{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T04:18:40Z","timestamp":1791778720285,"version":"4.3.4"},"reference-count":53,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thrombosis Research"],"published-print":{"date-parts":[[2008,1]]},"DOI":"10.1016\/j.thromres.2007.10.009","type":"journal-article","created":{"date-parts":[[2007,12,5]],"date-time":"2007-12-05T13:14:08Z","timestamp":1196860448000},"page":"299-306","source":"Crossref","is-referenced-by-count":107,"title":["Incidence, risk factors and consequences of portal vein and systemic thromboses in hepatocellular carcinoma"],"prefix":"10.1016","volume":"122","author":[{"given":"Gregory C.","family":"Connolly","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ollivier","family":"Hyrien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parvez","family":"Mantry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adel","family":"Bozorgzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Abt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alok A.","family":"Khorana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.thromres.2007.10.009_bib1","first-page":"61","article-title":"Causes of death in cancer patients","volume":"6","author":"Ambrus","year":"1975","journal-title":"J Med"},{"issue":"25","key":"10.1016\/j.thromres.2007.10.009_bib2","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1056\/NEJM200012213432504","article-title":"Prognosis of cancers associated with venous thromboembolism","volume":"343","author":"Sorensen","year":"2000","journal-title":"N Engl J Med"},{"issue":"6","key":"10.1016\/j.thromres.2007.10.009_bib3","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1001\/jama.293.6.715","article-title":"Malignancies, prothrombotic mutations, and the risk of venous thrombosis","volume":"293","author":"Blom","year":"2005","journal-title":"JAMA"},{"issue":"6","key":"10.1016\/j.thromres.2007.10.009_bib4","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1001\/archinte.160.6.809","article-title":"Risk factors for deep vein thrombosis and pulmonary embolism: a population-based case-control study","volume":"160","author":"Heit","year":"2000","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.thromres.2007.10.009_bib5","first-page":"117","article-title":"Venous thomboembolism and cancer: risks and outcomes","volume":"107","author":"Agnes","year":"2003","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/j.thromres.2007.10.009_bib6","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1001\/archinte.158.6.585","article-title":"Trends in the incidence of deep vein thrombosis and pulmonary embolism: a 25-year population-based study","volume":"158","author":"Silverstein","year":"1998","journal-title":"Arch Intern Med"},{"issue":"23 Suppl 1","key":"10.1016\/j.thromres.2007.10.009_bib7","first-page":"I4","article-title":"The epidemiology of venous thromboembolism","volume":"107","author":"White","year":"2003","journal-title":"Circulation"},{"issue":"9399","key":"10.1016\/j.thromres.2007.10.009_bib8","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1016\/S0140-6736(03)14964-1","article-title":"Hepatocellular carcinoma","volume":"362","author":"Llovet","year":"2003","journal-title":"Lancet"},{"issue":"10","key":"10.1016\/j.thromres.2007.10.009_bib9","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1056\/NEJM199903113401001","article-title":"Rising incidence of hepatocellular carcinoma in the United States","volume":"340","author":"El-Serag","year":"1999","journal-title":"N Engl J Med"},{"issue":"24","key":"10.1016\/j.thromres.2007.10.009_bib10","doi-asserted-by":"crossref","first-page":"15584","DOI":"10.1073\/pnas.242608099","article-title":"Inaugural Article: a comparison of the molecular clock of hepatitis C virus in the United States and Japan predicts that hepatocellular carcinoma incidence in the United States will increase over the next two decades","volume":"99","author":"Tanaka","year":"2002","journal-title":"Proc Natl Acad Sci U. S. A."},{"issue":"Suppl 1","key":"10.1016\/j.thromres.2007.10.009_bib11","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/S0168-8278(99)80381-X","article-title":"Hepatitis C virus infection in the United States","volume":"31","author":"Alter","year":"1999","journal-title":"J Hepatol"},{"issue":"3","key":"10.1016\/j.thromres.2007.10.009_bib12","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/j.1600-0676.1995.tb00664.x","article-title":"Long interval between HCV infection and development of hepatocellular carcinoma","volume":"15","author":"Castells","year":"1995","journal-title":"Liver"},{"issue":"4","key":"10.1016\/j.thromres.2007.10.009_bib13","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1002\/1097-0142(19850815)56:4<918::AID-CNCR2820560437>3.0.CO;2-E","article-title":"Natural history of hepatocellular carcinoma and prognosis in relation to treatment. Study of 850 patients","volume":"56","author":"Okuda","year":"1985","journal-title":"Cancer"},{"issue":"3","key":"10.1016\/j.thromres.2007.10.009_bib14","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1053\/jhep.2002.32089","article-title":"Prognostic prediction and treatment strategy in hepatocellular carcinoma","volume":"35","author":"Bruix","year":"2002","journal-title":"Hepatology"},{"issue":"5","key":"10.1016\/j.thromres.2007.10.009_bib15","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1002\/hep.510280511","article-title":"Early hepatocellular carcinoma as an entity with a high rate of surgical cure","volume":"28","author":"Takayama","year":"1998","journal-title":"Hepatology"},{"issue":"6","key":"10.1016\/j.thromres.2007.10.009_bib16","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1002\/hep.510300629","article-title":"Intention-to-treat analysis of surgical treatment for early hepatocellular carcinoma: resection versus transplantation","volume":"30","author":"Llovet","year":"1999","journal-title":"Hepatology"},{"issue":"6","key":"10.1016\/j.thromres.2007.10.009_bib17","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1053\/jhep.2000.20456","article-title":"Results of surgical and nonsurgical treatment for small-sized hepatocellular carcinomas: a retrospective and nationwide survey in Japan. The Liver Cancer Study Group of Japan","volume":"32","author":"Arii","year":"2000","journal-title":"Hepatology"},{"issue":"9232","key":"10.1016\/j.thromres.2007.10.009_bib18","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/S0140-6736(00)02654-4","article-title":"Adoptive immunotherapy to lower postsurgical recurrence rates of hepatocellular carcinoma: a randomised trial","volume":"356","author":"Takayama","year":"2000","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.thromres.2007.10.009_bib19","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1097\/00000658-200205000-00015","article-title":"Preoperative predictors of survival after resection of small hepatocellular carcinomas","volume":"235","author":"Wayne","year":"2002","journal-title":"Ann Surg"},{"issue":"3","key":"10.1016\/j.thromres.2007.10.009_bib20","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1097\/00000658-199109000-00005","article-title":"Hepatic resection versus transplantation for hepatocellular carcinoma","volume":"214","author":"Iwatsuki","year":"1991","journal-title":"Ann Surg"},{"issue":"3","key":"10.1016\/j.thromres.2007.10.009_bib21","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1055\/s-2007-1007120","article-title":"Liver transplantation for hepatocellular carcinoma","volume":"19","author":"Bismuth","year":"1999","journal-title":"Semin Liver Dis"},{"issue":"5","key":"10.1016\/j.thromres.2007.10.009_bib22","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1053\/jhep.2001.23561","article-title":"Vascular invasion and histopathologic grading determine outcome after liver transplantation for hepatocellular carcinoma in cirrhosis","volume":"33","author":"Jonas","year":"2001","journal-title":"Hepatology"},{"issue":"6","key":"10.1016\/j.thromres.2007.10.009_bib23","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1053\/jhep.2001.24563","article-title":"Liver transplantation for hepatocellular carcinoma: expansion of the tumor size limits does not adversely impact survival","volume":"33","author":"Yao","year":"2001","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.thromres.2007.10.009_bib24","doi-asserted-by":"crossref","first-page":"208","DOI":"10.3748\/wjg.v7.i2.208","article-title":"Clinical characteristics and outcome of a cohort of 101 patients with hepatocellular carcinoma","volume":"7","author":"Rabe","year":"2001","journal-title":"World J Gastroenterol"},{"issue":"8","key":"10.1016\/j.thromres.2007.10.009_bib25","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1097\/00042737-200012080-00015","article-title":"Hepatocellular carcinoma in Austria: aetiological and clinical characteristics at presentation","volume":"12","author":"Schoniger-Hekele","year":"2000","journal-title":"Eur J Gastroenterol Hepatol"},{"issue":"7","key":"10.1016\/j.thromres.2007.10.009_bib26","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s004320050189","article-title":"Portal vein thrombosis in hepatocellular carcinoma: age and sex distribution in an autopsy study","volume":"124","author":"Pirisi","year":"1998","journal-title":"J Cancer Res Clin Oncol"},{"issue":"1","key":"10.1016\/j.thromres.2007.10.009_bib27","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.hepres.2003.08.002","article-title":"Report of the 15th follow-up survey of primary liver cancer","volume":"28","author":"Ikai","year":"2004","journal-title":"Hepatol Res"},{"issue":"11","key":"10.1016\/j.thromres.2007.10.009_bib28","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1002\/(SICI)1097-0142(19960601)77:11<2217::AID-CNCR6>3.0.CO;2-M","article-title":"Hepatocellular carcinoma in the United States. Prognostic features, treatment outcome, and survival","volume":"77","author":"Stuart","year":"1996","journal-title":"Cancer"},{"issue":"5","key":"10.1016\/j.thromres.2007.10.009_bib29","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1097\/01.coc.0000136019.94333.09","article-title":"Prognostic features and survival of inoperable hepatocellular carcinoma in Turkish patients with cirrhosis","volume":"27","author":"Sakar","year":"2004","journal-title":"Am J Clin Oncol"},{"issue":"3","key":"10.1016\/j.thromres.2007.10.009_bib30","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1136\/gut.2004.048124","article-title":"Prognostic factors for survival in patients with early-intermediate hepatocellular carcinoma undergoing non-surgical therapy: comparison of Okuda, CLIP, and BCLC staging systems in a single Italian centre","volume":"54","author":"Grieco","year":"2005","journal-title":"Gut"},{"key":"10.1016\/j.thromres.2007.10.009_bib31","doi-asserted-by":"crossref","unstructured":"A new prognostic system for hepatocellular carcinoma: a retrospective study of 435 patients: the Cancer of the Liver Italian Program (CLIP) investigators. Hepatology. Sep 1998;28(3):751\u2013755.","DOI":"10.1002\/hep.510280322"},{"key":"10.1016\/j.thromres.2007.10.009_bib32","doi-asserted-by":"crossref","unstructured":"Predictive factors for long term prognosis after partial hepatectomy for patients with hepatocellular carcinoma in Japan. The Liver Cancer Study Group of Japan. Cancer. Nov 15 1994;74(10):2772\u20132780.","DOI":"10.1002\/1097-0142(19941115)74:10<2772::AID-CNCR2820741006>3.0.CO;2-V"},{"key":"10.1016\/j.thromres.2007.10.009_bib33","series-title":"AJCC Cancer Staging Manual","year":"2002"},{"issue":"3","key":"10.1016\/j.thromres.2007.10.009_bib34","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0168-8278(01)00130-1","article-title":"Clinical management of hepatocellular carcinoma. Conclusions of the Barcelona-2000 EASL conference. European Association for the Study of the Liver","volume":"35","author":"Bruix","year":"2001","journal-title":"J Hepatol"},{"issue":"5","key":"10.1016\/j.thromres.2007.10.009_bib35","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1097\/00005792-199909000-00001","article-title":"Rates of initial and recurrent thromboembolic disease among patients with malignancy versus those without malignancy. Risk analysis using Medicare claims data","volume":"78","author":"Levitan","year":"1999","journal-title":"Medicine (Baltimore)"},{"issue":"6","key":"10.1016\/j.thromres.2007.10.009_bib36","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1080\/10428190600560991","article-title":"Venous thromboembolism in patients with diffuse large B-cell lymphoma","volume":"47","author":"Komrokji","year":"2006","journal-title":"Leuk Lymphoma"},{"issue":"8","key":"10.1016\/j.thromres.2007.10.009_bib37","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1038\/sj.bjc.6602504","article-title":"Increased risk of thromboembolism in patients with malignant lymphoma: a single-centre analysis","volume":"92","author":"Mohren","year":"2005","journal-title":"Br J Cancer"},{"issue":"3","key":"10.1016\/j.thromres.2007.10.009_bib38","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/j.1600-0609.1995.tb00214.x","article-title":"Deep venous thrombosis and pulmonary artery embolism in high-grade non Hodgkin's lymphoma: incidence, causes and prognostic relevance","volume":"54","author":"Ottinger","year":"1995","journal-title":"Eur J Haematol"},{"issue":"12","key":"10.1016\/j.thromres.2007.10.009_bib39","doi-asserted-by":"crossref","first-page":"2822","DOI":"10.1002\/cncr.21496","article-title":"Risk factors for chemotherapy-associated venous thromboembolism in a prospective observational study","volume":"104","author":"Khorana","year":"2005","journal-title":"Cancer"},{"issue":"23 Suppl 1","key":"10.1016\/j.thromres.2007.10.009_bib40","first-page":"I17","article-title":"Venous thromboembolism and cancer: risks and outcomes","volume":"107","author":"Lee","year":"2003","journal-title":"Circulation"},{"issue":"11","key":"10.1016\/j.thromres.2007.10.009_bib41","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/S1470-2045(04)01606-7","article-title":"Pancreatic cancer and thromboembolic disease","volume":"5","author":"Khorana","year":"2004","journal-title":"Lancet Oncol"},{"issue":"3","key":"10.1016\/j.thromres.2007.10.009_bib42","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1200\/JCO.2005.03.8877","article-title":"Thromboembolism in hospitalized neutropenic cancer patients","volume":"24","author":"Khorana","year":"2006","journal-title":"J Clin Oncol"},{"issue":"2","key":"10.1016\/j.thromres.2007.10.009_bib43","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/0016-5085(85)90327-0","article-title":"Incidence of portal vein thrombosis in liver cirrhosis. An angiographic study in 708 patients","volume":"89","author":"Okuda","year":"1985","journal-title":"Gastroenterology"},{"issue":"5","key":"10.1016\/j.thromres.2007.10.009_bib44","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1002\/hep.1840160515","article-title":"The incidence of portal vein thrombosis at liver transplantation","volume":"16","author":"Nonami","year":"1992","journal-title":"Hepatology"},{"issue":"5","key":"10.1016\/j.thromres.2007.10.009_bib45","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/S0168-8278(00)80259-7","article-title":"Portal vein thrombosis in adults: pathophysiology, pathogenesis and management","volume":"32","author":"Valla","year":"2000","journal-title":"J Hepatol"},{"issue":"13","key":"10.1016\/j.thromres.2007.10.009_bib46","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.3748\/wjg.v12.i13.2115","article-title":"Portal vein thrombosis: prevalence, patient characteristics and lifetime risk: a population study based on 23,796 consecutive autopsies","volume":"12","author":"Ogren","year":"2006","journal-title":"World J Gastroenterol"},{"issue":"7","key":"10.1016\/j.thromres.2007.10.009_bib47","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1111\/j.1572-0241.2006.00588.x","article-title":"Coagulopathy does not fully protect hospitalized cirrhosis patients from peripheral venous thromboembolism","volume":"101","author":"Northup","year":"2006","journal-title":"Am J Gastroenterol"},{"issue":"1","key":"10.1016\/j.thromres.2007.10.009_bib48","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1440-1746.1997.tb00351.x","article-title":"Natural anticoagulants and the liver","volume":"12","author":"Castelino","year":"1997","journal-title":"J Gastroenterol Hepatol"},{"issue":"4","key":"10.1016\/j.thromres.2007.10.009_bib49","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1002\/hep.21303","article-title":"Coagulation disorders and hemostasis in liver disease: pathophysiology and critical assessment of current management","volume":"44","author":"Caldwell","year":"2006","journal-title":"Hepatology"},{"issue":"10","key":"10.1016\/j.thromres.2007.10.009_bib50","doi-asserted-by":"crossref","first-page":"2870","DOI":"10.1158\/1078-0432.CCR-06-2351","article-title":"Tissue factor expression, angiogenesis, and thrombosis in pancreatic cancer","volume":"13","author":"Khorana","year":"2007","journal-title":"Clin Cancer Res"},{"issue":"2","key":"10.1016\/j.thromres.2007.10.009_bib51","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/sj.bjc.6603552","article-title":"Tissue factor expression as a possible determinant of thromboembolism in ovarian cancer","volume":"96","author":"Uno","year":"2007","journal-title":"Br J Cancer"},{"issue":"14","key":"10.1016\/j.thromres.2007.10.009_bib52","first-page":"5339","article-title":"Tissue factor expression correlates with tumor angiogenesis and invasiveness in human hepatocellular carcinoma","volume":"9","author":"Poon","year":"2003","journal-title":"Clin Cancer Res"},{"issue":"65","key":"10.1016\/j.thromres.2007.10.009_bib53","first-page":"1383","article-title":"Tissue factor is a useful prognostic factor of recurrence in hepatocellular carcinoma in 5-year survivors","volume":"52","author":"Kaido","year":"2005","journal-title":"Hepato-gastroenterol"}],"container-title":["Thrombosis Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384807003945?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384807003945?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,5]],"date-time":"2019-05-05T11:25:17Z","timestamp":1557055517000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0049384807003945"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1]]},"references-count":53,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["S0049384807003945"],"URL":"https:\/\/doi.org\/10.1016\/j.thromres.2007.10.009","relation":{},"ISSN":["0049-3848"],"issn-type":[{"value":"0049-3848","type":"print"}],"subject":[],"published":{"date-parts":[[2008,1]]}}}