{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T09:37:04Z","timestamp":1779183424764,"version":"3.51.4"},"reference-count":23,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["thrombosisresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Thrombosis Research"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1016\/j.thromres.2014.07.035","type":"journal-article","created":{"date-parts":[[2014,8,6]],"date-time":"2014-08-06T06:30:17Z","timestamp":1407306617000},"page":"889-894","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Platelet activation biomarkers in Berkeley sickle cell mice and the response to prasugrel"],"prefix":"10.1016","volume":"134","author":[{"given":"Kousaku","family":"Ohno","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisako","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naozumi","family":"Samata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph A.","family":"Jakubowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuyuki","family":"Tomizawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Mizuno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuhiro","family":"Sugidachi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.thromres.2014.07.035_bb0005","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1016\/S0140-6736(10)61029-X","article-title":"Sickle-cell disease","volume":"376","author":"Rees","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.thromres.2014.07.035_bb0010","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1055\/s-2005-869524","article-title":"Pharmacology of CS-747 (prasugrel, LY640315), a novel, potent antiplatelet agent with in vivo P2Y12 receptor antagonist activity","volume":"31","author":"Niitsu","year":"2005","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.thromres.2014.07.035_bb0015","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1111\/bcp.12042","article-title":"A phase 1 study of prasugrel in patients with sickle cell disease: pharmacokinetics and effects on ex vivo platelet reactivity","volume":"75","author":"Jakubowski","year":"2013","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.thromres.2014.07.035_bb0020","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.thromres.2013.12.008","article-title":"A phase 1 study of prasugrel in patients with sickle cell disease: Effects on biomarkers of platelet activation and coagulation","volume":"133","author":"Jakubowski","year":"2014","journal-title":"Thromb Res"},{"key":"10.1016\/j.thromres.2014.07.035_bb0025","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1756-8722-6-17","article-title":"A double-blind, randomized, multicenter phase 2 study of prasugrel versus placebo in adult patients with sickle cell disease","volume":"6","author":"Wun","year":"2013","journal-title":"J Hematol Oncol"},{"issue":"1","key":"10.1016\/j.thromres.2014.07.035_bb0030","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3109\/09537104.2013.770136","article-title":"Platelet Activation and Inhibition in Sickle cell disease (PAINS) study","volume":"25","author":"Frelinger","year":"2014","journal-title":"Platelets"},{"key":"10.1016\/j.thromres.2014.07.035_bb0035","first-page":"199","article-title":"Clinical and biological double-blind-study of ticlopidine in preventive treatment of sickle-cell disease crises","volume":"15","author":"Cabannes","year":"1984","journal-title":"Agents Actions"},{"key":"10.1016\/j.thromres.2014.07.035_bb0040","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1126\/science.278.5339.876","article-title":"Transgenic knockout mice with exclusively human sickle hemoglobin and sickle cell disease","volume":"278","author":"P\u00e1szty","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.thromres.2014.07.035_bb0045","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1172\/JCI26857","article-title":"Heme oxygenase-1 is a modulator of inflammation and vaso-occlusion in transgenic sickle mice","volume":"116","author":"Belcher","year":"2006","journal-title":"J Clin Invest"},{"key":"10.1016\/j.thromres.2014.07.035_bb0050","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1182\/blood-2005-07-2839","article-title":"Pathology of Berkeley sickle cell mice: similarities and differences with human sickle cell disease","volume":"107","author":"Manci","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.thromres.2014.07.035_bb0055","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.bcmd.2008.01.008","article-title":"Morphological and functional platelet abnormalities in Berkeley sickle cell mice","volume":"41","author":"Shet","year":"2008","journal-title":"Blood Cells Mol Dis"},{"key":"10.1016\/j.thromres.2014.07.035_bb0060","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.bcp.2007.06.027","article-title":"The influence of P2Y12 receptor deficiency on the platelet inhibitory activities of prasugrel in a mouse model: evidence for specific inhibition of P2Y12 receptors by prasugrel","volume":"74","author":"Hashimoto","year":"2007","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.thromres.2014.07.035_bb0065","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0009-8981(84)90216-X","article-title":"ATP, ADP and AMP in plasma from peripheral venous blood","volume":"143","author":"Harkness","year":"1984","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.thromres.2014.07.035_bb0070","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/nm.2280","article-title":"Detrimental effects of adenosine signaling in sickle cell disease","volume":"17","author":"Zhang","year":"2011","journal-title":"Nat Med"},{"issue":"4\u20135","key":"10.1016\/j.thromres.2014.07.035_bb0075","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s002100000309","article-title":"Extracellular metabolism of ATP and other nucleotides","volume":"362","author":"Zimmermann","year":"2000","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"issue":"12","key":"10.1016\/j.thromres.2014.07.035_bb0080","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.1111\/jth.12422","article-title":"Mechanisms of hemolysis-associated platelet activation","volume":"11","author":"Helms","year":"2013","journal-title":"J Thromb Haemost"},{"issue":"11","key":"10.1016\/j.thromres.2014.07.035_bb0085","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1182\/blood-2013-08-523936","article-title":"Differential contribution of FXa and thrombin to vascular inflammation in a mouse model of sickle cell disease","volume":"123","author":"Sparkenbaugh","year":"2014","journal-title":"Blood"},{"issue":"28","key":"10.1016\/j.thromres.2014.07.035_bb0090","doi-asserted-by":"crossref","first-page":"20221","DOI":"10.1074\/jbc.M610737200","article-title":"Characterization of heme as activator of Toll-like receptor 4","volume":"282","author":"Figueiredo","year":"2007","journal-title":"J Biol Chem"},{"issue":"3","key":"10.1016\/j.thromres.2014.07.035_bb0095","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1182\/blood-2013-04-495887","article-title":"Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease","volume":"123","author":"Belcher","year":"2014","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.thromres.2014.07.035_bb0100","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1182\/blood-2005-06-2202","article-title":"Platelet Toll-like receptor expression modulates lipopolysaccharide-induced thrombocytopenia and tumor necrosis factor-alpha production in vivo","volume":"107","author":"Aslam","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.thromres.2014.07.035_bb0105","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1182\/blood.V46.4.579.579","article-title":"Elevated platelet count and megathrombocyte number in sickle cell anemia","volume":"46","author":"Freedman","year":"1975","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.thromres.2014.07.035_bb0110","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1182\/blood.V84.2.643.643","article-title":"The acute chest syndrome in sickle cell disease: incidence and risk factors. The Cooperative Study of Sickle Cell Disease","volume":"84","author":"Castro","year":"1994","journal-title":"Blood"},{"issue":"25","key":"10.1016\/j.thromres.2014.07.035_bb0115","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1056\/NEJM200006223422502","article-title":"Causes and outcomes of the acute chest syndrome in sickle cell disease. National Acute Chest Syndrome Study Group","volume":"342","author":"Vichinsky","year":"2000","journal-title":"N Engl J Med"}],"container-title":["Thrombosis Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384814004125?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384814004125?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,8,22]],"date-time":"2020-08-22T23:25:30Z","timestamp":1598138730000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0049384814004125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["S0049384814004125"],"URL":"https:\/\/doi.org\/10.1016\/j.thromres.2014.07.035","relation":{},"ISSN":["0049-3848"],"issn-type":[{"value":"0049-3848","type":"print"}],"subject":[],"published":{"date-parts":[[2014,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Platelet activation biomarkers in Berkeley sickle cell mice and the response to prasugrel","name":"articletitle","label":"Article Title"},{"value":"Thrombosis Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.thromres.2014.07.035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}