{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:58:44Z","timestamp":1791305924489,"version":"4.3.1"},"reference-count":35,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","thrombosisresearch.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Thrombosis Research"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1016\/j.thromres.2014.09.008","type":"journal-article","created":{"date-parts":[[2014,9,16]],"date-time":"2014-09-16T14:34:12Z","timestamp":1410878052000},"page":"1032-1037","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Changes in haemostatic parameters during the menstrual cycle and subsequent use of drospirenone-containing oral contraceptives"],"prefix":"10.1016","volume":"134","author":[{"given":"S.N.","family":"Tchaikovski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.C.L.G.D.","family":"Thomassen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.D.","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Bremme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Rosing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.thromres.2014.09.008_bb0005","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1161\/hq0202.102318","article-title":"Female hormones and thrombosis","volume":"22","author":"Rosendaal","year":"2002","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.thromres.2014.09.008_bb0010","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1016\/S0140-6736(95)91928-7","article-title":"Risk of idiopathic cardiovascular death and nonfatal venous thromboembolism in women using oral contraceptives with differing progestagen components","volume":"346","author":"Jick","year":"1995","journal-title":"Lancet"},{"key":"10.1016\/j.thromres.2014.09.008_bb0015","doi-asserted-by":"crossref","first-page":"b2921","DOI":"10.1136\/bmj.b2921","article-title":"The venous thrombotic risk of oral contraceptives, effects of oestrogen dose and progestogen type: results of the MEGA case\u2013control study","volume":"339","author":"van Hylckama","year":"2009","journal-title":"BMJ"},{"key":"10.1016\/j.thromres.2014.09.008_bb0020","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/j.1749-6632.1995.tb31386.x","article-title":"Drospirenone: a novel progestogen with antimineralocorticoid and antiandrogenic activity","volume":"761","author":"Muhn","year":"1995","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.thromres.2014.09.008_bb0025","doi-asserted-by":"crossref","first-page":"d6423","DOI":"10.1136\/bmj.d6423","article-title":"Risk of venous thromboembolism from use of oral contraceptives containing different progestogens and oestrogen doses: Danish cohort study, 2001\u20139","volume":"343","author":"Lidegaard","year":"2011","journal-title":"BMJ"},{"key":"10.1016\/j.thromres.2014.09.008_bb0030","first-page":"33","article-title":"In brief: FDA warning about drospirenone in oral contraceptives","volume":"54","year":"2012","journal-title":"Med Lett Drugs Ther"},{"key":"10.1016\/j.thromres.2014.09.008_bb0035","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.thromres.2010.01.045","article-title":"Mechanisms of estrogen-induced venous thromboembolism","volume":"126","author":"Tchaikovski","year":"2010","journal-title":"Thromb Res"},{"key":"10.1016\/j.thromres.2014.09.008_bb0040","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1055\/s-0037-1613960","article-title":"A randomized cross-over study on the effects of levonorgestrel- and desogestrel-containing oral contraceptives on the anticoagulant pathways","volume":"84","author":"Tans","year":"2000","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.thromres.2014.09.008_bb0045","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1055\/s-0037-1613958","article-title":"Effects on coagulation of levonorgestrel- and desogestrel-containing low dose oral contraceptives: a cross-over study","volume":"84","author":"Middeldorp","year":"2000","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.thromres.2014.09.008_bb0050","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1016\/S0140-6736(05)80081-9","article-title":"Venous thrombosis due to poor anticoagulant response to activated protein C: Leiden Thrombophilia Study","volume":"342","author":"Koster","year":"1993","journal-title":"Lancet"},{"key":"10.1016\/j.thromres.2014.09.008_bb0055","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1046\/j.1365-2141.2003.04443.x","article-title":"Activated protein C resistance determined with a thrombin generation-based test predicts for venous thrombosis in men and women","volume":"122","author":"Tans","year":"2003","journal-title":"Br J Haematol"},{"key":"10.1016\/j.thromres.2014.09.008_bb0060","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1016\/S0140-6736(99)06092-4","article-title":"Low-dose oral contraceptives and acquired resistance to activated protein C: a randomised cross-over study","volume":"354","author":"Rosing","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.thromres.2014.09.008_bb0065","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1160\/TH11-04-0244","article-title":"Role of protein S and tissue factor pathway inhibitor in the development of activated protein C resistance early in pregnancy in women with a history of preeclampsia","volume":"106","author":"Tchaikovski","year":"2011","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.thromres.2014.09.008_bb0070","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1177\/1076029612463426","article-title":"Comparison of the Impact of Four Generations of Progestins on Hemostatic Variables","volume":"20","author":"Oslakovic","year":"2014","journal-title":"Clin Appl Thromb Hemost"},{"key":"10.1016\/j.thromres.2014.09.008_bb0075","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.contraception.2005.09.015","article-title":"A prospective study on the effects on hemostasis of two oral contraceptives containing drospirenone in combination with either 30 or 20 microg ethinyl estradiol and a reference containing desogestrel and 30 microg ethinyl estradiol","volume":"73","author":"Kluft","year":"2006","journal-title":"Contraception"},{"key":"10.1016\/j.thromres.2014.09.008_bb0080","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.contraception.2009.08.009","article-title":"Effect of a continuous regimen of contraceptive combination of ethinylestradiol and drospirenone on lipid, carbohydrate and coagulation profiles","volume":"81","author":"Machado","year":"2010","journal-title":"Contraception"},{"key":"10.1016\/j.thromres.2014.09.008_bb0085","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.contraception.2004.12.005","article-title":"Effects of two combined oral contraceptives containing ethinyl estradiol 20 microg combined with either drospirenone or desogestrel on lipids, hemostatic parameters and carbohydrate metabolism","volume":"71","author":"Klipping","year":"2005","journal-title":"Contraception"},{"key":"10.1016\/j.thromres.2014.09.008_bb0090","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1111\/j.1538-7836.2008.02863.x","article-title":"Different effects of oral contraceptives containing different progestogens on protein S and tissue factor pathway inhibitor","volume":"6","author":"van Vliet","year":"2008","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.thromres.2014.09.008_bb0095","doi-asserted-by":"crossref","first-page":"3106","DOI":"10.1073\/pnas.0504240103","article-title":"Protein S stimulates inhibition of the tissue factor pathway by tissue factor pathway inhibitor","volume":"103","author":"Hackeng","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.thromres.2014.09.008_bb0100","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/j.1538-7836.2007.02824.x","article-title":"Coagulation factors and the protein C system as determinants of thrombin generation in a normal population","volume":"6","author":"Dielis","year":"2008","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.thromres.2014.09.008_bb0105","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1172\/JCI113721","article-title":"Inactivation of human factor VIII by activated protein C. Cofactor activity of protein S and protective effect of von Willebrand factor","volume":"82","author":"Koedam","year":"1988","journal-title":"J Clin Invest"},{"key":"10.1016\/j.thromres.2014.09.008_bb0110","doi-asserted-by":"crossref","first-page":"21130","DOI":"10.1016\/S0021-9258(19)36902-9","article-title":"Characterization of two forms of human factor Va with different cofactor activities","volume":"268","author":"Rosing","year":"1993","journal-title":"J Biol Chem"},{"key":"10.1016\/j.thromres.2014.09.008_bb0115","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1021\/bi00832a014","article-title":"Separation from Russell's viper venom of one fraction reacting with factor X and another reacting with factor V","volume":"8","author":"Schiffman","year":"1969","journal-title":"Biochemistry"},{"key":"10.1016\/j.thromres.2014.09.008_bb0120","unstructured":"Maurissen LFA. Characterisation of anticoagulant functions of protein S. PhD Thesis. Print and Copy Service Moons, Hasselt. Maastricht University, Maastricht, the Netherlands; 2009."},{"key":"10.1016\/j.thromres.2014.09.008_bb0125","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1111\/j.1538-7836.2010.03743.x","article-title":"Thrombin generation-based assays to measure the activity of the TFPI-protein S pathway in plasma from normal and protein S-deficient individuals","volume":"8","author":"Maurissen","year":"2010","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.thromres.2014.09.008_bb0130","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1160\/TH07-02-0139","article-title":"APC resistance during the normal menstrual cycle","volume":"98","author":"van Rooijen","year":"2007","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.thromres.2014.09.008_bb0135","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1055\/s-0038-1650591","article-title":"A prothrombinase-based assay for detection of resistance to activated protein C","volume":"76","author":"Nicolaes","year":"1996","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.thromres.2014.09.008_bb0140","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1159\/000071636","article-title":"Calibrated automated thrombin generation measurement in clotting plasma","volume":"33","author":"Hemker","year":"2003","journal-title":"Pathophysiol Haemost Thromb"},{"key":"10.1016\/j.thromres.2014.09.008_bb0145","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1160\/TH07-07-0439","article-title":"Effect of oral contraceptives on thrombin generation measured via calibrated automated thrombography","volume":"98","author":"Tchaikovski","year":"2007","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.thromres.2014.09.008_bb0150","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1160\/TH07-09-0581","article-title":"Influence of coagulation factors and tissue factor concentration on the thrombin generation test in plasma","volume":"99","author":"Duchemin","year":"2008","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.thromres.2014.09.008_bb0155","first-page":"551","article-title":"Heterogeneity of plasma tissue factor pathway inhibitor","volume":"5","author":"Broze","year":"1994","journal-title":"Blood Coagul Fibrinolysis"},{"key":"10.1016\/j.thromres.2014.09.008_bb0160","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/path.1871","article-title":"Tissue factor pathway inhibitor: structure, biology and involvement in disease","volume":"208","author":"Lwaleed","year":"2006","journal-title":"J Pathol"},{"key":"10.1016\/j.thromres.2014.09.008_bb0165","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1111\/j.1538-7836.2006.01896.x","article-title":"Disposition of tissue factor pathway inhibitor during cardiopulmonary bypass","volume":"4","author":"Donahue","year":"2006","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.thromres.2014.09.008_bb0170","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1177\/107602960501100308","article-title":"Hemostatic status and fibrinolytic response potential at different phases of the menstrual cycle","volume":"11","author":"Koh","year":"2005","journal-title":"Clin Appl Thromb Hemost"},{"key":"10.1016\/j.thromres.2014.09.008_bb0175","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1093\/humrep\/det092","article-title":"Endogenous thrombin potential is higher during the luteal phase than during the follicular phase of a normal menstrual cycle","volume":"28","author":"Chaireti","year":"2013","journal-title":"Hum Reprod"}],"container-title":["Thrombosis Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384814004903?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0049384814004903?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,4,17]],"date-time":"2022-04-17T04:18:36Z","timestamp":1650169116000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0049384814004903"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["S0049384814004903"],"URL":"https:\/\/doi.org\/10.1016\/j.thromres.2014.09.008","relation":{},"ISSN":["0049-3848"],"issn-type":[{"value":"0049-3848","type":"print"}],"subject":[],"published":{"date-parts":[[2014,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Changes in haemostatic parameters during the menstrual cycle and subsequent use of drospirenone-containing oral contraceptives","name":"articletitle","label":"Article Title"},{"value":"Thrombosis Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.thromres.2014.09.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}