{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:34:09Z","timestamp":1762004049894,"version":"3.44.0"},"reference-count":18,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thrombosisresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Thrombosis Research"],"published-print":{"date-parts":[[2008]]},"DOI":"10.1016\/j.thromres.2007.07.007","type":"journal-article","created":{"date-parts":[[2007,9,13]],"date-time":"2007-09-13T08:24:22Z","timestamp":1189671862000},"page":"773-780","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Dysfibrinogen Kagoshima with the amino acid substitution \u03b3Thr-314 to Ile: Analyses of molecular abnormalities and thrombophilic nature of this abnormal molecule"],"prefix":"10.1016","volume":"121","author":[{"given":"Kazuki","family":"Niwa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Mimuro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaaki","family":"Miyata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teruko","family":"Sugo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsukasa","family":"Ohmori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiji","family":"Madoiwa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuwa","family":"Tei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoichi","family":"Sakata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.thromres.2007.07.007_bib1","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1111\/j.1538-7836.2005.01365.x","article-title":"Fibrinogen and fibrin structure and functions","volume":"3","author":"Mosesson","year":"2005","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.thromres.2007.07.007_bib2","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0065-3233(05)70008-5","article-title":"Fibrinogen and fibrin","volume":"70","author":"Weisel","year":"2005","journal-title":"Adv Protein Chem"},{"issue":"12","key":"10.1016\/j.thromres.2007.07.007_bib3","doi-asserted-by":"crossref","first-page":"8919","DOI":"10.1016\/S0021-9258(18)52960-4","article-title":"Biosynthesis of human fibrinogen: subunit interactions and potential intermediates in the assembly","volume":"268","author":"Huang","year":"1993","journal-title":"J Biol Chem"},{"issue":"4","key":"10.1016\/j.thromres.2007.07.007_bib4","first-page":"436","article-title":"Structure and function of fibrinogen inferred from hereditary dysfibrinogens","volume":"72","author":"Matsuda","year":"2000","journal-title":"Int J Hematol"},{"issue":"1","key":"10.1016\/j.thromres.2007.07.007_bib5","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1055\/s-0038-1653741","article-title":"Familial dysfibrinogenemia and thrombophilia","volume":"73","author":"Haverkate","year":"1995","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.thromres.2007.07.007_bib6","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1749-6632.2001.tb03496.x","article-title":"Molecular mechanisms of hypo- and afibrinogenemia","volume":"936","author":"Brennan","year":"2001","journal-title":"Ann N Y Acad Sci"},{"issue":"8","key":"10.1016\/j.thromres.2007.07.007_bib7","doi-asserted-by":"crossref","first-page":"3162","DOI":"10.1182\/blood-2004-04-1621","article-title":"Fibrinogen Philadelphia, a hypodysfibrinogenemia characterized by abnormal polymerization and fibrinogen hypercatabolism due to \u03b3 S378P mutation","volume":"105","author":"Keller","year":"2005","journal-title":"Blood"},{"issue":"7","key":"10.1016\/j.thromres.2007.07.007_bib8","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1182\/blood.V92.7.2195","article-title":"\u03b3-chain dysfibrinogenemias: molecular structure\u2013function relationships of naturally occurring mutations in the chain \u03b3 of human fibrinogen","volume":"92","author":"Cote","year":"1998","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.thromres.2007.07.007_bib9","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1172\/JCI115841","article-title":"Molecular basis of fibrinogen Naples associated with defective thrombin binding and thrombophilia. Homozygous substitution of B\u03b2 68 Ala\u2192Thr","volume":"90","author":"Koopman","year":"1992","journal-title":"J Clin Invest"},{"issue":"4","key":"10.1016\/j.thromres.2007.07.007_bib10","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1172\/JCI116371","article-title":"Molecular basis for fibrinogen Dusart (A alpha 554 Arg\u2192Cys) and its association with abnormal fibrin polymerization and thrombophilia","volume":"91","author":"Koopman","year":"1993","journal-title":"J Clin Invest"},{"issue":"2","key":"10.1016\/j.thromres.2007.07.007_bib11","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1055\/s-0037-1614006","article-title":"Fibrinogen Caracas V, an abnormal fibrinogen with an A\u03b1 532 Ser\u2192Cys substitution associated with thrombosis","volume":"84","author":"Marchi","year":"2000","journal-title":"Thromb Haemost"},{"issue":"8","key":"10.1016\/j.thromres.2007.07.007_bib12","doi-asserted-by":"crossref","first-page":"3045","DOI":"10.1182\/blood-2003-07-2569","article-title":"Thrombophilic Dysfibrinogen Tokyo V with the amino acid substitution of \u03b3 Ala-327 to Thr: formation of fragile but fibrinolysis-resistant fibrin clots and its relevance to arterial thromboembolism","volume":"103","author":"Hamano","year":"2004","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.thromres.2007.07.007_bib13","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/j.1538-7836.2005.01139.x","article-title":"B\u03b2 14 Arg\u2192Cys variant dysfibrinogen and its association with thrombosis","volume":"3","author":"Castaman","year":"2005","journal-title":"J Thromb Haemost"},{"issue":"6","key":"10.1016\/j.thromres.2007.07.007_bib14","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1055\/s-0037-1614603","article-title":"A new type of Ser substitution for \u03b3Arg-275 in fibrinogen Kamogawa I characterized by impaired fibrin assembly","volume":"81","author":"Mimuro","year":"1999","journal-title":"Thromb Haemost"},{"issue":"11","key":"10.1016\/j.thromres.2007.07.007_bib15","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1046\/j.1538-7836.2003.00425.x","article-title":"Hypofibrinogenemia caused by a nonsense mutation in the fibrinogen B\u03b2 chain gene","volume":"1","author":"Mimuro","year":"2003","journal-title":"J Thromb Haemost"},{"issue":"6","key":"10.1016\/j.thromres.2007.07.007_bib16","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1097\/00001721-200408000-00003","article-title":"Investigation of residues in the fibrin(ogen) \u03b3 chain involved in tissue plasminogen activator binding an plasminogen activation","volume":"15","author":"Wilhelm","year":"2004","journal-title":"Blood Coagul Fibrinolysis"},{"issue":"11","key":"10.1016\/j.thromres.2007.07.007_bib17","doi-asserted-by":"crossref","first-page":"3806","DOI":"10.1182\/blood.V94.11.3806","article-title":"Fibrinogen Niigata with impaired fibrin assembly: an inherited dysfibrinogen with a B\u03b2 Asn-160 to Ser substitution associated with extra glycosylation at B\u03b2 Asn-158","volume":"94","author":"Sugo","year":"1999","journal-title":"Blood"},{"issue":"6650","key":"10.1016\/j.thromres.2007.07.007_bib18","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/38947","article-title":"Crystal structure of fragment D from human fibrinogen and its crosslinked counterpart from fibrin","volume":"389","author":"Spraggon","year":"1997","journal-title":"Nature"}],"container-title":["Thrombosis Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384807003052?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384807003052?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T17:34:29Z","timestamp":1758735269000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0049384807003052"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":18,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008]]}},"alternative-id":["S0049384807003052"],"URL":"https:\/\/doi.org\/10.1016\/j.thromres.2007.07.007","relation":{},"ISSN":["0049-3848"],"issn-type":[{"type":"print","value":"0049-3848"}],"subject":[],"published":{"date-parts":[[2008]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dysfibrinogen Kagoshima with the amino acid substitution \u03b3Thr-314 to Ile: Analyses of molecular abnormalities and thrombophilic nature of this abnormal molecule","name":"articletitle","label":"Article Title"},{"value":"Thrombosis Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.thromres.2007.07.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}