{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T04:57:48Z","timestamp":1761541068288},"reference-count":28,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thrombosis Research"],"published-print":{"date-parts":[[2012,11]]},"DOI":"10.1016\/j.thromres.2011.12.023","type":"journal-article","created":{"date-parts":[[2012,1,14]],"date-time":"2012-01-14T22:54:52Z","timestamp":1326581692000},"page":"775-779","source":"Crossref","is-referenced-by-count":19,"title":["The effect of total hip\/knee replacement surgery and prophylactic dabigatran on thrombin generation and coagulation parameters"],"prefix":"10.1016","volume":"130","author":[{"given":"Laura","family":"Green","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew S.","family":"Lawrie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahul","family":"Patel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert C.M.","family":"Stephens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian J.","family":"Mackie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Chitolie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fares S.","family":"Haddad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel J.","family":"Machin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.thromres.2011.12.023_bb0005","first-page":"381S","article-title":"Prevention of venous thromboembolism: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines","volume":"133","author":"Geerts","year":"2008"},{"issue":"6","key":"10.1016\/j.thromres.2011.12.023_bb0010","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/0049-3848(93)90087-5","article-title":"Sequential intrapulmonary and systemic activation of coagulation and fibrinolysis during and after total hip replacement surgery","volume":"70","author":"Dahl","year":"1993","journal-title":"Thromb Res"},{"issue":"4","key":"10.1016\/j.thromres.2011.12.023_bb0015","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/S0883-5403(05)80155-X","article-title":"Changes in circulatory indices of thrombosis and fibrinolysis during total knee arthroplasty performed under tourniquet","volume":"10","author":"Sharrock","year":"1995","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.thromres.2011.12.023_bb0020","first-page":"16","article-title":"The John Charnley Award. Thrombogenesis during total hip arthroplasty","volume":"319","author":"Sharrock","year":"1995","journal-title":"Clin Orthop Relat Res"},{"issue":"5","key":"10.1016\/j.thromres.2011.12.023_bb0025","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S0049-3848(00)00342-X","article-title":"The pre-, peri-, and postsurgical activation of coagulation and the thromboembolic risk for different risk groups","volume":"100","author":"Galster","year":"2000","journal-title":"Thromb Res"},{"issue":"5","key":"10.1016\/j.thromres.2011.12.023_bb0030","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1365-2141.2010.08433.x","article-title":"The impact of elective knee\/hip replacement surgery and thromboprophylaxis with rivaroxaban or dalteparin on thrombin generation","volume":"151","author":"Green","year":"2010","journal-title":"Br J Haematol"},{"key":"10.1016\/j.thromres.2011.12.023_bb0035","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1097\/00003086-199112000-00018","article-title":"Progression and regression of deep vein thrombosis after total knee arthroplasty","volume":"273","author":"Maynard","year":"1991","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.thromres.2011.12.023_bb0040","series-title":"NICE clinical guidance 92","first-page":"1","article-title":"Venous thromboembolism: reducing the risk of venous thromboembolism (deep vein thrombosis and pulmonary embolism) in patients admitted to hospital","year":"2010"},{"issue":"5","key":"10.1016\/j.thromres.2011.12.023_bb0045","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1177\/0091270005274550","article-title":"Pharmacokinetic profile of the oral direct thrombin inhibitor dabigatran etexilate in healthy volunteers and patients undergoing total hip replacement","volume":"45","author":"Stangier","year":"2005","journal-title":"J Clin Pharmacol"},{"issue":"3","key":"10.1016\/j.thromres.2011.12.023_bb0050","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1111\/j.1365-2125.2007.02899.x","article-title":"The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects","volume":"64","author":"Stangier","year":"2007","journal-title":"Br J Clin Pharmacol"},{"issue":"1","key":"10.1016\/j.thromres.2011.12.023_bb0055","doi-asserted-by":"crossref","first-page":"47","DOI":"10.2165\/00003088-200847010-00005","article-title":"Pharmacokinetics and pharmacodynamics of the direct oral thrombin inhibitor dabigatran in healthy elderly subjects","volume":"47","author":"Stangier","year":"2008","journal-title":"Clin Pharmacokinet"},{"issue":"6","key":"10.1016\/j.thromres.2011.12.023_bb0060","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1160\/TH09-11-0758","article-title":"Dabigatran etexilate\u2013a novel, reversible, oral direct thrombin inhibitor: interpretation of coagulation assays and reversal of anticoagulant activity","volume":"103","author":"van Ryn","year":"2010","journal-title":"Thromb Haemost"},{"issue":"8","key":"10.1016\/j.thromres.2011.12.023_bb0065","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1111\/j.1538-7836.2004.00798.x","article-title":"Thrombin generation for the control of heparin treatment, comparison with the activated partial thromboplastin time","volume":"2","author":"al Dieri","year":"2004","journal-title":"J Thromb Haemost"},{"issue":"1","key":"10.1016\/j.thromres.2011.12.023_bb0070","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1538-7836.2005.01672.x","article-title":"Fixed dosage of low-molecular-weight heparins causes large individual variation in coagulability, only partly correlated to body weight","volume":"4","author":"al Dieri","year":"2006","journal-title":"J Thromb Haemost"},{"issue":"2","key":"10.1016\/j.thromres.2011.12.023_bb0075","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1160\/TH07-05-0357","article-title":"Thrombin generation assays are superior to traditional tests in assessing anticoagulation reversal in vitro","volume":"100","author":"Gatt","year":"2008","journal-title":"Thromb Haemost"},{"issue":"11","key":"10.1016\/j.thromres.2011.12.023_bb0080","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1111\/j.1538-7836.2004.00964.x","article-title":"Clinical measurement of thrombin generation by calibrated automated thrombography requires contact factor inhibition","volume":"2","author":"Luddington","year":"2004","journal-title":"J Thromb Haemost"},{"issue":"1","key":"10.1016\/j.thromres.2011.12.023_bb0085","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1159\/000071636","article-title":"Calibrated automated thrombin generation measurement in clotting plasma","volume":"33","author":"Hemker","year":"2003","journal-title":"Pathophysiol Haemost Thromb"},{"issue":"5","key":"10.1016\/j.thromres.2011.12.023_bb0090","first-page":"547","article-title":"Thrombin generation assessed as endogenous thrombin potential in patients with hyper- or hypo-coagulability","volume":"88","author":"Chantarangkul","year":"2003","journal-title":"Haematologica"},{"issue":"3","key":"10.1016\/j.thromres.2011.12.023_bb0095","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1097\/MBC.0b013e3282f4bb47","article-title":"Corn trypsin inhibitor in fluorogenic thrombin-generation measurements is only necessary at low tissue factor concentrations and influences the relationship between factor VIII coagulant activity and thrombogram parameters","volume":"19","author":"van Veen","year":"2008","journal-title":"Blood Coagul Fibrinolysis"},{"issue":"9022","key":"10.1016\/j.thromres.2011.12.023_bb0100","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/S0140-6736(96)01453-5","article-title":"Risk of deep-venous thrombosis after hospital discharge in patients having undergone total hip replacement: double-blind randomised comparison of enoxaparin versus placebo","volume":"348","author":"Planes","year":"1996","journal-title":"Lancet"},{"issue":"6640","key":"10.1016\/j.thromres.2011.12.023_bb0105","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1136\/bmj.297.6640.28","article-title":"Deep venous thrombosis: a continuing problem","volume":"297","author":"Scurr","year":"1988","journal-title":"BMJ"},{"issue":"6","key":"10.1016\/j.thromres.2011.12.023_bb0110","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1111\/j.1538-7836.2010.03822.x","article-title":"The paradoxical stimulation by a reversible thrombin inhibitor of thrombin generation in plasma measured with thrombinography is caused by alpha-macroglobulin-thrombin","volume":"8","author":"Wagenvoord","year":"2010","journal-title":"J Thromb Haemost"},{"issue":"5","key":"10.1016\/j.thromres.2011.12.023_bb0115","doi-asserted-by":"crossref","first-page":"285","DOI":"10.2165\/00003088-200847050-00001","article-title":"Clinical pharmacokinetics and pharmacodynamics of the oral direct thrombin inhibitor dabigatran etexilate","volume":"47","author":"Stangier","year":"2008","journal-title":"Clin Pharmacokinet"},{"issue":"11","key":"10.1016\/j.thromres.2011.12.023_bb0120","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1111\/j.1538-7836.2007.02748.x","article-title":"Oral dabigatran etexilate vs. subcutaneous enoxaparin for the prevention of venous thromboembolism after total knee replacement: the RE-MODEL randomized trial","volume":"5","author":"Eriksson","year":"2007","journal-title":"J Thromb Haemost"},{"issue":"9591","key":"10.1016\/j.thromres.2011.12.023_bb0125","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/S0140-6736(07)61445-7","article-title":"Dabigatran etexilate versus enoxaparin for prevention of venous thromboembolism after total hip replacement: a randomised, double-blind, non-inferiority trial","volume":"370","author":"Eriksson","year":"2007","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.thromres.2011.12.023_bb0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.arth.2008.01.132","article-title":"Oral thrombin inhibitor dabigatran etexilate vs North American enoxaparin regimen for prevention of venous thromboembolism after knee arthroplasty surgery","volume":"24","author":"Ginsberg","year":"2009","journal-title":"J Arthroplasty"},{"issue":"3","key":"10.1016\/j.thromres.2011.12.023_bb0135","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1097\/HPC.0b013e3182315c03","article-title":"Dabigatran: a review of clinical and pharmacoeconomic evidence","volume":"10","author":"Reddy","year":"2011","journal-title":"Crit Pathw Cardiol"},{"issue":"10","key":"10.1016\/j.thromres.2011.12.023_bb0140","doi-asserted-by":"crossref","first-page":"795","DOI":"10.3928\/01477447-20110826-24","article-title":"Novel oral anticoagulants for VTE prevention in orthopedic surgery: overview of phase 3 trials","volume":"34","author":"Friedman","year":"2011","journal-title":"Orthopedics"}],"container-title":["Thrombosis Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384811006888?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384811006888?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T15:36:28Z","timestamp":1686670588000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0049384811006888"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["S0049384811006888"],"URL":"https:\/\/doi.org\/10.1016\/j.thromres.2011.12.023","relation":{},"ISSN":["0049-3848"],"issn-type":[{"value":"0049-3848","type":"print"}],"subject":[],"published":{"date-parts":[[2012,11]]}}}