{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:45:38Z","timestamp":1792788338943,"version":"4.5.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"NIHR Bristol Cardiovascular Biomedical Research Unit","id":[{"id":"https:\/\/ror.org\/03gna4510","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["thrombosisresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Thrombosis Research"],"published-print":{"date-parts":[[2013,8]]},"DOI":"10.1016\/j.thromres.2013.07.006","type":"journal-article","created":{"date-parts":[[2013,7,30]],"date-time":"2013-07-30T02:02:16Z","timestamp":1375149736000},"page":"e145-e151","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["High haematocrit in cyanotic congenital heart disease affects how fibrinogen activity is determined by rotational thromboelastometry"],"prefix":"10.1016","volume":"132","author":[{"given":"Sarah K.","family":"Westbury","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurtis","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Reilly-Stitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Tulloh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew D.","family":"Mumford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.thromres.2013.07.006_bb0005","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.1365-2257.2005.00681.x","article-title":"Thrombelastography\/thromboelastometry","volume":"27","author":"Luddington","year":"2005","journal-title":"Clin Lab Haematol"},{"key":"10.1016\/j.thromres.2013.07.006_bb0010","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1093\/bja\/69.3.307","article-title":"Thrombelastography","volume":"69","author":"Mallett","year":"1992","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.thromres.2013.07.006_bb0015","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1213\/ane.0b013e3181966675","article-title":"The effects of fibrinogen levels on thromboelastometric variables in the presence of thrombocytopenia","volume":"108","author":"Lang","year":"2009","journal-title":"Anesth Analg"},{"key":"10.1016\/j.thromres.2013.07.006_bb0020","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1213\/ANE.0b013e31824724c8","article-title":"Comparison of whole blood fibrin-based clot tests in thrombelastography and thromboelastometry","volume":"114","author":"Solomon","year":"2012","journal-title":"Anesth Analg"},{"key":"10.1016\/j.thromres.2013.07.006_bb0025","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1111\/j.1538-7836.2006.01715.x","article-title":"Validation of rotation thrombelastography in a model of systemic activation of fibrinolysis and coagulation in humans","volume":"4","author":"Spiel","year":"2006","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.thromres.2013.07.006_bb0030","doi-asserted-by":"crossref","first-page":"R55","DOI":"10.1186\/cc8948","article-title":"Goal-directed coagulation management of major trauma patients using thromboelastometry (ROTEM)-guided administration of fibrinogen concentrate and prothrombin complex concentrate","volume":"14","author":"Schochl","year":"2010","journal-title":"Crit Care"},{"key":"10.1016\/j.thromres.2013.07.006_bb0035","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1097\/SLA.0b013e3181d3599c","article-title":"Postinjury coagulopathy management: goal directed resuscitation via POC thrombelastography","volume":"251","author":"Kashuk","year":"2010","journal-title":"Ann Surg"},{"key":"10.1016\/j.thromres.2013.07.006_bb0040","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1053\/j.jvca.2006.01.016","article-title":"Transfusion triggers in orthotopic liver transplantation: a comparison of the thromboelastometry analyzer, the thromboelastogram, and conventional coagulation tests","volume":"20","author":"Coakley","year":"2006","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1016\/j.thromres.2013.07.006_bb0045","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.jtcvs.2008.11.065","article-title":"Thromboelastometry-guided administration of fibrinogen concentrate for the treatment of excessive intraoperative bleeding in thoracoabdominal aortic aneurysm surgery","volume":"138","author":"Rahe-Meyer","year":"2009","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.thromres.2013.07.006_bb0050","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1213\/00000539-199902000-00016","article-title":"Thromboelastography-guided transfusion algorithm reduces transfusions in complex cardiac surgery","volume":"88","author":"Shore-Lesserson","year":"1999","journal-title":"Anesth Analg"},{"key":"10.1016\/j.thromres.2013.07.006_bb0055","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1097\/00000542-200105000-00014","article-title":"Efficacy of a simple intraoperative transfusion algorithm for nonerythrocyte component utilization after cardiopulmonary bypass","volume":"94","author":"Nuttall","year":"2001","journal-title":"Anesthesiology"},{"key":"10.1016\/j.thromres.2013.07.006_bb0060","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1093\/bja\/aeh037","article-title":"Comparison of structured use of routine laboratory tests or near-patient assessment with clinical judgement in the management of bleeding after cardiac surgery","volume":"92","author":"Avidan","year":"2004","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.thromres.2013.07.006_bb0065","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1097\/ALN.0b013e318264c644","article-title":"Point-of-care testing: a prospective, randomized clinical trial of efficacy in coagulopathic cardiac surgery patients","volume":"117","author":"Weber","year":"2012","journal-title":"Anesthesiology"},{"key":"10.1016\/j.thromres.2013.07.006_bb0070","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1093\/bja\/aep039","article-title":"Assessment of platelet inhibition secondary to clopidogrel and aspirin therapy in preoperative acute surgical patients measured by Thrombelastography Platelet Mapping","volume":"102","author":"Collyer","year":"2009","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.thromres.2013.07.006_bb0075","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1160\/TH08-04-0243","article-title":"Peculiar whole blood rotation thromboelastometry (Rotem) profile in 40 sideropenic anaemia patients","volume":"100","author":"Spiezia","year":"2008","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.thromres.2013.07.006_bb0080","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1213\/ANE.0b013e31824d523b","article-title":"The impact of hematocrit on fibrin clot formation assessed by rotational thromboelastometry","volume":"115","author":"Ogawa","year":"2012","journal-title":"Anesth Analg"},{"key":"10.1016\/j.thromres.2013.07.006_bb0085","first-page":"1","article-title":"Effect of haematocrit on fibrin-based clot firmness in the FIBTEM test","volume":"20","author":"Solomon","year":"2012","journal-title":"Blood Transfus"},{"key":"10.1016\/j.thromres.2013.07.006_bb0090","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/j.1537-2995.2011.03241.x","article-title":"A comparative evaluation of rotation thromboelastometry and standard coagulation tests in hemodilution-induced coagulation changes after cardiac surgery","volume":"52","author":"Ogawa","year":"2012","journal-title":"Transfusion"},{"key":"10.1016\/j.thromres.2013.07.006_bb0095","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1093\/bja\/aer342","article-title":"Comparison of thromboelastometry (ROTEM(R)) with standard plasmatic coagulation testing in paediatric surgery","volume":"108","author":"Haas","year":"2012","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.thromres.2013.07.006_bb0100","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1097\/MBC.0b013e32833e4228","article-title":"Use of fibrin-based thromboelastometry for cryoprecipitate transfusion in cardiac surgery involving deep hypothermic circulatory arrest during cardiopulmonary bypass","volume":"21","author":"Lee","year":"2010","journal-title":"Blood Coagul Fibrinolysis"},{"key":"10.1016\/j.thromres.2013.07.006_bb0105","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1097\/MBC.0b013e3282f54532","article-title":"Whole blood coagulation measured by modified thrombelastography (ROTEM) is impaired in infants with congenital heart diseases","volume":"19","author":"Osthaus","year":"2008","journal-title":"Blood Coagul Fibrinolysis"},{"key":"10.1016\/j.thromres.2013.07.006_bb0110","article-title":"Fibrinogen function is impaired in whole blood from patients with cyanotic congenital heart disease","author":"Jensen","year":"2012","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.thromres.2013.07.006_bb0115","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.thromres.2013.01.009","article-title":"Impact of changes in haematocrit level and platelet count on thromboelastometry parameters","volume":"131","author":"Nagler","year":"2013","journal-title":"Thromb Res"},{"key":"10.1016\/j.thromres.2013.07.006_bb0120","series-title":"Collection, transport and Processing of Blood Specimens for Testing Plasma-Based Coagulation Assays; Approved Guideline H21\u2013A3","first-page":"P1","author":"NCCLS Guideline","year":"1998"},{"key":"10.1016\/j.thromres.2013.07.006_bb0125","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1160\/TH12-01-0004","article-title":"Reduced coagulation at high altitude identified by thromboelastography","volume":"107","author":"Martin","year":"2012","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.thromres.2013.07.006_bb0130","doi-asserted-by":"crossref","first-page":"4416","DOI":"10.1182\/blood-2002-09-2814","article-title":"Hemostasis and coagulation at a hematocrit level of 0.85: functional consequences of erythrocytosis","volume":"101","author":"Shibata","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.thromres.2013.07.006_bb0135","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1097\/MBC.0b013e3283464f83","article-title":"In-vitro hypocoagulability on whole blood thromboelastometry associated with in-vivo expansion of red cell mass in an equine model","volume":"22","author":"McMichael","year":"2011","journal-title":"Blood Coagul Fibrinolysis"},{"key":"10.1016\/j.thromres.2013.07.006_bb0140","doi-asserted-by":"crossref","first-page":"789","DOI":"10.2460\/ajvr.73.6.789","article-title":"Correlation of hematocrit, platelet concentration, and plasma coagulation factors with results of thromboelastometry in canine whole blood samples","volume":"73","author":"Smith","year":"2012","journal-title":"Am J Vet Res"},{"key":"10.1016\/j.thromres.2013.07.006_bb0145","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1097\/00000542-200005000-00011","article-title":"Citrate storage affects Thrombelastograph analysis","volume":"92","author":"Camenzind","year":"2000","journal-title":"Anesthesiology"},{"key":"10.1016\/j.thromres.2013.07.006_bb0150","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/S0022-5223(96)70374-4","article-title":"The effect of preoperative tranexamic acid on blood loss after cardiac operations in children","volume":"111","author":"Zonis","year":"1996","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.thromres.2013.07.006_bb0155","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1213\/ANE.0b013e3181cd6d20","article-title":"The relationship among thromboelastography, hemostatic variables, and bleeding after cardiopulmonary bypass surgery in children","volume":"110","author":"Moganasundram","year":"2010","journal-title":"Anesth Analg"},{"key":"10.1016\/j.thromres.2013.07.006_bb0160","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.amjcard.2006.01.083","article-title":"Pathogenesis of thrombocytopenia in cyanotic congenital heart disease","volume":"98","author":"Lill","year":"2006","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.thromres.2013.07.006_bb0165","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1093\/cvr\/16.7.391","article-title":"Platelet kinetics in congenital heart disease","volume":"16","author":"Peters","year":"1982","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.thromres.2013.07.006_bb0170","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1097\/MBC.0b013e328352cb3f","article-title":"The in-vitro effect of fibrinogen, factor XIII and thrombin-activatable fibrinolysis inhibitor on clot formation and susceptibility to tissue plasminogen activator-induced fibrinolysis in hemodilution model","volume":"23","author":"Shenkman","year":"2012","journal-title":"Blood Coagul Fibrinolysis"},{"key":"10.1016\/j.thromres.2013.07.006_bb0175","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1093\/bja\/aes374","article-title":"Fast interpretation of thromboelastometry in non-cardiac surgery: reliability in patients with hypo-, normo-, and hypercoagulability","volume":"110","author":"Gorlinger","year":"2013","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.thromres.2013.07.006_bb0180","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/j.1538-7836.2004.00528.x","article-title":"Whole blood clot formation phenotypes in hemophilia A and rare coagulation disorders. Patterns of response to recombinant factor VIIa","volume":"2","author":"Sorensen","year":"2004","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.thromres.2013.07.006_bb0185","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1111\/j.1365-2516.2011.02710.x","article-title":"Whole blood rotation thromboelastometry (ROTEM) in nine severe factor V deficient patients and evaluation of the role of intraplatelets factor V","volume":"18","author":"Spiezia","year":"2012","journal-title":"Haemophilia"}],"container-title":["Thrombosis Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384813002843?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384813002843?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T09:37:27Z","timestamp":1646213847000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0049384813002843"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["S0049384813002843"],"URL":"https:\/\/doi.org\/10.1016\/j.thromres.2013.07.006","relation":{},"ISSN":["0049-3848"],"issn-type":[{"value":"0049-3848","type":"print"}],"subject":[],"published":{"date-parts":[[2013,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"High haematocrit in cyanotic congenital heart disease affects how fibrinogen activity is determined by rotational thromboelastometry","name":"articletitle","label":"Article Title"},{"value":"Thrombosis Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.thromres.2013.07.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}