016\/S0140-6736(05)77135-X","article-title":"Soluble thrombomodulin and endothelial dysfunction in early atherosclerosis","volume":"354","author":"John","year":"1999","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.thromres.2005.03.010_bib17","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0021-9150(00)00729-2","article-title":"Cross-sectional association of soluble thrombomodulin with mild peripheral artery disease; the ARIC study. Atherosclerosis Risk in Communities","volume":"157","author":"Salomaa","year":"2001","journal-title":"Atherosclerosis"},{"issue":"3","key":"10.1016\/j.thromres.2005.03.010_bib18","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1161\/01.ATV.17.3.505","article-title":"Circulating vascular cell adhesion molecule-1 correlates with the extent of human atherosclerosis in contrast to circulating intercellular adhesion molecule-1, E-selectin, P-selectin, and thrombomodulin","volume":"17","author":"Peter","year":"1997","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"4","key":"10.1016\/j.thromres.2005.03.010_bib19","first-page":"347","article-title":"Thrombomodulin is a marker of microvascular, but not for macrovascular endothelial cell damage","volume":"24","author":"Sernau","year":"1995","journal-title":"Vasa"},{"issue":"2","key":"10.1016\/j.thromres.2005.03.010_bib20","article-title":"Transatlantic Inter-Society Consensus\u2014Management of Peripheral Arterial Disease (PAD)","volume":"1","author":"TASC","year":"2000","journal-title":"J Vasc Surg"},{"issue":"4","key":"10.1016\/j.thromres.2005.03.010_bib21","first-page":"525","article-title":"The evaluation of exercise performance in patients with peripheral vascular disease","volume":"12","author":"Hiatt","year":"1998","journal-title":"J Cardiopulm Rehabil"},{"issue":"19","key":"10.1016\/j.thromres.2005.03.010_bib22","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.1001\/archinte.163.19.2296","article-title":"Evaluation of walking capacity over time in 500 patients with intermittent claudication who underwent clinical treatment","volume":"163","author":"Wolosker","year":"2003","journal-title":"Arch Intern Med"},{"issue":"10","key":"10.1016\/j.thromres.2005.03.010_bib23","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1002\/bjs.1800571016","article-title":"Haemodynamic studies in peripheral arterial disease","volume":"57","author":"Yao","year":"1970","journal-title":"Br J Surg"},{"issue":"3","key":"10.1016\/j.thromres.2005.03.010_bib24","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1055\/s-0038-1648889","article-title":"Elevated thrombomodulin plasma levels as a result of endothelial involvement in Plasmodium falciparum malaria","volume":"72","author":"Hemmer","year":"1994","journal-title":"Thromb Haemost"},{"issue":"5","key":"10.1016\/j.thromres.2005.03.010_bib25","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1007\/BF02779371","article-title":"Plasma thrombomodulin in liver diseases","volume":"25","author":"Iwabuchi","year":"1990","journal-title":"Gastroenterol Jpn"},{"issue":"2-3","key":"10.1016\/j.thromres.2005.03.010_bib26","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0049-3848(03)00291-3","article-title":"Endothelial markers and HIV infection in the era of highly active antiretroviral treatment","volume":"110","author":"de Larranaga","year":"2003","journal-title":"Thromb Res"},{"issue":"6","key":"10.1016\/j.thromres.2005.03.010_bib27","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1097\/00001721-199809000-00004","article-title":"Soluble adhesion molecules, endothelial markers and atherosclerosis risk factors in abdominal aortic aneurysm: a comparison with claudicants and healthy controls","volume":"9","author":"Blann","year":"1998","journal-title":"Blood Coagul Fibrinolysis"},{"issue":"10","key":"10.1016\/j.thromres.2005.03.010_bib28","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1182\/blood.V76.10.2024.2024","article-title":"Plasma thrombomodulin in health and diseases","volume":"76","author":"Takano","year":"1990","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.thromres.2005.03.010_bib29","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/ajh.2830390306","article-title":"Increased levels of plasma thrombomodulin in chronic myelogenous leukemia","volume":"39","author":"Morishita","year":"1992","journal-title":"Am J Hematol"},{"issue":"6","key":"10.1016\/j.thromres.2005.03.010_bib30","first-page":"293","article-title":"Thrombomodulin levels in patients with coronary artery disease","volume":"22","author":"Mihara","year":"1997","journal-title":"Artery"},{"issue":"1","key":"10.1016\/j.thromres.2005.03.010_bib31","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0021-9150(98)00175-0","article-title":"Circulating cell adhesion molecules and endothelial markers before and after transluminal angioplasty in peripheral arterial occlusive disease","volume":"142","author":"Tsakiris","year":"1999","journal-title":"Atherosclerosis"},{"issue":"4","key":"10.1016\/j.thromres.2005.03.010_bib32","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1073\/pnas.78.4.2249","article-title":"Identification of an endothelial cell cofactor for thrombin-catalyzed activation of protein C","volume":"78","author":"Esmon","year":"1981","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"suppl II","key":"10.1016\/j.thromres.2005.03.010_bib33","first-page":"A89","article-title":"Plasma thrombomodulin concentrations in healthy persons depends on age and sex","volume":"74","author":"Loreth","year":"1997","journal-title":"Ann Hematol"},{"issue":"7","key":"10.1016\/j.thromres.2005.03.010_bib34","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1046\/j.1538-7836.2003.00306.x","article-title":"Thrombomodulin","volume":"1","author":"Weiler","year":"2003","journal-title":"J Thromb Haemost"},{"issue":"13","key":"10.1016\/j.thromres.2005.03.010_bib35","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1161\/01.CIR.0000064894.97094.4F","article-title":"Interaction between soluble thrombomodulin and intercellular adhesion molecule-1 in predicting risk of coronary heart disease","volume":"107","author":"Wu","year":"2003","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.thromres.2005.03.010_bib36","first-page":"59","article-title":"Clinical importance of thrombomodulin serum levels","volume":"4","author":"Califano","year":"2000","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"6","key":"10.1016\/j.thromres.2005.03.010_bib37","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1097\/00001721-200309000-00010","article-title":"Statins increase thrombomodulin expression and function in human endothelial cells by a nitric oxide-dependent mechanism and counteract tumor necrosis factor alpha-induced thrombomodulin downregulation","volume":"14","author":"Shi","year":"2003","journal-title":"Blood Coagul Fibrinolysis"},{"issue":"6","key":"10.1016\/j.thromres.2005.03.010_bib38","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1007\/s001250051677","article-title":"Physical training decreases plasma thrombomodulin in type I and type II diabetic patients","volume":"44","author":"Rigla","year":"2001","journal-title":"Diabetologia"},{"issue":"8","key":"10.1016\/j.thromres.2005.03.010_bib39","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1097\/01.LAB.0000080606.96797.A5","article-title":"Capillary endothelial thrombomodulin expression and fibrin deposition in rats with continuous and bolus lipopolysaccharide administration","volume":"83","author":"Terada","year":"2003","journal-title":"Lab Invest"},{"issue":"14","key":"10.1016\/j.thromres.2005.03.010_bib40","doi-asserted-by":"crossref","first-page":"8458","DOI":"10.1074\/jbc.271.14.8458","article-title":"Oxidized low density lipoprotein reduces thrombomodulin transcription in cultured human endothelial cells through degradation of the lipoprotein in lysosomes","volume":"271","author":"Ishii","year":"1996","journal-title":"J Biol Chem"},{"issue":"5","key":"10.1016\/j.thromres.2005.03.010_bib41","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1111\/j.1468-1331.2004.00776.x","article-title":"Significance of serum soluble thrombomodulin level in acute cerebral infarction","volume":"11","author":"Nomura","year":"2004","journal-title":"Eur J Neurol"},{"issue":"1","key":"10.1016\/j.thromres.2005.03.010_bib42","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/S0002-9149(99)00597-4","article-title":"G-33A mutation in the promoter region of thrombomodulin gene and its association with coronary artery disease and plasma soluble thrombomodulin levels","volume":"85","author":"Li","year":"2000","journal-title":"Am J Cardiol"},{"issue":"3","key":"10.1016\/j.thromres.2005.03.010_bib43","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/S0021-9150(00)00639-0","article-title":"Functional mutation in the promoter region of thrombomodulin gene in relation to carotid atherosclerosis","volume":"154","author":"Li","year":"2001","journal-title":"Atherosclerosis"},{"issue":"1","key":"10.1016\/j.thromres.2005.03.010_bib44","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1161\/01.RES.0000048196.11060.A0","article-title":"Wall tension is a potent negative regulator of in vivo thrombomodulin expression","volume":"92","author":"Sperry","year":"2003","journal-title":"Circ Res"},{"issue":"11","key":"10.1016\/j.thromres.2005.03.010_bib45","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1161\/01.CIR.0000120705.55512.EC","article-title":"Endothelial cell markers and the risk of coronary heart disease: the Prospective Epidemiological Study of Myocardial Infarction (PRIME) study","volume":"109","author":"Morange","year":"2004","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.thromres.2005.03.010_bib46","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/S0002-9440(10)61753-1","article-title":"Down-regulation of endothelial expression of endothelial cell protein C receptor and thrombomodulin in coronary atherosclerosis","volume":"159","author":"Laszik","year":"2001","journal-title":"Am J Pathol"},{"issue":"1","key":"10.1016\/j.thromres.2005.03.010_bib47","first-page":"42","article-title":"Expression of endothelial protein C receptor and thrombomodulin in human coronary atherosclerotic plaques","volume":"5","author":"Merlini","year":"2004","journal-title":"Ital Heart J"},{"issue":"11","key":"10.1016\/j.thromres.2005.03.010_bib48","doi-asserted-by":"crossref","first-page":"4188","DOI":"10.1182\/blood.V92.11.4188","article-title":"Intravascular coagulation activation in a murine model of thrombomodulin deficiency: effects of lesion size, age, and hypoxia on fibrin deposition","volume":"92","author":"Healy","year":"1998","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.thromres.2005.03.010_bib49","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0049-3848(02)00021-X","article-title":"Association of postmenopausal hormone replacement therapy with carotid atherosclerosis and soluble thrombomodulin: the vascular aging (EVA) study. Etude du Vieillissement Arteriel","volume":"105","author":"Petit","year":"2002","journal-title":"Thromb Res"},{"issue":"2","key":"10.1016\/j.thromres.2005.03.010_bib50","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1530\/eje.0.1500125","article-title":"Change in von Willebrand factor and carotid intima\u2013media thickness in hypothyroid patients with normal thyroid function after levothyroxine replacement therapy","volume":"150","author":"Nagasaki","year":"2004","journal-title":"Eur J Endocrinol"},{"issue":"3","key":"10.1016\/j.thromres.2005.03.010_bib51","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1046\/j.1365-2567.2002.01469.x","article-title":"Kinetics of thrombomodulin release and endothelial cell injury by neutrophil-derived proteases and oxygen radicals","volume":"107","author":"Boehme","year":"2002","journal-title":"Immunology"},{"issue":"10","key":"10.1016\/j.thromres.2005.03.010_bib52","doi-asserted-by":"crossref","first-page":"3646","DOI":"10.1182\/blood.V99.10.3646","article-title":"Naturally occurring mutations in the thrombomodulin gene leading to impaired expression and function","volume":"99","author":"Kunz","year":"2002","journal-title":"Blood"}],"container-title":["Thrombosis Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384805001490?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384805001490?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,7,10]],"date-time":"2021-07-10T22:20:28Z","timestamp":1625955628000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0049384805001490"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1]]},"references-count":52,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["S0049384805001490"],"URL":"https:\/\/doi.org\/10.1016\/j.thromres.2005.03.010","relation":{},"ISSN":["0049-3848"],"issn-type":[{"value":"0049-3848","type":"print"}],"subject":[],"published":{"date-parts":[[2006,1]]}}}