{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:32:11Z","timestamp":1791909131188,"version":"4.3.4"},"reference-count":39,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","thrombosisresearch.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Thrombosis Research"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1016\/j.thromres.2014.05.020","type":"journal-article","created":{"date-parts":[[2014,5,21]],"date-time":"2014-05-21T11:32:23Z","timestamp":1400671943000},"page":"393-403","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":61,"title":["Evaluating errors in the laboratory identification of von Willebrand disease in the real world"],"prefix":"10.1016","volume":"134","author":[{"given":"Emmanuel J.","family":"Favaloro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roslyn A.","family":"Bonar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muriel","family":"Meiring","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Duncan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soma","family":"Mohammed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Sioufi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Marsden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.thromres.2014.05.020_bb0005","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1055\/s-0031-1281028","article-title":"Von Willebrand disease: local diagnosis and management of a globally distributed bleeding disorder","volume":"37","author":"Favaloro","year":"2011","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.thromres.2014.05.020_bb0010","first-page":"41","article-title":"Perils, problems, and progress in laboratory diagnosis of von Willebrand disease","volume":"40","author":"Flood","year":"2014","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.thromres.2014.05.020_bb0015","first-page":"17","article-title":"von Willebrand Factor: Form for Function","volume":"40","author":"Yee","year":"2014","journal-title":"Semin Thromb Hemost"},{"issue":"Suppl. 2","key":"10.1016\/j.thromres.2014.05.020_bb0020","doi-asserted-by":"crossref","first-page":"s17","DOI":"10.1016\/S0049-3848(10)70149-3","article-title":"Rethinking the diagnosis of von Willebrand disease","volume":"127","author":"Favaloro","year":"2011","journal-title":"Thromb Res"},{"key":"10.1016\/j.thromres.2014.05.020_bb0025","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1111\/j.1538-7836.2006.02146.x","article-title":"Working Party on von Willebrand Disease Classification. Update on the pathophysiology and classification of von Willebrand disease: a report of the Subcommittee on von Willebrand Factor","volume":"4","author":"Sadler","year":"2006","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.thromres.2014.05.020_bb0030","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1517\/14712598.2012.667398","article-title":"Biological therapies for von Willebrand Disease","volume":"12","author":"Favaloro","year":"2012","journal-title":"Expert Opin Biol Ther"},{"key":"10.1016\/j.thromres.2014.05.020_bb0035","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1111\/j.1538-7836.2011.04460.x","article-title":"Validation of an automated latex particle-enhanced immunoturbidimetric von Willebrand factor activity assay","volume":"9","author":"Chen","year":"2011","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.thromres.2014.05.020_bb0040","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1111\/hae.12064","article-title":"A comparative evaluation of a new automated assay for von Willebrand factor activity","volume":"19","author":"Lawrie","year":"2013","journal-title":"Haemophilia"},{"key":"10.1016\/j.thromres.2014.05.020_bb0045","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1111\/hae.12203","article-title":"Comparison of a new chemiluminescent immunoassay for von Willebrand factor activity with the ristocetin cofactor induced platelet agglutination method","volume":"19","author":"Cabrera","year":"2013","journal-title":"Haemophilia"},{"key":"10.1016\/j.thromres.2014.05.020_bb0050","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/hae.12264","article-title":"A two-centre comparative evaluation of new automated assays for von Willebrand factor ristocetin cofactor activity and antigen","volume":"20","author":"Stufano","year":"2014","journal-title":"Haemophilia"},{"key":"10.1016\/j.thromres.2014.05.020_bb0055","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1160\/TH12-05-0294","article-title":"A novel flow cytometry single tube bead assay for quantitation of von Willebrand factor antigen and collagen-binding","volume":"108","author":"Mina","year":"2012","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.thromres.2014.05.020_bb0060","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1111\/j.1538-7836.2008.02845.x","article-title":"A highly-sensitive plasma von Willebrand factor ristocetin cofactor (VWF:RCo) activity assay by flow cytometry","volume":"6","author":"Chen","year":"2008","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.thromres.2014.05.020_bb0065","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1055\/s-2006-947866","article-title":"Laboratory testing for von Willebrand disease: contribution of multimer analysis to diagnosis and classification","volume":"32","author":"Budde","year":"2006","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.thromres.2014.05.020_bb0070","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1365-2516.2007.01643.x","article-title":"Willebrand disease (VWD): evidence-based diagnosis and management guidelines, the National Heart, Lung, and Blood Institute (NHLBI) Expert Panel report (USA)","volume":"14","author":"Nichols","year":"2008","journal-title":"Haemophilia"},{"key":"10.1016\/j.thromres.2014.05.020_bb0075","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1055\/s-0037-1614375","article-title":"Laboratory testing for von Willebrand's disease: An assessment of current diagnostic practice and efficacy by means of a multi-laboratory survey","volume":"82","author":"Favaloro","year":"1999","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.thromres.2014.05.020_bb0080","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1097\/00001721-200012000-00006","article-title":"Assessment of current diagnostic practice and efficacy in testing for von Willebrand's disorder: Results from the second Australasian multi-laboratory survey","volume":"11","author":"Favaloro","year":"2000","journal-title":"Blood Coagul Fibrinolysis"},{"key":"10.1016\/j.thromres.2014.05.020_bb0085","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1309\/8WVANM7H0DKTGB9F","article-title":"Laboratory diagnosis of von Willebrand Disorder: Current practice in the Southern Hemisphere","volume":"119","author":"Favaloro","year":"2003","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.thromres.2014.05.020_bb0090","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1111\/j.1365-2516.2004.00897.x","article-title":"Laboratory diagnosis of von Willebrand Disorder: Quality and diagnostic improvements driven by peer review in a multi-laboratory test process","volume":"10","author":"Favaloro","year":"2004","journal-title":"Haemophilia"},{"key":"10.1016\/j.thromres.2014.05.020_bb0095","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1532\/LH96.04063","article-title":"Laboratory diagnosis of von Willebrand Disorder: Use of multiple functional assays reduces diagnostic error rates","volume":"11","author":"Favaloro","year":"2005","journal-title":"Lab Hematol"},{"key":"10.1016\/j.thromres.2014.05.020_bb0100","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1055\/s-2006-947865","article-title":"Reducing errors in identification of von Willebrand disease: The experience of the Royal college of Pathologists of Australasia Quality Assurance Program","volume":"32","author":"Favaloro","year":"2006","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.thromres.2014.05.020_bb0105","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1160\/TH06-12-0693","article-title":"2B or not 2B? Disparate discrimination of functional VWF discordance using different assay panels or methodologies may lead to success or failure in the early identification of Type 2B VWD","volume":"98","author":"Favaloro","year":"2007","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.thromres.2014.05.020_bb0205","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1055\/s-2006-947863","article-title":"Laboratory tests for measurement of von Willebrand factor show poor agreement among different centers: results from the United Kingdom National External Quality Assessment Scheme for Blood Coagulation","volume":"32","author":"Kitchen","year":"2006","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.thromres.2014.05.020_bb0120","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1055\/s-2006-947864","article-title":"External peer review quality assurance testing in von Willebrand disease: the recent experience of the United States College of American Pathologists proficiency testing program","volume":"32","author":"Hayes","year":"2006","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.thromres.2014.05.020_bb0125","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1055\/s-2006-947862","article-title":"An external quality assessment program for von Willebrand factor laboratory analysis: an overview from the European concerted action on thrombosis and disabilities foundation","volume":"32","author":"Meijer","year":"2006","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.thromres.2014.05.020_bb0130","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1309\/AJCPH5JK4ONENPAE","article-title":"von Willebrand factor assay proficiency testing. The North American specialized coagulation laboratory association experience","volume":"135","author":"Chandler","year":"2011","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.thromres.2014.05.020_bb0135","first-page":"178","article-title":"Lower limit of assay sensitivity: an under-recognised and significant problem in von Willebrand disease identification and classification","volume":"21","author":"Favaloro","year":"2008","journal-title":"Clin Lab Sci"},{"key":"10.1016\/j.thromres.2014.05.020_bb0140","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1111\/j.1538-7836.2012.04729.x","article-title":"Differential sensitivity of von Willebrand factor 'activity' assays to large and small VWF molecular weight forms: a cross-laboratory study comparing ristocetin cofactor, collagen binding and monoclonal antibody based assays","volume":"10","author":"Favaloro","year":"2012","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.thromres.2014.05.020_bb0145","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1160\/TH10-06-0360","article-title":"Evaluation of commercial von Willebrand factor collagen binding assays to assist the discrimination of types 1 and 2 von Willebrand disease","volume":"104","author":"Favaloro","year":"2010","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.thromres.2014.05.020_bb0150","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1097\/00001721-199104000-00011","article-title":"Development of a simple collagen binding assay aids in the diagnosis of, and permits sensitive discrimination between, Type I and Type II von Willebrand's disease","volume":"2","author":"Favaloro","year":"1991","journal-title":"Blood Coagul Fibrinolysis"},{"key":"10.1016\/j.thromres.2014.05.020_bb0155","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1080\/00313029700169365","article-title":"Laboratory assays for von Willebrand Factor: Relative contribution to the diagnosis of von Willebrand's disease","volume":"29","author":"Favaloro","year":"1997","journal-title":"Pathology"},{"key":"10.1016\/j.thromres.2014.05.020_bb0160","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1055\/s-0031-1281040","article-title":"Diagnosis and management of adult patients with von Willebrand disease in South Australia","volume":"37","author":"Rodgers","year":"2011","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.thromres.2014.05.020_bb0165","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1055\/s-0031-1281041","article-title":"Diagnosis and management of von Willebrand disease in Australia","volume":"37","author":"Favaloro","year":"2011","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.thromres.2014.05.020_bb0170","doi-asserted-by":"crossref","first-page":"e9","DOI":"10.1111\/j.1365-2516.2011.02628.x","article-title":"Diagnosis of type 1 versus 2A and 2M von Willebrand disease","volume":"18","author":"Favaloro","year":"2012","journal-title":"Haemophilia"},{"key":"10.1016\/j.thromres.2014.05.020_bb0175","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/j.1751-553X.2011.01362.x","article-title":"Distinguishing types 1 and 2M von Willebrand disease","volume":"34","author":"Favaloro","year":"2012","journal-title":"Int J Lab Hematol"},{"key":"10.1016\/j.thromres.2014.05.020_bb0180","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1111\/j.1538-7836.2008.03090.x","article-title":"Detailed von Willebrand factor multimer analysis in patients with von Willebrand disease in the European study, molecular and clinical markers for the diagnosis and management of type 1 von Willebrand disease (MCMDM-1VWD) \u2013 a rebuttal","volume":"6","author":"Favaloro","year":"2008","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.thromres.2014.05.020_bb0185","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1055\/s-0031-1281037","article-title":"Management of inherited von Willebrand disease in Italy: results from the retrospective study on 1234 patients","volume":"37","author":"Federici","year":"2011","journal-title":"Semin Thromb Hemost"},{"issue":"3","key":"10.1016\/j.thromres.2014.05.020_bb0190","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1055\/s-0033-1336833","article-title":"Regulation in hemostasis and thrombosis: Part I-in vitro diagnostics","volume":"39","author":"Favaloro","year":"2013","journal-title":"Semin Thromb Hemost"},{"issue":"5","key":"10.1016\/j.thromres.2014.05.020_bb0195","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1055\/s-2006-947860","article-title":"Diagnosing von Willebrand disease: a large reference laboratory's perspective","volume":"32","author":"Adcock","year":"2006","journal-title":"Semin Thromb Hemost"},{"issue":"4","key":"10.1016\/j.thromres.2014.05.020_bb0200","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1373\/clinchem.2012.199000","article-title":"Collagen binding provides a sensitive screen for variant von Willebrand disease","volume":"59","author":"Flood","year":"2013","journal-title":"Clin Chem"}],"container-title":["Thrombosis Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384814002862?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384814002862?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,10]],"date-time":"2019-08-10T17:54:18Z","timestamp":1565459658000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0049384814002862"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["S0049384814002862"],"URL":"https:\/\/doi.org\/10.1016\/j.thromres.2014.05.020","relation":{},"ISSN":["0049-3848"],"issn-type":[{"value":"0049-3848","type":"print"}],"subject":[],"published":{"date-parts":[[2014,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluating errors in the laboratory identification of von Willebrand disease in the real world","name":"articletitle","label":"Article Title"},{"value":"Thrombosis Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.thromres.2014.05.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown copyright \u00a9 2014 Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}