{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T06:01:16Z","timestamp":1760853676906},"reference-count":28,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"crossref","award":["JKP2011002"],"award-info":[{"award-number":["JKP2011002"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Enterprise Innovation Drug Incubation Funds base of the Ministry of Science and Technology","award":["2012ZX09401-006"],"award-info":[{"award-number":["2012ZX09401-006"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thrombosis Research"],"published-print":{"date-parts":[[2013,5]]},"DOI":"10.1016\/j.thromres.2013.03.004","type":"journal-article","created":{"date-parts":[[2013,3,25]],"date-time":"2013-03-25T03:04:31Z","timestamp":1364180671000},"page":"425-435","source":"Crossref","is-referenced-by-count":11,"title":["Antithrombotic activity of HY023016, a novel Dabigatran prodrug evaluated in animal thrombosis models"],"prefix":"10.1016","volume":"131","author":[{"given":"Yun-Zhan","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo-Qing","family":"Gong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Hui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin-Hui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei-Ling","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Zhi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun-Gen","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guang-Wei","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.thromres.2013.03.004_bb0005","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.thromres.2011.11.001","article-title":"Mechanisms of platelet activation by thrombin: A short history","volume":"129","author":"De Candia","year":"2012","journal-title":"Thromb Res"},{"key":"10.1016\/j.thromres.2013.03.004_bb0010","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.pharmthera.2010.12.007","article-title":"The potential role of new enteral anticoagulants in the prevention and treatment of thromboembolism","volume":"130","author":"Mavrakanas","year":"2011","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.thromres.2013.03.004_bb0015","first-page":"60","article-title":"The novel anticoagulants: Entering a new era","volume":"139","author":"Bounameaux","year":"2009","journal-title":"Swiss Med Wkly"},{"key":"10.1016\/j.thromres.2013.03.004_bb0020","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1160\/TH09-02-0134","article-title":"Direct inhibitors of coagulation proteins \u2014The end of the heparin and low-molecular-weig ht heparin era for anticoagulant therapy?","volume":"102","author":"Laux","year":"2009","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.thromres.2013.03.004_bb0025","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1111\/j.1538-7836.2005.01374.x","article-title":"New anticoagulants","volume":"3","author":"Weitz","year":"2005","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.thromres.2013.03.004_bb0030","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1161\/ATVBAHA.110.203604","article-title":"Dabigatran: An enteral novel potent reversible nonpeptide inhibitor of thrombin","volume":"30","author":"Eisert","year":"2010","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.thromres.2013.03.004_bb0035","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1111\/j.1538-7836.2007.02748.x","article-title":"Enteral dabigatran etexilate vs. subcutaneous enoxaparin for the prevention of vnous thromboembolism after total knee replacement: The RE-MODEL randomized trial","volume":"5","author":"Eriksson","year":"2007","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.thromres.2013.03.004_bb0040","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.1056\/NEJMoa0906598","article-title":"Dabigatran versus warfarin in the treatment of acute venous thromboembolism","volume":"361","author":"Schulman","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.thromres.2013.03.004_bb0045","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1056\/NEJMc1007378","article-title":"Newly identified events in the RE-LY trial","volume":"363","author":"Connolly","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.thromres.2013.03.004_bb0050","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1016\/j.amjcard.2007.06.034","article-title":"Dabigatran With or Without Concomitant Aspirin Compared With Warfarin Alone in Patients With Nonvalvular Atrial Fibrillation (PETRO Study)","volume":"100","author":"Ezekowitz","year":"2007","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.thromres.2013.03.004_bb0055","doi-asserted-by":"crossref","first-page":"e327","DOI":"10.1016\/j.thromres.2010.03.019","article-title":"The Influence of Direct Thrombin Inhibitors on the Formation of Platelet-leukocyte Aggregates and Tissue Factor Expression","volume":"126","author":"Christersson","year":"2010","journal-title":"Thromb Res"},{"key":"10.1016\/j.thromres.2013.03.004_bb0060","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ejmech.2012.09.016","article-title":"Synthesis and antithrombotic evaluation of novel dabigatran prodrugs containing a cleavable moiety with anti-platelet activity","volume":"57","author":"Yang","year":"2012","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.thromres.2013.03.004_bb0065","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ejphar.2007.05.043","article-title":"Antithrombotic and hemostatic effects of a small molecule factor Xia inhibitor in rats","volume":"570","author":"Schumacher","year":"2007","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.thromres.2013.03.004_bb0070","first-page":"124","article-title":"Prevention of experimental venous thrombosis in rabbits with different low molecular weight heparins, dermatan sulphate and hirudin","volume":"25","author":"Matthiasson","year":"1995","journal-title":"Haemostasis"},{"key":"10.1016\/j.thromres.2013.03.004_bb0075","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1113\/jphysiol.1963.sp007185","article-title":"The aggregation of blood platelets","volume":"168","author":"Born","year":"1963","journal-title":"J Physiol"},{"key":"10.1016\/j.thromres.2013.03.004_bb0080","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1055\/s-0038-1642436","article-title":"DX-9065a, a new synthetic, potent anticoagulant and selective inhibitor for factor Xa","volume":"71","author":"Hara","year":"1994","journal-title":"Thromb Haemost"},{"issue":"9","key":"10.1016\/j.thromres.2013.03.004_bb0085","doi-asserted-by":"crossref","first-page":"6161","DOI":"10.1074\/jbc.M004164200","article-title":"Platelet Glycoprotein Ib\u03b1 Binds to Thrombin Anion-binding Exosite II Inducing Allosteric Changes in the Activity of Thrombin","volume":"276","author":"Li","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.thromres.2013.03.004_bb0090","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0003-2697(87)90021-2","article-title":"Single-step method of RNA isolation by acid guanidinium thiocynate-pheno-chloroform extraction","volume":"162","author":"Chomczynski","year":"1987","journal-title":"Anal Biochem"},{"key":"10.1016\/j.thromres.2013.03.004_bb0095","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1111\/j.1538-7836.2008.02939.x","article-title":"Apixaban, an oral, direct and highly selective factor Xa inhibitor: in vitro, antithrombotic and antihemostatic studies","volume":"6","author":"Wong","year":"2008","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.thromres.2013.03.004_bb0100","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.jep.2009.07.038","article-title":"Antiplatelet and anticoagulant effects of Panax notoginseng: Comparison of raw and steamed Panax notoginseng with Panax ginseng and Panax quinquefolium","volume":"126","author":"Lau","year":"2009","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.thromres.2013.03.004_bb0105","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.ejim.2007.10.019","article-title":"Pier Mannuccio Mannucci. Venous and arterial thrombosis: Different sides of the same coin?","volume":"19","author":"Franchini","year":"2008","journal-title":"Eur J Intern Med"},{"key":"10.1016\/j.thromres.2013.03.004_bb0110","first-page":"22","article-title":"Coagulation for the clinician","volume":"44","author":"Ruttmann","year":"2006","journal-title":"S Afr J Surg"},{"key":"10.1016\/j.thromres.2013.03.004_bb0115","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1055\/s-2004-861511","article-title":"Monitoring the new antithrombotic drugs","volume":"30","author":"Walenga","year":"2004","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.thromres.2013.03.004_bb0120","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1160\/TH07-02-0113","article-title":"Effects of the direct thromb ininhibit or dabigatran and its enterally Active prodrug, dabigatran etexilate, on thrombus formation and bleeding time in rats","volume":"98","author":"Wienen","year":"2007","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.thromres.2013.03.004_bb0125","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1111\/j.1538-7836.2007.02526.x","article-title":"Antithrombotic and anticoagulant effects of the direct thrombin inhibitor dabigatran, and its enteral prodrug, dabigatran etexilate, in a rabbit model of venous thrombosis","volume":"5","author":"Wienen","year":"2007","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.thromres.2013.03.004_bb0130","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.thromres.2012.05.014","article-title":"Evaluation of the acute coronary syndrome safety profile of dabigatran etexilate in patients undergoing major orthopedic surgery: Findings from four Phase 3 trials","volume":"130","author":"Eriksson","year":"2012","journal-title":"Thromb Res"},{"key":"10.1016\/j.thromres.2013.03.004_bb0135","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0049-3848(01)00343-7","article-title":"Specific Inhibiting Characteristics of Tetramethylpyrazine, One of the Active Ingredi ents of the Chinese Herbal Medicine \u2018Chuan xiong\u2019 on Platelet Thrombus Formation Under High Shear Rates","volume":"104","author":"Li","year":"2001","journal-title":"Thromb Res"},{"key":"10.1016\/j.thromres.2013.03.004_bb0140","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.thromres.2003.11.011","article-title":"Activated platelets stimulate tissue factor expression in smooth muscle cells","volume":"112","author":"Cirillo","year":"2003","journal-title":"Thromb Res"}],"container-title":["Thrombosis Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384813000911?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384813000911?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T08:58:08Z","timestamp":1588841888000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0049384813000911"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["S0049384813000911"],"URL":"https:\/\/doi.org\/10.1016\/j.thromres.2013.03.004","relation":{},"ISSN":["0049-3848"],"issn-type":[{"value":"0049-3848","type":"print"}],"subject":[],"published":{"date-parts":[[2013,5]]}}}