{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:07:45Z","timestamp":1790744865807,"version":"4.1.0"},"reference-count":20,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thrombosis Research"],"published-print":{"date-parts":[[2008,1]]},"DOI":"10.1016\/j.thromres.2007.10.014","type":"journal-article","created":{"date-parts":[[2007,12,5]],"date-time":"2007-12-05T13:14:08Z","timestamp":1196860448000},"page":"314-319","source":"Crossref","is-referenced-by-count":29,"title":["Differential associations between lipid-lowering drugs, statins and fibrates, and venous thromboembolism: Role of drug induced homocysteinemia?"],"prefix":"10.1016","volume":"122","author":[{"given":"Karine","family":"Lacut","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gr\u00e9goire","family":"Le Gal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Herv\u00e9","family":"Abalain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Mottier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Oger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.thromres.2007.10.014_bib1","doi-asserted-by":"crossref","first-page":"689","DOI":"10.7326\/0003-4819-132-9-200005020-00002","article-title":"Postmenopausal hormone replacement therapy increases risk for venous thromboembolic disease. The Heart and Estrogen\/progestin Replacement Study","volume":"132","author":"Grady","year":"2000","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.thromres.2007.10.014_bib2","doi-asserted-by":"crossref","first-page":"2962","DOI":"10.1161\/01.CIR.0000019406.74017.B2","article-title":"Statin therapy, cardiovascular events, and total mortality in the Heart and Estrogen\/Progestin Replacement Study (HERS)","volume":"105","author":"Herrington","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.thromres.2007.10.014_bib3","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1001\/archinte.161.11.1405","article-title":"Use of statins and the subsequent development of deep vein thrombosis","volume":"161","author":"Ray","year":"2001","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.thromres.2007.10.014_bib4","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1111\/j.1472-8206.2004.00252.x","article-title":"Statins but not fibrates are associated with a reduced risk of venous thromboembolism: a hospitalised-based case-control study","volume":"18","author":"Lacut","year":"2004","journal-title":"Fundam Clin Pharmacol"},{"key":"10.1016\/j.thromres.2007.10.014_bib5","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1016\/S0140-6736(05)67667-2","article-title":"Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): randomised controlled trial","volume":"366","author":"Keech","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.thromres.2007.10.014_bib6","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1111\/j.1538-7836.2005.01141.x","article-title":"Homocysteine, MTHFR and risk of venous thrombosis: a meta-analysis of published epidemiological studies","volume":"3","author":"den Heijer","year":"2005","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.thromres.2007.10.014_bib7","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0140-6736(05)77220-2","article-title":"Lipid-lowering drugs and homocysteine","volume":"353","author":"De Lorgeril","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.thromres.2007.10.014_bib8","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0140-6736(99)02153-4","article-title":"Serum homocysteine increases after therapy with fenofibrate or bezafibrate","volume":"354","author":"Dierkes","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.thromres.2007.10.014_bib9","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0021-9150(00)00474-3","article-title":"Homocysteine and lipid lowering agents. A comparison between atorvastatin and fenofibrate in patients with mixed hyperlipidemia","volume":"154","author":"Giral","year":"2001","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.thromres.2007.10.014_bib10","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1160\/TH03-04-0250","article-title":"Statin and fibrate treatment of combined hyperlipidemia: the effects on some novel risk factors","volume":"92","author":"Sebestjen","year":"2004","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.thromres.2007.10.014_bib11","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1177\/0091270003255920","article-title":"Comparative effects of atorvastatin, simvastatin, and fenofibrate on serum homocysteine levels in patients with primary hyperlipidemia","volume":"43","author":"Milionis","year":"2003","journal-title":"J Clin Pharmacol"},{"key":"10.1016\/j.thromres.2007.10.014_bib12","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.thromres.2006.10.002","article-title":"Interrelation of hyperhomocysteinemia and inherited risk factors for venous thromboembolism. Results from the E.D.I.TH. study: A hospital-based case-control study","volume":"120","author":"Oger","year":"2007","journal-title":"Thromb Res"},{"key":"10.1016\/j.thromres.2007.10.014_bib13","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1001\/jama.279.20.1643","article-title":"Anti-atherothrombotic properties of statins. Implication for cardiovascular event reduction","volume":"279","author":"Rosenson","year":"1998","journal-title":"JAMA"},{"key":"10.1016\/j.thromres.2007.10.014_bib14","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1007\/s11883-000-0022-3","article-title":"Pleiotropic effects of statins","volume":"2","author":"Farmer","year":"2000","journal-title":"Curr Atheroscl Rep"},{"key":"10.1016\/j.thromres.2007.10.014_bib15","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/S0002-9149(99)00408-7","article-title":"Gender differences in blood thrombogenicity in hyperlipidemic patients and response to pravastatin","volume":"84","author":"Dangas","year":"1999","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.thromres.2007.10.014_bib16","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1016\/S0735-1097(99)00023-6","article-title":"Inhibition of thrombin generation by simvastatin and lack of additive effects of ASA in patients with marked hypercholesterolemia","volume":"33","author":"Szczeklik","year":"1999","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.thromres.2007.10.014_bib17","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1001\/jama.231.4.360","article-title":"Clofibrate and niacin in coronary heart disease","volume":"231","year":"1975","journal-title":"JAMA"},{"key":"10.1016\/j.thromres.2007.10.014_bib18","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1111\/j.1538-7836.2006.01856.x","article-title":"Hyperhomocysteinemia and low B vitamin levels are independently associated with venous thromboembolism: results from the EDITH study: a hospital-based case-control study","volume":"4","author":"Oger","year":"2006","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.thromres.2007.10.014_bib19","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1111\/j.1538-7836.2006.02132.x","article-title":"The metabolic syndrome and the risk of venous thrombosis: a case-control study","volume":"4","author":"Ageno","year":"2006","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.thromres.2007.10.014_bib20","doi-asserted-by":"crossref","first-page":"374","DOI":"10.3324\/haematol.10828","article-title":"Venous thromboembolism\u2014a manifestation of the metabolic syndrome","volume":"92","author":"Ay","year":"2007","journal-title":"Haematologica"}],"container-title":["Thrombosis Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004938480700401X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004938480700401X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,5]],"date-time":"2019-05-05T11:25:12Z","timestamp":1557055512000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S004938480700401X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["S004938480700401X"],"URL":"https:\/\/doi.org\/10.1016\/j.thromres.2007.10.014","relation":{},"ISSN":["0049-3848"],"issn-type":[{"value":"0049-3848","type":"print"}],"subject":[],"published":{"date-parts":[[2008,1]]}}}