{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T10:22:54Z","timestamp":1792664574155,"version":"4.5.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["thrombosisresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Thrombosis Research"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1016\/j.thromres.2013.09.030","type":"journal-article","created":{"date-parts":[[2013,9,26]],"date-time":"2013-09-26T11:32:53Z","timestamp":1380195173000},"page":"5-9","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":65,"title":["Coagulopathy in malaria"],"prefix":"10.1016","volume":"133","author":[{"given":"Pantep","family":"Angchaisuksiri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.thromres.2013.09.030_bb0005","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1056\/NEJMp038127","article-title":"Two worlds of malaria","volume":"349","author":"Miller","year":"2003","journal-title":"N Engl J Med"},{"issue":"Suppl. 1","key":"10.1016\/j.thromres.2013.09.030_bb0010","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/S0035-9203(00)90300-6","article-title":"Severe falciparum malaria","volume":"94","author":"World Health Organization, Communicable Diseases Cluster","year":"2000","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.1016\/j.thromres.2013.09.030_bb0015","first-page":"86","article-title":"Hemostatic alterations in malaria","volume":"24","author":"Srichaikul","year":"1993","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"10.1016\/j.thromres.2013.09.030_bb0020","doi-asserted-by":"crossref","first-page":"551","DOI":"10.4269\/ajtmh.1974.23.551","article-title":"Acute pulmonary insufficiency in falciparum malaria: summary of 12 cases with evidence of disseminated intravascular coagulation","volume":"23","author":"Punyagupta","year":"1974","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.thromres.2013.09.030_bb0025","first-page":"305","article-title":"The importance of anaemia in cerebral and uncomplicated falciparum malaria: role of complications, dyserythropoiesis and iron sequestration","volume":"58","author":"Phillips","year":"1986","journal-title":"Q J Med"},{"key":"10.1016\/j.thromres.2013.09.030_bb0030","series-title":"Handbook of Experimental Pharmacology","first-page":"127","article-title":"Clinical pathology in malaria","author":"Boonpucknavig","year":"1984"},{"key":"10.1016\/j.thromres.2013.09.030_bb0035","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/s10096-003-0984-5","article-title":"Plasmodium falciparum cerebral malaria complicated by disseminated intravascular coagulation and symmetrical peripheral gangrene: case report and review","volume":"22","author":"Liechti","year":"2003","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1016\/j.thromres.2013.09.030_bb0040","doi-asserted-by":"crossref","first-page":"262","DOI":"10.4103\/0976-9668.107323","article-title":"Symmetrical peripheral gangrene with Plasmodium falciparum malaria","volume":"4","author":"Gupta","year":"2013","journal-title":"J Nat Sci Biol Med"},{"key":"10.1016\/j.thromres.2013.09.030_bb0045","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.trstmh.2007.04.015","article-title":"Purpura fulminans: an unusual manifestation of severe falciparum malaria","volume":"101","author":"Kato","year":"2007","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.1016\/j.thromres.2013.09.030_bb0050","doi-asserted-by":"crossref","first-page":"790","DOI":"10.4269\/ajtmh.2006.75.790","article-title":"Malarial retinopathy: a newly established diagnostic sign in severe malaria","volume":"75","author":"Beare","year":"2006","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.thromres.2013.09.030_bb0055","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1111\/j.1365-2141.2010.08399.x","article-title":"Thrombocytopenia in early malaria is associated with GP1b shedding in absence of systemic platelet activation and consumptive coagulopathy","volume":"151","author":"de Mast","year":"2010","journal-title":"Br J Haematol"},{"key":"10.1016\/j.thromres.2013.09.030_bb0060","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/0035-9203(88)90122-8","article-title":"Functional and ultrastructural changes in malarial infection","volume":"82","author":"Mohanty","year":"1988","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.1016\/j.thromres.2013.09.030_bb0065","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/0035-9203(76)90004-3","article-title":"Histamine changes in Plasmodium falciparum malaria","volume":"70","author":"Srichaikul","year":"1976","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.1016\/j.thromres.2013.09.030_bb0070","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1111\/j.1365-2141.1994.tb04877.x","article-title":"Activation of the coagulation cascade in severe falciparum malaria through the intrinsic pathway","volume":"87","author":"Clemens","year":"1994","journal-title":"Br J Haematol"},{"key":"10.1016\/j.thromres.2013.09.030_bb0075","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/0035-9203(89)90321-0","article-title":"Activation of the coagulation cascade in falciparum malaria","volume":"83","author":"Pukrittayakamee","year":"1989","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.1016\/j.thromres.2013.09.030_bb0080","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/(SICI)1096-8652(199701)54:1<23::AID-AJH4>3.0.CO;2-6","article-title":"Fibrinolysis, inhibitors of blood coagulation, and monocyte derived coagulant activity in acute malaria","volume":"54","author":"Mohanty","year":"1997","journal-title":"Am J Hematol"},{"key":"10.1016\/j.thromres.2013.09.030_bb0085","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0002-9343(91)90071-5","article-title":"Activation of the host response in human Plasmodium falciparum malaria: relation of parasitemia to tumor necrosis factor\/cachectin, thrombin-antithrombin III, and protein C levels","volume":"91","author":"Hemmer","year":"1991","journal-title":"Am J Med"},{"key":"10.1016\/j.thromres.2013.09.030_bb0090","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0002-9343(89)80688-6","article-title":"Elevated tumor necrosis factor alpha and interleukin-6 serum levels as markers for complicated Plasmodium falciparum malaria","volume":"87","author":"Kern","year":"1989","journal-title":"Am J Med"},{"key":"10.1016\/j.thromres.2013.09.030_bb0095","first-page":"227","article-title":"Malarial parasites induce TNF production by macrophage","volume":"64","author":"Bate","year":"1988","journal-title":"Immunology"},{"key":"10.1016\/j.thromres.2013.09.030_bb0100","first-page":"600","article-title":"Soluble malarial antigens are toxic and induce the production of tumor necrosis factor in vivo","volume":"66","author":"Bate","year":"1989","journal-title":"Immunology"},{"key":"10.1016\/j.thromres.2013.09.030_bb0105","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1111\/j.1365-2141.2006.06067.x","article-title":"von Willebrand factor propeptide in malaria: evidence of acute endothelial cell activation","volume":"133","author":"Hollestelle","year":"2006","journal-title":"Br J Haematol"},{"key":"10.1016\/j.thromres.2013.09.030_bb0110","doi-asserted-by":"crossref","first-page":"e1000349","DOI":"10.1371\/journal.ppat.1000349","article-title":"Severe Plasmodium falciparum malaria is associated with circulating ultra-large von Willebrand multimers and ADAMTS13 inhibition","volume":"5","author":"Larkin","year":"2009","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.thromres.2013.09.030_bb0115","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1160\/TH09-04-0223","article-title":"Severe malaria is associated with a deficiency of von Willebrand factor cleaving protease, ADAMTS13","volume":"103","author":"L\u00f6wenberg","year":"2010","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.thromres.2013.09.030_bb0120","first-page":"2542","article-title":"Circulating endothelial microparticles in malawian children with severe falciparum malaria complicated with coma","volume":"291","author":"Combes","year":"2004","journal-title":"JAMA"},{"key":"10.1016\/j.thromres.2013.09.030_bb0125","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.mib.2006.06.006","article-title":"A family affair: var genes, PfEMP1 binding, and malaria disease","volume":"9","author":"Kraemer","year":"2006","journal-title":"Curr Opin Microbiol"},{"key":"10.1016\/j.thromres.2013.09.030_bb0130","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1182\/blood-2009-07-235150","article-title":"Rapid activation of endothelial cells enables Plasmodium falciparum adhesion to platelet-decorated von Willebrand factor strings","volume":"115","author":"Bridges","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.thromres.2013.09.030_bb0135","doi-asserted-by":"crossref","first-page":"3449","DOI":"10.1096\/fj.09-135822","article-title":"Platelet microparticles: a new player inmalaria parasite cytoadherence to human brain endothelium","volume":"23","author":"Faille","year":"2009","journal-title":"FASEB J"},{"key":"10.1016\/j.thromres.2013.09.030_bb0140","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/nature12216","article-title":"Severe malaria is associated with parasite binding to endothelial C receptor","volume":"498","author":"Turner","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.thromres.2013.09.030_bb0145","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1182\/blood-2013-03-490219","article-title":"Loss of endothelial protein C receptors links coagulation and inflammation to parasite sequestration in cerebral malaria in African children","volume":"122","author":"Moxon","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.thromres.2013.09.030_bb0150","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/j.1538-7836.2006.02232.x","article-title":"Plasmodium falciparum-infected erythrocytes induce tissue factor expression in endothelial cells and support the assembly of multimolecular coagulation complexes","volume":"5","author":"Francischetti","year":"2007","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.thromres.2013.09.030_bb0155","first-page":"100","article-title":"Exchange transfusion therapy in severe complicated malaria","volume":"24","author":"Srichaikul","year":"1993","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"10.1016\/j.thromres.2013.09.030_bb0160","first-page":"1192","article-title":"Exchange transfusion as an adjunct therapy in severe complicated Plasmodium falciparum malaria: a meta-analysis","volume":"34","author":"Riddle","year":"2002","journal-title":"CJD"},{"key":"10.1016\/j.thromres.2013.09.030_bb0165","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1046\/j.1365-2141.2003.04790.x","article-title":"Current understanding of disseminated intravascular coagulation","volume":"124","author":"Levi","year":"2004","journal-title":"Br J Haematol"},{"key":"10.1016\/j.thromres.2013.09.030_bb0170","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1126\/science.1166296","article-title":"Platelets kill intraerythrocytic malarial parasites and mediate survival to infection","volume":"323","author":"McMorran","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.thromres.2013.09.030_bb0175","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1126\/science.1228892","article-title":"Platelets factor 4 and Duffy antigen required for platelet killing of Plasmodium falciparum","volume":"338","author":"McMorran","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.thromres.2013.09.030_bb0180","first-page":"91","article-title":"Anti-TNF therapy inhibits fever in cerebral malaria","volume":"86","author":"Kwiatkowski","year":"1993","journal-title":"Q J Med"},{"key":"10.1016\/j.thromres.2013.09.030_bb0185","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1093\/infdis\/174.5.1091","article-title":"The effect of a monoclonal antibody to tumor necrosis factor on survival from childhood malaria","volume":"174","author":"van Hoensbroek","year":"1996","journal-title":"J Infect Dis"},{"key":"10.1016\/j.thromres.2013.09.030_bb0190","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1111\/j.1365-2044.2006.04752.x","article-title":"Drotrecogin alfa (activated) in severe falciparum malaria","volume":"61","author":"Kendrick","year":"2006","journal-title":"Anaesthesia"},{"key":"10.1016\/j.thromres.2013.09.030_bb0195","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1177\/0310057X0703500320","article-title":"The use of activated protein C in severe Plasmodium falciparum malaria","volume":"35","author":"Rankin","year":"2007","journal-title":"Anaesth Intensive Care"},{"key":"10.1016\/j.thromres.2013.09.030_bb0200","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1056\/NEJMoa1202290","article-title":"Drotrecogin alfa (activated) in adults with septic shock","volume":"366","author":"Ranieri","year":"2012","journal-title":"N Engl J Med"}],"container-title":["Thrombosis Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384813004441?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384813004441?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T19:16:14Z","timestamp":1564082174000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0049384813004441"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["S0049384813004441"],"URL":"https:\/\/doi.org\/10.1016\/j.thromres.2013.09.030","relation":{},"ISSN":["0049-3848"],"issn-type":[{"value":"0049-3848","type":"print"}],"subject":[],"published":{"date-parts":[[2014,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Coagulopathy in malaria","name":"articletitle","label":"Article Title"},{"value":"Thrombosis Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.thromres.2013.09.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}