{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T21:19:15Z","timestamp":1780694355306,"version":"3.54.1"},"reference-count":54,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thrombosis Research"],"published-print":{"date-parts":[[2012,5]]},"DOI":"10.1016\/j.thromres.2011.07.035","type":"journal-article","created":{"date-parts":[[2011,8,16]],"date-time":"2011-08-16T22:48:14Z","timestamp":1313534894000},"page":"652-659","source":"Crossref","is-referenced-by-count":59,"title":["Pentadecapeptide BPC 157 reduces bleeding time and thrombocytopenia after amputation in rats treated with heparin, warfarin or aspirin"],"prefix":"10.1016","volume":"129","author":[{"given":"Mirjana","family":"Stupnisek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Franjic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domagoj","family":"Drmic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masa","family":"Hrelec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danijela","family":"Kolenc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bozo","family":"Radic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davor","family":"Bojic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandar","family":"Vcev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Seiwerth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Predrag","family":"Sikiric","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.thromres.2011.07.035_bb0005","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.2174\/138161210790945977","article-title":"Revised Robert's cytoprotection and adaptive cytoprotection and stable gastric pentadecapeptide BPC 157. Possible significance and implications for novel mediator","volume":"16","author":"Sikiric","year":"2010","journal-title":"Curr Pharm Des"},{"issue":"Suppl 7","key":"10.1016\/j.thromres.2011.07.035_bb0010","first-page":"161","article-title":"Abdominal aorta anastomosis in rats and stable gastric pentadecapeptide BPC 157, prophylaxis and therapy","volume":"60","author":"Hrelec","year":"2009","journal-title":"J Physiol Pharmacol"},{"key":"10.1016\/j.thromres.2011.07.035_bb0015","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/0016-5085(79)90235-X","article-title":"Cytoprotection by prostaglandins","volume":"77","author":"Robert","year":"1979","journal-title":"Gastroenterology"},{"key":"10.1016\/j.thromres.2011.07.035_bb0020","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/S0016-5085(85)80176-1","article-title":"Early vascular injury and increased vascular permeability in gastric mucosal injury caused by ethanol in the rat","volume":"88","author":"Szabo","year":"1985","journal-title":"Gastroenterology"},{"key":"10.1016\/j.thromres.2011.07.035_bb0025","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1179\/acb.2006.036","article-title":"The pivotal role of the endothelium in haemostasis and thrombosis","volume":"61","author":"Verhamme","year":"2006","journal-title":"Acta Clin Belg"},{"key":"10.1016\/j.thromres.2011.07.035_bb0030","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0305-4179(03)00004-4","article-title":"Corticosteroid-impairment of healing and gastric pentadecapeptide BPC-157 creams in burned mice","volume":"29","author":"Sikiric","year":"2003","journal-title":"Burns"},{"issue":"570","key":"10.1016\/j.thromres.2011.07.035_bb0035","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.ejphar.2007.05.072","article-title":"Enhancement by PL 14736 of granulation and collagen organization in healing wounds and the potential role of egr-1 expression","volume":"10","author":"Tkalcevi\u0107","year":"2007","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.thromres.2011.07.035_bb0040","doi-asserted-by":"crossref","first-page":"PL63-8","DOI":"10.1016\/0024-3205(94)00796-9","article-title":"The beneficial effect of BPC 157, a 15 amino acid peptide BPC fragment, on gastric and duodenal lesions induced by restraint stress, cysteamine and 96% ethanol in rats. A comparative study with H2 receptor antagonists, dopamine promotors and gut peptides","volume":"54","author":"Sikiric","year":"1994","journal-title":"Life Sci"},{"key":"10.1016\/j.thromres.2011.07.035_bb0045","first-page":"191","article-title":"Modulatory effect of gastric pentadecapeptide BPC 157 on angiogenesis in muscle and tendon healing","volume":"60","author":"Brcic","year":"2009","journal-title":"J Physiol Pharmacol"},{"key":"10.1016\/j.thromres.2011.07.035_bb0050","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1007\/s10787-006-1531-7","article-title":"Stable gastric pentadecapeptide BPC 157 in trials for inflammatory bowel disease (PL-10, PLD-116, PL 14736, Pliva, Croatia). Full and distended stomach and vascular response","volume":"14","author":"Sikiric","year":"2006","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.thromres.2011.07.035_bb0055","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/S0928-4257(99)00123-0","article-title":"The effect of pentadecapeptide BPC 157, H2-blockers, omeprazole and sucralfate on new vessels and new granulation tissue formation","volume":"93","author":"Sikiric","year":"1999","journal-title":"J Physiol Paris"},{"issue":"332","key":"10.1016\/j.thromres.2011.07.035_bb0060","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0014-2999(97)01033-9","article-title":"The influence of a novel pentadecapeptide, BPC 157, on N(G)-nitro-L-arginine methylester and L-arginine effects on stomach mucosa integrity and blood pressure","volume":"30","author":"Sikiri\u0107","year":"1997","journal-title":"Eur J Pharmacol"},{"issue":"156","key":"10.1016\/j.thromres.2011.07.035_bb0065","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.regpep.2009.05.008","article-title":"Inhibition of methyldigoxin-induced arrhythmias by pentadecapeptide BPC 157: a relation with NO-system","volume":"7","author":"Balenovic","year":"2009","journal-title":"Regul Pept"},{"key":"10.1016\/j.thromres.2011.07.035_bb0070","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1254\/jphs.95.19","article-title":"Doxorubicine-congestive heart failure-increased big endothelin-1 plasma concentration: reversal by amlodipine, losartan, and gastric pentadecapeptide BPC157 in rat and mouse","volume":"95","author":"Lovric-Bencic","year":"2004","journal-title":"J Pharmacol Sci"},{"key":"10.1016\/j.thromres.2011.07.035_bb0075","first-page":"H1864","article-title":"Inhibitory role of capsaicin-sensitive afferent neurons and nitric oxide in hemostasis","volume":"265","author":"Lippe","year":"1993","journal-title":"Am J Physiol"},{"key":"10.1016\/j.thromres.2011.07.035_bb0080","first-page":"15","article-title":"Advances in experimental subarachnoid hemorrhage","volume":"110","author":"Zhou","year":"2011","journal-title":"Acta Neurochir Suppl"},{"key":"10.1016\/j.thromres.2011.07.035_bb0085","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0928-4257(97)89480-6","article-title":"BPC 157's effect on healing","volume":"91","author":"Seiwerth","year":"1997","journal-title":"J Physiol Paris"},{"key":"10.1016\/j.thromres.2011.07.035_bb0090","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/S0305-4179(01)00055-9","article-title":"Pentadecapeptide BPC 157 cream improves burn-wound healing and attenuates burn-gastric lesions in mice","volume":"27","author":"Mikus","year":"2001","journal-title":"Burns"},{"key":"10.1016\/j.thromres.2011.07.035_bb0095","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1002\/jor.20089","article-title":"Effective therapy of transected quadriceps muscle in rat: Gastric pentadecapeptide BPC 157","volume":"24","author":"Staresinic","year":"2006","journal-title":"J Orthop Res"},{"key":"10.1016\/j.thromres.2011.07.035_bb0100","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/S0736-0266(03)00110-4","article-title":"Gastric pentadecapeptide BPC 157 accelerates healing of transected rat Achilles tendon and in vitro stimulates tendocytes growth","volume":"21","author":"Staresinic","year":"2003","journal-title":"J Orthop Res"},{"key":"10.1016\/j.thromres.2011.07.035_bb0105","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1002\/jor.21107","article-title":"Pentadecapeptide BPC 157 (PL 14736) improves ligament healing in the rat","volume":"28","author":"Cerovecki","year":"2010","journal-title":"J Orthop Res"},{"key":"10.1016\/j.thromres.2011.07.035_bb0110","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1007\/s00595-006-3498-9","article-title":"Stable gastric pentadecapeptide BPC 157 in trials for inflammatory bowel disease (PL-10, PLD-116, PL14736, Pliva, Croatia) heals ileoileal anastomosis in the rat","volume":"37","author":"Vuksic","year":"2007","journal-title":"Surg Today"},{"key":"10.1016\/j.thromres.2011.07.035_bb0115","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1007\/s10620-008-0598-y","article-title":"Gastric pentadecapeptide BPC 157 and short bowel syndrome in rats","volume":"54","author":"Sever","year":"2009","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.thromres.2011.07.035_bb0120","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/j.suc.2010.08.003","article-title":"Wound healing primer","volume":"90","author":"Goldberg","year":"2010","journal-title":"Surg Clin North Am"},{"key":"10.1016\/j.thromres.2011.07.035_bb0125","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0305-4179(98)00028-X","article-title":"A study of vascular response to thermal injury on hairless mice by fibre optic confocal imaging, laser doppler flowmetry and conventional histology","volume":"24","author":"Vo","year":"1998","journal-title":"Burns"},{"key":"10.1016\/j.thromres.2011.07.035_bb0130","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1177\/0363546509349921","article-title":"Platelet-rich plasma: from basic science to clinical applications","volume":"37","author":"Foster","year":"2009","journal-title":"Am J Sports Med"},{"key":"10.1016\/j.thromres.2011.07.035_bb0135","series-title":"An Algorithmic Approach to Hemostasis Testing","first-page":"1","article-title":"Section\u00a01. Hemostasis Physiology, Chapter 1. Coagulation Pathway and Physiology","author":"Lefkowitz","year":"2008"},{"key":"10.1016\/j.thromres.2011.07.035_bb0140","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1182\/blood-2008-02-078014","article-title":"Heparin-induced thrombocytopenia: a historical perspective","volume":"112","author":"Kelton","year":"2008","journal-title":"Blood"},{"issue":"110","key":"10.1016\/j.thromres.2011.07.035_bb0145","doi-asserted-by":"crossref","first-page":"e454","DOI":"10.1161\/01.CIR.0000147537.72829.1B","article-title":"Heparin-induced thrombocytopenia: diagnosis and management","volume":"2","author":"Warkentin","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.thromres.2011.07.035_bb0150","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1136\/jcp.2003.008904","article-title":"Warfarin reversal","volume":"57","author":"Hanley","year":"2004","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.thromres.2011.07.035_bb0155","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0049-3848(00)00336-4","article-title":"Time related neutralization of two doses acetyl salicylic acid","volume":"100","author":"Aguejouf","year":"2000","journal-title":"Thromb Res"},{"key":"10.1016\/j.thromres.2011.07.035_bb0160","first-page":"241","article-title":"High hepatotoxic dose of paracetamol produces generalized convulsions and brain damage in rats. A counteraction with the stable gastric pentadecapeptide BPC 157 (PL 14736)","volume":"61","author":"Ilic","year":"2010","journal-title":"J Physiol Pharmacol"},{"key":"10.1016\/j.thromres.2011.07.035_bb0165","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.lfs.2011.01.015","article-title":"Pentadecapeptide BPC 157 and its effects on a NSAID toxicity model: diclofenac-induced gastrointestinal, liver, and encephalopathy lesions","volume":"88","author":"Ilic","year":"2011","journal-title":"Life Sci"},{"key":"10.1016\/j.thromres.2011.07.035_bb0170","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.ejphar.2011.05.038","article-title":"Ibuprofen hepatic encephalopathy, hepatomegaly, gastric lesion and gastric pentadecapeptide BPC 157 in rats","volume":"667","author":"Ilic","year":"2011","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.thromres.2011.07.035_bb0175","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0928-4257(97)89474-0","article-title":"Pentadecapeptide BPC 157 positively affects both non-steroidal anti-inflammatory agent-induced gastrointestinal lesions and adjuvant arthritis in rats","volume":"91","author":"Sikiric","year":"1997","journal-title":"J Physiol Paris"},{"key":"10.1016\/j.thromres.2011.07.035_bb0180","series-title":"Collection, Transport, and Processing of Blood Speciments for Testing Plasma-Based Coagulation Assays and Molecular Hemostasis Assays; Approved Guideline-Fifth Edition, CLSI document H21-A5 (ISBN 1-56238-657-3)","author":"CLSI","year":"2008"},{"key":"10.1016\/j.thromres.2011.07.035_bb0185","series-title":"One-Stage Prothrombin Time (PT) Test and Activated Partial Thromboplastin Time (APTT) Test; Approved Guideline-Second Edition, CLSI document H47-A2 (ISBN 1-56238-672-7)","author":"CLSI","year":"2008"},{"key":"10.1016\/j.thromres.2011.07.035_bb0190","first-page":"73","article-title":"The prothrombin time in hemophilia and in obstructive jaundice","volume":"109","author":"Quick","year":"1935","journal-title":"J Biol Chem"},{"key":"10.1016\/j.thromres.2011.07.035_bb0195","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1097\/00000441-193510000-00009","article-title":"A study of the coagulation defect in hemophilia and in obstructive jaundice","volume":"190","author":"Quick","year":"1935","journal-title":"Am J Med Sci"},{"key":"10.1016\/j.thromres.2011.07.035_bb0200","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1126\/science.92.2379.113-a","article-title":"The Thromboplastin Reagent for the determination of prothrombin","volume":"92","author":"Quick","year":"1940","journal-title":"Science"},{"key":"10.1016\/j.thromres.2011.07.035_bb0205","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1159\/000205234","article-title":"Gerinnungs physiologische Schnellmethode zur Bestimmung des Fibrinogens","volume":"17","author":"Clauss","year":"1957","journal-title":"Acta Haematol"},{"key":"10.1016\/j.thromres.2011.07.035_bb0210","first-page":"1812","article-title":"The standardization of certain factors in the cataneous \u2018venostasis\u2019 bleeding time technique","volume":"26","author":"Ivy","year":"1941","journal-title":"J Lab Clin Med"},{"key":"10.1016\/j.thromres.2011.07.035_bb0215","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1309\/6922EWGPHVDX9EQJ","article-title":"Clinical significance of a borderline titer in a negative ELISA test for heparin-induced thrombocytopenia","volume":"119","author":"Refaai","year":"2003","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.thromres.2011.07.035_bb0220","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/IAE.0b013e31819091dc","article-title":"Recent advances in haemostasis and thrombosis","volume":"29","author":"Vine","year":"2009","journal-title":"Retina"},{"key":"10.1016\/j.thromres.2011.07.035_bb0225","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.lfs.2004.08.010","article-title":"Effects of pentadecapeptide BPC157 on regional serotonin synthesis in the rat brain: alpha-methyl-L-tryptophan autoradiographic measurements","volume":"76","author":"Tohyama","year":"2004","journal-title":"Life Sci"},{"key":"10.1016\/j.thromres.2011.07.035_bb0230","first-page":"29","article-title":"Serotonin and the blood vessel wall","volume":"4","author":"Vanhoutte","year":"1986","journal-title":"J Hypertens Suppl"},{"key":"10.1016\/j.thromres.2011.07.035_bb0235","first-page":"1063","article-title":"Serotonin, histamine and platelets in vascular disease with special reference to peripheral vascular disease","volume":"25","author":"Barradas","year":"1992","journal-title":"Braz J Med Biol Res"},{"key":"10.1016\/j.thromres.2011.07.035_bb0240","first-page":"341","article-title":"The heparin target organ\u2013the endothelium. Studies in a rat model","volume":"86","author":"Hiebert","year":"1993","journal-title":"Q J Med"},{"key":"10.1016\/j.thromres.2011.07.035_bb0245","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1007\/s000180050358","article-title":"Endothelium-derived nitric oxide and vascular physiology and pathology","volume":"55","author":"Arnal","year":"1999","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.thromres.2011.07.035_bb0250","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1007\/s00424-009-0765-9","article-title":"Cellular signaling and NO production","volume":"459","author":"Michel","year":"2010","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.thromres.2011.07.035_bb0255","first-page":"254","article-title":"To what extent might deep venous thrombosis and chronic venous insufficiency share a common etiology?","volume":"28","author":"Malone","year":"2009","journal-title":"Int Angiol"},{"key":"10.1016\/j.thromres.2011.07.035_bb0260","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0928-4257(01)00044-4","article-title":"Portal hypertension and liver lesions in chronically alcohol drinking rats prevented and reversed by stable gastric pentadecapeptide BPC 157 (PL-10, PLD-116), and propranolol, but not ranitidine","volume":"95","author":"Prkacin","year":"2001","journal-title":"J Physiol Paris"},{"key":"10.1016\/j.thromres.2011.07.035_bb0265","doi-asserted-by":"crossref","first-page":"204S","DOI":"10.1378\/chest.126.3_suppl.204S","article-title":"The pharmacology and management of the vitamin K antagonists: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy","volume":"126","author":"Ansell","year":"2004","journal-title":"Chest"},{"key":"10.1016\/j.thromres.2011.07.035_bb0270","series-title":"Discoveries in pharmacology","first-page":"127","article-title":"The treatment of thrombosis","volume":"Volume 2","author":"Beck","year":"1984"}],"container-title":["Thrombosis Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384811004075?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384811004075?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,14]],"date-time":"2019-06-14T03:25:00Z","timestamp":1560482700000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0049384811004075"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5]]},"references-count":54,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["S0049384811004075"],"URL":"https:\/\/doi.org\/10.1016\/j.thromres.2011.07.035","relation":{},"ISSN":["0049-3848"],"issn-type":[{"value":"0049-3848","type":"print"}],"subject":[],"published":{"date-parts":[[2012,5]]}}}