{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T11:52:56Z","timestamp":1763725976572},"reference-count":21,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thrombosis Research"],"published-print":{"date-parts":[[2006,1]]},"DOI":"10.1016\/j.thromres.2005.09.010","type":"journal-article","created":{"date-parts":[[2005,11,3]],"date-time":"2005-11-03T12:48:22Z","timestamp":1131022102000},"page":"523-528","source":"Crossref","is-referenced-by-count":42,"title":["The dilution effect of equal volume mixing studies compromises confirmation of inhibition by lupus anticoagulants even when mixture specific reference ranges are applied"],"prefix":"10.1016","volume":"118","author":[{"given":"Gary W.","family":"Moore","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoffrey F.","family":"Savidge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.thromres.2005.09.010_bib1","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1055\/s-0037-1616204","article-title":"Antiphospholipid syndrome: diagnostic aspects of lupus anticoagulants","volume":"86","author":"Arnout","year":"2001","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.thromres.2005.09.010_bib2","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1055\/s-0038-1649901","article-title":"Criteria for the diagnosis of lupus anticoagulants: an update","volume":"74","author":"Brandt","year":"1995","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.thromres.2005.09.010_bib3","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1046\/j.1365-2141.2000.02069.x","article-title":"Guidelines on the investigation and management of the antiphospholipid syndrome","volume":"109","author":"Greaves","year":"2000","journal-title":"Br J Haematol"},{"key":"10.1016\/j.thromres.2005.09.010_bib4","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1006\/jaut.2000.0414","article-title":"Use of the dilute Russell Viper venom time (dRVVT): its importance and pitfalls","volume":"15","author":"Triplett","year":"2000","journal-title":"J Autoimm"},{"key":"10.1016\/j.thromres.2005.09.010_bib5","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1055\/s-0038-1648521","article-title":"Comparison between a one-point dilute phospholipid APTT and the dilute Russell Viper Venom Time for verification of lupus anticoagulants","volume":"67","author":"Alving","year":"1992","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.thromres.2005.09.010_bib6","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1097\/00001721-200204000-00013","article-title":"The activated seven lupus anticoagulant (ASLA) assay: a new test for lupus anticoagulants (LAs). Evidence that some LAs are detectable only in extrinsic pathway based assays","volume":"13","author":"Moore","year":"2002","journal-title":"Blood Coagul Fibrinolysis"},{"key":"10.1016\/j.thromres.2005.09.010_bib7","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1097\/01.mbc.0000061283.28953.39","article-title":"The Ecarin time is an improved confirmatory test for the Taipan snake venom time in warfarinised patients with lupus anticoagulants","volume":"14","author":"Moore","year":"2003","journal-title":"Blood Coagul Fibrinolysis"},{"key":"10.1016\/j.thromres.2005.09.010_bib8","first-page":"885","article-title":"Guidelines on testing for the lupus anticoagulant","volume":"44","author":"Machin","year":"1991","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.thromres.2005.09.010_bib9","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1046\/j.1365-2141.2000.02466.x","article-title":"The importance of locally derived reference ranges and standardized calculation of dilute Russell's viper venom time results in screening for lupus anticoagulant","volume":"111","author":"Gardiner","year":"2000","journal-title":"Br J Haematol"},{"key":"10.1016\/j.thromres.2005.09.010_bib10","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1080\/09674845.2005.11732681","article-title":"Low frequency of elevated prothrombin times in patients with lupus anticoagulants when using a recombinant thromboplastin reagent: implications for dosing and monitoring of oral anticoagulant therapy","volume":"62","author":"Moore","year":"2005","journal-title":"Br J Biomed Sci"},{"key":"10.1016\/j.thromres.2005.09.010_bib11","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1055\/s-0037-1613777","article-title":"Transient lupus anticoagulants in children: stepwise disappearance of diagnostic features","volume":"83","author":"Male","year":"2000","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.thromres.2005.09.010_bib12","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.1111\/j.1538-7836.2003.0543h.x","article-title":"Normal plasma mixing studies in the laboratory diagnosis of lupus anticoagulant","volume":"1","author":"Thom","year":"2003","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.thromres.2005.09.010_bib13","first-page":"595","article-title":"The lupus anticoagulant. High incidence of \u2018negative\u2019 mixing studies in a human immunodeficiency virus-positive population","volume":"117","author":"Clyne","year":"1993","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.thromres.2005.09.010_bib14","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1097\/00001721-200012000-00011","article-title":"Improved detection of lupus anticoagulants by the dilute Russell's Viper venom time","volume":"11","author":"Moore","year":"2000","journal-title":"Blood Coagul Fibrinolysis"},{"key":"10.1016\/j.thromres.2005.09.010_bib15","first-page":"155","article-title":"New diagnostic strategies for lupus anticoagulant and antiphospholipid antibodies","volume":"24","author":"Triplett","year":"1994","journal-title":"Haemostasis"},{"key":"10.1016\/j.thromres.2005.09.010_bib16","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1093\/ajcp\/95.3.408","article-title":"Evaluation of different mixing study reagents and dilution effect in lupus anticoagulant testing","volume":"95","author":"Kaczor","year":"1991","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.thromres.2005.09.010_bib17","first-page":"627","article-title":"Detection of lupus anticoagulant by means of dilute Russell's viper venom time is affected by oral anticoagulant therapy","volume":"1","author":"Jouhikainen","year":"1990","journal-title":"Blood Coagul Fibrinolysis"},{"key":"10.1016\/j.thromres.2005.09.010_bib18","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1111\/j.1365-2141.1994.tb04790.x","article-title":"The role of lipids in the detection of lupus anticoagulant by the dilute Russell Viper venom test: are platelets or reagents containing hexagonal HII phases necessary?","volume":"86","author":"Stevenson","year":"1994","journal-title":"Br J Haematol"},{"key":"10.1016\/j.thromres.2005.09.010_bib19","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1001\/archinte.148.5.1060","article-title":"Time dependency of lupus-like anticoagulants","volume":"148","author":"Clyne","year":"1988","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.thromres.2005.09.010_bib20","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1006\/jaut.2000.0392","article-title":"Conceptions and misconceptions in testing for lupus anticoagulants","volume":"15","author":"Exner","year":"2000","journal-title":"J Autoimmun"},{"key":"10.1016\/j.thromres.2005.09.010_bib21","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1046\/j.1365-2141.2002.03821.x","article-title":"Lupus anticoagulant testing: improvements in performance in a UK NEQAS proficiency testing exercise after dissemination of national guidelines on laboratory methods","volume":"119","author":"Jennings","year":"2002","journal-title":"Br J Haematol"}],"container-title":["Thrombosis Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384805003920?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384805003920?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,4]],"date-time":"2019-04-04T03:12:38Z","timestamp":1554347558000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0049384805003920"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["S0049384805003920"],"URL":"https:\/\/doi.org\/10.1016\/j.thromres.2005.09.010","relation":{},"ISSN":["0049-3848"],"issn-type":[{"value":"0049-3848","type":"print"}],"subject":[],"published":{"date-parts":[[2006,1]]}}}