{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:25:10Z","timestamp":1790745910596,"version":"4.1.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thrombosis Research"],"published-print":{"date-parts":[[2007,1]]},"DOI":"10.1016\/j.thromres.2006.04.004","type":"journal-article","created":{"date-parts":[[2006,6,22]],"date-time":"2006-06-22T11:34:42Z","timestamp":1150976082000},"page":"517-524","source":"Crossref","is-referenced-by-count":33,"title":["Increased basal platelet activity, plasma adiponectin levels, and diabetes mellitus are associated with poor platelet responsiveness to in vitro effect of aspirin"],"prefix":"10.1016","volume":"119","author":[{"given":"Shinichi","family":"Takahashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miho","family":"Ushida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Risa","family":"Komine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aya","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiro","family":"Uchida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Ishihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiro","family":"Shibano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gentaro","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuo","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuru","family":"Murata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.thromres.2006.04.004_bib1","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1161\/01.CIR.101.10.1206","article-title":"Aspirin","volume":"10","author":"Awtry","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.thromres.2006.04.004_bib2","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1136\/bmj.324.7329.71","article-title":"Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients","volume":"324","author":"Antithrombotic Trialists' Collaboration","year":"2002","journal-title":"BMJ"},{"key":"10.1016\/j.thromres.2006.04.004_bib3","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/0049-3848(91)90085-B","article-title":"Effects of acetylsalicylic acid in stroke patients. Evidence of nonresponders in a subpopulation of treated patients","volume":"63","author":"Grotemeyer","year":"1991","journal-title":"Thromb Res"},{"key":"10.1016\/j.thromres.2006.04.004_bib4","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1161\/01.STR.25.12.2331","article-title":"Development of aspirin resistance in persons with previous ischemic stroke","volume":"12","author":"Helgason","year":"1994","journal-title":"Stroke"},{"key":"10.1016\/j.thromres.2006.04.004_bib5","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1161\/01.STR.24.3.345","article-title":"Aspirin response and failure in cerebral infarction","volume":"24","author":"Helgason","year":"1993","journal-title":"Stroke"},{"key":"10.1016\/j.thromres.2006.04.004_bib6","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1055\/s-0038-1657677","article-title":"Variable platelet response to low-dose ASA and the risk of limb deterioration in patients submitted to peripheral arterial angioplasty","volume":"78","author":"Mueller","year":"1997","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.thromres.2006.04.004_bib7","first-page":"221","article-title":"Individual variation in the effects of ASA on platelet function: implications for the use of ASA clinically","volume":"11","author":"Buchanan","year":"1995","journal-title":"Can J Cardiol"},{"key":"10.1016\/j.thromres.2006.04.004_bib8","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1161\/01.CIR.0000013777.21160.07","article-title":"Aspirin-resistant thromboxane biosynthesis and the risk of myocardial infarction, stroke, or cardiovascular death in patients at high risk for cardiovascular events","volume":"105","author":"Eikelboom","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.thromres.2006.04.004_bib9","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/S0735-1097(02)03014-0","article-title":"A prospective, blinded determination of the natural history of aspirin resistance among stable patients with cardiovascular disease","volume":"41","author":"Gum","year":"2003","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.thromres.2006.04.004_bib10","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1055\/s-0037-1613290","article-title":"Aspirin resistance in cardiovascular disease: a review of prevalence, mechanisms, and clinical significance","volume":"88","author":"McKee","year":"2002","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.thromres.2006.04.004_bib11","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1080\/09537100120104890","article-title":"Towards a definition of aspirin resistance: a typological approach","volume":"13","author":"Weber","year":"2002","journal-title":"Platelets"},{"key":"10.1016\/j.thromres.2006.04.004_bib12","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.2165\/00003088-200342120-00004","article-title":"Pharmacokinetic and pharmacodynamic differences between two low dosages of aspirin may affect therapeutic outcomes","volume":"42","author":"Cerletti","year":"2003","journal-title":"Clin Pharmacokinet"},{"key":"10.1016\/j.thromres.2006.04.004_bib13","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1002\/j.1552-4604.1995.tb04044.x","article-title":"Variability in the pharmacokinetics and pharmacodynamics of low dose aspirin in healthy male volunteers","volume":"35","author":"Benedek","year":"1995","journal-title":"J Clin Pharmacol"},{"key":"10.1016\/j.thromres.2006.04.004_bib14","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/0167-5699(93)90267-O","article-title":"Circulating adhesion molecules in disease","volume":"14","author":"Gearing","year":"1993","journal-title":"Immunol Today"},{"key":"10.1016\/j.thromres.2006.04.004_bib15","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1161\/01.CIR.103.8.1057","article-title":"Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages","volume":"103","author":"Ouchi","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.thromres.2006.04.004_bib16","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1074\/jbc.M209033200","article-title":"Globular adiponectin protected ob\/ob mice from diabetes and ApoE-deficient mice from atherosclerosis","volume":"278","author":"Yamauchi","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.thromres.2006.04.004_bib17","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1055\/s-2007-995840","article-title":"PFA-100 system: a new method for assessment of platelet dysfunction","volume":"24","author":"Mammen","year":"1998","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.thromres.2006.04.004_bib18","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1055\/s-0037-1613805","article-title":"Monitoring of aspirin (ASA) pharmacodynamics with the platelet function analyzer PFA-100","volume":"83","author":"Homoncik","year":"2000","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.thromres.2006.04.004_bib19","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1097\/00062752-200209000-00004","article-title":"Clinical application of the PFA-100\u00ae","volume":"9","author":"Favaloro","year":"2002","journal-title":"Curr Opin Hematol"},{"key":"10.1016\/j.thromres.2006.04.004_bib20","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0049-3848(97)00115-1","article-title":"Comparison of four commercial citrate blood collection systems for platelet function analysis by the PFA-100 system","volume":"87","author":"Heilmann","year":"1997","journal-title":"Thromb Res"},{"key":"10.1016\/j.thromres.2006.04.004_bib21","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1056\/NEJM196110122651503","article-title":"Alteration of blood on storage: measurement of adhesiveness of \u201caging\u201d platelets and leukocytes and their removal by filtration","volume":"265","author":"Swank","year":"1961","journal-title":"N Engl J Med"},{"key":"10.1016\/j.thromres.2006.04.004_bib22","doi-asserted-by":"crossref","first-page":"239","DOI":"10.2337\/diabetes.52.2.239","article-title":"Plasma adiponectin concentrations predict insulin sensitivity of both glucose and lipid metabolism","volume":"52","author":"Tschritter","year":"2003","journal-title":"Diabetes"},{"key":"10.1016\/j.thromres.2006.04.004_bib23","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1042\/CS20010336","article-title":"Correlation of the adipocyte-derived protein adiponectin with insulin resistance index and serum high-density lipoprotein-cholesterol, independent of body mass index, in the Japanese population","volume":"103","author":"Yamamoto","year":"2002","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.thromres.2006.04.004_bib24","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1161\/01.STR.31.3.591","article-title":"Increased platelet sensitivity to collagen in individuals resistant to low-dose aspirin","volume":"31","author":"Kawasaki","year":"2000","journal-title":"Stroke"},{"key":"10.1016\/j.thromres.2006.04.004_bib25","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0049-3848(02)00210-4","article-title":"Resistance to aspirin in vitro is associated with increased platelet sensitivity to adenosine diphosphate","volume":"107","author":"Macchi","year":"2002","journal-title":"Thromb Res"},{"key":"10.1016\/j.thromres.2006.04.004_bib26","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1006\/bbrc.1999.0255","article-title":"Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity","volume":"257","author":"Arita","year":"1999","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.thromres.2006.04.004_bib27","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.1161\/01.CIR.0000042707.50032.19","article-title":"Adiponectin reduces atherosclerosis in apolipoprotein E-deficient mice","volume":"106","author":"Okamoto","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.thromres.2006.04.004_bib28","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1161\/01.ATV.0000194076.84568.81","article-title":"Adiponectin acts as an endogenous antithrombotic factor","volume":"26","author":"Kato","year":"2006","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.thromres.2006.04.004_bib29","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.thromres.2003.12.016","article-title":"Reduced sensitivity of platelets from type 2 diabetic patients to acetylsalicylic acid (aspirin)\u2014its relation to metabolic control","volume":"113","author":"Watala","year":"2004","journal-title":"Thromb Res"},{"key":"10.1016\/j.thromres.2006.04.004_bib30","doi-asserted-by":"crossref","first-page":"261","DOI":"10.2337\/diabetes.41.3.261","article-title":"Differential effect of aspirin on platelet aggregation in IDDM","volume":"4","author":"Mori","year":"1992","journal-title":"Diabetes"},{"key":"10.1016\/j.thromres.2006.04.004_bib31","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1007\/s00109-004-0600-x","article-title":"Increased protein glycation in diabetes mellitus is associated with decreased aspirin-mediated protein acetylation and reduced sensitivity of blood platelets to aspirin","volume":"83","author":"Watala","year":"2005","journal-title":"J Mol Med"},{"key":"10.1016\/j.thromres.2006.04.004_bib32","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.2337\/diacare.26.7.2181","article-title":"The platelet in diabetes: focus on prevention of ischemic events","volume":"26","author":"Colwell","year":"2003","journal-title":"Diabetes Care"},{"key":"10.1016\/j.thromres.2006.04.004_bib33","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1182\/blood.V68.4.886.886","article-title":"Trial of repeated low-dose aspirin in diabetic angiopathy","volume":"6","author":"DiMinno","year":"1986","journal-title":"Blood"},{"key":"10.1016\/j.thromres.2006.04.004_bib34","doi-asserted-by":"crossref","first-page":"H1480","DOI":"10.1152\/ajpheart.2001.280.4.H1480","article-title":"Platelet hyperactivity and abnormal Ca2+ homeostasis in diabetes mellitus","volume":"280","author":"Li","year":"2001","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.thromres.2006.04.004_bib35","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.2337\/diacare.24.8.1476","article-title":"Platelet dysfunction in type 2 diabetes","volume":"24","author":"Vinik","year":"2001","journal-title":"Diabetes Care"}],"container-title":["Thrombosis Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384806001514?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384806001514?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T18:06:01Z","timestamp":1586973961000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0049384806001514"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["S0049384806001514"],"URL":"https:\/\/doi.org\/10.1016\/j.thromres.2006.04.004","relation":{},"ISSN":["0049-3848"],"issn-type":[{"value":"0049-3848","type":"print"}],"subject":[],"published":{"date-parts":[[2007,1]]}}}