{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:08:53Z","timestamp":1791407333221,"version":"4.3.3"},"reference-count":37,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2010,2,1]],"date-time":"2010-02-01T00:00:00Z","timestamp":1264982400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,2,1]],"date-time":"2010-02-01T00:00:00Z","timestamp":1264982400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thrombosisresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Thrombosis Research"],"published-print":{"date-parts":[[2010,2]]},"DOI":"10.1016\/j.thromres.2009.08.015","type":"journal-article","created":{"date-parts":[[2009,9,19]],"date-time":"2009-09-19T05:09:48Z","timestamp":1253336988000},"page":"e23-e32","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Role of NMDA receptor in homocysteine-induced activation of Mitogen-Activated Protein Kinase and Phosphatidyl Inositol 3-Kinase pathways in cultured human vascular smooth muscle cells"],"prefix":"10.1016","volume":"125","author":[{"given":"Gabriella","family":"Doronzo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Russo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Del Mese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Viretto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Mattiello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariella","family":"Trovati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Anfossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"15","key":"10.1016\/j.thromres.2009.08.015_bib1","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1056\/NEJM199804093381507","article-title":"Homocysteine and atherothrombosis","volume":"338","author":"Welch","year":"1998","journal-title":"N Engl J Med"},{"issue":"9","key":"10.1016\/j.thromres.2009.08.015_bib2","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/S0895-4356(02)00434-1","article-title":"Total plasma homocysteine level and risk of cardiovascular disease: a meta-analysis of prospective cohort studies","volume":"55","author":"Bautista","year":"2002","journal-title":"J Clin Epidemiol"},{"issue":"1","key":"10.1016\/j.thromres.2009.08.015_bib3","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1172\/JCI118776","article-title":"The oxidant stress of hyperhomocist(e)inemia","volume":"98","author":"Loscalzo","year":"1996","journal-title":"J Clin Invest"},{"issue":"3","key":"10.1016\/j.thromres.2009.08.015_bib4","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1007\/s11883-000-0020-5","article-title":"Blood levels of homocysteine and atherosclerotic vascular disease","volume":"2","author":"Christen","year":"2000","journal-title":"Curr Atheroscler Rep"},{"issue":"3","key":"10.1016\/j.thromres.2009.08.015_bib5","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1055\/s-2000-8472","article-title":"Hyperhomocysteinemia, vascular pathology, and endothelial dysfunction","volume":"26","author":"Van Guldener","year":"2000","journal-title":"Semin Thromb Hemost"},{"issue":"5","key":"10.1016\/j.thromres.2009.08.015_bib6","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1161\/01.CIR.95.5.1119","article-title":"Hyperhomocysteinemia is associated with impaired endothelium-dependent vasodilation in humans","volume":"95","author":"Tawakol","year":"1997","journal-title":"Circulation"},{"issue":"14","key":"10.1016\/j.thromres.2009.08.015_bib7","doi-asserted-by":"crossref","first-page":"6369","DOI":"10.1073\/pnas.91.14.6369","article-title":"Promotion of vascular smooth muscle cell growth by homocysteine: a link to atherosclerosis","volume":"91","author":"Tsai","year":"1994","journal-title":"Proc Natl Acad Sci USA"},{"issue":"8","key":"10.1016\/j.thromres.2009.08.015_bib8","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1096\/fasebj.11.8.9240971","article-title":"Homocysteine signal cascade: production of phospholipids, activation of protein kinase C, and the induction of c-fos and c-myb in smooth muscle cells","volume":"11","author":"Dalton","year":"1997","journal-title":"FASEB J"},{"issue":"1","key":"10.1016\/j.thromres.2009.08.015_bib9","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/jcb.20137","article-title":"Homocysteine induces metalloproteinase and shedding of beta-1 integrin in microvessel endothelial cells","volume":"93","author":"Shastry","year":"2004","journal-title":"J Cell Biochem"},{"issue":"3","key":"10.1016\/j.thromres.2009.08.015_bib10","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1002\/jcb.1175","article-title":"Induction of oxidative stress by homocyst(e)ine impairs endothelial function","volume":"82","author":"Mujumdar","year":"2001","journal-title":"J Cell Biochem"},{"issue":"6","key":"10.1016\/j.thromres.2009.08.015_bib11","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1160\/TH05-04-0221","article-title":"Homocysteine rapidly increases matrix metalloproteinase-2 expression and activity in cultured human vascular smooth muscle cells. Role of phosphatidyl inositol 3-kinase and mitogen activated protein kinase pathways","volume":"94","author":"Doronzo","year":"2005","journal-title":"Thromb Haemost"},{"issue":"3","key":"10.1016\/j.thromres.2009.08.015_bib12","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1161\/res.90.3.251","article-title":"Matrix metalloproteinases in vascular remodeling and atherogenesis: the good, the bad and the ugly","volume":"90","author":"Galis","year":"2002","journal-title":"Circ Res"},{"issue":"5","key":"10.1016\/j.thromres.2009.08.015_bib13","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1002\/jnr.10416","article-title":"Multiple aspects of homocysteine neurotoxicity: glutamate excitotoxicity, kinase hyperactivation and DNA damage","volume":"70","author":"Ho","year":"2002","journal-title":"J Neurosci Res"},{"issue":"1","key":"10.1016\/j.thromres.2009.08.015_bib14","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.coph.2006.08.011","article-title":"NMDA receptor subunits: function and pharmacology","volume":"7","author":"Paoletti","year":"2007","journal-title":"Curr Opin Pharmacol"},{"issue":"6","key":"10.1016\/j.thromres.2009.08.015_bib15","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1002\/(SICI)1097-4547(19981215)54:6<814::AID-JNR9>3.0.CO;2-3","article-title":"Expression of glutamate receptors on cultured cerebral endothelial cells","volume":"54","author":"Krizbai","year":"1998","journal-title":"J Neurosci Res"},{"issue":"4","key":"10.1016\/j.thromres.2009.08.015_bib16","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1016\/j.bbrc.2005.10.164","article-title":"Human T lymphocytes express N-methyl-D-aspartate receptors functionally active in controlling T cell activation","volume":"338","author":"Miglio","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"issue":"11","key":"10.1016\/j.thromres.2009.08.015_bib17","doi-asserted-by":"crossref","first-page":"5923","DOI":"10.1073\/pnas.94.11.5923","article-title":"Neurotoxicity associated with dual actions of homocysteine at the N-methyl-D-aspartate receptor","volume":"94","author":"Lipton","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"issue":"5","key":"10.1016\/j.thromres.2009.08.015_bib18","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.jvs.2005.02.021","article-title":"Identification of a homocysteine receptor in the peripheral endothelium and its role in proliferation","volume":"41","author":"Chen","year":"2005","journal-title":"J Vasc Surg"},{"issue":"3","key":"10.1016\/j.thromres.2009.08.015_bib19","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1191\/1358863x05vm626oa","article-title":"Homocysteine-induced vascular dysregulation is mediated by the NMDA receptor","volume":"10","author":"Qureshi","year":"2005","journal-title":"Vasc Med"},{"issue":"1","key":"10.1016\/j.thromres.2009.08.015_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1471-4159.2006.04208.x","article-title":"Regulation of mitogen-activated protein kinases by glutamate receptors","volume":"100","author":"Wang","year":"2007","journal-title":"J Neurochem"},{"issue":"14 Suppl","key":"10.1016\/j.thromres.2009.08.015_bib21","doi-asserted-by":"crossref","first-page":"E36","DOI":"10.2527\/jas.2007-0567","article-title":"The mammalian target of rapamycin \u2013signaling pathway in regulating metabolism and growth","volume":"86","author":"Yang","year":"2008","journal-title":"J Anim Sci"},{"issue":"2","key":"10.1016\/j.thromres.2009.08.015_bib22","doi-asserted-by":"crossref","first-page":"H890","DOI":"10.1152\/ajpheart.00099.2008","article-title":"Mitochondrial matrix metalloproteinase activation decreases myocyte contractility in hyperhomocysteinemia","volume":"295","author":"Moshal","year":"2008","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"4","key":"10.1016\/j.thromres.2009.08.015_bib23","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1111\/j.1476-5381.1996.tb15245.x","article-title":"Effects of memantine and MK-801 on NMDA-induced currents in cultured neurones and on synaptic transmission and LTP in area CA1 of rat hippocampal slices","volume":"117","author":"Frankiewicz","year":"1996","journal-title":"Br J Pharmacol"},{"issue":"6929","key":"10.1016\/j.thromres.2009.08.015_bib24","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/nature01497","article-title":"Glycine binding primes NMDA receptor internalization","volume":"422","author":"Nong","year":"2003","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.thromres.2009.08.015_bib25","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1006\/bbrc.1998.9535","article-title":"ERK2 activation by homocysteine in vascular smooth muscle cells","volume":"251","author":"Brown","year":"1998","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"10.1016\/j.thromres.2009.08.015_bib26","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1067\/msy.2000.106531","article-title":"Homocysteine stimulates MAP kinase in bovine aortic smooth muscle cells","volume":"128","author":"Woo","year":"2000","journal-title":"Surgery"},{"issue":"3","key":"10.1016\/j.thromres.2009.08.015_bib27","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.jvs.2004.12.043","article-title":"Homocysteine promotes p38-dependent chemotaxis in bovine aortic smooth muscle cells","volume":"41","author":"Akasaka","year":"2005","journal-title":"J Vasc Surg"},{"issue":"4","key":"10.1016\/j.thromres.2009.08.015_bib28","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/j.neuroscience.2005.03.034","article-title":"Regulation of extracellular signal-regulated kinase by homocysteine in hippocampus","volume":"133","author":"Robert","year":"2005","journal-title":"Neuroscience"},{"issue":"3","key":"10.1016\/j.thromres.2009.08.015_bib29","doi-asserted-by":"crossref","first-page":"H887","DOI":"10.1152\/ajpheart.00750.2008","article-title":"Restoration of contractility in hyperhomocysteinemia by cardiac-specific deletion of NMDA-R1","volume":"296","author":"Moshal","year":"2009","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"4","key":"10.1016\/j.thromres.2009.08.015_bib30","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/sj.ki.5002031","article-title":"Homocysteine induces mesangial cell apoptosis via activation of p38-mitogen-activated protein kinase","volume":"71","author":"Shastry","year":"2007","journal-title":"Kidney Int"},{"key":"10.1016\/j.thromres.2009.08.015_bib31","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1146\/annurev.biochem.70.1.535","article-title":"Synthesis and function of 3-phosphorylated inositol lipids","volume":"70","author":"Vanhaesebroeck","year":"2001","journal-title":"Ann Rev Biochem"},{"issue":"16","key":"10.1016\/j.thromres.2009.08.015_bib32","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1101\/gad.1212704","article-title":"Upstream and downstream of mTOR","volume":"18","author":"Hay","year":"2004","journal-title":"Genes Dev"},{"issue":"38","key":"10.1016\/j.thromres.2009.08.015_bib33","doi-asserted-by":"crossref","first-page":"26776","DOI":"10.1074\/jbc.274.38.26776","article-title":"p70 S6 kinase-mediated protein synthesis is a critical step for vascular endothelial cell proliferation","volume":"274","author":"Vinals","year":"1999","journal-title":"J Biol Chem"},{"issue":"3","key":"10.1016\/j.thromres.2009.08.015_bib34","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.cardiores.2005.01.006","article-title":"Rapamycin inhibits human in stent restenosis vascular smooth muscle cells independently of pRB phosphorylation and p53","volume":"66","author":"Rosner","year":"2005","journal-title":"Cardiovasc Res"},{"issue":"1","key":"10.1016\/j.thromres.2009.08.015_bib35","first-page":"158","article-title":"Neointimal hyperplasia in balloon-injured rat carotid arteries: the influence of hyperhomocysteinemia","volume":"35","author":"Cook","year":"2002","journal-title":"J Vasc Surg"},{"issue":"1","key":"10.1016\/j.thromres.2009.08.015_bib36","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1002\/jcp.21757","article-title":"Activation of GABA-A receptor ameliorates homocysteine-induced MMP-9 activation by ERK pathway","volume":"220","author":"Tyagi","year":"2009","journal-title":"J Cell Physiol"},{"issue":"27","key":"10.1016\/j.thromres.2009.08.015_bib37","doi-asserted-by":"crossref","first-page":"18802","DOI":"10.1074\/jbc.M512524200","article-title":"Roles of glutamate receptors and the mammalian target of rapamycin (mTOR) signaling pathway in activity-dependent dendritic protein synthesis in hippocampal neurons","volume":"281","author":"Gong","year":"2006","journal-title":"J Biol Chem"}],"container-title":["Thrombosis Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384809003867?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384809003867?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T17:35:02Z","timestamp":1758735302000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0049384809003867"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,2]]}},"alternative-id":["S0049384809003867"],"URL":"https:\/\/doi.org\/10.1016\/j.thromres.2009.08.015","relation":{},"ISSN":["0049-3848"],"issn-type":[{"value":"0049-3848","type":"print"}],"subject":[],"published":{"date-parts":[[2010,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of NMDA receptor in homocysteine-induced activation of Mitogen-Activated Protein Kinase and Phosphatidyl Inositol 3-Kinase pathways in cultured human vascular smooth muscle cells","name":"articletitle","label":"Article Title"},{"value":"Thrombosis Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.thromres.2009.08.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}