{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:26:28Z","timestamp":1777458388360,"version":"3.51.4"},"reference-count":39,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thrombosis Research"],"published-print":{"date-parts":[[2006,1]]},"DOI":"10.1016\/j.thromres.2005.10.012","type":"journal-article","created":{"date-parts":[[2005,12,15]],"date-time":"2005-12-15T17:59:32Z","timestamp":1134669572000},"page":"619-626","source":"Crossref","is-referenced-by-count":23,"title":["Circulating CD40 ligand is elevated only in patients with more advanced symptomatic peripheral arterial diseases"],"prefix":"10.1016","volume":"118","author":[{"given":"Wen-Jane","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wayne Huey-Herng","family":"Sheu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying-Tsung","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsun-Jui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kae-Woei","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih-Tai","family":"Ting","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Lieng","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.thromres.2005.10.012_bib1","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1161\/hc0902.104353","article-title":"Inflammation and atherosclerosis","volume":"105","author":"Libby","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.thromres.2005.10.012_bib2","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1161\/01.CIR.0000089093.75585.98","article-title":"Biomarkers of vascular disease linking inflammation to endothelial activation: Part II","volume":"108","author":"Szmitko","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.thromres.2005.10.012_bib3","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1161\/01.CIR.0000089190.95415.9F","article-title":"New markers of inflammation and endothelial cell activation: Part I","volume":"108","author":"Szmitko","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.thromres.2005.10.012_bib4","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1161\/hh2401.101272","article-title":"CD40 signaling and plaque instability","volume":"89","author":"Schonbeck","year":"2001","journal-title":"Circ Res"},{"key":"10.1016\/j.thromres.2005.10.012_bib5","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1161\/01.CIR.0000028962.04520.01","article-title":"Platelet-derived CD40L: the switch-hitting player of cardiovascular disease","volume":"106","author":"Andre","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.thromres.2005.10.012_bib6","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1073\/pnas.94.5.1931","article-title":"Functional CD40 ligand is expressed on human vascular endothelial cells, smooth muscle cells, and macrophages: implications for CD40\u2013CD40 ligand signaling in atherosclerosis","volume":"94","author":"Mach","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.thromres.2005.10.012_bib7","doi-asserted-by":"crossref","first-page":"4342","DOI":"10.1073\/pnas.92.10.4342","article-title":"CD40 on human endothelial cells: inducibility by cytokines and functional regulation of adhesion molecule expression","volume":"92","author":"Karmann","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.thromres.2005.10.012_bib8","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1007\/PL00000776","article-title":"The CD40\/CD154 receptor\/ligand dyad","volume":"58","author":"Schonbeck","year":"2001","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.thromres.2005.10.012_bib9","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1161\/01.CIR.96.2.396","article-title":"Activation of monocyte\/macrophage functions related to acute atheroma complication by ligation of CD40: induction of collagenase, stromelysin, and tissue factor","volume":"96","author":"Mach","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.thromres.2005.10.012_bib10","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1161\/01.ATV.21.3.327","article-title":"Elevated circulating levels of monocyte chemoattractant protein-1 in patients with restenosis after coronary angioplasty","volume":"21","author":"Cipollone","year":"2001","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.thromres.2005.10.012_bib11","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1161\/01.CIR.0000027107.54614.1A","article-title":"CD40 ligand inhibits endothelial cell migration by increasing production of endothelial reactive oxygen species","volume":"106","author":"Urbich","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.thromres.2005.10.012_bib12","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1161\/01.CIR.100.6.614","article-title":"Enhanced levels of soluble and membrane-bound CD40 ligand in patients with unstable angina. Possible reflection of T lymphocyte and platelet involvement in the pathogenesis of acute coronary syndromes","volume":"100","author":"Aukrust","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.thromres.2005.10.012_bib13","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1161\/01.CIR.0000025419.95769.F0","article-title":"Association between enhanced soluble CD40L and prothrombotic state in hypercholesterolemia: effects of statin therapy","volume":"106","author":"Cipollone","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.thromres.2005.10.012_bib14","doi-asserted-by":"crossref","first-page":"2266","DOI":"10.1161\/hc4401.099447","article-title":"Soluble CD40L and cardiovascular risk in women","volume":"104","author":"Schonbeck","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.thromres.2005.10.012_bib15","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1056\/NEJMoa022600","article-title":"Soluble CD40 ligand in acute coronary syndromes","volume":"348","author":"Heeschen","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.thromres.2005.10.012_bib16","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1160\/TH04-09-0586","article-title":"Soluble CD40L in peripheral artery disease. Relationship with disease severity, platelet markers and the effects of angioplasty","volume":"93","author":"Blann","year":"2005","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.thromres.2005.10.012_bib17","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1097\/00001721-200011020-00008","article-title":"Platelets and cytokines in concert with endothelial activation in patients with peripheral arterial occlusive disease","volume":"11","author":"Tsakiris","year":"2000","journal-title":"Blood Coagul Fibrinolysis"},{"key":"10.1016\/j.thromres.2005.10.012_bib18","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1056\/NEJM200105243442108","article-title":"Medical treatment of peripheral arterial disease and claudication","volume":"344","author":"Hiatt","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.thromres.2005.10.012_bib19","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1161\/01.CIR.71.3.510","article-title":"The prevalence of peripheral arterial disease in a defined population","volume":"71","author":"Criqui","year":"1985","journal-title":"Circulation"},{"key":"10.1016\/j.thromres.2005.10.012_bib20","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1056\/NEJM199202063260605","article-title":"Mortality over a period of 10 years in patients with peripheral arterial disease","volume":"326","author":"Criqui","year":"1992","journal-title":"N Engl J Med"},{"key":"10.1016\/j.thromres.2005.10.012_bib21","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1161\/01.ATV.19.3.538","article-title":"Ankle\u2013arm index as a predictor of cardiovascular disease and mortality in the Cardiovascular Health Study. The Cardiovascular Health Study Group","volume":"19","author":"Newman","year":"1999","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.thromres.2005.10.012_bib22","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/35393","article-title":"CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells","volume":"391","author":"Henn","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.thromres.2005.10.012_bib23","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0049-3848(03)00098-7","article-title":"Shear-induced von Willebrand factor-mediated platelet surface translocation of the CD40 ligand","volume":"108","author":"Tamura","year":"2002","journal-title":"Thromb Res"},{"key":"10.1016\/j.thromres.2005.10.012_bib24","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/28204","article-title":"Reduction of atherosclerosis in mice by inhibition of CD40 signalling","volume":"394","author":"Mach","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.thromres.2005.10.012_bib25","doi-asserted-by":"crossref","first-page":"7458","DOI":"10.1073\/pnas.97.13.7458","article-title":"Inhibition of CD40 signaling limits evolution of established atherosclerosis in mice","volume":"97","author":"Schonbeck","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.thromres.2005.10.012_bib26","doi-asserted-by":"crossref","first-page":"2776","DOI":"10.1161\/01.CIR.0000103700.05109.0D","article-title":"Preprocedural level of soluble CD40L is predictive of enhanced inflammatory response and restenosis after coronary angioplasty","volume":"108","author":"Cipollone","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.thromres.2005.10.012_bib27","doi-asserted-by":"crossref","first-page":"3801","DOI":"10.1182\/blood.V96.12.3801","article-title":"Ligation of CD40 induces the expression of vascular endothelial growth factor by endothelial cells and monocytes and promotes angiogenesis in vivo","volume":"96","author":"Melter","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.thromres.2005.10.012_bib28","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/S0002-9440(10)65230-3","article-title":"Augmented expression of cyclooxygenase-2 in human atherosclerotic lesions","volume":"155","author":"Schonbeck","year":"1999","journal-title":"Am J Pathol"},{"key":"10.1016\/j.thromres.2005.10.012_bib29","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/sj.bjp.0703327","article-title":"Cyclo-oxygenase-2 enhances basic fibroblast growth factor-induced angiogenesis through induction of vascular endothelial growth factor in rat sponge implants","volume":"130","author":"Majima","year":"2000","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.thromres.2005.10.012_bib30","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1161\/hc4501.099312","article-title":"Upregulation of CD40 and CD40 ligand (CD154) in patients with moderate hypercholesterolemia","volume":"104","author":"Garlichs","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.thromres.2005.10.012_bib31","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1161\/01.CIR.0000088521.04017.13","article-title":"Soluble CD40L: risk prediction after acute coronary syndromes","volume":"108","author":"Varo","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.thromres.2005.10.012_bib32","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1056\/NEJM198602203140806","article-title":"The pathogenesis of atherosclerosis\u2014an update","volume":"314","author":"Ross","year":"1986","journal-title":"N Engl J Med"},{"key":"10.1016\/j.thromres.2005.10.012_bib33","doi-asserted-by":"crossref","first-page":"2524","DOI":"10.1161\/01.CIR.0000129773.70647.94","article-title":"Soluble CD40 ligand, soluble P-selectin, interleukin-6, and tissue factor in diabetes mellitus: relationships to cardiovascular disease and risk factor intervention","volume":"109","author":"Lim","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.thromres.2005.10.012_bib34","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1161\/01.CIR.0000053559.46158.AD","article-title":"Inhibitory effects of glycoprotein IIb\/IIIa antagonists and aspirin on the release of soluble CD40 ligand during platelet stimulation","volume":"107","author":"Nannizzi-Alaimo","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.thromres.2005.10.012_bib35","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1080\/09537100020031207","article-title":"Platelet CD40 ligand (CD40L)\u2014subcellular localization, regulation of expression, and inhibition by clopidogrel","volume":"12","author":"Hermann","year":"2001","journal-title":"Platelets"},{"key":"10.1016\/j.thromres.2005.10.012_bib36","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1080\/09629350410001664752","article-title":"Monocyte chemoattractant protein-1 in patients with peripheral arterial disease","volume":"13","author":"Petrkova","year":"2004","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.thromres.2005.10.012_bib37","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1161\/01.ATV.19.10.2355","article-title":"Systemic inflammatory parameters in patients with atherosclerosis of the coronary and peripheral arteries","volume":"19","author":"Erren","year":"1999","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.thromres.2005.10.012_bib38","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0021-9150(99)00013-1","article-title":"Atherosclerosis and inflammation. Patterns of cytokine regulation in patients with peripheral arterial disease","volume":"145","author":"Fiotti","year":"1999","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.thromres.2005.10.012_bib39","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.atherosclerosis.2004.03.024","article-title":"The short-\/intermediate-term changes in novel vascular inflammatory markers after angioplasty plus stenting in patients with symptomatic advanced systemic arterial diseases","volume":"176","author":"Lee","year":"2004","journal-title":"Atherosclerosis"}],"container-title":["Thrombosis Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384805004330?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384805004330?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,11]],"date-time":"2020-04-11T16:11:28Z","timestamp":1586621488000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0049384805004330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["S0049384805004330"],"URL":"https:\/\/doi.org\/10.1016\/j.thromres.2005.10.012","relation":{},"ISSN":["0049-3848"],"issn-type":[{"value":"0049-3848","type":"print"}],"subject":[],"published":{"date-parts":[[2006,1]]}}}