{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T20:55:06Z","timestamp":1791752106639,"version":"4.3.4"},"reference-count":32,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thrombosis Research"],"published-print":{"date-parts":[[2012,9]]},"DOI":"10.1016\/j.thromres.2012.04.001","type":"journal-article","created":{"date-parts":[[2012,4,28]],"date-time":"2012-04-28T16:06:04Z","timestamp":1335629164000},"page":"361-368","source":"Crossref","is-referenced-by-count":63,"title":["Eculizumab therapy results in rapid and sustained decreases in markers of thrombin generation and inflammation in patients with PNH independent of its effects on hemolysis and microparticle formation"],"prefix":"10.1016","volume":"130","author":[{"given":"Ilene C.","family":"Weitz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedram","family":"Razavi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leanne","family":"Rochanda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Zwicker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"Furie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Manly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigel","family":"Mackman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph","family":"Green","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard A.","family":"Liebman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.thromres.2012.04.001_bb0005","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1097\/00005792-199703000-00001","article-title":"Paroxysmal Nocturnal Hemoglobinuria as a molecular disease","volume":"76","author":"Rosse","year":"1997","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.thromres.2012.04.001_bb0010","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/0092-8674(93)90250-T","article-title":"Deficiency of GPI anchor caused by a somatic mutation of the PIG-A gene in Paroxysmal Nocturnal Hemoglobinuria","volume":"73","author":"Takeda","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.thromres.2012.04.001_bb0015","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1111\/j.1365-2141.1961.tb00354.x","article-title":"Paroxysmal Nocturnal hemoglobinuria: variation in clinical severity and association with bone marrow hypoplasia","volume":"7","author":"Dacie","year":"1961","journal-title":"Br J Haematol"},{"key":"10.1016\/j.thromres.2012.04.001_bb0020","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1056\/NEJM199511093331904","article-title":"Natural history of paroxysmal nocturnal hemoglobinuria","volume":"33","author":"Hillmen","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1016\/j.thromres.2012.04.001_bb0025","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1056\/NEJMoa061648","article-title":"The Complement Inhibitor Eculizumab in Paroxysmal Nocturnal Hemoglobinuria","volume":"355","author":"Hillmen","year":"2006","journal-title":"N Engl J Med"},{"issue":"12","key":"10.1016\/j.thromres.2012.04.001_bb0030","doi-asserted-by":"crossref","first-page":"4123","DOI":"10.1182\/blood-2007-06-095646","article-title":"Effect of the complement inhibitor eculizumab on thromboembolism in patients with paroxysmal nocturnal hemoglobinuria","volume":"110","author":"Hillmen","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.thromres.2012.04.001_bb0035","doi-asserted-by":"crossref","DOI":"10.1182\/blood.V112.11.407.407","article-title":"Eculizumab therapy results in rapid and sustained decreases in markers of thrombin generation and inflammation in patients with PNH","volume":"112","author":"Weitz","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.thromres.2012.04.001_bb0040","doi-asserted-by":"crossref","first-page":"574","DOI":"10.3324\/haematol.2009.016121","article-title":"Evaluation of hemostasis and endothelial function in patients with paroxysmal nocturnal hemoglobinuria receiving Eculizumab","volume":"95","author":"Helley","year":"2010","journal-title":"Haematologica"},{"key":"10.1016\/j.thromres.2012.04.001_bb0045","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.thromres.2003.09.018","article-title":"Thrombosis in patients with paroxysmal nocturnal hemoglobinuria is associated with markedly elevated plasma levels of leukocyte derived tissue factor","volume":"111","author":"Liebman","year":"2003","journal-title":"Thromb Res"},{"key":"10.1016\/j.thromres.2012.04.001_bb0050","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1055\/s-0037-1613190","article-title":"Chemotherapy-induced hemostatic activation: Effect of a low molecular weight heparin (Dalteparin sodium) on plasma markers of activation","volume":"88","author":"Weitz","year":"2002","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.thromres.2012.04.001_bb0055","doi-asserted-by":"crossref","first-page":"6830","DOI":"10.1158\/1078-0432.CCR-09-0371","article-title":"Tumor-derived tissue factor-positive microparticles are associated with venous thromboembolic events in malignancy","volume":"15","author":"Zwicker","year":"2009","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.thromres.2012.04.001_bb0060","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1111\/j.1538-7836.2008.03156.x","article-title":"Plasma tissue factor may be predictive of venous thromboembolism in pancreatic cancer","volume":"6","author":"Khorana","year":"2008","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.thromres.2012.04.001_bb0065","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1111\/j.1476-5381.2009.00408.x","article-title":"Platelet aggregation responses are critically regulated in vivo, by endogenous nitric oxide but not endothelial nitric oxide synthetase","volume":"158","author":"Tymvious","year":"2009","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.thromres.2012.04.001_bb0070","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/BF02983211","article-title":"Management Issues in paroxysmal Nocturnal Hemoglobinuria","volume":"77","author":"Meyers","year":"2003","journal-title":"Int J Hematol"},{"key":"10.1016\/j.thromres.2012.04.001_bb0075","doi-asserted-by":"crossref","first-page":"4029","DOI":"10.1182\/blood.V114.22.4029.4029","article-title":"Clinical Impact of Unregulated Terminal Complement Activity in Never-Transfused Patients with Paroxysmal Nocturnal Hemoglobinuria","volume":"114","author":"Muus","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.thromres.2012.04.001_bb0080","doi-asserted-by":"crossref","first-page":"3699","DOI":"10.1182\/blood-2005-04-1717","article-title":"Diagnosis and management of paroxysmal nocturnal hemoglobinuria","volume":"106","author":"Parker","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.thromres.2012.04.001_bb0085","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1056\/NEJMoa063369","article-title":"Targeted therapy for inherited GPI deficiency","volume":"356","author":"Alemida","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.thromres.2012.04.001_bb0090","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/j.1365-2141.1984.tb03954.x","article-title":"Phospholipids accelerate Factor IX activation by Factor Xa","volume":"56","author":"Mannhalter","year":"1984","journal-title":"Br J Haematol"},{"issue":"4","key":"10.1016\/j.thromres.2012.04.001_bb0095","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/S0022-2143(99)90149-X","article-title":"Antiphospholipid antibodies, protein C and S and coagulation changes in patients with sickle cell disease","volume":"134","author":"Westerman","year":"1999","journal-title":"J Lab Clin Med"},{"key":"10.1016\/j.thromres.2012.04.001_bb0100","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1182\/blood.V82.4.1192.1192","article-title":"Complement-induced vesiculation and exposure of membrane prothrombinase sites in platelets of paroxysmal nocturnal hemoglobinuria","volume":"82","author":"Weidmer","year":"1993","journal-title":"Blood"},{"key":"10.1016\/j.thromres.2012.04.001_bb0105","doi-asserted-by":"crossref","first-page":"3451","DOI":"10.1182\/blood.V93.10.3451.410k27_3451_3456","article-title":"Elevated levels of circulating procoagulant microparticles in patients with paroxysmal nocturnal hemoglobinuria and aplastic anemia","volume":"93","author":"Hugel","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.thromres.2012.04.001_bb0110","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1111\/j.1365-2141.2004.04974.x","article-title":"Elevated circulating endothelial membrane microparticles in paroxysmal nocturnal haemoglobinuria","volume":"125","author":"Simak","year":"2004","journal-title":"Br J Haematol"},{"key":"10.1016\/j.thromres.2012.04.001_bb0115","doi-asserted-by":"crossref","first-page":"3587","DOI":"10.1182\/blood-2003-01-0009","article-title":"Primary prophylaxis with warfarin prevents thrombosis in paroxysmal nocturnal hemoglobinuria","volume":"102","author":"Hall","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.thromres.2012.04.001_bb0120","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/j.1365-2141.2004.04992.x","article-title":"Natural history of paroxysmal nocturnal hemoglobinuria","volume":"126","author":"Moyo","year":"2004","journal-title":"Br J Haematol"},{"key":"10.1016\/j.thromres.2012.04.001_bb0125","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1182\/blood-2004-05-2042","article-title":"Oncogenic events regulate tissue factor expression in colorectal cancer cells: Implications for tumor progression and angiogenesis","volume":"105","author":"Yu","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.thromres.2012.04.001_bb0130","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.1365-3083.2006.01772.x","article-title":"Induction of interlukin-6 from monocytes by serine proteases and its potential mechanisms","volume":"64","author":"Li","year":"2006","journal-title":"Scand J Immunl"},{"key":"10.1016\/j.thromres.2012.04.001_bb0135","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1046\/j.1365-2141.2001.03061.x","article-title":"Interleukin 6 and haemostasis","volume":"115","author":"Kerr","year":"2001","journal-title":"Br J Haematol"},{"key":"10.1016\/j.thromres.2012.04.001_bb0140","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1055\/s-0038-1650653","article-title":"Interleukin-6 stimulates coagulation, not fibrinolysis, in humans","volume":"76","author":"Stouthard","year":"1996","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.thromres.2012.04.001_bb0145","doi-asserted-by":"crossref","first-page":"3399","DOI":"10.1161\/01.ATV.17.12.3399","article-title":"Effect of human recombinant interleukin-6 and interleukin-8 on monocyte procoagulant activity","volume":"17","author":"Neumann","year":"1997","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.thromres.2012.04.001_bb0150","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1161\/01.RES.0000171805.24799.fa","article-title":"Procoagulant soluble tissue factor is released from endothelial cells in response to inflammatory cytokines","volume":"96","author":"Szotowski","year":"2005","journal-title":"Circ Res"},{"key":"10.1016\/j.thromres.2012.04.001_bb0155","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/0090-1229(90)90043-P","article-title":"C5amediated release of Interleukin-6 by human monocytes","volume":"57","author":"Scholtz","year":"1990","journal-title":"Clin Immunol Immunopathol"},{"key":"10.1016\/j.thromres.2012.04.001_bb0160","doi-asserted-by":"crossref","DOI":"10.1182\/blood.V114.22.4030.4030","article-title":"Terminal complement inhibitor Eculizumab improves complement-mediated platelet consumption and thrombocytopenia in patients with paroxysmal nocturnal hemoglobinuria (PNH)","volume":"114","author":"Socie","year":"2009","journal-title":"Blood"}],"container-title":["Thrombosis Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384812001600?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384812001600?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,7,6]],"date-time":"2020-07-06T17:44:00Z","timestamp":1594057440000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0049384812001600"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["S0049384812001600"],"URL":"https:\/\/doi.org\/10.1016\/j.thromres.2012.04.001","relation":{},"ISSN":["0049-3848"],"issn-type":[{"value":"0049-3848","type":"print"}],"subject":[],"published":{"date-parts":[[2012,9]]}}}